The Env proteins of the Avian Sarcoma and Leukosis virus (ASLV) and the Murine Leukemia Virus (MLV) are both trimers of SU-TM heterodimers. (wikipedia.org)
[18] Cosset FL, Legras C, Thomas JL, Molina RM, Chebloune Y, Faure C, Nigon VM, Verdier G. Improvement of avian leukosis virus (ALV)-based retrovirus vectors by using different cis-acting sequences from ALVs. (org.ua)
Influenza Viruses3
The Epidemiology, Virology, and Pathogenicity of Human Infections with Avian Influenza Viruses. (cdc.gov)
Quantifying within-host diversity of H5N1 influenza viruses in humans and poultry in Cambodia. (cdc.gov)
Although it has been known that cleavage site and glycosylation patterns of the HA protein play important roles in determining the pathogenicity of H5 avian influenza viruses, it has only recently been shown that an additional glycosylation site within the globular head of the neuraminidase protein also contributes to the high virulence of the H5N1 virus. (mitokor.com)
Rous3
cis-Acting RNA packaging locus in the 115-nucleotide direct repeat of Rous sarcoma virus. (org.ua)
Efficiency and selectivity of RNA packaging by Rous sarcoma virus Gag deletion mutants. (org.ua)
Expression of Rous sarcoma virus-derived retroviral vectors in the avian blastoderm: potential as stable genetic markers. (org.ua)
Virology2
Margaret Hosie is Professor of Comparative Virology at the MRC-University of Glasgow Centre for Virus Research. (gla.ac.uk)
Prof Hosie has served as a member of the Editorial Boards of Virus Genes and BMC Veterinary Research and has acted as a guest editor for Viruses Special Issues on companion animal virology. (gla.ac.uk)
Retroviral5
The retroviral glycoproteins are oligomeric complexes that are composed of SU-TM heterodimers, which are made in the endoplasmic reticulum after the translation of the glycosylated Env precursor. (wikipedia.org)
[4] Aronoff R, Hajjar AM, Linial ML. Avian retroviral RNA encapsidation: reexamination of functional 5' RNA sequences and the role of nucleocapsid Cys-His motifs. (org.ua)
Identification of a sequence likely to be required for avian retroviral packaging. (org.ua)
Appropriate in vivo expression of a muscle-specific promoter by using avian retroviral vectors for gene transfer [corrected]. (org.ua)
[19] Benchaibi M, Mallet F, Thoraval P, Savatier P, Xiao JH, Verdier G, Samarut J, Nigon V. Avian retroviral vectors derived from avian defective leukemia virus: role of the translational context of the inserted gene on efficiency of the vectors. (org.ua)
ASLV2
We have identified the mutations responsible for the block to virus entry in chicken lines resistant to infection by subgroup A ASLVs [ASLV(A)]. The tva genetic locus determines the susceptibility of chicken cells to ASLV(A) viruses. (elsevierpure.com)
The natural binding of coronaviruses' spike (S) glycoprotein occurs with various receptors - ACE2, APN, DPP4, CEACAM, Sia, and O-acSia of human cells. (openaccesspub.org)
Antigens1
Herpesvirus of turkeys (HVT), used originally as a vaccine against Marek's disease (MD), has recently been shown to be a highly effective viral vector for generation of recombinant vaccines that deliver protective antigens of other avian pathogens. (mdpi.com)
Viral1
Exposed on the surface of the viral envelope, the glycoprotein gp120 binds to the CD4 receptor on any target cell that has such a receptor, particularly the helper T-cell. (wikipedia.org)
Vectors3
Replication-defective vectors of reticuloendotheliosis virus transduce exogenous genes into somatic stem cells of the unincubated chicken embryo. (org.ua)
It is becoming clear that vectors based upon adeno-associated virus (AAV) are the vectors of choice for certain gene therapy applications such as muscle delivery. (justia.com)
The present invention provides chimeric virus vectors that have been designed to exhibit one or more properties of interest (e.g., enhanced tissue tropism). (justia.com)
Homologous recombination within the spike glycoprotein of the newly identified coronavirus may boost cross-species transmission from snake to human. (cdc.gov)
Infections1
Her most significant scientific contributions have included the identification of determinants of virulence amongst feline immunodeficiency virus (FIV) isolates, the development of methods to confirm FIV and feline leukaemia virus infections in diagnostic samples, the identification of vaccine-induced enhancement of FIV infection and elucidation of the mechanism of protection induced by whole inactivated FIV vaccines. (gla.ac.uk)
Expression1
In particular embodiments, the chimeric viruses of the invention have enhanced transduction capability (e.g., transduction of skeletal muscle, cardiac muscle, glial cells, astrocytes, liver, retina and/or lung, etc.), enhanced levels of transgene expression and/or earlier onset of transgene expression. (justia.com)
Genetic4
Deoxyribonucleic acid that makes up the genetic material of viruses. (lookformedical.com)
Whole genome sequencing and genetic variations in several dengue virus type 1 strains from unusual dengue epidemic of 2017 in Vietnam. (cdc.gov)
Genetic characterization of influenza A(H3N2) viruses circulating in coastal Kenya, 2009-2017. (cdc.gov)
Recombinant1
To prevent infected cell lysis, recombinant replication deficiency virus has been developed as a gene delivery tool to replace wild-type adenovirus (recombinant AdV in "application" part). (genemedi.com)
Tumor3
At the other end of the spectrum, MMTV (Mouse Mammary Tumor Virus has only 4 sites for oligosaccharide addition (two on gp52 and two on gp37). (wikipedia.org)
The molecular biology of RNA tumor virus. (org.ua)
The mechanism by which latent viruses, such as genetically transmitted tumor viruses ( PROVIRUSES ) or PROPHAGES of lysogenic bacteria, are induced to replicate and then released as infectious viruses. (lookformedical.com)
Gene1
Any of the processes by which cytoplasmic factors influence the differential control of gene action in viruses. (lookformedical.com)
H5N12
During 1997, an H5N1 avian influenza virus was determined to be the cause of death in 6 of 18 infected patients in Hong Kong. (mitokor.com)
Virus isolated from a human infected with the H5N1 strain in 1997 could bind to oligosaccharides from human as well as avian sources, indicating its species-jumping ability. (mitokor.com)
Strains1
Novel influenza virus strains emerge periodically to which humans have little or no immunity, resulting in devastating pandemics. (mitokor.com)
Infectious2
Virus shedding is an important means of vertical transmission (INFECTIOUS DISEASE TRANSMISSION, VERTICAL). (lookformedical.com)
She conducts research in infectious disease pathogenesis, diagnostics and vaccine development, with a focus on feline viruses. (gla.ac.uk)
Genome2
Comparative genomic analysis reveals an 'open' pan-genome of African swine fever virus. (cdc.gov)
It is a medium sized (90-100nm) and non-enveloped virus with an icosahedral nucleocapsid containing a 36kb double stranded DNA genome (Fig. 7A). (genemedi.com)
Efficiency1
There was some evidence of human to human spread of this virus, but it is thought that the transmission efficiency was fairly low. (mitokor.com)
Molecular1
Specific molecular components of the cell capable of recognizing and interacting with a virus, and which, after binding it, are capable of generating some signal that initiates the chain of events leading to the biological response. (lookformedical.com)
Structure2
The Env protein of Human Immunodeficiency Virus (HIV) also has a trimeric structure of heterodimers. (wikipedia.org)
[7] Knight JB, Si ZH, Stoltzfus CM. A base-paired structure in the avian sarcoma virus 5' leader is required for efficient encapsidation of RNA. (org.ua)
Repeat1
Further, in particular embodiments, the chimeric virus has a different immunological profile than one or both of the parent viruses (i.e., is only weakly or not at all recognized by neutralizing antisera or antibodies against the parent virus), thereby allowing for administration to subjects that have antibodies directed against the parent virus or repeat administration following administration of another serotype. (justia.com)
Determines1
The SU domain therefore determines the specificity of the virus for a single receptor molecule. (wikipedia.org)
Cell1
The ability of a pathogenic virus to lie dormant within a cell (latent infection). (lookformedical.com)
Research1
A veterinarian, she completed her Ph.D. studies on feline immunodeficiency virus in 1991 and subsequently she has pursued an academic research and teaching career in Glasgow, collaborating with colleagues in Europe, US, Australia and Japan. (gla.ac.uk)
Type1
The type species of ORTHOPOXVIRUS, related to COWPOX VIRUS , but whose true origin is unknown. (lookformedical.com)
Spread1
How quickly does the Wuhan virus spread? (cdc.gov)
Clear1
Additionally, the hexon component of AdV capsid can bind to coagulation factor X (FX) to activate TLR4 on the surface of splenic macrophages and thereby stimulate NF-κB dependent activation of IL-1β, which may help recruit polymorphonuclear leukocytes to the marginal zone of the spleen and clear virus from the spleen rapidly [49, 50]. (genemedi.com)
Cells2
Process of growing viruses in live animals, plants, or cultured cells. (lookformedical.com)
The chimeric virus can also have a reduced transduction capability with respect to one or more cells or tissues (e.g., liver), which can be desirable in terms of targeting the vector to the target tissue of interest and reducing dosage of vector to be administered. (justia.com)
Thought1
The subgroup A to E avian sarcoma and leukosis viruses (ASLVs) are highly related and are thought to have evolved from a common ancestor. (elsevierpure.com)
Responsible1
The tropism of the virus is determined by the SU protein domain because it is responsible for the receptor-binding function of the virus. (wikipedia.org)