Vitro homologous spleen cell transplantation homologous. Medical search. Frequent questions

Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways. (cusabio.com)
Mechanistically, over-expression of PTTG3P up-regulated PTTG1, activated PI3K/AKT signaling and its downstream signals including cell cycle progression, cell apoptosis and epithelial-mesenchymal transition (EMT)-associated genes. (biomedcentral.com)
Natural product anticancer agents enhance intracellular levels of ceramide, a sphingolipid that promotes cell apoptosis. (sphingolipidclub.com)

In July 2022, the European Union released a Proposal [ 5 ] to significantly change its regulation of cells and tissues and repeal Directive 2004/23/EC, the cornerstone of such regulation for the last two decades. (biomedcentral.com)

Liver Transplantation for Porto-Sinusoidal Vascular Liver Disorder: Long-term Outcome. (liver.at)
The impact of COVID-19 on liver transplantation programs in Austria. (liver.at)
The same reasons apply to the use of organs for transplantation including but not limited to the heart, lung, liver and kidney. (justia.com)
We now report that MT-Exendin mice develop extensive tissue lymphocytic infiltration with increased numbers of CD4 + and CD8a + cells in the liver and/or kidney and increased numbers of B220 + cells present in the pancreas and liver. (diabetesjournals.org)
Ligustrazine and Danshensu levels in the heart, liver, spleen, lung, kidney, and brain were detected at different time points by ultra-high performance liquid chromatography/ tandem mass spectrometry. (alljournal.net.cn)

There are several comprehensive reviews on Cn (4, 68), more recent brief updates (3, 37, 44), information on Cn inhibitors (42, 55), and disease- or organ/tissue-specific reviews relating to Cn in the neurosciences (29), muscle (65), islet cells (35). (pancreapedia.org)
Cancer is not a chaotic malignant cell mass, but a delicate "hostile" organ, where many other cells are recruited and domesticated to become "accomplices", thereby protecting themselves from recognition and attack by the immune system [ 1 ]. (biomedcentral.com)
It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (lookformedical.com)
Solid organ transplantation is an important therapeutic option for children with a variety of end stage diseases. (stanford.edu)
High-dimensional profiling of pediatric immune responses to solid organ transplantation. (stanford.edu)
The field of the subject invention is the use of major histocompatibility complex antigen lacking cells and organs which may serve as universal donors in cellular and organ therapies including transplantation and to produce chimeric non-human mammals. (justia.com)

The latter is a tool previously developed by Jacopo, 2020, able to identify tumor antigens similar to pathogen antigens in order to exploit molecular mimicry and tumor pathogen cross-reactive T cells in cancer vaccine development. (elifesciences.org)
Taking advantage of the diverse γδ TCR repertoire or other ligand-receptor interactions, γδ T cells can recognize a broad spectrum of tumor-associated antigens (TAAs) in a major histocompatibility complex (MHC)-independent manner, thereby activating downstream pleiotropic effects. (explorationpub.com)
Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains. (lookformedical.com)
or actively by prior immunization of the recipient with graft antigens which evoke specific antibodies and form antigen-antibody complexes which bind to the antigen receptor sites of the T-cells and block their cytotoxic activity. (lookformedical.com)
Homologous recombination is employed to inactivate genes, particularly genes associated with MHC antigens. (justia.com)
It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES. (lookformedical.com)

Another CFU, the colony-forming unit-spleen (CFU-S), was the basis of an in vivo clonal colony formation, which depends on the ability of infused bone marrow cells to give rise to clones of maturing hematopoietic cells in the spleens of irradiated mice after 8 to 12 days. (wikipedia.org)
We examined the consequences of CTCF depletion in immortalised human and mouse cells using shRNA knockdown and CRISPR/Cas9 genome editing and examined the growth and development of heterozygous Ctcf ( Ctcf +/- ) mice. (preprints.org)

Here we exploited this option by assessing the impact of nafamostat, a serine protease inhibitor known to neutralize mast cell tryptase. (bvsalud.org)
CnA ( Figure 1 ) contains the catalytic domain, which is homologous to other serine/threonine protein phosphatases (4). (pancreapedia.org)

First, we are interested in Epstein Barr Virus-mediated mechanisms of immune evasion with particular emphasis on pathways that promote survival and proliferation of EBV B cell lymphomas, the characterization of the human T cell and NK cell response to EBV and the identification of novel therapeutics for treatment of EBV B cell lymphomas. (stanford.edu)
Myeloproliferative diseases are a heterogenous group of disorders characterized by cellular proliferation of 1 or more hematologic cell lines in the peripheral blood, distinct from acute leukemia. (medscape.com)
Likewise, they have the ability to activate the angiogenesis, proliferation, migration, and differentiation of the main cell types involved in skin regeneration. (frontiersin.org)
Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. (cusabio.com)
They confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions. (lookformedical.com)
Enforced expression of PTTG3P significantly promoted cell proliferation, migration, and invasion in vitro, as well as tumorigenesis and metastasis in vivo. (biomedcentral.com)

Because BRCA mutations are observed in fewer than 10% of cancer patients (cBioPortal: 6.7%) 11 , 12 , 13 the identification of additional genes that share synthetic lethal sensitivity relationships with mutated oncogenes or tumor suppressors would greatly enhance the implementation of tumor cell-specific synthetic lethal sensitivity to improve an anticancer therapeutic response. (nature.com)
Because most tumors are deficient in one or more aspects of the function of the p53 tumor suppressor, either as a consequence of mutations within p53, or impairment of upstream and downstream modulators of p53 activity 19 , targeting MK2 has the potential to selectively enhance tumor cell killing without increasing the genotoxic effects of chemotherapy on normal p53-wild type tissues. (nature.com)
8000 peptide targets from the CT26 tumor cell line. (elifesciences.org)
It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. (lookformedical.com)

The hematopoietic tissue contains cells with long-term and short-term regeneration capacities and committed multipotent, oligopotent, and unipotent progenitors. (wikipedia.org)
Hematopoietic stem cells constitute 1:10,000 of cells in myeloid tissue. (wikipedia.org)
ECM is a macromolecular substance secreted by cells into the extracellular space and constitutes a complex network that supports tissue structure and the physiological activities of cells, including collagen, elastin fibrils, proteinases, proteoglycans (PGs), glycoproteins and glycosaminoglycans (GAGs). (biomedcentral.com)
An induced state of non-reactivity to grafted tissue from a donor organism that would ordinarily trigger a cell-mediated or humoral immune response. (lookformedical.com)
Stem cell therapy raised hope of overcoming these issues, but created new risks including tumour formation and limited benefit if the desired target tissue does not form. (biomedcentral.com)
This article details the potential health risks of 3-dimensional organoid and tissue therapy versus dissociated stem cell therapy. (biomedcentral.com)
The current ethical and regulatory issues surrounding 3-dimensional organoid and tissue therapy are presented with a focus on the highly influential FDA and International Society of Stem Cell Research (ISSCR) guidelines. (biomedcentral.com)
Stem cells can be obtained from a donor or be autologous, eliminating any issues from the use of animals in tissue harvesting. (biomedcentral.com)
It is therefore expected that clinical trials implanting more complex 3-dimensional stem cell-derived tissue constructs (SCTCs) in humans will occur in the near future, including a recent report of autologous intestinal epithelial organoids being implanted into a patient with ulcerative colitis (jRCTb032190207) [ 2 ]. (biomedcentral.com)
They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. (lookformedical.com)

Besides the isolation and identification of major histocompatibility complex I-restricted peptides from the surface of cancer cells, one of the challenges is eliciting an effective antitumor CD8+ T-cell-mediated response as part of therapeutic cancer vaccine. (elifesciences.org)
Here, we describe for the first time a streamlined pipeline for the generation of personalized cancer vaccines starting from the isolation and selection of the most immunogenic peptide candidates expressed on the tumor cells and ending in the generation of efficient therapeutic oncolytic cancer vaccines. (elifesciences.org)
Until recently, the treatment of cancer has been largely focused on the development of therapeutic agents or techniques that kill cancer cells. (justia.com)

Conversely, ectopic expression of PRDM16 in myoblasts induces their differentiation into brown fat cells. (bioseek.eu)

Hematopoietic stem cells (HSCs) are the stem cells that give rise to other blood cells. (wikipedia.org)
In vertebrates, the vast majority of hematopoiesis occurs in the bone marrow and is derived from a limited number of hematopoietic stem cells that are multipotent and capable of extensive self-renewal. (wikipedia.org)
Hematopoietic stem cells give rise to different types of blood cells, in lines called myeloid and lymphoid. (wikipedia.org)
In shape, hematopoietic stem cells resemble lymphocytes. (wikipedia.org)
The very first hematopoietic stem cells during (mouse and human) embryonic development are found in aorta-gonad-mesonephros region and the vitelline and umbilical arteries. (wikipedia.org)
Hematopoietic stem cells are found in the bone marrow of adults, especially in the pelvis, femur, and sternum. (wikipedia.org)
Since hematopoietic stem cells cannot be isolated as a pure population, it is not possible to identify them in a microscope. (wikipedia.org)
citation needed] Hematopoietic stem cells can be identified or isolated by the use of flow cytometry where the combination of several different cell surface markers (particularly CD34) are used to separate the rare Hematopoietic stem cells from the surrounding blood cells. (wikipedia.org)
Lack of expression of lineage markers is used in combination with detection of several positive cell-surface markers to isolate hematopoietic stem cells. (wikipedia.org)
In addition, hematopoietic stem cells are characterised by their small size and low staining with vital dyes such as rhodamine 123 (rhodamine lo) or Hoechst 33342 (side population). (wikipedia.org)
Hematopoietic stem cells are essential to haematopoiesis, the formation of the cells within blood. (wikipedia.org)
Hematopoietic stem cells can replenish all blood cell types (i.e., are multipotent) and self-renew. (wikipedia.org)
A small number of Hematopoietic stem cells can expand to generate a very large number of daughter Hematopoietic stem cells. (wikipedia.org)

These findings establish a mechanism for co-targeting DNA damage-induced cell cycle checkpoints in combination with repair of cisplatin-DNA lesions in vivo using RNAi nanocarriers, and motivate further exploration of ASL as a generalized strategy to improve cancer treatment. (nature.com)
Generally, the uptake of particles increased the expression of CD40 and CD86 in all DC populations, Crenigacestat cell line independent of particle size, whereas 20-nm particles induced enhanced antigen presentation to CD4(+) T cells in LDLNs in vivo. (jakenzyme.com)
The immune system which results from cells of the lymphoid and myeloid lineages is developed in vivo, so as to recognize self from non-self. (justia.com)
Here we show by in vivo fate mapping that brown, but not white, fat cells arise from precursors that express Myf5, a gene previously thought to be expressed only in the myogenic lineage. (bioseek.eu)
Artificial modulation of PTTG3P (down- and over-expression) was performed to explore the role of PTTG3P in tumor growth and metastasis in vitro and in vivo. (biomedcentral.com)

Success of conventional chemotherapeutic regiment is based on the principle that tumors with high growth fractions (such as acute myelogenous leukemia and the lymphomas, including Hodgkin's disease) are more sensitive to chemotherapy because a larger proportion of the targeted cells are undergoing cell division at any given time. (justia.com)

By making normal cells more resistant to chemotherapeutic agents, a patient's tolerance for cytotoxicity is improved, which, in turn, also improves the effectiveness of chemotherapy. (justia.com)
Wang S, Tasch J, Kheradmand T , Ulaszek J, Ely S, Zhang X, Hering BJ, Miller SD, Luo X. Transient B-cell depletion combined with apoptotic donor splenocytes induces xeno-specific T- and B-cell tolerance to islet xenografts. (uchicago.edu)
Chen G, Kheradmand T , Bryant J, Wang S, Tasch J, Wang JJ, Zhang Z, Luo X. Intragraft CD11b(+) IDO(+) cells mediate cardiac allograft tolerance by ECDI-fixed donor splenocyte infusions. (uchicago.edu)

One relevant sample type for investigating chronic lung inflammation is bronchoalveolar lavage fluid (BALF), which provides a snapshot of the immune cells present in the alveolar space. (bvsalud.org)
This review further emphasizes the diversified cross-talk between γδ T cells and other immune cells. (explorationpub.com)
Among the components of TME, distinct populations of innate and adaptive immune cells consist of tumor immune microenvironment (TIME). (biomedcentral.com)
TIME primarily consists of myeloid cells, lymphocytes and some other innate immune cells. (biomedcentral.com)
and the innate immune cells contain natural killer (NK) cells and dendritic cells (DCs) (Fig. 1 ). (biomedcentral.com)
Substantial cells are divided into immune cells and non-immune cells. (biomedcentral.com)
The infiltrating immune cells in the TME constitute the main body of TIME. (biomedcentral.com)
Unfortunately, scientists have yet to be able to locate specific features of malignant and immune cells that would make them uniquely targetable (barring some recent examples, such as the Philadelphia chromosome as targeted by imatinib). (justia.com)

Stem and progenitor cells can be taken from the pelvis, at the iliac crest, using a needle and syringe. (wikipedia.org)

In other cases, where certain cells are lacking, such as islets of Langerhans in the case of diabetes, or cells which secrete dopamine in the case of Parkinson's disease, or bone marrow cells in various hematopoietic diseases, or muscle cells in muscle wasting disease, or retinal epithelial cells in visual disorders, it would be desirable to be able to provide cells which could fulfill the desired function. (justia.com)

[ 5 ] Thus, the inability to productively rearrange VDJ regions in T-cell and B-cell receptors leads to abnormal T cells and absent B cells. (medscape.com)

In addition to antiviral activity, it activates NATURAL KILLER CELLS and B-LYMPHOCYTES , and down-regulates VASCULAR ENDOTHELIAL GROWTH FACTOR expression through PI-3 KINASE and MAPK KINASES signaling pathways. (lookformedical.com)

Therefore, research on exosomes produced by MSC has been intensified for use in cell-free regenerative medicine. (frontiersin.org)
Stem cell therapy is one approach to regenerative medicine. (biomedcentral.com)

While epidemiological studies show a temporal correlation between enteroviral infections and appearance of anti-islet auto-antibodies (aAbs) [5], investigations using the NOD mouse model suggest that enteroviral infections may accelerate rather than initiate T1D progression, as they are effective only once autoimmune T cells have already accumulated in the islets [6]. (healthweblognews.info)
The pathophysiological mechanisms through which enteroviral infections may favor T1D development include promoting local islet inflammation, cytolytic effects on cells and molecular mimicry [7]. (healthweblognews.info)

γδ T cells recruited into the tumor microenvironment can act as effector cells to mediate cancer immune surveillance. (explorationpub.com)
Therefore, an in-depth understanding of γδ T cells that play conflicting roles in the tumor microenvironment is necessary. (explorationpub.com)
Through them, the cells modify their microenvironment and the behavior of neighboring cells. (frontiersin.org)

BACKGROUND: Mast cells (MCs) develop from a rare population of peripheral blood circulating MC progenitors (MCps). (bvsalud.org)
One of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells. (lookformedical.com)

Impaired V(D)J recombination process leads to the generation of a few T cells expanding in the periphery, infiltrating target organs such as skin and gut, resulting in the erythroderma and colitis typical of this syndrome. (medscape.com)
Anaplastic large cell lymphoma with anaplastic lymphoma kinase gene translocations (ALK+ ALCL) is a mature T-cell lymphoma that primarily affects lymph nodes, but also gives rise to tumors in extranodal organs and occasional characteristic skin lesions. (biomedcentral.com)
In addition, embryonic stem cells may be modified by homologous recombination for use in producing chimeric or transgenic mammalian hosts, which may be used as source of universal donor organs. (justia.com)

TME consists of cell component, the extracellular matrix (ECM) and abundant soluble signaling molecules. (biomedcentral.com)
Organisms usually contain large numbers of sphingolipid subspecies (for a pathway based compilation, see www.sphingomap.org) and knowledge about the types and amounts is imperative because they influence membrane structure, interactions with the extracellular matrix and neighboring cells, vesicular traffic and the formation of specialized structures such as phagosomes and autophagosomes, as well as participate in intracellular and extracellular signaling. (sphingolipidclub.com)

Myeloid and lymphoid lineages both are involved in dendritic cell formation. (wikipedia.org)
TIME possesses distinct populations of myeloid cells and lymphocytes to influence the immune escape of cancer, the response to immunotherapy, and the survival of patients. (biomedcentral.com)
A wide variety of hematopoietic cells exist, with the major protective lineages being lymphoid and myeloid. (justia.com)

γδ T cells express unique T cell receptor (TCR) γ and TCR δ chains, with structural and functional heterogeneity. (explorationpub.com)
Specifically, we found that the WNT signaling cell surface receptor ROR2 represented a robust and genuine marker of all ALK+ ALCL patient tumor samples. (biomedcentral.com)

The National Academies of Sciences, Engineering and Medicine have also released guidance for "Human Embryonic Stem Cell Research" (2005 and updated in 2010) which provides no guidance on induced pluripotent stem cells (iPSCs) [ 3 ], and "The emerging field of human neural organoids, transplants, and chimeras" (2021) which didn't include other stem cell-derived tissues and deliberately excluded transplantation of organoids in humans [ 4 ]. (biomedcentral.com)
While CTCF is essential for embryonic development, little is known of its absolute requirement in somatic cells and the consequences of CTCF haploinsufficiency. (preprints.org)

[ 8 ] These abnormal T cells presumably secrete cytokines that promote autoimmune as well as allergic inflammation. (medscape.com)
The cells secrete extracellular vesicles (EV) that may have an endosomal origin, or from evaginations of the plasma membrane. (frontiersin.org)

SL originally described a relationship between two genes, where alteration of either gene alone results in viable cells, but alteration (mutation, loss, or inhibition) of both genes simultaneously was lethal. (nature.com)
c production of replication incompetent AAV vectors via transient plasmid transfection into 293 producer cells that express adenovirus type 5 E1 genes. (biomedcentral.com)

Over the past two decades, a series of significant advances have been achieved in exploring the biogenesis, abundance, and function of lncRNAs across different species and cell types. (biomedcentral.com)

Cancer cells that are defective in p53 function are deficient in their ability to transcriptionally upregulate the CDK inhibitor p21 after genotoxic stress. (nature.com)
The primary purpose of this study is to determine whether breast cancer tumors respond (as measured by pathologic complete response: the absence of microscopic evidence of invasive tumor cells in the breast) to combined chemotherapy of AC(doxorubicin and cyclophosphamide) followed by paclitaxel plus trastuzumab or lapatinib or both given before surgery to patients with HER2-positive breast cancer. (stanford.edu)
This invention relates to methods of inducing differential stress resistance in a subject with cancer by starving the subject for a short term, administering a cell growth inhibitor to the subject, or reducing the caloric or glucose intake by the subject. (justia.com)
In particular, the present invention provides methods for enhancing the effectiveness of chemotherapy by inducing differential stress resistance in normal cells and cancer cells via short-term starvation, cell growth inhibitors, or reduced caloric or glucose intake. (justia.com)
The present invention provides a novel approach to cancer therapy by providing a method to differentially enhance the resistance of normal cells to chemotherapeutic agents, thereby, improving the effectiveness of chemotherapeutic agents in killing cancerous cells. (justia.com)
In another aspect, the invention features methods of contacting a cancer cell with a chemotherapy agent and methods of increasing resistance of a non-cancer cell to a chemotherapy agent. (justia.com)
The epidemic of obesity, closely associated with increases in diabetes, hypertension, hyperlipidemia, cancer and other disorders, has propelled a major interest in adipose cells and tissues. (bioseek.eu)
However, multidrug-resistant (MDR) cancer cells may avoid the cytotoxic effects of chemotherapy by glycosylating ceramide. (sphingolipidclub.com)
In the present study we examined the relationship between ceramide, ceramide metabolites and expression of the MDR1 gene in human breast cancer cell lines. (sphingolipidclub.com)
Four wild-type (drug-sensitive) human breast cancer cell lines (MCF-7, T47D,MDA-MB-231, MDA-MB-435) were used to evaluate the influence of acute and chronic exposure to ceramide and ceramide metabolites on MDR1 mRNA,P-gp, and resistance to chemotherapeutic agents. (sphingolipidclub.com)
These data are the first evidence that chronic exposure to ceramide and its metabolites enhances expression of the MDR phenotype in cancer cells. (sphingolipidclub.com)

It was used extensively in early studies, but is now considered to measure more mature progenitor or transit-amplifying cells rather than stem cells[citation needed]. (wikipedia.org)
Stem cells have the ability to differentiate into specialised cells and have been transplanted into patients in an effort to treat various diseases. (biomedcentral.com)
Clinical trials have been run for the implantation of stem cells and their derived products. (biomedcentral.com)
Mitochondria isolated from two fibroblast cell lines and induced pluripotent stem cells derived from one affected individual and differentiated neuroepithelial stem cells showed reduced PMPCB levels and accumulation of the processing intermediate of frataxin, a sensitive substrate for MPP dysfunction. (regenerativemedicine.net)

a technique of derivatization of proline (pro) and 4-hydroxyproline (hyp) by 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole permitted the measurement of pro and hyp radioactivities, concentrations, and specific activities in the main fractions separated from cultures of fibroblast cells (extracellular collagen and non-collagen proteins, intracellular free pro and hyp, pro- and hyp-containing peptides, procollagen, and non-collagen proteins). (liverpool.ac.uk)

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. (stanford.edu)
The induced differential stress resistance results in improved resistance to cytotoxicity in normal cells, which, in turn, reduces cytotoxic side-effects due to chemotherapy, as well as improved effectiveness of chemotherapeutic agents. (justia.com)
Because chemotherapy affects cell division, both normal and cancerous cells are susceptible to the cytotoxic effects of chemotherapeutic agents. (justia.com)
Another method of the invention comprises administering a cell growth inhibitor to the subject and administering to the subject a chemotherapy agent. (justia.com)

The protective mechanism which protects the host from disease, as a result of invasion of viruses, bacteria, or other pathogens, is also able to recognize cells which come from a different mammalian host, even an allogeneic host. (justia.com)

Accordingly, Omenn syndrome is best viewed, not as a specific form of SCID, but rather as an aberrant inflammatory condition that can be associated with multiple genetic abnormalities, which can significantly impair (but not abolish) T-cell development in the thymus. (medscape.com)
a case report of inflammatory pseudotumor of the spleen]. (liverpool.ac.uk)
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. (lookformedical.com)

Lymphoid cells include T cells, B cells, natural killer cells, and innate lymphoid cells. (wikipedia.org)

Therefore, compared to normal p53-proficient cells, p53-defective cells are more reliant on MK2 activity, which drives an alternative cell cycle checkpoint pathway that stabilizes the CKI inhibitors p27 Kip1 and Gadd45α in order to maintain G 1 /S and G 2 /M arrest after certain types of DNA damage 16 , 18 . (nature.com)

Additionally, these cells show highly flexible and dynamic plasticity and are extremely easily polarized into regulatory phenotypes. (explorationpub.com)
Lerret NM, Houlihan JL, Kheradmand T , Pothoven KL, Zhang ZJ, Luo X. Donor-specific CD8+ Foxp3+ T cells protect skin allografts and facilitate induction of conventional CD4+ Foxp3+ regulatory T cells. (uchicago.edu)

As long-lived viral DNA within specific cellular reservoirs is responsible for persistent hepatitis B virus, Herpes simplex virus, and human immunodeficiency virus infections, the discovery of AAV vectors with strong tropism for hepatocytes, sensory neurons and T cells, respectively, is of particular interest. (biomedcentral.com)
Introduction of the identified PMPCB variants into the homologous S. cerevisiae Mas1 protein resulted in a severe growth and MPP processing defect leading to the accumulation of mitochondrial precursor proteins and early impairment of the biogenesis of iron-sulfur clusters, which are indispensable for a broad range of crucial cellular functions. (regenerativemedicine.net)

We characterized the major immune cell populations present in equine BALF, as well as subtypes thereof. (bvsalud.org)

Activated γδ T cells exhibit strong cytotoxic activity and cytokine secretion functions and are effective antitumor lymphocytes with simple and direct recognition modes and rapid responses. (explorationpub.com)

In addition to tumor cells, there are also important stromal components in tumor niche. (biomedcentral.com)
The mesenchymal stromal cells (MSC) have immunomodulatory properties and a high regenerative capacity. (frontiersin.org)

The cells can be removed as liquid (to perform a smear to look at the cell morphology) or they can be removed via a core biopsy (to maintain the architecture or relationship of the cells to each other and to the bone). (wikipedia.org)

First, γδ T cells exposed to complicated cytokine networks are potentially affected by multiple inhibitory mechanisms. (explorationpub.com)
Laboratory work has centered on the mechanisms of how cells acquire specific fates during growth and development, providing insights into normal and abnormal mechanisms of growth control. (stanford.edu)
In mammals, the immune systems serves as the primary defense with many different types of cells and mechanisms to protect the host. (justia.com)
Objective Explore euscaphic acid uptake and transport mechanisms in Caco-2 cells. (alljournal.net.cn)

Anaplastic large cell lymphoma positive for ALK (ALK+ ALCL) is a rare type of non-Hodgkin lymphoma. (biomedcentral.com)
and one follicular mixed small cleaved and large cell (fm) lymphoma according to the working formulation) are presented. (liverpool.ac.uk)

The EV composition depends on the producer cell type and its physiological conditions. (frontiersin.org)

The oncogenic potential of the NPM-ALK fusion gene was first demonstrated in vitro using murine cell lines and primary cells. (biomedcentral.com)
Representative stream cytometry histograms depicting Compact disc16 amounts on the average person cell lines (A) and their matching exosomes (B) are proven. (healthweblognews.info)

When the host is immunocompromised, there may be an interest in transfusing specific white cells, particularly T-cells, which may protect the host from various diseases. (justia.com)
The complexity of the sphingolipidome is hard to imagine, but one hopes that, when partnered with other systems biology approaches, the causes and consequences of the complexity will explain how these intriguing compounds are involved in almost every aspect of cell behavior and the malfunctions of many diseases. (sphingolipidclub.com)

In response to DNA damage, a synthetic lethal relationship exists between the cell cycle checkpoint kinase MK2 and the tumor suppressor p53. (nature.com)

In Omenn syndrome, the mutated RAG-1 and RAG-2 proteins remain normally distributed in the nucleus of cells. (medscape.com)
Selleck GW786034 Our data suggest that Pk1b acts at least partially independently of core planar cell polarity molecules at the plasma membrane, and might instead be acting at the nucleus. (jakenzyme.com)
PHOSPHORYLATION of IRF-3 causes the protein to be translocated from the CYTOPLASM to CELL NUCLEUS where it binds DNA , and activates transcription. (lookformedical.com)

According to current challenges, there is a need to explore innovative immunotherapies, maximize the tumor-killing efficacy of γδ T cells, and attenuate or eliminate tumor immunosuppression. (explorationpub.com)

hence, no development of T-lineage and B-lineage cells occurs. (medscape.com)
Where transplantation from another allogeneic host occurs, unless the transplant is matched with the host or the host is immunocompromised, the transplant may be attacked and destroyed by the immune system. (justia.com)

a study of collagen metabolism in cell cultures by fluorometric determination of proline and hydroxyproline. (liverpool.ac.uk)

Anatomy30

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