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  • Assay
  • Although an option in the international guidelines for genotoxicity testing, in general, this assay is beginning to be superceded by the in vitro micronucleus test, which has the advantage of detecting aneugens as well as clastogens more easily ( Lynch and Parry, 1993). (smadsignaling.com)
  • The in vitro micronucleus assay is a cytogenetic test that measures genetic damage using the formation of micronuclei as an endpoint ( OECD, 2010). (smadsignaling.com)
  • ligament
  • The most recognized theory of the pathogenesis of SUI is the integral theory, which indicated that mechanical trauma-induced ligament and nerve injury, as well as the damage to the vaginal wall and its suspensory structures, resulting from vaginal delivery is one of the widely recognized risk factors of SUI genesis in women [ 3 , 4 ]. (hindawi.com)
  • 1985
  • Larval motoneurons persist through this transformation, but their larval muscle targets degenerate and are replaced by new muscles that grow during adult differentiation ( Nüesch, 1985 ). (jneurosci.org)
  • subunit
  • Indeed, we have shown previously that mutation of a tyrosine phosphorylation site in the long cytoplasmic loop of the β subunit impairs agrin-induced cytoskeletal anchoring and aggregation of mutant AChR in muscle cells ( Borges and Ferns, 2001 ). (jneurosci.org)
  • Immunohistochemical analysis has demonstrated presence of the α 3 nAChR subunit at the presynaptic motor nerve ending. (asahq.org)
  • Drugs
  • Aminopyridines and Similarly Acting Drugs: Effects on Nerves, Muscles and Synapses presents the proceedings of a IUPHAR Satellite Symposium in conjunction with the eighth International Congress of Pharmacology held in Paris, France on July 27-29, 1981. (elsevier.com)
  • McDougal MD, West GB (1953) The action of drugs on isolated mammalian bronchial muscle. (springer.com)
  • studies
  • This technology has been shown to create nerve stem cell fiber growth in culture and to double the rate of production of ECM (extracellular matrix - the connective structure between cells) in at least two scientific studies. (electromeds.com)
  • Previous studies have shown that the number of satellite cells is increased by long-term or acute exercise training in humans and animals [ 4 , 5 ] and decreases during aging in conjunction with a reduction in the muscle quality and functional potential [ 6 ]. (hindawi.com)
  • Pharmacokinetics, i.e. absorption, distribution, metabolism and elimination of caraway oil and its constituents were investigated in vitro , in animal and in human studies. (escop.com)
  • widely
  • Both the physiological and pathological changes in the mechanical behavior of tracheobronchial smooth muscles (shortening or development of tension) have been widely studied. (springer.com)
  • metabolic
  • and 2) determine the relationship between muscle metabolic economy and muscle oxidative capacity and fiber type. (springer.com)
  • Muscle oxidative phosphorylation rate (OxPhos), and muscle metabolic economy (force/ATP) were measured in calf muscle using 31 P MRS during isometric plantar flexion at 70 and 100% of maximum force, (HI) and (MI) respectively. (springer.com)
  • Type IIa fiber distribution was inversely related to all measures of exercise economy ( r from −0.51 to −0.64) and citrate synthase activity was inversely related to muscle metabolic economy at MI ( r =−0.56). (springer.com)
  • Metabolic adaptations of skeletal muscle to voluntary wheel running exercise in hypertensive heart failure rats," Physiological Research , vol. 62, no. 4, pp. 361-369, 2013. (hindawi.com)
  • excitability
  • This critical finding was initially puzzling because the Ca 2+ channel, although having a dual voltage-sensing role in controlling the opening of the SR Ca 2+ release channel as well as itself, is not directly involved in muscle excitability. (rupress.org)
  • Carvone decreased nerve excitability. (escop.com)
  • respectively
  • For example, gating pores in Na v 1.5 and K v 7.2 channels may underlie mixed arrhythmias associated with dilated cardiomyopathy (DCM) phenotypes and peripheral nerve hyperexcitability (PNH), respectively. (frontiersin.org)
  • activity
  • In particular, this review surveys our recently developed in vitro models of SCI by evoking excitotoxic (or even hypoxic/dysmetabolic) damage to spinal networks and assessing the impact on rhythmic activity and cell survival. (frontiersin.org)
  • Muscle fiber type and citrate synthase activity were determined in the lateral gastrocnemius. (springer.com)
  • In addition, Type IIa fiber distribution and citrate synthase activity were positively related to \(\dot{V}\hbox{O}_{2{\rm max}}\) and muscle OxPhos at HI and MI ( r from 0.49 to 0.70). (springer.com)
  • We investigated the effects of the odor of jasmine tea on autonomic nerve activity and mood states in a total of 24 healthy volunteers. (springer.com)
  • chemical
  • This procedure serves as a convenient bioassay for a neurotrophic process and indicates that the trophic effect is mediated by a diffusible chemical substance produced by nerves. (sciencemag.org)
  • exercise
  • Significant inverse relationships ( r from −0.28 to −0.74) were observed between oxidative metabolism measures and exercise economy (walking and muscle). (springer.com)