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  • Hepatitis B Vir
  • ANA380 Exhibits Activity In Vitro Against Multiple Clinically,Relevant Hepatitis B Virus Mutants ( Poster Presentation at EASL on April 13. (bio-medicine.org)
  • A precore mutant is a variety of hepatitis B virus that does not produce hepatitis B virus e antigen (HBeAg). (wikipedia.org)
  • Since the introduction of vaccination against hepatitis B virus (HBV) infection in South Africa, at least one case of infection despite vaccination has occurred. (wits.ac.za)
  • Liver failure caused by reactivation of hepatitis B virus (HBV) is an uncommon complication of bone marrow transplantation [1-. (annals.org)
  • Hepatitis B virus precore mutant infection has been associated with liver failure after cytotoxic chemotherapy and with fibrosing cholestatic hepatitis after liver transplantation [5, , but the relation is unclear. (annals.org)
  • Hepatitis B virus could not be sequenced before transplantation because both donor and recipient were HBV-DNA-negative by polymerase chain reaction . (annals.org)
  • McIvor C, Morton J, Bryant A, Cooksley WG, Durrant S, Walker N. Fatal Reactivation of Precore Mutant Hepatitis B Virus Associated with Fibrosing Cholestatic Hepatitis after Bone Marrow Transplantation. (annals.org)
  • variants
  • D) Three types of standard nucleotide (Std-YY, Std-YH, and Std-HH) were prepared, which includes binary target sequences, corresponding to wild (Y) or mutant (H) variants, and annealing sites with the internal primers at each end. (blogspot.com)
  • vaccine
  • The standard influenza vaccine still protects against the mutant virus, said Dr. Hayden and Dr. Alicia Fry, an influenza epidemiologist at the Centers for Disease Control and Prevention in Atlanta. (goupstate.com)
  • Anytime you understand how a virus causes a disease, you can find ways to interrupt that process," says senior author William Klimstra, associate professor at the University of Pittsburgh's Center for Vaccine Research. (futurity.org)
  • Ultimately, these results suggest that the mutant virus could be used as an EEEV vaccine and that microRNA blockers could have potential for use as a therapeutic treatment for EEEV-infected patients who currently can be treated only with supportive care. (futurity.org)
  • On the other hand, not publishing this information would slow, or even block, the development of a vaccine against a virus that still has the potential to mutate naturally to a pandemic form, which could cause huge numbers of fatalities worldwide. (medindia.net)
  • It could be demonstrated that a novel recombinant double deletion mutant is a safe and efficacious vaccine candidate. (asm.org)
  • Therefore, the described vaccine also represents the first model for a broad range of related viruses and is of high importance to the field. (asm.org)
  • vaccines
  • The present invention relates to infectious bovine rhinotracheitis viruses which fail to produce any functional thymidine kinase as a result of an insertion in the thymidine kinase gene, vaccines against infectious bovine rhinotracheitis containing the same and methods for production and use of same. (google.com.au)
  • The deletion viruses that are produced no longer contain a selectable marker, which may be preferable for the production of vaccines. (bio-protocol.org)
  • The discovery, which is published in the journal Nature , could aid in the development of vaccines and treatments for eastern equine encephalitis virus (EEEV), a rare but deadly disease that is found primarily in the Atlantic and Gulf States. (futurity.org)
  • Therefore, the double deletion mutant will provide the basis for further developments of safe and efficacious modified live SBV vaccines which could be also a model for other viruses of the Simbu serogroup and related orthobunyaviruses. (asm.org)
  • Here, mutant viruses lacking one or two proteins that essentially contribute to viral pathogenicity were tested as modified live vaccines in cattle. (asm.org)
  • defect
  • Growth of a m41.1 mutant was attenuated in multiple organs, a defect that was not apparent in Bak(-/-) mice. (nih.gov)
  • avian
  • This risk is all too present in nature, especially in pigs, which can mix avian, human and porcine viruses. (medindia.net)
  • The avian flu now spreading in Asia is part of the H1 family of flu viruses. (chron.com)
  • There had been appearances of the H1-type of avian viruses in other years, but nothing like the H5 now rampaging through the birds of Asia. (chron.com)
  • genotype
  • This blog is all about current FDA approved drugs to treat the hepatitis C virus (HCV) with a focus on treating HCV according to genotype, using information extracted from peer-reviewed journals, liver meetings/conferences, and interactive learning activities. (blogspot.com)
  • chronic
  • Perhaps any one of several viruses can be a trigger in susceptible individuals - e.g. those of us with certain genetic polymorphisms, nutrient deficiencies, toxin exposure, chronic stress, PTSD, etc. (blogspot.com)
  • mice
  • Nevertheless, in IFNAR −/− mice, all mutants were virulent, with the highest mortality rate for rSBVΔNSs and a reduced virulence for the NSm-deleted virus. (asm.org)
  • mosquito
  • Semliki Forest virus (SFV) is an enveloped alphavirus that is transmitted in the wild by mosquito vectors. (semanticscholar.org)
  • However, it has a 30 to 70 percent fatality rate, the highest of any North American mosquito-borne virus, and causes significant brain damage in most survivors. (futurity.org)
  • Researchers
  • When this manufactured mutant version was tested in the laboratory, the researchers found that the host's immune system was able to mount an effective response to the mutant virus. (futurity.org)
  • binding sequence
  • However, analyses of interactions between Src SH2 domain mutants and peptides deviating from its consensus pYEEI peptide binding sequence have suggested that specificity reflects more complex interactions ( 5 ). (asm.org)
  • wild type
  • In the cytosol of infected cells, the A87E and A87D capsids remained in particulate form longer than the wild-type SIVmac239 capsid, suggesting that the mutants uncoat more slowly than the wild-type capsid. (asm.org)
  • Both mutants exhibited much higher levels of autointegrated DNA forms than wild-type SIVmac239. (asm.org)
  • The mutant CPΔ63(Asp198Glu) exhibited different spectral properties following circular dichroism analysis showing a lower amount of α-helix compared to the wild type molecule. (deepdyve.com)
  • This result, coupled with the finding that several of the nc mutants are capable of wild-type levels of fusion from within, suggests that the ability to cause such fusion does not correlate with the ability to kill cells. (asm.org)
  • respiratory droplets
  • Currently, studies with these viruses, which were engineered to spread via respiratory droplets between ferrets , are being done at BSL-3 or higher facilities. (yahoo.com)
  • The infected ferrets passed on the virus to others in respiratory droplets, thus proving that the new virus could be spread through coughs and sneezes. (medindia.net)
  • humans
  • In the hopes of understanding how H5N1, which primarily infects birds, could mutate into a disease that passes easily among humans, and so could cause a flu pandemic , scientists in two separate labs modified the virus so it could spread airborne between ferrets. (yahoo.com)
  • It's not known if these viruses could infect humans. (yahoo.com)
  • H5N1
  • While research on the lab-altered H5N1 virus that can be transmitted between mammals in laboratories is put on hold, scientists are debating how to balance biosecurity with the need for research that could help thwart a pandemic. (yahoo.com)
  • While some maintain this research is crucial to preventing or mitigating an H5N1 pandemic, others fear this work could lead to an accidental release of the mutant virus or fall into the wrong hands. (yahoo.com)
  • dengue
  • ZIKV is a member of the genus Flavivirus and is closely related to the dengue, West Nile, yellow fever, and Japanese encephalitis viruses ( 13 ). (asm.org)
  • interactions
  • Identifying substrates that interact with SH2 domains and probing the way these interactions contribute to transformation provide one approach to understanding how SH2-mediated signaling specificity contributes to host-virus interaction. (asm.org)
  • novel
  • Since its emergence, Schmallenberg virus (SBV), a novel insect-transmitted orthobunyavirus which predominantly infects ruminants, has caused a large epidemic in European livestock. (asm.org)