While we have applied this approach in the specific context of COVID-19, this in vitro-in vivo translational methodology is also broadly applicable to repurposing drugs for diseases of the lower respiratory tract. (medrxiv.org)
Da für das Dipyridamol eine in vitro Hemmung der cGMP-spezifischen Phosphodiesterase 5 (PDE 5) nachgewiesen ist, wurde in dieser Arbeit untersucht, ob Dipyridamol in therapeutisch relevanten Konzentrationen die NO/cGMP vermittelte Effekte auf die Plättchenfunktion unter ex vivo Bedingungen verstärkt. (uni-wuerzburg.de)
The combination of prednisolone and the antithrombotic drug dipyridamole was profiled using in vitro and in vivo models of anti-inflammatory activity and glucocorticoid-induced adverse effects to demonstrate a dissociated activity profile. (biomedcentral.com)
The immune-specific amplification of prednisolone anti-inflammatory activity by dipyridamole did not extend to glucocorticoid-mediated adverse effects, including corticosterone suppression or increased expression of tyrosine aminotransferase, in vivo after repeat dosing in rats. (biomedcentral.com)
The valine prodrug of NU3153, NU3166, rapidly broke down to NU3153 in vitro and in vivo. (figshare.com)
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Dipyridamole inhibits phosphodiesterase (PDE) in various tissues. (guidelinecentral.com)
The cardiovascular drug dipyridamole inhibits nucleoside transport and enhances antifolate cytotoxicity in vitro, but its clinical activity is compromised by binding to the plasma protein α1-acid glycoprotein (AGP). (figshare.com)
We report the development of a novel pyrimidopyrimidine analogue of dipyridamole, NU3153, which has equivalent potency to dipyridamole, remains active in the presence of physiologic levels of AGP, inhibits thymidine incorporation into DNA, and prevents thymidine and hypoxanthine rescue from the multitargeted antifolate, pemetrexed. (figshare.com)
Adenosine2
and adenosine response curves were obtained with and without the adenosine uptake blocker, dipyridamole, and the adenosine-deaminase inhibitor, erythro-9,2-hydroxyl-3-nonyl-adenine (EHNA), in the incubation medium. (cdc.gov)
Adenosine effects were comparable in intact and epithelium stripped preparations in the absence of dipyridamole and EHNA. (cdc.gov)
Uptake1
Nucleoside uptake inhibitors, dipyridamole or 6-[(4-Nitrobenzyl)thio]-9-β-D-ribofuranosylpurine (NBTI), antagonized the inhibitory effects induced by guanosine without interfering with guanine. (unict.it)
Inhibitor3
PERSANTINE® (dipyridamole USP) is a platelet inhibitor chemically described as 2,2',2",2"'-[(4,8- Dipiperidinopyrimido[5,4- d ]pyrimidine-2,6-diyl)dinitrilo]-tetraethanol. (guidelinecentral.com)
Having previously fast-tracked this paper to publication in summary form, we now expand on why cimetidine/famotidine (histamine type-2 receptor antagonists), dipyridamole (antiplatelet agent), fenofibrate/bezafibrate (cholesterol/triglyceride-lowering agents), and sildenafil (phosphodiesterase-5 inhibitor) are worth considering for patients with COVID-19 based on their antiviral, anti-inflammatory, renoprotective, cardioprotective, and anticoagulation properties. (jmir.org)
Having recently published a short summary of our thesis [ 2 ], the current paper expands on why cimetidine or famotidine (histamine type-2 receptor antagonists), dipyridamole (antiplatelet agent), fenofibrate or bezafibrate (cholesterol/triglycerides-lowering agents), and sildenafil (phosphodiesterase-5 inhibitor) are worth considering for patients with COVID-19. (jmir.org)
Cytotoxicity1
This paper describes the effect of dipyridamole (DIP) on the cytotoxicity of cisplatin in HEp-2 human larynx cancer cells in vitro and the nature of the interaction between cisplatin and dipyridamole. (scielo.org)
Therapeutic levels2
While the inhibition of cAMP-PDE is weak, therapeutic levels of dipyridamole inhibit cyclic-3',5'-guanosine monophosphate-PDE (cGMP-PDE), thereby augmenting the increase in cGMP produced by EDRF (endothelium-derived relaxing factor, now identified as nitric oxide). (guidelinecentral.com)
Minor) In vitro studies showed that therapeutic levels of aspirin, ASA increased the plasma concentrations of free buspirone by 23% through plasma protein binding displacement. (pdr.net)
Enhances1
PURPOSE: Available evidence indicates that dipyridamole enhances the anti-thrombotic effects of aspirin for the prevention of secondary strokes. (lu.se)
Aspirin9
Here, we aimed to explore whether the anti-cancer effect of aspirin against CRC could be improved by combined administration with dipyridamole. (lu.se)
METHODS: Population-based clinical data analysis was conducted to assess a possible therapeutic effect of combined dipyridamole and aspirin treatment in inhibiting CRC compared with either monotherapy. (lu.se)
RESULTS: We found that dipyridamole combined with aspirin had a better inhibitory effect on CRC than either monotherapy alone. (lu.se)
The enhanced anti-cancer effect of the combined use of dipyridamole with aspirin was found to rely on the induction of an overwhelmed endoplasmic reticulum (ER) stress and subsequent pro-apoptotic unfolded protein response (UPR), which was different from the anti-platelet effect. (lu.se)
CONCLUSIONS: Our data indicate that the anti-cancer effect of aspirin against CRC may be enhanced by combined administration with dipyridamole. (lu.se)
Post-Marketing Experience The following is a list of additional adverse reactions that have been reported either in the literature or are from post-marketing spontaneous reports for either dipyridamole or aspirin. (ngt.co.id)
Combinations of dipyridamole and aspirin have not been evaluated for effects on fertility and reproductive performance. (ngt.co.id)
Reproduction studies with dipyridamole in mice, rabbits, and rats have revealed no evidence of harm to the fetus up to doses about 25 times the maximum recommended daily human dose of aspirin-dipyridamole. (ngt.co.id)
Nonclinical data are suggestive of a possible potentiation of aspirin-related fetal toxicity when combined with dipyridamole see Data. (ngt.co.id)
Inhibition1
Plasma NU3153 concentrations commensurate with rescue inhibition in vitro were maintained for at least 16 hours following administration of NU3166 to mice at 120 mg/kg. (figshare.com)
Dissolution3
Our in vitro tool IDAS is a dissolution vessel, which uses the Caco-2 colon carcinoma cell line as the biorelevant barrier to evaluate the dissolution and permeation of new drug compounds simultaneously. (absorption.com)
Data for the Class II drug dipyridamole (with limited solubility at neutral pH) and the Class I drug minoxidil (with high solubility throughout the physiological pH range) show that the dissolution and permeation of dipyridamole significantly increases in the two-stage setup. (absorption.com)
However, in-vitro comparative dissolution profile (CDP) study between the test and reference product need to be conducted to prove similarity. (npra.gov.my)
Mechanism1
These data suggest that the multi-target mechanism of low-dose prednisolone and dipyridamole creates a dissociated activity profile with an increased therapeutic window through cellular network selective amplification of glucocorticoid-mediated anti-inflammatory signaling. (biomedcentral.com)
Spontaneous1
Spontaneous and neurally-evoked mechanical activity was recorded in vitro as changes in isometric tension in circular muscle strips from mouse distal colon. (unict.it)
Weak1
And some weak base drugs such as dipyridamole (see below) maintain higher dissolved concentrations, even after the switch to pH 6.5, and correspondingly higher permeation, in the pH shift protocol compared to FaSSIF (pH 6.5) without the initial low-pH stage. (absorption.com)
Produces2
Hypotension Dipyridamole produces peripheral Köp Aggrenox Utan Rx, which can exacerbate pre-existing hypotension. (ngt.co.id)
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Data1
As a result, a wealth of in vitro candidate validation data is available, and some of these drugs have already been tested in COVID-19 patients. (medrxiv.org)
Effects2
The in vitro effects of the drugs on CRC cells were tested using CCK8 and flow cytometry assays. (lu.se)
Similar effects were observed following intravenous dipyridamole in doses ranging from 0.025 to 2.0 mg/kg. (guidelinecentral.com)
Occurs1
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Cells3
Additionally, amplification was not observed in the cellular network of corticotroph AtT-20/D16v-F2 cells in vitro , as measured by pro-opiomelanocortin expression and adrenocorticotropic hormone secretion. (biomedcentral.com)
XPOT knockdown inhibited TNBC cell proliferation in vitro, and RNA-seq indicated that XPOT is involved in the completion of cytokinesis in TNBC cells. (bvsalud.org)
One of them is in vitro endothelialization, i.e. colonization of the prosthesis with the patient's cells before the implantation procedure. (biomedcentral.com)
Administration2
However, acute intravenous administration of dipyridamole may worsen regional myocardial perfusion distal to partial occlusion of coronary arteries. (guidelinecentral.com)
especially the systemic, as indicated by the reduced levels of CRP(33).administration and relative cost.rio IIEF (â œInternational Index of Erectile Functionâ) on the dis-taken for inhalation gives rise to dipyridamole, equally selective forStudies, ahead in time, on a large population but the Frequency of ed (erectile dysfunction) in Italy. (icte.at)
Coupon1
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Price1
Because some herpes symptoms have a tendency to be discreet yet highly contagious, pharmacy dipyridamole price buy dipyridamole united states dipyridamole com ordered online no prescription buying dipyridamole over counter uk this drink comes with an added bonus: no prescription dipyridamole florida type 2 diabetes and certain types of cancer are directly linked to obesity. (radiobiblioteka.ru)
Hours1
In these trials, the coumarin anticoagulant was begun between 24 hours and 4 days postoperatively, and the Persantine® (dipyridamole USP) tablets were begun between 24 hours and 10 days postoperatively. (guidelinecentral.com)
Antithrombotic drug dipyridamole1
Secondary assays demonstrated that one of the hits, the antithrombotic drug dipyridamole, enhances Abl kinase activity in vitro to a greater extent than the previously described Abl agonist, DPH. (aacrjournals.org)
Multidrug1
Tafenoquine inhibits organic cation transporter-2 (OCT2) and multidrug and toxin extrusion (MATE) transporters in vitro. (medscape.com)
Therapeutic2
These data suggest that the multi-target mechanism of low-dose prednisolone and dipyridamole creates a dissociated activity profile with an increased therapeutic window through cellular network selective amplification of glucocorticoid-mediated anti-inflammatory signaling. (biomedcentral.com)
When therapeutic concentrations of furosemide, propranolol, dipyridamole, warfarin, quinidine or naproxen were added to human plasma (in vitro), the plasma protein binding of CARDENE was not altered. (druglib.com)
Effectively2
These highlights do not include all the information needed to use ASPIRIN AND EXTENDED-RELEASE DIPYRIDAMOLE CAPSULES safely and effectively. (nih.gov)
Its guna salep voltaren is and effectively to Dipyridamole may also album that caters sexually harassment by. (quicklase.com)
Activity1
In vitro it showed activity against Legionella pneumophila, Mycoplasma pneumoia Ø hominis, Helicobacter pylori, Toxoplasma gondii, Ureaplasma urealiticum. (us.org)
Human1
In addition, an experiment conducted in vitro using human CRC cell observed that sildenafil could inhibit metastases by restoring the cytotoxicity of MDSCs-dependent inhibition of NK cell 22 . (nature.com)
Patients1
Although preliminary hemodynamic studies in patients with congestive heart failure have shown that CARDENE reduced afterload without impairing myocardial contractility, it has a negative inotropic effect in vitro and in some patients. (druglib.com)
Model2
They also prevented cyst growth in an in vitro renal epithelial cell model of polycystic kidney disease. (biongenex.com)
It may also increases in interval in vitro model administration of alcohol in the mail. (quicklase.com)
Effect2
The effect of food on the dissolution of vericiguat was evaluated in vitro using media simulating the gastrointestinal tract under fed and fasted conditions. (springeropen.com)
Specific solubility factors, obtained from the in vitro measurements, were implemented to account for the effect of ethanol on the solubility of the investigated compounds. (pparsignaling.com)
Study1
However, since the gastric solubility was measured in this study, both gastric and intestinal in vitro values were used as input in the simulations. (pparsignaling.com)
Intact1
In vitro dissolution of intact vs crushed vericiguat tablet was assessed in quality control medium (HCl at pH 2), acetate buffer at pH 4.5, and phosphate buffer at pH 6.8. (springeropen.com)
Food1
Aspirin and extended-release dipyridamole capsules can be administered with or without food. (nih.gov)