Vitro study. Medical search. Frequent questions

In vitro and in vivo studies. (aspetjournals.org)
Toxicological in vivo studies revealed high toxicity in mice after intraperitoneal administration (LD50~μg/Kg), whilst very low toxicity (no lethality) was found after acute or repeated oral administration. (units.it)
Results obtained from this study correspond with those from our previous in vivo studies, indicating that the increase in inflammatory mediators occur without associated membrane damage. (cdc.gov)

The thermal, thermo-mechanical, and shape memory properties of thermoplastic polyurethane were studied by means of differential scanning calorimetry (DSC), dynamic mechanical analysis (DMA), and various practical experiments. (mdpi.com)
Five in vitro experiments were performed. (ajnr.org)
The experiments indicate that the cell lines may not discriminate between the surface chemistry and topography of the metals used in the study. (ucl.ac.uk)
Additionally, in-vitro experiments, indicated that OEO/thymol interacts with DNA via minor grooves confirmed by docking method. (irost.org)
Studying this toxin is limited by its non-commercial supply: YTX needed for this experiments was a kind gift of Professor T. Yasumoto. (units.it)
The pattern of ciliary polypeptides labeled in vivo was similar to that observed in the in vitro experiments, although the relative intensities of labeling differed. (rupress.org)
The Latin term in vitro, meaning "in glass", is used because early biological experiments involving cultivation of tissues outside the living organism were carried out in glass containers, such as beakers, test tubes, or Petri dishes. (wikipedia.org)

The extent of ATP-hydrolysis in vitro may also be a useful parameter for in vivo prediction, particularly for eliminating P-gp substrates in high-throughput screening procedures. (nih.gov)
This in vitro study investigated the effects of implant material composition and surface roughness on the early behaviour of three transformed human osteoblast-like cell lines, MG-63, HOS and U-2 OS, cultured on commercially pure titanium and zirconium substrates of different surface roughness. (ucl.ac.uk)
Endogenous protein substrates for in vitro and in vivo phosphorylation in cilia and ciliary membranes. (rupress.org)

This study investigated the effects of EO on the main GABAergic targets for anticonvulsant drugs, analyzing the effect on the GABA receptor's benzodiazepine and picrotoxinin binding sites and the GABA uptake. (hindawi.com)
Concentration-dependent uptake studies reveal more than one taurine carrier in taut+ and taut- strains. (jci.org)
The former leads to high uptake ratios in vitro, the latter to high clearance rates in vivo. (jci.org)

Radiosensitisation caused by titanium dioxide nanoparticles (TiO 2 -NPs) is investigated using phantoms (PRESAGE ® dosimeters) and in vitro using two types of cell lines, cultured human keratinocyte (HaCaT) and prostate cancer (DU145) cells. (medsci.org)
Comparable levels of radiosensitisation were observed in both phantoms and cells at kilovoltage ranges of x-ray energies (slightly higher in vitro) . (medsci.org)

This study explores the experiences of women in South Africa who are involuntary childless and explores their psychological and emotional experiences of In Vitro Fertilisation and Embryo Transfer (IVF-ET). (scirp.org)
Today, the scientific term "in vitro" is used to refer to any biological procedure that is performed outside the organism in which it would normally have occurred, to distinguish it from an in vivo procedure (such as in vivo fertilisation), where the tissue remains inside the living organism in which it is normally found. (wikipedia.org)

In vitro anti-inflammatory activity of S. argentea was confirmed by inhibition of egg albumin denaturation and erythrocyte membrane stabilizing methods. (banglajol.info)

Six behavioral mutants of Paramecium, known to have defects in the excitable membrane that regulates the ciliary beat, showed normal patterns of ciliary protein phosphorylation in vitro, with and without added cyclic nucleotides, at both pH 6.0 and pH 8.0. (rupress.org)

The development of a protocol for the routine continuous in vitro culture of Plasmodium falciparum in 1976 1 released malaria researcher from the reliance on in vivo observations. (nature.com)
1976. The in vitro effect of zinc on the inhibition of human *-aminolevulinic acid dehydratase by lead. (cdc.gov)

After isolation and amplification of several strains of XP-C keratinocytes and fibroblasts, a three-dimensional skin model in vitro comprising both epidermis and a dermal equivalent could be obtained. (bioone.org)

Considering that PTZ blocks the chloride channel coupled to the GABA A receptor complex, the present study aimed to analyze the possible modulation of GABAergic homeostasis within synaptic clefts in vitro . (hindawi.com)
A number of electrophysiological techniques have been employed to study synaptic function in the rat hippocampal slice preparation. (soton.ac.uk)

Qualitative and quantitative analyses of the rare phenotypic variants in in vitro culture systems is necessary for the understanding of cell differentiation in cell culture of primary cells or cell lines. (nih.gov)

The current study emphasizes the pharmacological investigations of n -hexane, chloroform and aqueous soluble fractions of ethanol extract of leaves of S. argentea to justify the traditional uses of this plant species in Bangladesh. (banglajol.info)
It contains descriptions and evaluations of studies and presents levels of significant exposure for pyridine based on toxicological studies and epidemiological investigations. (cdc.gov)

Slide-based cytometry combines image acquisition and data treatment, and associates the power of flow cytometry (FCM) and the resolution of the microscopic studies making it suitable for the analysis of cells with rare phenotype. (nih.gov)
An in vitro electron microscopic study of human blood was performed to elucidate the role that electrothrombosis might play in triggering the biologic response of thrombosis of the aneurysmal sac. (ajnr.org)
Electron microscopic studies were performed on GDCs that had been electrically charged and on GDCs that had not. (ajnr.org)
All electron microscopic studies revealed that the electrically charged GDCs were covered by blood elements and fibrin adherent to the surface of the coil. (ajnr.org)
Using human blood, an in vitro scanning electron microscopic (SEM) study was performed to elucidate the role of electrothrombosis in the treatment of aneurysms. (ajnr.org)

The capability of cell-penetrating peptides (CPPs) to transport cargos over different cellular membranes both in vitro and in vivo have drawn major attention in the past decade. (avhandlingar.se)

There's so much one can learn from the waste product that microbiologist Aadra Bhatt at the University of North Carolina at Chapel Hill decided there should be a word for that research - something in the same vein as "in vivo" (research done in living animals) and "in vitro" (research done in a petri dish). (sciencenews.org)

In the previous study, four doses of clarified açaí juice (10 μ l/g body weight, equivalent to approximately 700 ml/day for a person weighing 70 kg) were sufficient to significantly protect against PTZ-induced seizures and seizure-related oxidative stress in mice [ 2 ]. (hindawi.com)
Localization of the membrane defect in transepithelial transport of taurine by parallel studies in vivo and in vitro in hypertaurinuric mice. (jci.org)
The test materials were subjected to evaluate for the anti-diabetic activity by both in vitro starch iodine method as well as by oral glucose tolerance test in Swiss albino mice. (banglajol.info)
Salutary effects of adiponectin on colon cancer: in vivo and in vitro studies in mice. (nuthealth.org)

New Aspects in Physiological Antitumor SubstancesExperimental and Clinical Studies with Xenogeneic Peptides and Proteins1st Oncology Workshop of the Soc. (karger.com)
Experimental and Clinical Studies with Xenogeneic Peptides and Proteins1st Oncology Workshop of the Soc. (karger.com)

In vivo and in vitro experimental study on the effect of fluoride-induced autophagy in rat HAT-7 cell line]. (fluoridealert.org)

Thus, both the ability of antitumor drugs to kill tumor cells and their effects on immune function and normal tissue cells should be studied. (hindawi.com)
The aim of this study was to determinate the effect of different chemotherapy protocols used in the clinic on tumor stem cell markers in vitro . (isciii.es)
Tenacigenin B had anti-tumor effects on lymphoma via regulation of Aurora-A in vitro and in vivo . (medscimonit.com)
A preliminary in vitro experiment was accomplished, using a 169 Er-PSMA-617, to show the potential of 169 Er to reduce tumor cell viability. (frontiersin.org)

Belfroid, AC & Jonas, AJG 2000, Toxicity bioscreening of waste water samples with in vitro bioassays: results of the pilot study OVOC . (vu.nl)
This study investigated the inhalation toxicity of the emissions from 3-D printing with acrylonitrile butadiene styrene (ABS) filament using an air-liquid interface (ALI) in vitro model. (cdc.gov)
Animal studies are insufficient with respect to reproductive toxicity (see section 5.3). (janusinfo.se)

In vitro exposure of human lymphocytes to 900 MHz CW and GSM modulated radiofrequency: studies of proliferation, apoptosis and mitochondrial membrane potential med. (emf-portal.org)
Are there additional studies or data characterizing exposure to RCF which should be included? (cdc.gov)
1999. Bioindicator and exposure data for a population based study of manganese. (cdc.gov)
The points in the figures showing noobserved-adverse-effect levels (NOAELs) or lowest- observed-adverse-effect levels (LOAELs) reflect the actual doses (levels of exposure) used in the studies. (cdc.gov)
No studies were located regarding death in humans after inhalation exposure to pyridine. (cdc.gov)
There are limited studies regarding neurological effects in humans after inhalation exposure to pyridine. (cdc.gov)

The findings of this study suggest the need for the incorporation of a mandatory psychosocial intervention as part of infertility management. (scirp.org)
This in vitro study was inspired by the histologic and SEM findings in a patient with subarachnoid hemorrhage who died 16 h after GDC treatment of a basilar tip aneurysm. (ajnr.org)
These findings prompted us to perform in vitro studies to assess the effect of the electric current on the platinum portion of GDCs. (ajnr.org)
The in vitro findings, presented ahead of publication at the 7th International Conference on Polyphenols and Health in late October in France, found Vitis vinifera L. extracts supplied by Italian botanicals giant Indena reduced effects of gastrointestinal inflammation via reduced pro-inflammatory signaling protein cytokine activity (Il-8). (nutraingredients.com)

As an in vitro method, the transcellular transport of 12 compounds across the monolayer of Caco-2- and MDR1-transfected cells was examined. (nih.gov)
Collectively, the in vitro flux ratio across monolayers of P-gp-expressing cells may be used to predict in vivo P-gp function. (nih.gov)
In this work, in vitro systems, including stable cells lines with estrogen induced green fluorescence protein (GFP) expression and micro cell culture analog (microCCA) devices, were developed to study EDs. (cornell.edu)
In this paper we develop a method that applies these principles to a particularly hot problem in cell biology, the study of stem cell like cells in cultures of primary cells, cancer cells, and various cell lines. (nih.gov)
Molecular docking studies indicated that all three complexes primarily bind to HSA in subdomain IIA with amino acid residues such as Arg218 and Lys199 which are located at the entrance of Sudlow's site I. The in vitro cytotoxicities of complexes 1-3 against HeLa cells showed promising anticancer activity (IC 50 = 3.5, 3.9 and 16.9 μM for 1 , 2 and 3 , respectively). (rsc.org)
When dissociated, they can be co-cultured with SC-like adipose-derived stem cells (ASC), providing a valuable model to study in vitro nerve regeneration and myelination, mimicking the in vivo environment at the injury site. (jove.com)
Short-term in vitro studies have shown that bone cells react more favourably to rough substrate surfaces than to smooth ones. (ucl.ac.uk)
Immunofluorescence studies detected no marked variation in the integrin subunit expression and organisation of the cytoskeletal network of the cells. (ucl.ac.uk)
The translocation of CPPs into plant protoplasts might open up a new method for transformation of plant cells.Next, the cell-penetrating ability of the novel peptide YTA2 was characterized and it was established that chemical coupling between YTA2 and the protein cargo is not needed for the transport of the cargo over the cellular membrane in vitro. (avhandlingar.se)
Both, PEGA-pVEC and CREKA-pVEC were taken up by different breast cancer cells in vitro. (avhandlingar.se)
Their research was confined to cells - in vitro, not in vivo. (techstartups.com)
This study was performed on neonatal rat cardiomyocytes to study toxin effects on various fundamental aspects of cardiac muscle cells activity: cell beating, intracellular Ca2+ and cAMP levels, cell vitality, mitochondrial membrane potential and type of cell death occurrence. (units.it)
To study the nonthermal effects of radiofrequency fields on human immune cells ( peripheral blood mononuclear cells ) exposed to a Global System for Mobile Communication ( GSM ) signal generated by a commercial cellular phone and by a sinusoidal non- modulated signal ( continuous wave ). (emf-portal.org)

2003). Notwithstanding many in vitro studies highlighted numerous intracellular targets, YTX mechanism of action is unclear and the effects on the cardiac functional properties remain unknown. (units.it)
In this study, an electromagnetic isotope separation technique was applied after neutron irradiation to boost the specific activity by separating 169 Er from 168 Er targets. (frontiersin.org)

To this aim, in this work an in vitro generation of M. tuberculosis mutants resistant to BDQ was performed starting from two MDR clinical isolates as parental cultures. (frontiersin.org)
These BDQ resistant mutants were further characterized by studying their growth rate that could be related to their spreading in clinical settings. (frontiersin.org)
Since Usutu virus was of minor clinical importance until its emergence in central Europe, its biologic features, host spectrum, and pathogenesis had not previously been studied. (cdc.gov)
The quality of the 169 Er product permitted radiolabeling and pre-clinical studies. (frontiersin.org)
One of the most intriguing features of the radiolanthanides, other than having promising physical decay properties, is that they have similar chemical characteristics, and analogous coordination chemistry, which allows one to perform comparative pre-clinical studies. (frontiersin.org)

To assess, in vitro , variables potentially influencing implant blooming using a human -like imaging phantom and 3D-printed mandibles . (bvsalud.org)

Cytogenetic damage induced by mouthrinses formulations in vivo and in vitro. (aaem.pl)
The aim of the present study was to compare the antibacterial effects of coffee extract with those of 0.2% sodium fluoride and chlorhexidine (CHX) mouthrinses on Streptococcus mutans and Lactobacillus plantarum in vitro. (magiran.com)

The root of the development is to supply a flexible in vitro tool that can bring us closer to the real human body and patient's specific conditions, where physicians can test in a safe environment, the best treatment approach. (ni.com)
C(H)-C 6 H 4 OH- o , o -phen = 1,10-phenanthroline, and OAc = CH 3 COO − ) with human serum albumin (HSA) was studied using fluorescence quenching, synchronous and 3D fluorescence measurements and UV-vis spectroscopy. (rsc.org)
The high potency of Ro 25-1553 extends to studies on isolated, histamine-contracted, human bronchial smooth muscle, where Ro 25-1553 exhibits a 390-fold enhancement over native VIP and is more potent than other bronchodilating drugs, such as the beta 2-adrenoceptor agonists isoproterenol and salbutamol. (aspetjournals.org)
In vitro, it was found that adiponectin directly controls malignant potential (cell proliferation, adhesion, invasion and colony formation) and regulates metabolic (AMPK/S6), inflammatory (STAT3/VEGF) and cell cycle (p21/p27/p53/cyclins) signalling pathways in both mouse MCA38 and human HT29, HCT116 and LoVo colon cancer cell lines in a LKB1-dependent way. (nuthealth.org)
No studies on the effects on human fertility have been conducted. (janusinfo.se)

The impact of implant-related characteristics on dental implant blooming: An in vitro study. (bvsalud.org)

relative mRNA expression was evaluated by real-time polymerase chain reaction (RT-PCR), and relative protein expressions were measured by western blot assay in an in vitro study. (medscimonit.com)
During their study, the two scientists found that the spike protein appeared to interfere with our own DNA repair proteins: "Mechanistically, we found that the spike protein localizes in the nucleus and inhibits DNA damage repair by impeding key DNA repair protein BRCA1 and 53BP1 recruitment to the damage site. (techstartups.com)
The endogenous protein kinases of isolated Paramecium tetraurelia cilia phosphorylated approximately 30 ciliary polypeptides in vitro. (rupress.org)

PURPOSE: To study the effect of fluoride on autophagy in rat ameloblasts both in vitro and in vivo. (fluoridealert.org)
CONCLUSIONS: Excessive fluoride induced autophagy in ameloblasts both in vitro and in vivo. (fluoridealert.org)
In this experimental in vitro study, the minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and disk diffusion method were determined for different concentrations of coffee extract, 0.2% CHX, and 0.2% fluoride against S. mutans and L. plantrum. (magiran.com)

Furthermore, immunoblotting studies revealed the activation of intrinsic and maybe extrinsic apoptosis pathways by OEO/thymol. (irost.org)

In order to enable a comparison between the in vitro and in vivo measurements, systematic measurements should be carried out where the flow rate in the channel can be both controlled and optically measured. (utwente.nl)

The results indicate the potential use of PDMS microCCA devices to study EDs. (cornell.edu)
The results of the study indicated that the women perceived themselves as not conforming to a dominant belief system and as a result felt compelled to explore all the medical options available. (scirp.org)
These results show a very cell-specific response to YTX if compared to previous studies, and a severe damage to in vitro cardiomyocytes. (units.it)
Title : Urinary Phthalate Metabolite Concentrations and Reproductive Outcomes among Women Undergoing in Vitro Fertilization: Results from the EARTH Study Personal Author(s) : Hauser, Russ;Gaskins, Audrey J.;Souter, Irene;Smith, Kristen W.;Dodge, Laura E.;Ehrlich, Shelley;Meeker, John D.;Calafat, Antonia M.;Williams, Paige L. (cdc.gov)

Radial and median nerve conduction velocities in workers exposed to lead, copper, and zinc: A follow-up study for 2 years. (cdc.gov)
Assessment of the effects of occupational and environmental factors on all faster and slower large myelinated nerve fibers: A study of the distribution of nerve conduction velocities. (cdc.gov)

Comment on any additional information that should be included regarding the Maximum Tolerated Dose discussion in the rat chronic inhalation study. (cdc.gov)

TY - JOUR T1 - Benzimidazoles as new scaffold of sirtuin inhibitors: green synthesis, in vitro studies, molecular docking analysis and evaluation of their anti-cancer properties. (unboundmedicine.com)

In conclusion, reconstruction of XP skin in vitro provides a very promising system to study genetic hyperphotosensitivity and opens a rational perspective to XP tissue therapy. (bioone.org)
Conclusion: These new mechanistic and pathophysiology studies provide evidence for an important role of adiponectin in colon cancer. (nuthealth.org)

The aim of this study was to investigate the in vitro antitumor effects of Nidus Vespae on gastric cancer and its ability to promote immune function. (hindawi.com)
The aim of this study was to examine the effects and mechanisms of tenacigenin B in lymphoma treatment by in vitro and in vivo experiment. (medscimonit.com)
No previous studies have directly investigated the mechanistic effects of adiponectin on colon cancer in the settings of obesity, a high-fat diet and/or adiponectin deficiency. (nuthealth.org)
Recently, some studies have been performed on biological effects of Oliveria essential oil (OEO). (irost.org)
No studies on the effects on the ability to drive and use machines have been performed. (janusinfo.se)

Anatase TiO 2 -NPs were synthesised, characterised and functionalised to allow dispersion in culture-medium for in vitro studies and halocarbons (PRESAGE ® chemical compositions). (medsci.org)
PANsys 3000 is a multi-system fully-automated cell culture device used for in vitro culture and to study a variety of cell lines under conditions similar to in vivo . (aaem.pl)
Here, we define the conditions under which P. cynomolgi can be adapted to long term in vitro culture to yield parasites that share many of the morphological and phenotypic features of P. vivax . (nature.com)

A Model to Study Hypersensitivity to UV Light," Photochemistry and Photobiology 81(1), 19-24, (1 January 2005). (bioone.org)

Epidemiological studies of occupational cancer as related to complex mixtures of trace elements. (cdc.gov)

The potent smooth muscle relaxant activity exhibited in vitro by Ro 25-1553 is also evident after in vivo intratracheal administration or aerosolization of the compound. (aspetjournals.org)

However, research on P. vivax remains severely hampered because, to date, attempts to maintain this parasite in routine in vitro blood cultures have been hindered by the strict restriction to invasion of reticulocytes, a minor short-lived fraction of peripheral blood. (nature.com)

A dual cell-line GFP expression system was constructed to study EDs with activities as estrogen receptor agonists or antagonists. (cornell.edu)
The second project was an extracellular electrophysiological study of CA1 pyramidal cell region in the slice. (soton.ac.uk)
Cell attachment, proliferation and differentiation were studied using enzyme-linked immunosorbant assays, and immunofluorescence microscopy was used to detect integrin subunits and cytoskeletal arrangement 24 h after cellular attachment. (ucl.ac.uk)
We investigated the in vitro susceptibility of various cell cultures and embryonated eggs to Usutu virus infection. (cdc.gov)
In-vitro evaluation of apoptotic effect of OEO and thymol in 2D and 3D cell cultures and the study of their interaction mode with DNA. (irost.org)

Studies have shown that upon irradiation, anatase TiO 2 -NPs generate free radicals that facilitate the spontaneous generation of reactive oxygen species (ROS), which can damage nucleic acids (e.g. (medsci.org)

Enzyme-linked immunosorbent assay was used to detect cytokine production, and multicolor flow cytometry was used to study the phenotype and functionality of THP-1 DCs. (hindawi.com)

This does not necessarily mean that the result of Vitro studies translates "irectly to what would happen in the much more complex biological environment of the body. (techstartups.com)

White wine extract shows gastro benefits in vitro. (nutraingredients.com)

The aim of our work was the study of the interaction of three red wine polyphenols-quercetin, resveratrol and caffeic acid-alone and in their equimolar binary and ternary mixtures in different antioxidant/scavenging assays (inhibition of 2-deoxy-D-ribose degradation by hydroxyl radical, FRAP, Fe(III) reducing power, DPPH, ABTS and NO scavenging, respectively). (mdpi.com)

A 2019 study that explores 10 adjuncts with IVF (screening hysteroscopy, DHEA, testosterone, GH, aspirin, heparin, antioxidants in males and females, seminal plasma and PRP) suggests that until more evidence is done to show that these adjuncts are safe and effective, they should be avoided. (wikipedia.org)

Thanks to their multiple mechanism of action, dietary polyphenols are extensively recognised to have a potential role in the protection from chronic conditions and several studies already reported their possible role in modulating challenging processes at gastrointestinal level. (nutraingredients.com)

The girl, named Durga, was conceived in vitro using a method developed independently by Subhash Mukhopadhyay, a physician and researcher from Kolkata. (wikipedia.org)

To better understand the spreading of BDQ resistance in MDR- and XDR-TB, in vitro studies could be a valuable tool. (frontiersin.org)

Anatomy33

Organisms21

Diseases9

Chemicals and Drugs84

Analytical, Diagnostic and Therapeutic Techniques and Equipment61

Phenomena and Processes44

Disciplines and Occupations1

Technology, Industry, Agriculture39

Information Science4

Health Care3

Vivo studies3

Experiments7

Substrates3

Uptake3

Phantoms2

Fertilisation2

Methods1

Cyclic1

19762

Keratinocytes1

Synaptic2

Variants1

Investigations2

Microscopic5

Membranes1

Petri1

Mice4

Peptides2

Experimental study1

Tumor4

Toxicity3

Exposure6

Findings4

Cells13

Targets2

Clinical5

Assess1

Mouthrinses2

Human5

Implant1

Protein3

Fluoride3

Apoptosis1

Systematic1

Results4

Nerve2

Inhalation1

Molecular1

Conclusion2

Effects5

Culture3

Model1

Epidemiological1

Activity1

Research1

Cell5

Species1

Flow cytometry1

Biological1

Extract1

Mixtures1

Explores1

Gastrointestinal1

Method1

Tool1