Virus particles sendai virus. Medical search. Frequent questions

The rule of six, a basic feature for efficient replication of Sendai virus defective interfering RNA. (microbiologyresearch.org)
It was shown that resistance to the lethal effects of Sendai virus in mice is genetically controlled and expressed through control of viral replication within the first 72 hours of infection. (wikipedia.org)
In contrast disease launch from untransformed human being fibroblasts or main human being hepatocytes was found to be reduced by about three log PF-04620110 methods in a time course experiment which enables the cumulation of kinetic variations of the unique phases of viral replication such as primary PF-04620110 target cell illness target cell replication and progeny disease particle release. (siamtech.net)
Non-structural proteins are involved in the transcription and replication of the virus. (medsci.org)
Like all viruses, the EBOV largely relies on host cell factors and physiological processes for its entry, replication, and egress. (biomedcentral.com)

Murine respirovirus, formerly Sendai virus (SeV) and previously also known as murine parainfluenza virus type 1 or hemagglutinating virus of Japan (HVJ), is an enveloped, 150-200 nm-diameter, negative sense, single-stranded RNA virus of the family Paramyxoviridae. (wikipedia.org)
Unmodified crazy type Sendai disease (murine parainfluenzavirus type I SeV) another well-known member of this disease family was actually used like a vaccine vector against hPIV1 and has PF-04620110 been demonstrated to be safe in medical tests [16]. (siamtech.net)
Some of the first iPSCs were generated with Moloney murine leukemia virus (MMLV)-derived retroviruses. (addgene.org)

The virus is responsible for a highly transmissible respiratory tract infection in mice, hamsters, guinea pigs, rats, and occasionally marmosets, with infection passing through both air and direct contact routes. (wikipedia.org)
Inbred and outbred mouse and rat strains have very different susceptibility to Sendai virus infection. (wikipedia.org)
Respiratory epithelium appears to be the major site of virus binding and subsequent infection. (medscape.com)
Vaccine-induced antibody and T cell responses correlated with protection against lethal influenza virus infection. (researchsquare.com)
Moreover, antibody responses induced by influenza virus vaccines are usually short-lived and less cross-reactive against antigenically drifted virus variants than those induced by a natural influenza virus infection 1 . (researchsquare.com)
Type I interferons (IFN-α/β) are potent, antivirally active cytokines which can be produced by most, if not all, body cells in response to virus infection. (biomedcentral.com)
A new immunotherapeutic method of treating lower respiratory tract infection caused by respiratory syncytial virus (RSV) is disclosed. (justia.com)
The above and various other objects and advantages of the present invention are achieved by a method of treating respiratory disease, comprising topically administering to a host susceptible to or suffering from infection by respiratory syncytial virus (RSV), an effective amount of neutralizing antibodies to produce prophylactic or therapeutic effect against virus infection. (justia.com)
The ability of a pathogenic virus to lie dormant within a cell (latent infection). (lookformedical.com)
Low levels of reactive oxygen species (ROS) play a role in mitogenic activation, and the early phase of lytic and nonlytic virus infection indeed resembles that of mitogenic cell activation. (foundationforhealthresearch.org)
Oxidative stress has also been shown in human immunodeficiency virus (HIV) infection in humans. (foundationforhealthresearch.org)

Infectious transcripts and cDNA clones of RNA viruses. (microbiologyresearch.org)
The virus is infectious for many cancer cell lines (see below), and has oncolytic properties demonstrated in animal models and in naturally-occurring cancers in animals. (wikipedia.org)
The mechanism by which latent viruses, such as genetically transmitted tumor viruses ( PROVIRUSES ) or PROPHAGES of lysogenic bacteria, are induced to replicate and then released as infectious viruses. (lookformedical.com)
and sometimes LIPIDS, and their assembly into a new infectious particle. (lookformedical.com)
Virus shedding is an important means of vertical transmission (INFECTIOUS DISEASE TRANSMISSION, VERTICAL). (lookformedical.com)
It has been shown for LASV, as well as for other arenaviruses, Rabbit polyclonal to IFIH1 that during the course of contamination, infectious computer virus particles are released from epithelia into body fluids and urine (32, 45, 71). (esbiomech2012.org)

SeV has several features that are important in a vector for a successful vaccine: the virus does not integrate into the host genome, it does not undergo genetic recombination, it replicates only in the cytoplasm without DNA intermediates or a nuclear phase and it is does not cause any disease in humans or domestic animals. (wikipedia.org)
Rapid Genome Sequencing of RNA Viruses performed within 90 min. (cdc.gov)
Near-Complete Genome Sequence of Lötschberg Virus (Mononegavirales: Filoviridae) Identified in European Perch (Perca fluviatilis Linnaeus, 1758). (unibe.ch)
8 It has an envelope and contains a very large RNA virus genome. (medsci.org)

Hands on experience in techniques involving recombinant DNA technology such as preparation of plasmid DNA, transformation of bacteria by plasmid DNA, characterization of plasmids, cloning of DNA fragments into vectors, vaccinia virus, hybridization and electrophoretic procedures. (sprayprotectgo.com)
Additionally a first-in-man software of recombinant Sendai disease has been reported very recently like a vector for gene delivery of human being FGF-2 to treat peripheral arterial disease and was shown to be safe and well tolerated [17]. (siamtech.net)
ZMapp), anti-sense phosphorodiamidate morpholino oligomers (PMO AVI-6002), lipid nanoparticle small interfering RNA (LNP-siRNA: TKM-Ebola), and an EBOV glycoprotein-based vaccine using live-attenuated recombinant vesicular stomatitis virus (rVSV-EBOGP) or a chimpanzee adenovirus (rChAd-EBOGP)-based vector. (biomedcentral.com)

The Sendai virus nucleocapsid exists in at least four different helical states. (microbiologyresearch.org)
We show that GP determines the apical release of Lassa computer virus from epithelial cells, presumably by recruiting the matrix protein Z to the site of computer virus assembly, which is usually in turn essential for nucleocapsid incorporation into virions. (esbiomech2012.org)

Sigma-Aldrich, Saint Louis, MO, USA), which was devel- drome (SARS) provided important lessons on how oped for amplification of genomic DNA, was used to unknown viruses should be detected rapidly. (cdc.gov)

It typically infects rodents and it is not pathogenic for humans or domestic animals Sendai virus (SeV) is a member of the genus Respirovirus. (wikipedia.org)

other popular cell reprograming approaches include Sendai virus and mRNA-based technologies. (rootsanalysis.com)

HPIV transmission occurs via direct inoculation of contagious secretions from the hands or via large-particle aerosols into the eyes and nose. (medscape.com)
Viruses that are transmitted through aerosols or surface contact with body fluids are generally thought to enter the epithelial barrier from the apical side, whereas computer virus infections due to injuries or transmission from animals' bites and scratches enter epithelial cell layers from the basolateral side. (esbiomech2012.org)

Structure of adenovirus particles. (what-when-how.com)
a schematic cross section through an adenovirus particle, showing the locations of minor polypeptide components (right). (what-when-how.com)

Despite several vaccine candidates available on the market, influenza virus is responsible for severe illness in humans, with a substantial global death toll every year (https://gis.cdc.gov/grasp/fluview/flu_by_age_virus.html). (researchsquare.com)
Seasonal Influenza A virus (IAV) and influenza B virus (IBV) co-circulate in the human population and keep evolving with time. (researchsquare.com)
However, due to antigenic drift in influenza viruses, vaccines need to be updated every year to protect against the circulating strains of the virus. (researchsquare.com)
Protective anti-influenza immunity often correlates with antibody responses to influenza surface glycoproteins, particularly hemagglutinin (HA), the main antigenic determinant on the surface of both influenza virus and infected cells. (researchsquare.com)
In addition to these subtle cell-activating effects shared by many viruses, influenza and paramyxoviruses activate a respiratory burst in phagocytic cells. (foundationforhealthresearch.org)
Cells lavaged from the lungs of mice infected with influenza virus are primed for enhanced superoxide generation. (foundationforhealthresearch.org)

The latter include Human Respiratory Syncytial Virus (HRSV), Human Metapneumovirus (HMPV) and Human Parainfluenza Viruses (HPIV). (wikipedia.org)
Parainfluenza viruses (PIVs) are paramyxoviruses of the order Mononegavirales, the family Paramyxoviridae, and the subfamily Paramyxovirinae. (medscape.com)

As a consequence IFN-sensitive viruses preferentially replicate in malignancy cells while normal cell types and cells are able to launch a powerful counterattack [9]. (siamtech.net)
Because viruses replicate in living cells, such metabolites influence the growth of viruses in addition to serving as a host defense mechanism. (foundationforhealthresearch.org)

Rabbitpox virus is a subspecies of VACCINIA VIRUS . (lookformedical.com)

As epithelial layers play a pivotal role not only in initial computer virus contamination but also in release of computer virus progeny during the early stages of contamination, computer virus spread within the organism and computer virus release for further transmission, the polarity of entry and release from polarized epithelia has been studied extensively with various viruses. (esbiomech2012.org)
Furthermore, we have elucidated how Lassa computer virus proteins interact to direct budding and release of LASV progeny from epithelial cell layers. (esbiomech2012.org)

The virus can be detected in mouse colonies worldwide, generally in suckling to young adult mice. (wikipedia.org)
Epizootic infections of mice are usually associated with a high mortality rate, while enzootic disease patterns suggest that the virus is latent and can be cleared over the course of a year. (wikipedia.org)
C57BL/6 mice are highly resistant to the virus, while DBA/2J mice are sensitive. (wikipedia.org)

Sendai virus is used as a backbone for vaccine development against Mycobacterium tuberculosis that causes tuberculosis, against HIV-1 that causes AIDS and against other viruses, including those that cause severe respiratory infections in children. (wikipedia.org)

The primary transmission route of LASV from its host to humans is usually by direct exposure to virus-containing urine, which may occur via the respiratory tract, through inhalation of Piperonyl butoxide infected particulates, or via ingestion of contaminated food (62). (esbiomech2012.org)

Newcastle disease virus is a rubulavirus that infects poultry, penguins, and other birds and has been responsible for conjunctivitis in bird handlers and laboratory workers. (medscape.com)

Substances elaborated by viruses that have antigenic activity. (lookformedical.com)

HPIV is closely related to Hendra virus, Nipah virus, and metapneumoviruses. (medscape.com)
HPIV-3 is second only to respiratory syncytial virus (RSV) as a cause of pneumonia and bronchiolitis in infants and young children. (medscape.com)
Chimpanzees, macaques, squirrels, owls, and rhesus monkeys have been asymptomatically infected with HPIV-3 or HPIV-4, and only marmosets have developed symptomatic upper respiratory tract infections (URTIs) with HPIV-3 and Sendai virus. (medscape.com)

Substitution of Val 113 in Sendai virus (SeV) M protein generates non-functional polypeptides, characterized by their exclusion from virus particles and by their ability to interfere with virus particle production. (microbiologyresearch.org)
Analysis of the Sendai virus M gene and protein. (microbiologyresearch.org)
Sendai virus M protein is found in two distinct isoforms defined by monoclonal antibodies. (microbiologyresearch.org)
13 , 14 However, the amino acid perfectly maintains the stability of the mutual structural conformation of the virus S-protein and the ACE2 receptor in a holistic manner. (medsci.org)
Spiropoulou, J. finding that, when expressed individually, both the glycoprotein GP and matrix protein Z form virus-like particles. (esbiomech2012.org)

We con- obtained from cultured virus isolates without subcloning firmed that DNA was effectively eliminated by this RNA into plasmid vectors. (cdc.gov)
Here we describe a model system, SELective Expression and Controlled Transduction In Vivo (SELECTIV), that enables efficient and specific expression of transgenes by coupling adeno-associated virus (AAV) vectors with Cre-inducible overexpression of the multi-serotype AAV receptor, AAVR. (nature.com)

Proteins found in any species of virus. (lookformedical.com)

Intramembrane structural differentiation in Sendai virus maturation. (microbiologyresearch.org)

LRP6 Is a Functional Receptor for Attenuated Canine Distemper Virus. (unibe.ch)
They are essential for virus-cell receptor binding and the production of structurally complete virus particles. (medsci.org)
Virus entry in polarized cells is usually correlated with the apical or basolateral localization of the responsible computer virus receptor (24, 34, 68). (esbiomech2012.org)

The virus was isolated in the city of Sendai in Japan in the early 1950s. (wikipedia.org)
In Japan intranasal Sendai virus-based SARS-CoV-2 vaccine was created and tested in a mouse model. (wikipedia.org)
A joint study by the Virus Research Centre at Sendai Medical Center and QleanAir Japan center has succeeded in measuring this. (greenlodgingnews.com)
It hit about 130 kilometres east of Sendai which is in Honshu, which is the big main island, and the epicentre was in the Japan Trench, which is where you have the Pacific plates subducting under parts of the Eurasian plates. (thenakedscientists.com)

The viruses attach to the host cells through hemagglutinin, which specifically combines with neuraminic acid receptors in the host cells. (medscape.com)
This reduction in the potential ability of NK cells to kill virus-infected host cells may increase the susceptibility to viral infections after DEP exposure. (biomedcentral.com)
Different immunoglobulin G (IgG) subclasses produced by class-switched B cells help in opsonization and virus neutralization and hence, facilitate viral clearance from the host. (researchsquare.com)
For most viruses, the initial encounter with the host takes place in cells of non-lymphatic origin. (biomedcentral.com)
Viruses, on the other hand, have evolved various mechanisms to counteract the host's cytokine response [ 3 ], and their ability to induce or inhibit cytokine production in infected cells has direct consequences for the balance between host defense and virus propagation. (biomedcentral.com)
as activation of viral particles by cancer-specific proteases access through malignancy cell-specific receptors or exploiting specific defects of malignancy cells [5]. (siamtech.net)
We describe the first report of RNA sequencing of 5' capped (Pol II) RNAs isolated from acutely hepatitis C virus (HCV) infected Huh 7.5 cells that provides a general approach to identifying differentially expressed annotated and unannotated genes that participate in viral-host interactions. (mdpi.com)
Process of growing viruses in live animals, plants, or cultured cells. (lookformedical.com)
During the contamination process, computer virus contacts the epithelial layers of the body and, after breaking through the epithelial tissue barrier, exploits dendritic cells for further dissemination (3, 15). (esbiomech2012.org)
Further, the spread of disease is also dependent on the directional release of the computer virus from epithelial cells. (esbiomech2012.org)
Fitting with this model, budding of wild-type Sendai computer virus is restricted to the apical domain name of polarized cells and causes a local respiratory contamination, whereas systemic spread of a Sendai computer virus mutant could be attributed mainly to its bipolar computer virus release (66). (esbiomech2012.org)
The direction of entry Piperonyl butoxide and release can also be highly dependent on the type of tissue involved, as Sindbis and Semliki Forest viruses show differences in directed release in colon and thyroid gland cells (75). (esbiomech2012.org)
Cloning, expression and biological activity of a new variant of human interferon alpha identified in virus induced lymphoblastoid cells. (nih.gov)

Here, we describe the StemCellFactory, an automated, modular platform covering the entire process of hiPSC production, ranging from adult human fibroblast expansion, Sendai virus-based reprogramming to automated isolation, and parallel expansion of hiPSC clones. (frontiersin.org)
Adult cotton rats were immunized with inactivated Sendai virus vaccine (Microbiological Associates) at least 3 weeks before study. (justia.com)

This Mask does not protect users or others against human pathogens including bacteria, viruses, germs or other disease organisms. (notanothermask.com)
Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes. (nih.gov)

Most vaccines are made with killed or weakened viruses. (healthline.com)
Live vector vaccines use non-HIV viruses to carry HIV genes into the body to trigger an immune response. (healthline.com)

Due to the PF-04620110 diversity of the so far founded viral systems and the plethora of different tumor types that have to be tackled it is demanding to identify or develop unique oncolytic viruses that are most suitable for any subset of tumor entities. (siamtech.net)

We have developed a feeder-free, Sendai virus-mediated reprogramming protocol suitable for cell culture processing via a robotic liquid handling unit that delivers footprint-free hiPSCs within 3 weeks with state-of-the-art efficiencies. (frontiersin.org)
Whether and how exposure to diesel exhaust particles (DEP) affects NK cell function in the context of viral infections has not been investigated. (biomedcentral.com)
However, synthesis of IP-10 and IL-8, which are established markers for acute-stage SARS, escapes the virus-induced silencing at least in some cell types. (biomedcentral.com)
Virus titer was determined by plaque assay on HEp-2 cell monolayers as described by Prince et al (1978) Am. J. Pathol. (justia.com)
Specific molecular components of the cell capable of recognizing and interacting with a virus, and which, after binding it, are capable of generating some signal that initiates the chain of events leading to the biological response. (lookformedical.com)
In order to understand computer virus dissemination within the organism, it is of interest to determine on which side viruses enter and leave polarized epithelial cell layers. (esbiomech2012.org)
MATERIALS AND METHODS Viruses and cell cultures. (esbiomech2012.org)

As a result of vaccination against HPIV1 a significant boost in virus-specific neutralizing antibodies was observed. (wikipedia.org)

Virus-induced cytokines not only play a significant role in host defense, but also in immunopathogenesis. (biomedcentral.com)

The outgoing chief executive "actively considered" visiting Tokyo and Sendai from May 14 to May 16. (cleartheair.org.hk)

Molecular cloning and characterization of a Sendai virus internal deletion defective RNA. (microbiologyresearch.org)

The EBOV is an enveloped filamentous RNA virus belonging to the family Filoviridae . (biomedcentral.com)

First, they require the use of potentially harmful viral particles that express oncogenes, such as Myc. (addgene.org)

In accordance with the Invitrogen manual, cDNA was emerging viruses. (cdc.gov)

The visit was also to include a stop in Sendai to meet residents affected by last year's tsunami and would have been Tsang's last overseas trip before stepping down as chief executive next month. (cleartheair.org.hk)

Pathogenesis of rabies in dogs inoculated with an Ethiopian rabies virus strain. (microbiologyresearch.org)

For vaccination purpose the Sendai virus-based constructs could be delivered in a form of nasal drops, which may be beneficial in inducing a mucosal immune response. (wikipedia.org)
Steadily increasing urbanization, significant numbers of diesel engine-driven vehicles on the roads, and high peaks of particulate matter concentrations in urban areas raise the question about the effects of diesel exhaust particles (DEP) on the immune system. (biomedcentral.com)
Other virus-induced cytokines and chemokines activate the adaptive immune system and direct the migration of leukocytes [ 2 ]. (biomedcentral.com)
The immune system, which fights disease, doesn't respond to the HIV virus. (healthline.com)

Archival wild-type poliovirus 1 infected central nervous system tissues of the pre-vaccination era in Switzerland reveal a distinct virus genotype. (unibe.ch)

The present invention is related to immunotherapy of respiratory disease caused by respiratory syncytial virus (RSV) or other respiratory viruses. (justia.com)
It is, therefore, an object of the present invention to provide a more efficacious, simpler and quick acting method of treating virus-caused respiratory disease than the currently available therapeutic modalities. (justia.com)

To that download today, these virus physics were retaining into a modernist library done on both change server and primary identity. (holzbau-bauer.info)

Virus diseases caused by the HERPESVIRIDAE. (lookformedical.com)
A general term for diseases produced by viruses. (lookformedical.com)

The type species of ORTHOPOXVIRUS, related to COWPOX VIRUS , but whose true origin is unknown. (lookformedical.com)

These viruses are toxic when injected in animals. (foundationforhealthresearch.org)

A comparison with established cytokine-inducing viruses revealed that SARS-CoV only weakly triggered a cytokine response. (biomedcentral.com)

The virus is using its own RNA polymerase. (wikipedia.org)

Structure and supramolecular organization of the canine distemper virus attachment glycoprotein. (unibe.ch)
Dr. Takizawa in Wolf Unit determined the structure of the dinucleosome-HP1 complex by single particle cryo-EM at 1 nm resolution. (oist.jp)
Our asymmetric reconstruction revealed the interaction sites of FoxA1 on the nucleosome and represented the highest resolution single particle cryo-EM structure of this complex without the use of a phase plate. (oist.jp)

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