AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth CareGeographicals
Schistosoma mansoniSchistosomiasis mansoniBiomphalariaSchistosomiasisSchistosomaSchistosoma haematobiumAntigens, HelminthParasite Egg CountPraziquantelOxamniquineAntibodies, HelminthSchistosomicidesHelminth ProteinsAnthelminticsLiver Diseases, ParasiticDNA, HelminthSchistosomiasis haematobiaSchistosomiasis japonicaSnailsGranulomaDisease VectorsOvumHost-Parasite InteractionsCercariaLung Diseases, ParasiticNeuroschistosomiasisGenome, HelminthFecesEchinostomaMolluscacidesBulinusHepatomegalyCote d'IvoireHycanthoneLife Cycle StagesAntiplatyhelmintic AgentsEgyptGenes, HelminthBrazilSchistosoma japonicumAncylostomatoideaParasitologyHelminthiasisHookworm InfectionsHelminthsVaccinesWest IndiesMice, Inbred CBALarvaSplenic DiseasesSenegalSplenomegalyEndemic DiseasesGranuloma, Respiratory TractMolecular Sequence DataHemocytesSudanTh2 CellsFasciola hepaticaIntestinal Diseases, ParasiticSchistosomatidaeRNA, HelminthUgandaKenyaOocystsParasite LoadFatty Acid Transport ProteinsNitroquinolinesImmunoglobulin EImmunoglobulin IsotypesEosinophilsPlasma Cell Granuloma, PulmonaryImmunoglobulin GNiclosamidePrevalenceAntigens, CD15Amino Acid SequenceHemolymphUrine
VivoSchistosomulaHaematobiumInfectionJaponicumWormsSchistosomicidalSchistosomiasis mansoniSolubleAntigensIntestinalImmuneParasitePlasmodiumMekongiEfficacyFasciolaInfestationSpeciesInflammationParasiticIncubationAntigenMacrophagesViabilityInterleukinInducesRecombinantAntischistosomalVaccineAdultsSchistosomeEggsStagesDrugMiceAcquisitionStudyFieldTestsResearchDevelopmentEffect
Vivo16
  • However, they might play a role in the infection in vivo via the modulation of the host immune response or secretory molecules from S. mansoni. (bvsalud.org)
  • To the best of our knowledge , this is the first study to investigate the direct effect of galectins on S. mansoni and helps in understanding the roles of galectins in S. mansoni infection in vivo. (bvsalud.org)
  • Despite its use in folk medicine, there is a lack of data regarding its in vivo/in vitro cytotoxic/genotoxic and clastogenic effects. (scite.ai)
  • oil (APMO) in vitro and in vivo. (scite.ai)
  • ex Spreng does not cause cytotoxicity, genotoxicity and clastogenicity in experimental models in vitro and in vivo following oral administration in this study. (scite.ai)
  • His Antigen research includes themes of Cell, In vitro, Cellular differentiation, In vivo and Heligmosomoides polygyrus. (research.com)
  • The in vitro and in vivo assays that are performed along the drug-screening cascade are also described. (unibas.ch)
  • Finally, the modalities for testing and evaluating a compound in vivo, constituting a procedure lasting up to 10 weeks, are presented in order to go from in vitro hit identification to the selection of early lead candidates. (unibas.ch)
  • We tested the in vitro and in vivo activity of emodepside on nematode species that serve as models for human soil-transmitted helminth infection as well as on schistosomes. (unibas.ch)
  • The good in vitro activity was confirmed in vivo. (unibas.ch)
  • Emodepside is highly active against a broad range of nematode species both in vitro and in vivo. (unibas.ch)
  • I have more than 20 years of experience studying the biochemistry and molecular biology of schistosome parasites with extensive experience with both in vitro and in vivo methods. (rush.edu)
  • However, currently B. thuringiensis is considered as a bacterium antagonistic of parasites used in investigations in vitro and in vivo therapeutic in laboratory and farm animals [3, 4]. (fortunepublish.com)
  • Mutations in these histidine residues lead to the inactivation of RNase T2 both in vivo and in vitro ( Figure 1A ). (frontiersin.org)
  • IL-4 induces Raldh2 expression in bone marrow-derived macrophages in vitro and peritoneal macrophages in vivo . (prolekarniky.cz)
  • Apoptosis induced in vitro and in vivo during infection by Ebola and Marburg viruses. (prolekarniky.cz)
Schistosomula3
  • Here, we screened the Pathogen Box against the post-infective larvae (schistosomula) of Schistosoma mansoni using assays particular to the three contributing institutions, namely, the University of California San Diego (UCSD) in the USA, the Swiss Tropical and Public Health Institute (Swiss TPH) in Switzerland, and the Fundação Oswaldo Cruz (FIOCRUZ) in Brazil. (biomedcentral.com)
  • Importantly, IgG to these epitopes can kill schistosomula by a complement-dependent process in vitro. (cdc.gov)
  • However, no protein was detected in schistosomula maintained in vitro for 7 days. (unifesp.br)
Haematobium4
Infection13
  • They are involved in mediating infection by Schistosoma mansoni , a parasitic trematode that causes schistosomiasis . (bvsalud.org)
  • Objectives: The overall aim was therefore, to elucidate the impact of S. mansoni infection on protective T helper immune responses on P. falciparum and S. mansoni co-infection. (scirp.org)
  • Methodology: This study evaluated the T helper immune responses in individuals with independent S. mansoni infection, independent P. falciparum infection, co-infection and non-infection in school attending children in a co-endemic area along Lake Victoria shores, Uganda. (scirp.org)
  • S. mansoni infection is a major contributor of a reduced effective T helper immune response against P. falciparum in P. falciparum and S. mansoni co-infection. (scirp.org)
  • AbstrAct to determine the safety and efficacy of 2 consecutive doses of triclabendazole (tcbZ) in the treatment of Schistosoma mansoni infection in human cases infected with both S . mansoni and Fasciola sp. (who.int)
  • Administration of tcbZ should precede praziquantel in treatment of combined infection, however tcbZ cannot be recommended for infection with S . mansoni alone. (who.int)
  • Infection with flukes (trematodes) of the genus SCHISTOSOMA. (lookformedical.com)
  • To understand the basis of this protection, we explored the nature of the immune response in the brown rat to infection by Schistosoma mansoni. (cdc.gov)
  • In vitro, SHIVIG demonstrated complement-mediated Ab-dependent enhancement of infection (C'-ADE) at concentrations similar to those observed in plasmas of RMs treated with 25 mg/kg of SHIVIG. (biomedcentral.com)
  • Here, we show that retinal dehydrogenases (Raldh), required for the synthesis of RA, are induced during a retinoid-dependent type-2 immune response elicited by Schistosoma mansoni infection, but not during a retinoid-independent anti-viral immune response. (prolekarniky.cz)
  • A combination of in situ imaging, intra-vital imaging, and sort purification revealed that alternatively activated macrophages (AAMφ) express high levels of Raldh2 during S. mansoni infection. (prolekarniky.cz)
  • The effect of the number of stool samples on the ob-served prevalence and the infection intensity with Schistosoma mansoni among a population in an area of low transmission. (ac.ir)
  • RÉSUMÉ L'infection par le virus de l'hépatite B et C (VHB et VHC) reste un problème de santé publique majeur en Égypte et des données sur les facteurs de risque pour cette infection sont nécessaires. (who.int)
Japonicum1
Worms6
  • Barbatic acid is cytotoxic, and kills the worms of Schistosoma mansoni in in vitro studies. (wikipedia.org)
  • Praziquantel (55268741) and hycanthone-mesylate were dissolved in the medium for incubation of the worms, or in water for in-vitro ATP studies. (cdc.gov)
  • were tested against adult worms of Schistosoma mansoni. (scite.ai)
  • The in vitro activity was evaluated in terms of mortality, number of separated worms and number of worms with reduced motor activity. (scite.ai)
  • We have recombinantly expressed Schistosoma mansoni cytochrome P450, screened a preliminary series of cytochrome P450 inhibitors, and found that RNA interference silencing of cytochrome P450 in larval worms is lethal, indicating that cytochrome P450 is an essential and druggable protein. (rush.edu)
  • In vitro schistosomicidal activity of curcumin against Schistosoma mansoni adult worms. (ac.ir)
Schistosomicidal3
  • A dose and time dependent schistosomicidal effect of albumin- and polyethylenglycol-conjugates and the antimalarials was demonstrated in vitro. (uni-rostock.de)
  • The present study aimed to investigate the schistosomicidal effects of the methanolic extract of Argemone mexicana L. and its active component, berberine against Schistosoma mansoni on in-vitro experiments. (ac.ir)
  • Schistosoma mansoni: In vitro schistosomicidal ac-tivity of essential oil of Baccharis trimera (less) DC. (ac.ir)
Schistosomiasis mansoni2
Soluble2
Antigens2
Intestinal2
  • Schistosoma mansoni is one of the causative agents of intestinal schistosomiasis and Plasmodium falciparum is the major causative agent of malaria. (scirp.org)
  • I have also studied the human T cell response to Schistosoma mansoni, an intestinal parasite, by utilizing human T cell clones. (tamu.edu)
Immune4
  • Suboptimal T helper immune responses were detected in independent S. mansoni infections characterized by significantly down regulated Th1 (Z = -1.425, p = 0.0313) response in comparison to the non-infected group. (scirp.org)
  • P. falciparum and S. mansoni infections initiate a T helper immune response [4] [5] , which links the innate and adaptive immune responses against the parasites. (scirp.org)
  • The scientist's investigation covers issues in Immunology, Cell biology, Interleukin 4, Immune system and Schistosoma mansoni. (research.com)
  • Immunology, Cell biology, Immune system, Schistosoma mansoni and Dendritic cell are his primary areas of study. (research.com)
Parasite2
  • In experiments performed at Universidade Guarulhos (UnG) in the state of São Paulo, Brazil, with FAPESP's support, 400 milligrams per kilogram of body weight was a sufficient dose of red propolis to reduce the parasite load by more than 60% in mice infected with the flatworm Schistosoma mansoni. (blogspot.com)
  • Schistosoma mansoni : the parasite surface in relation to host immunity / Diane J. McLaren. (who.int)
Plasmodium1
  • Schistosoma mansoni and Plasmodium falciparum are co-endemic in Uganda and are the leading parasitic causes of public health problems across sub-Saharan Africa. (scirp.org)
Mekongi1
Efficacy1
  • Short communication: In vitro efficacy testing of praziquantel, ivermectin, and oxfendazole against Taenia solium cysts. (ac.ir)
Fasciola1
  • Human fascioliasis has emerged both Schistosoma sp.and Fasciola sp.A inEgyptoverthepast3decadesand censusoftheinhabitantswasperformed Statistical analysis prevalenceratesinruralareasrange anddemographicdatawerecol ected Data were processed using SPSS , between2%and19%[2-5].Asaresult, andrecorded.Allindividualsover5 version11.Intensityofinfectionwas schistosomiasisandfascioliasisco-exist yearsofage( n =6314)wereaskedto expressedasgeometricmeaneggcount inthesameenvironmentandtheypre- submitastoolsample;therewereno (GMEC).Curerateswerecalculated vailinsomevillages[6,7].Adrugeffec- refusals to comply. (who.int)
Infestation2
  • Un cas de triple infestation bilharzienne à Schistosoma mansoni. (parasite-journal.org)
  • L'administration de triclabendazole doit précéder celle du praziquantel dans le traitement de l'infestation double, toutefois le triclabendazole ne peut être recommandé pour traiter une infestation unique par S. mansoni . (who.int)
Species1
Inflammation1
  • Granulomatous inflammation triggered by S. mansoni eggs and the subsequent fibrosis has been considered a Th2-cytokine-driven inflammation [ 20 ]. (hindawi.com)
Parasitic2
  • In vitro studies and experiments with mice show that the natural extract was more effective than the only drug available to combat this parasitic disease. (blogspot.com)
  • Schistosomiasis is a parasitic disease caused by trematodes of the genus Schistosoma . (biomedcentral.com)
Incubation1
  • Following in vitro incubation, they found the drug to be highly effective, reporting extensive tegumental damage of the immature stage, which intensified progressively as the incubation period and the MFQ concentration increased. (eg.net)
Antigen2
  • Kato Katz thick smears and circulating cathodic antigen tests were performed for S. mansoni screening, whereas thick and thin blood smear techniques were performed for P. falciparum screening. (scirp.org)
  • point-of-care circulating cathodic antigen (POC-CCA) urine cassette test for S. mansoni, etc. (swisstph.ch)
Macrophages1
  • Schistosoma mansoni hemozoin modulates alternative activation of macrophages via specific suppression of Retnla expression and secretion. (rush.edu)
Viability2
  • The viability of S. mansoni was confirmed with an invertoscope-microscope. (ac.ir)
  • The viability tests on S. mansoni showed that A. mexicana at 50 μg/mL is lethal at 48 h and berberine at 10 μM is lethal at 24 h. (ac.ir)
Interleukin1
Induces1
  • Increasing both CoCrMo-alloy particle size and surface irregularity induces increased macrophage inflammasome activation in vitro potentially through lysosomal destabilization mechanisms. (rush.edu)
Recombinant1
  • Adult S. mansoni were treated with recombinant galectin-1 , 2, and 3 proteins or praziquantel , a positive control. (bvsalud.org)
Antischistosomal2
  • The effects of ions and antischistosomal drugs on adenosine- triphosphatase (ATPase) activity in Schistosoma-mansoni were investigated. (cdc.gov)
  • The extract of A. mexicana and berberine demonstrated high antischistosomal activities in low concentration and short exposure time on the in-vitro model. (ac.ir)
Vaccine1
Adults2
  • Chromatographic fractionation of the dichloromethane fraction of P. amalago leaves led to the isolation of its major compound, which was also tested against adults of S. mansoni. (scite.ai)
  • S. mansoni adults were used. (ac.ir)
Schistosome1
  • In this report, RNA interference approaches were employed to investigate the effects of knockdown of schistosome cathepsin D. Cultured schistosomules of Schistosoma mansoni were exposed by square wave electroporation to double stranded RNA (dsRNA) specific for cDNA encoding S. mansoni cathepsin D. RNAi-mediated reductions in transcript levels led to phenotypic changes including significant growth retardation in vitro and suppression of aspartic protease enzyme activity. (aber.ac.uk)
Eggs2
  • Herein, we show that i.p. injection of OVA + Al(OH) 3 minutes before i.v. injection of Schistosoma mansoni eggs into OVA tolerant mice blocked the increase of pulmonary granulomas. (hindawi.com)
  • Schistosoma mansoni eggs injected into the tail vein of mice are transported into the lung tissue via the pulmonary arteries where they become trapped within the lung parenchyma [ 22 , 23 ]. (hindawi.com)
Stages3
  • the putative Sm USP transcripts analysed were detected in all investigated stages, showing distinct expression during S. mansoni development. (biomedcentral.com)
  • S. mansoni USPs showed changes in expression levels for different life cycle stages indicating their involvement in cellular processes required for S. mansoni development. (biomedcentral.com)
  • Specifically, we detail the establishment and maintenance of the complex and several-week-long Schistosoma mansoni life cycle in a laboratory setting, as well as the means of retrieving and culturing the parasites at their relevant life stages. (unibas.ch)
Drug1
Mice1
  • Vitamin A deficient mice have a selective defect in T H 2 responses to S. mansoni , but retained normal LCMV specific T H 1 responses. (prolekarniky.cz)
Acquisition1
  • Although SHIVIG neutralized SHIV-2873Nip in vitro, this polyclonal IgG preparation failed to prevent acquisition after repeated intrarectal low-dose virus challenges, but at a dose of 400 mg/kg, it significantly lowered peak viremia ( P = 0.001). (biomedcentral.com)
Study2
Field1
  • His work carried out in the field of Schistosoma mansoni brings together such families of science as Gut flora, Microbiology, Pathogenesis and Regulatory B cells. (research.com)
Tests1
  • In vitro tests also showed that red propolis blocked reproduction and oviposition (egg-laying). (blogspot.com)
Research1
  • His Schistosoma mansoni research is multidisciplinary, incorporating elements of Fold change, RNA extraction, DNA microarray, microRNA and Disease. (research.com)
Development1
  • Considering the role that the ubiquitin-proteasome system has been shown to play during the development of Schistosoma mansoni , our main goal was to identify and characterize Sm USPs. (biomedcentral.com)
Effect3
  • In vitro evaluation of the effect of galectins on Schistosoma mansoni motility. (bvsalud.org)
  • Treatment with galectin-1 , 2, and 3 had no significant effect on S. mansoni motility, and no other differences were observed under a stereoscopic microscope. (bvsalud.org)
  • Hence, galectin-1 , 2, and 3 may have a little direct effect on S. mansoni. (bvsalud.org)