• In addition, both mechanical allodynia and thermal hyperalgesia was significantly inhibited by a JAK2 inhibitor, AG490. (bvsalud.org)
  • Peripheral administration of nerve growth factor in the adult rat produces a thermal hyperalgesia that requires the presence of sympathetic post-ganglionic neurones. (2medicalcare.com)
  • Pain can be of cutaneous, somatic or visceral origin caused by stimulation of pain receptors [nociceptors], which decline in number in these respective tissues. (abdel-gadir.com)
  • Nociceptive pain (pain caused by tissue injury) may be somatic or visceral. (msdmanuals.com)
  • Finally, neuropathic pain may be referred from one viscus to the other, or to a cutaneous or muscular area not involved in the initial pathological process. (abdel-gadir.com)
  • Hargreaves methods and Von Frey fibrofilaments were used to evaluate the symptoms of neuropathic pain including allodynia and hyperalgesia in rats. (bvsalud.org)
  • Repeated stimulation can lead to sensitisation of the peripheral nerve fibres, lowering pain thresholds and leading to spontaneous pain, e.g. sunburn leading to cutaneous hypersensitivity. (postgraduateorthopaedics.co.uk)
  • Cutaneous pain has a sharp quality, as it is conveyed by the fast A-delta fibres. (abdel-gadir.com)
  • On the other hand, sensitisation of the dorsal horn receptors may lead to secondary hyperalgesia, causing pain in normal areas neighbouring the injured nerve. (abdel-gadir.com)
  • Visceral pain receptors are located in most viscera and the surrounding connective tissue. (msdmanuals.com)
  • Visceral pain due to obstruction of a hollow organ is poorly localized, deep, and sometimes cramping and may be referred to remote cutaneous sites. (msdmanuals.com)
  • Visceral pain due to injury of organ capsules or other deep connective tissues may be more localized and sharp. (msdmanuals.com)
  • Allodynia: Pain due to a stimulus that normally would not provoke pain. (postgraduateorthopaedics.co.uk)
  • Visceral organs only have C fibre nociceptors and therefore no reflex action due to visceral organ pain. (postgraduateorthopaedics.co.uk)
  • Allodynia is pain experienced in response to a normally painless stimulus. (wikipedia.org)
  • Paraplegia, the loss of sensation and voluntary motor control after serious spinal cord damage, may be accompanied by girdle pain at the level of the spinal cord damage, visceral pain evoked by a filling bladder or bowel, or, in five to ten per cent of paraplegics, phantom body pain in areas of complete sensory loss. (wikipedia.org)
  • 11 Furthermore, we previously demonstrated that the prevention of mast cell degranulation largely reduced hyperalgesia in a model of postoperative pain. (asahq.org)
  • We observed a decreased mechanical allodynia threshold in the intervention group, although there were no changes in heat- or cold-induced pain. (bvsalud.org)
  • 40. Central activation of TRPV1 and TRPA1 by novel endogenous agonists contributes to mechanical allodynia and thermal hyperalgesia after burn injury. (nih.gov)
  • Inflammation or nerve injury can disrupt this sensory coding and result in maladaptive pain states, including mechanical allodynia, the development of pain in response to innocuous touch. (nih.gov)
  • Implantation of tumor cells into the tibias induced significant thermal hyperalgesia and mechanical allodynia, and enhanced glutamatergic strength in the ipsilateral dorsal horn. (biomedcentral.com)
  • Significantly increased brain-derived neurotrophic factor (BDNF) expression was detected in the dorsal horn, and blockade of spinal BDNF signaling attenuated the enhancement of glutamatergic strength, thermal hyperalgesia and mechanical allodynia in the rats with bone cancer pain. (biomedcentral.com)
  • Significantly increased spinal PAR2 expression was also observed, and inhibition of PAR2 signaling ameliorated BDNF upsurge, enhanced glutamatergic strength, and thermal hyperalgesia and mechanical allodynia. (biomedcentral.com)
  • Inhibition of NF-κB pathway, the downstream of PAR2 signaling, also significantly decreased the spinal BDNF expression, glutamatergic strength of dorsal horn neurons, and thermal hyperalgesia and mechanical allodynia. (biomedcentral.com)
  • In our previous study, 10 mg/kg [6]-shogaol (i.p.) significantly alleviated cold and mechanical allodynia induced by a 6 mg/kg oxaliplatin injection (i.p. (researchgate.net)
  • Irritable bowel syndrome (IBS) and bladder pain syndrome/interstitial cystitis (BPS/IC) are comorbid visceral pain disorders seen commonly in women with unknown etiology and limited treatment options and can involve visceral organ cross-sensitization. (bvsalud.org)
  • Up-regulation of NMDA receptor subunits may reflect part of the basis for chronic visceral hypersensitivity in conditions such as post-infectious irritable bowel syndrome. (biomedcentral.com)
  • Visceral pain is a common symptom involved in many gastrointestinal disorders such as inflammatory bowel disease and irritable bowel syndrome. (biomedcentral.com)
  • 35. A syngeneic inoculation mouse model of endometriosis that develops multiple comorbid visceral and cutaneous pain like behaviours. (nih.gov)
  • 25. The Different Dynamic Changes of Nerve Growth Factor in the Dorsal Horn and Dorsal Root Ganglion Leads to Hyperalgesia and Allodynia in Diabetic Neuropathic Pain. (nih.gov)
  • Furthermore, a number of receptors, neurotransmitters, cytokines and second messenger systems in these neurons have been implicated in the enhancement of visceral nociception [ 8 - 12 ]. (biomedcentral.com)
  • The potential role of altered enteric nervous system function on visceral nociception has not been fully explored. (biomedcentral.com)
  • The brush of a feather and a pinprick are perceived as distinct sensations because they are detected by discrete cutaneous sensory neurons. (nih.gov)
  • Visceral organ cross-sensitization was induced in adult female rats via transurethral infusion of protamine sulfate (PS) into the urinary bladder or infusion into the colon of trinitrobenzene sulfonic acid (TNBS). (bvsalud.org)
  • Tumors treated and possibly cured with surgery alone include canine oral squamous cell carcinoma and sarcomas, cutaneous mast cell tumors, mammary tumors, soft-tissue sarcomas, splenic or hepatic tumors with painful capsular distension, nailbed tumors, synovial cell sarcoma, and tumors of the ear canal. (dvm360.com)
  • A sentence has been added to the note on Hyperalgesia to refer to current views on its physiology, although as with other definitions, that for Hyperalgesia remains tied to clinical criteria. (iasp-pain.org)
  • In three rodent models, we employed a monoclonal anti-CGRP F(ab')2 to investigate the hypothesis that visceral organ cross-sensitization is mediated by abnormal CGRP signaling. (bvsalud.org)
  • These results suggest a role for colonic myenteric plexus NMDA receptors in the development of neuronal plasticity and visceral hypersensitivity in the colon. (biomedcentral.com)