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  • genomes
  • Through cloning of the junctional regions between EBV and host genomes, one of the integration sites was identified on the BamHI-C fragments around oriP sequences and another on the EcoRI-I fragment. (nii.ac.jp)
  • Retroviruses have the potential to acquire host cell-derived genetic material during reverse transcription and can integrate into the genomes of larger, more complex DNA viruses. (sciencemag.org)
  • thus
  • The fact that AAV has evolved to integrate into this ubiquitously transcribed region and that the chromosomal motifs required for integration are located a few nucleotides upstream of the translation initiation start codon of MBS85 suggests that the transcriptional activity of MBS85 might influence site-specific integration and thus might be involved in the evolution of this mechanism. (pubmedcentralcanada.ca)
  • Thus, RNA viruses should be closely scrutinized for any capacity to interact with endogenous retroviral elements before their approval for therapeutic use in humans. (sciencemag.org)
  • gene
  • Furthermore, we provide evidence for bidirectional MBS85 promoter activity and demonstrate that the minimal motifs required for AAV site-specific integration are present in the 5′ untranslated region of the gene and play a posttranscriptional role in the regulation of MBS85 expression. (pubmedcentralcanada.ca)
  • Molecular cloning and DNA sequence analyses demonstrated that the rearrangement involves the insertion of a 3.5-kilobase-pair segment of Friend virus that includes the envelope gene (env) and 3' long terminal repeat. (pnas.org)
  • Because BACH2 is a putative tumor suppressor gene, loss of its expression through EBV integration might contribute to lymphomagenesis. (nii.ac.jp)
  • HVBS8 (Hepatitis B Virus Integration Site 8) is an Uncategorized gene. (genecards.org)
  • Integration of hepatitis B virus DNA into the myeloid/lymphoid or mixed-lineage leukemia (MLL4) gene and rearrangements of MLL4 in human hepatocellular carcinoma. (semanticscholar.org)
  • By using an adaptor-ligation/suppression-PCR, we identified four integrations into the myeloid/lymphoid or mixed-lineage leukemia 4 (MLL4) gene from 10 HCC patients with positive HBV surface antigen (HBsAg). (semanticscholar.org)
  • Alteration of gene expression in human hepatocellular carcinoma with integrated hepatitis B virus DNA. (semanticscholar.org)
  • strain
  • The NGS provides an incomparable level of resolution on EBV integration and a convenient approach to obtain viral strain compared to any research technology before. (jcancer.org)
  • type
  • This assay showed that kinetics in viral DNA sysnthesis was cell-type dependent and that the kinetics of HIV-1 DNA integration was very rapid in Jurkat T cell line. (springer.com)
  • We found that illegitimate recombination between an exogenous nonretroviral RNA virus, lymphocytic choriomeningitis virus, and the endogenous intracisternal A-type particle (IAP) retrotransposon occurred and led to reverse transcription of exogenous viral RNA. (sciencemag.org)
  • cellular
  • Subsequently, AAV DNA integration is speculated to occur through limited viral and cellular DNA synthesis following template strand switches, resulting in partial duplication of MBS85 sequences ( 19 , 38 , 39 ). (pubmedcentralcanada.ca)
  • method
  • This method may provide new insights into the integration processes and be useful in evaluating future integrase inhibitors. (springer.com)
  • high
  • HIV integration did not require a high-energy cofactor, and the enzymatic activities required for integration were recovered with the viral DNA when cell extracts were fractionated by gel exclusion chromatography. (asm.org)