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  • mechanisms
  • Although latency suggests itself as an attractive target for novel anti-HSV1 therapies, progress in their development has been slowed due in part to a lack of agreement about the basic biochemical mechanisms involved. (hindawi.com)
  • The pathway to identification of the desired inhibitors would be easier, however, if investigators had a clear understanding of the molecular mechanisms involved in latency. (hindawi.com)
  • The great efficiency with which EBV is able to infect and immortalize primary B lymphocytes in vitro into lymphoblastoid cell lines (LCLs) ( 39 ) that maintain latency III has greatly facilitated our understanding of the transcriptional regulatory mechanisms involved in the early stages of establishment of EBV latency within the B-cell pool. (asm.org)
  • We need to better understand the mechanisms that regulate HIV latency so we can identify new opportunities for intervention and develop better drugs that can either lock viral particles in a latent state, or kill latent cells, or both,' Liang said. (news-medical.net)
  • Of particular interest in our laboratory, has been the mechanisms of control of latent virus. (duke.edu)
  • 15. Mechanisms in Virus Latency. (wiley.com)
  • regulator
  • Interferon-γ-inducible protein 16 (IFI16) is a well-established innate immune sensor and viral transcriptional regulator involved in response to invading DNA viruses. (biomedcentral.com)
  • establishment
  • Finally, mutant EBV lacking the Cp CTCF binding site exhibited sustained Cp activity relative to wild-type EBV in a recently developed B-cell superinfection model but ultimately was able to transition to latency I, suggesting that CTCF contributes to but is not necessarily essential for the establishment of restricted latency. (asm.org)
  • antiretroviral
  • People infected with the HIV virus can live relatively normal lives with exceedingly low or even undetectable viral loads thanks to powerful antiretroviral therapies that work to suppress viral replication. (news-medical.net)
  • Although not essential for persistence, latency has clinical importance as a mechanism of HIV-1 persistence in individuals treated with antiretroviral drugs. (asm.org)
  • Latency causes the virus to go into hibernation, enabling it to escape eradication by currently available antiretroviral therapies. (medicalnewstoday.com)
  • Our study suggests that there may be means of activating latent virus in the body while the patient is on antiretroviral drugs to prevent the virus from spreading, and that this may eliminate at least some of the latent reservoir. (pressreleasepoint.com)
  • immune
  • These findings strongly suggest that TGF-β signaling, which generally functions to dampen immune responses, results in increased HSV-1 latency. (asm.org)
  • However, this immune control fails to completely arrest the replication of the virus. (asm.org)
  • the infected immune cell naturally "relaxes" into a resting state, incidentally causing the virus to be suppressed. (medicalnewstoday.com)
  • This inflammation is thought to prevent an effective immune response against the virus and is mediated at least in part by gut epithelial permeability and microbial translocation. (clinicaltrials.gov)
  • Bovine leukemia virus (BLV) proviral latency represents a viral strategy to escape the host immune system and allow tumor development. (biomedcentral.com)
  • When a person with HIV stops treatment, the virus emerges and replicates in the body, weakening the immune system and raising the likelihood of opportunistic infections or cancers that can sicken or kill the patient. (pressreleasepoint.com)
  • Thus, the replication of ICP0 - viruses is potently repressed in vivo by an innate immune response that is dependent on the IFN-α/β receptor and the downstream transcription factor, Stat 1. (biomedcentral.com)
  • IFN-sensitive ICP0 - viruses are avirulent, establish long-term latent infections, and induce an adaptive immune response that is highly protective against lethal challenge with HSV-1. (biomedcentral.com)
  • 12. The Immune System and Virus Neutralization. (wiley.com)
  • disease
  • There is no simple explanation for why latent viruses, such as those in the family Herpesviridae , that are present in the tissues of most adult humans can be activated to cause disease in some people but not in others. (britannica.com)
  • Hepatitis , for example, is a subacute or chronic disease, with a long latent period, that is caused by at least five viruses with different properties. (britannica.com)
  • The Epstein-Barr virus is widespread in all human populations and is strongly associated with human disease, ranging from infectious mononucleosis to cancer. (biomedcentral.com)
  • Virus Latency Causes Cattle Disease? (the-scientist.com)
  • We have chosen to examine viruses as our systems of interest not only because of relevance to human disease, but also because viral genomes, unlike human chromosomes, are genetically tractable and well annotated. (ucsf.edu)
  • Therefore, ICP0 - viruses appear to possess the desired safety and efficacy profile of a live vaccine against herpetic disease. (biomedcentral.com)
  • Providing an integrated account of the subject across different host systems, with an emphasis on human and animal viruses, this book covers the field of virology from molecular biology to disease processes using a unique systems approach. (wiley.com)
  • There is a new chapter on Human Viral Disease and rapidly developing areas, such as the use of viruses as gene therapy vectors, have been included. (wiley.com)
  • Updated throughout, including a new chapter on human viral disease and new material on the use of viruses as gene therapy vectors. (wiley.com)
  • inhibitors
  • The important role of latency in HSV1 pathogenesis has suggested that novel inhibitors targeting latency may be effective as an adjunct to acyclovir for HSV1 therapy. (hindawi.com)
  • LMP1
  • C-Terminal Farnesylation of UCH-L1 Plays a Role in Transport of Epstein-Barr Virus Primary Oncoprotein LMP1 to Exosomes. (nih.gov)
  • LMP1-Induced Sumoylation Influences the Maintenance of Epstein-Barr Virus Latency through KAP1. (nih.gov)
  • Virology
  • Provides integrated account of virology across different host systems, with an emphasis on human and animal viruses. (wiley.com)
  • experimental
  • There follows a description of the proposed repair-centered pathway, a summary of the experimental evidence that supports it and an account of how the proposed pathway is compatible with the main features of HSV1 latency and reactivation as they are currently understood. (hindawi.com)
  • Transcription Factor
  • Altogether, these findings suggest that site-specific DNA methylation of the BLV promoter represses viral transcription by directly inhibiting transcription factor binding, thereby contributing to true proviral latency. (biomedcentral.com)
  • Chromatin
  • LAT leads to chromatin changes by serving as a precursor to an miRNA that reduces ICP0 expression through studies of miRNA mutant viruses. (grantome.com)
  • KSHV
  • Dysregulation of Pin1 is implicated in human cancers, and KSHV is the latest virus known to co-opt Pin1 function. (nih.gov)