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  • hESCs
  • Here we show a near complete restriction of hESCs to ventral spinal progenitors (Olig2+, NKX2.2+, Irx3+/Pax7−) and efficient differentiation of motor neurons (HB9+) by a simple sequential application of retinoid acid (RA), and sonic hedgehog (SHH) in a chemically defined condition. (justia.com)
  • Rats grafted with hESCs predifferentiated in vitro for 16 days developed severe teratomas, whereas most rats grafted with hESCs predifferentiated for 20 and 23 days remained healthy until the end of the experiment. (unica.it)
  • This indicates that prolonged in vitro differentiation of hESCs is essential for preventing formation of teratomas. (unica.it)
  • adipocytes
  • GB produces metabolically favorable changes in differentiating adipocytes, mature adipocytes, and macrophages in vitro, suggesting its potential use as a dietary supplement or nutraceutical to support metabolic health and resiliency. (mdpi.com)
  • Journal
  • Effect of carbon nanotubes on cellular functions in vitro," Journal of Biomedical Materials Research , vol. 91, no. 1, pp. 132-139, 2009. (hindawi.com)
  • cultures
  • Addition of osteoprotegerin (OPG) to the cultures together with FGF8 inhibited stimulation of osteoclast differentiation suggesting that the osteoclastogenic effect of FGF8 was RANKL-mediated. (aacrjournals.org)
  • culture
  • This differentiation only takes place when the correct stimulus is present in the culture media. (hindawi.com)
  • Design PCs were subject to several in vitro culture conditions in an attempt to drive myogenic conversion. (cf.ac.uk)
  • The chondrogenic potential of these factors was then assessed in vitro using the micropellet culture system both by RT-PCR and immunohistochemistry. (biomedcentral.com)
  • function
  • By contrast, challenging in vitro conditions have been developed for T. vivax in the past, and this per se has contributed to defer both its genetic manipulation and subsequent gene function studies. (plos.org)
  • In vitro T cell development of Pax5-/- progenitors strictly depends on Notch1 function and progresses through normal developmental stages by expressing T cell markers and rearranging TCRbeta, gamma, and delta loci in the correct temporal sequence. (epfl.ch)
  • conditions
  • The work presented herein focused on determining axenic conditions for culturing and growing insect (epimastigote) forms of T. vivax and prompting their differentiation into metacyclic forms that are infectious for the mammalian host. (plos.org)
  • mice
  • In vitro, 20 alpha SDH can be induced in splenic lymphocytes from nu/nu mice by conditioned media from mitogen- or alloantigen-stimulated normal lymphocytes. (jimmunol.org)
  • Impaired c-Jun amino terminal kinase activity and T cell differentiation in death receptor 6-deficient mice. (nih.gov)
  • system
  • Studies on its biology, metabolism and interaction with the host immune system have been hindered by a lack of suitable tools for its maintenance in vitro and its genetic engineering. (plos.org)