• The involvement of immune cells, cytokines and chemokines was evaluated, using depleting antibodies. (nih.gov)
  • A membrane-based antibody array for the parallel determination of the relative levels of selected mouse cytokines and chemokines. (rndsystems.com)
  • The integration of pathogen-associated molecular patterns (PAMPs) from microorganisms with their surface receptors in the immune cells, induces the production of several cytokines and chemokines that presents either a pro- and/or anti-inflammatory role by stimulating the secretion of a great variety of antibody subtypes and the activation of mechanisms of controlling the disease, such as the regulatory T cells. (bvsalud.org)
  • It is activated by chemokines CCL19 and CCL21, which are scavenged by the atypical chemokine receptor ACKR4. (aai.org)
  • In this article, we have incorporated multiple biochemical processes describing the CCL19-CCL21-CCR7-ACKR4 network into our model of LN fluid flow to establish a computational model to investigate intranodal chemokine gradients. (aai.org)
  • CCR receptors with specificity for CHEMOKINE CCL19 and CHEMOKINE CCL21. (lookformedical.com)
  • Ibrutinib has also been reported to reduce chronic lymphocytic leukemia cell chemotaxis towards the chemokines CXCL12 and CXCL13, and inhibit cellular adhesion following stimulation at the B-cell receptor (BCR). (wikipedia.org)
  • In addition, VCAM-1, MMP-1, TGF-ß1, and some chemokines (CCL2 and CXCL12 cytokines) are more highly expressed in IL18-hUCMSCs. (bvsalud.org)
  • Recently, it has been found that both chemokine C-X-C motif ligand 12 (CXCL12) and its receptor CXCR4 were upregulated in spinal glial cells of mice with partial sciatic nerve ligation (pSNL)-induced neuropathic pain or chronic post-ischemia-induced inflammatory pain [ 5 ]. (biomedcentral.com)
  • Binds to chemokine receptor CCR7. (cusabio.com)
  • Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. (cusabio.com)
  • The chemokine receptor CCR7 drives leukocyte migration into and within lymph nodes (LNs). (aai.org)
  • CXCR3 chemokine receptor-ligand interactions in the lymph node optimize CD4+ T helper 1 cell differentiation. (umassmed.edu)
  • Chemokine CXC receptor 4 (CXCR4) in spinal glial cells has been implicated in neuropathic pain. (biomedcentral.com)
  • Chemokine CXC receptor 4 (CXCR4) belongs to the family of G protein-coupled receptors. (biomedcentral.com)
  • This recruitment is due to the capacity of transforming growth factor β to drive Chemokine (C-X-C motif) Ligand 13 expression, a chemoattractant of Tfh, by intratumor CD8 + T cells. (nih.gov)
  • Like the CHEMOKINES themselves, the receptors can be divided into at least three structural branches: CR, CCR, and CXCR, according to variations in a shared cysteine motif. (lookformedical.com)
  • APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F: Candida albicans enhanced the production of the CCR5-interacting chemokines CCL3, CCL4, and CCL5, and stimulates the production of interferon-a and the restriction factors APOBEC3G, APOBEC3F, and tetherin (BST2) in macrophages Rodriguez et al, 2013 . (polygenicpathways.co.uk)
  • BST2 bone marrow stromal cell antigen 2 (Tetherin): Candida albicans enhanced the production of the CCR5-interacting chemokines CCL3, CCL4, and CCL5, and stimulates the production of interferon-a and the restriction factors APOBEC3G, APOBEC3F, and tetherin (BST2) in macrophages Rodriguez et al, 2013 . (polygenicpathways.co.uk)
  • However, global transcriptomics highlight differences between T PH cells and T follicular helper cells, including altered expression of BCL6 and BLIMP1 and unique expression of chemokine receptors that direct migration to inflamed sites, such as CCR2, CX3CR1, and CCR5, in T PH cells. (nature.com)
  • This is largely orchestrated by chemokines, which are sensed by heptahelical G protein-coupled chemokine receptors on leukocytes ( 1 , 2 ). (aai.org)
  • A CC-type chemokine with specificity for CCR10 RECEPTORS. (lookformedical.com)
  • A CC-type chemokine that is found at high levels in the THYMUS and has specificity for CCR4 RECEPTORS. (lookformedical.com)
  • A CC chemokine with specificity for CCR1 RECEPTORS and CCR5 RECEPTORS. (lookformedical.com)
  • CCR receptors with specificity for CHEMOKINE CCL27. (lookformedical.com)
  • CCR receptors with specificity for a broad variety of CC CHEMOKINES. (lookformedical.com)
  • Chemokine CCL8 has specificity for CCR3 RECEPTORS and CCR5 RECEPTORS. (lookformedical.com)
  • Chemokine receptors that are specific for CC CHEMOKINES. (lookformedical.com)
  • A CC-type chemokine that is specific for CCR3 RECEPTORS. (lookformedical.com)
  • We assessed cardiac response in two experimental models of CKD and tested macrophage and chemokine implication in monocytopenic CCR2 −/− and anti-CXCL10 treated mice. (biomedcentral.com)
  • Parameter variation analysis indicates that the directionality of these gradients is robust, but their magnitude is sensitive to these key parameters: chemokine production, diffusivity, matrix binding site availability, and CCR7 abundance. (aai.org)
  • Additionally, ibrutinib inhibited proliferation of CLL cells in vitro, effectively blocking survival signals provided externally to CLL cells from the microenvironment including soluble factors (BAFF, IL-6, IL-4, and TNF-α), fibronectin engagement and stromal cell contact. (wikipedia.org)
  • Rather, using multidimensional cytometry, transcriptomics, and functional assays, we define a population of PD-1 hi CXCR5 − 'peripheral helper' T (T PH ) cells that express factors enabling B-cell help, including IL-21, CXCL13, ICOS, and MAF. (nature.com)
  • Thus, when cultured alone without special treatment, CLL cells do not proliferate under in vitro conditions. (biomedcentral.com)
  • In human, the impact of immune cells and chemokines on survival was evaluated by analyzing transcriptomic data from public databases and from our own patient cohorts. (nih.gov)
  • Cells grown in vitro from neoplastic tissue. (lookformedical.com)
  • In the paper titled 'Characterization of Bone Marrow Mononuclear Cells on Biomaterials for Bone Tissue Engineering In Vitro,' there was an error in the Acknowledgments. (uni-frankfurt.de)
  • Impact of class A, B and C CpG-oligodeoxynucleotides on in vitro activation of innate immune cells in human immunodeficiency virus-1 infected individuals. (umassmed.edu)
  • Preclinical studies have shown that ibrutinib effectively inhibits malignant B-cell proliferation and survival in vivo as well as cell migration and substrate adhesion in vitro. (wikipedia.org)
  • In this study, we selected an appropriate cytokine, IL-18, based on the special cytokine expression profile in severe pneumonia of mice induced by H1N1virus to prime hUC-MSCs in vitro and improve the therapeutic effect of hUC-MSCs in vivo. (bvsalud.org)
  • In vivo and in vitro studies suggest, however, that in some instances terminal differentiation and isotype switching can occur. (omicsdi.org)
  • Specifically, the study focused on Kupffer cell proinflammatory cytokines IL-6 and TNF-α and activation of NF-κB after chronic ethanol feeding followed by in vitro stimulation with lipopolysaccharide (LPS). (uni-frankfurt.de)
  • Acute alcohol intoxication suppresses the pulmonary ELR-negative CXC chemokine response to lipopolysaccharide. (umassmed.edu)
  • Salmonella enterica Typhimurium SipA induces CXC-chemokine expression through p38MAPK and JUN pathways. (umassmed.edu)
  • In vitro differentiated and mouse cell sorted Tfh phenotype was evaluated by flow cytometry and quantitative PCR (qPCR). (nih.gov)
  • Chemokines and cytokines expression and production were evaluated by qPCR and ELISA. (nih.gov)
  • An in vitro cell model was employed to investigate the roles of noncanonical inflammasomes in macrophages in response to HAdV infection. (bvsalud.org)
  • Importantly, the model recapitulates CCL21 gradients observed experimentally in B cell follicles and interfollicular regions, building confidence in its ability to accurately predict intranodal chemokine distribution. (aai.org)
  • Moreover, it acts as a framework to investigate gradients at other locations, including those that cannot be visualized experimentally or involve other chemokines. (aai.org)
  • Arterial-venous network formation during brain vascularization involves hemodynamic regulation of chemokine signaling. (umassmed.edu)
  • In vitro experiments revealed that HAdV infection promoted caspase-4/5 expression, activation and pyroptosis in differentiated THP-1 (dTHP-1) human macrophages via NF-κB, rather than STING signaling pathway. (bvsalud.org)
  • This graph shows the total number of publications written about "Chemokines, CXC" by people in this website by year, and whether "Chemokines, CXC" was a major or minor topic of these publications. (umassmed.edu)
  • The Mouse Cytokine Array, Panel A utilizes capture antibodies spotted onto a nitrocellulose membrane to allow high-throughput multi-analyte profiling of 40 cytokines, chemokines, and more in a single sample. (rndsystems.com)
  • In vitro, we demonstrated that IL-18-primed hUC-MSCs (IL18-hUCMSC) have higher proliferative ability than non-primed hUC-MSCs (hUCMSCcon). (bvsalud.org)
  • That compares the baking soda dry-mist system as well as a Zero.5% hypochlorite remedy with regards to remarkable ability for you to sanitize Clostridium difficile-contaminated materials in vitro and in situ. (mirnaarray.com)