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  • vivo and in vitro
  • Studies in the past have indicated that Mechano-growth factor, an alternatively spliced variant of insulin-like growth factor 1 (IGF-1), is found to function independently from the rest of the molecule and demonstrated a neuroprotective effect in vivo and in vitro and the C-terminal peptide (MGF) has the potential to be developed into a therapeutic modality for the prevention of neuronal damage. (isteroids.com)
  • Investigators established in vivo and in vitro models to investigate the role of αB-Crystallin and assess the ability of aspirin to protect the myocardium during prolonged heat stress. (musclecellnews.com)
  • inhibit
  • The fact that use of IGF-1 is closely associated with burning of fat as a source of energy and it has the ability to inhibit insulin from transporting glucose across cell membranes means that it is an exceptional choice for sportsmen and bodybuilders who bridge between cycles. (isteroids.com)
  • neonatal
  • In this paper, we isolated cardiac progenitors from neonatal β-sarcoglycan ( Sgcb )-null mouse hearts affected by dilated cardiomyopathy. (rupress.org)
  • basal
  • Populations of primary pMEC were then separated by FACS using markers to distinguish epithelial cells (CD140a-) from stromal cells (CD140a+), with or without further enrichment for basal and luminal progenitor cells (CD49f+). (biomedcentral.com)
  • fibroblasts
  • Using lineage tracing, murine models of heart calcification and in vivo transplantation assays, investigators showed that cardiac fibroblasts adopt an osteoblast cell-like fate and contribute directly to heart muscle calcification. (musclecellnews.com)
  • quiescent
  • In resting muscle, these quiescent mononuclear cells express the paired box transcription factor Pax7 and, in some muscle types, Pax3. (physiology.org)
  • Recently, it has been shown that Id3 is expressed in quiescent satellite cells, and it has been proposed that it is a direct transcriptional target of Pax7, suggesting Id3 may be involved directly in the maintenance of the quiescent state ( 27 ). (physiology.org)
  • myofibers
  • In the absence of Syndecan-3, satellite cells stall in S phase, leading to reduced proliferation, increased cell death, delayed onset of differentiation, and markedly reduced numbers of Pax7 + satellite cells accompanied by myofiber hypertrophy and an increased number of centrally nucleated myofibers. (rupress.org)
  • They further examined the impact of genetic modulation of NF-κB signaling in muscle satellite cells or myofibers on recovery after damage. (musclecellnews.com)
  • Inflammation also plays a determinant role in the process, as upon injuring macrophages are attracted by the damaged myofibers and the activated satellite cells and act as key elements of dynamic muscle supportive stroma. (unipd.it)
  • Experiments with satellite cells mechanically isolated from suspensions of single myofibers also showed that mMCM inhibited their mesenchimal potential towards adipogenesis. (unipd.it)
  • respectively
  • C2C12 and A204 cells were cultured in Dulbecco's modified Eagle's Medium (DMEM) and McCoy's 5A (Modified) medium, respectively, each with 10% fetal bovine serum (FBS). (ijbs.com)
  • Primary mouse ASMCs were cultured with or without ACh treatment, then cell viability, TRPC3 expression, nonselective cation channel currents and [Ca 2+ ] i changes were examined by MTT assay, cell counting, Western blotting, standard whole-cell patch clamp recording and calcium imaging, respectively. (musclecellnews.com)
  • epithelial cells
  • In light of these results were developed two experimental models, an animal model of Barrett's esophagus and a crop of primary esophageal epithelial cells. (unipd.it)
  • Here we sought to establish a model for the efficient manipulation and transformation of porcine mammary epithelial cells (pMEC) in vitro and tumor growth in vivo . (biomedcentral.com)
  • suggests
  • This finding reveals an added level of complexity in the mechanism of the fate choice of mesoderm progenitors and suggests that using endogenous cardiac stem cells therapeutically will require specially tailored procedures for certain genetic diseases. (rupress.org)
  • increases
  • Up-regulation of miR-146a increases the sensitivity of non-small cell lung cancer to DDP by downregulating cyclin J. BMC Cancer 17:138 (2017). (abcam.com)
  • pathway
  • We show, for the first time, that CLB induces cell cycle arrest by repressing p27 degradation, via a pathway that depends on β 2 -AR and β-arrestin 2. (ijbs.com)
  • Therefore, the response of stem cells to the β-catenin pathway is cell-type specific. (biologists.org)
  • transcription
  • β-Catenin then translocates to the nucleus and induces target gene expression together with transcription factors of the T cell factor/lymphoid enhancer factor (TCF/LEF) family. (biologists.org)
  • tissue
  • In this review, we mainly summarize the structure, tissue distribution, and signal transduction of MSTN and explore the role of MSTN in the adipogenesis of preadipocytes, multipotent stem cells and transgenic animals in mammals. (biomedcentral.com)
  • When it comes to stimulating cell growth and promoting normal and balanced growth and development of muscle, cartilage, bone, liver, kidney, skin tissue, lungs, and nerves, there is hardly anything as potent as Insulin-like Growth Factor 1 or IGF-1. (isteroids.com)
  • The CeAbs identified in various types of cancer have been identified as a potential cause of the loss of cell and tissue and as a possible source of instability (nucleation and disruption in the organization of microtubules, incorrect segregation of chromosomes resulting in aneuploidy). (unipd.it)