• The cowpea chlorotic mottle virus (CCMV) is an RNA virus that infects a variety of bean. (u-psud.fr)
  • The hepatitis B virus (HBV) core protein serves multiple essential functions in the viral life cycle, and antiviral agents that target the core protein are being developed. (asm.org)
  • Hepatitis B virus (HBV) is a major cause of serious liver disease, including cirrhosis and hepatocellular carcinoma. (asm.org)
  • The hepatitis B virus (HBV) is an important global human pathogen and represents a major cause of hepatitis, liver cirrhosis and liver cancer. (bio-protocol.org)
  • Hepatitis B Virus (HBV) is an enveloped DNA virus with an RNA intermediate. (grantome.com)
  • Chronic hepatitis B virus infection remains a huge public health problem. (grantome.com)
  • Porcine circoviruses (PCVs), classified as a member of the family Circoviridae, are small icosahedral non-enveloped viruses (size ~17 nm) containing a circular single-stranded DNA molecule of about 1.7 kb. (pubmedcentralcanada.ca)
  • A team from the Laboratoire de Physique des Solides [Laboratory of Solid-State Physics] (Univ Paris-Sud/CNRS), also involving researchers from Institut de Biologie Intégrative de la Cellule [Institute of Integrative Biology of the Cell] (Univ Paris-Sud/CNRS/CEA), Laboratoire Léon Brillouin (CNRS/CEA) and the European Synchrotron Radiation Facility, has solved the assembly dynamics of a plant virus which has a 20-faced or icosahedral shell. (u-psud.fr)
  • A critical component of the virus is the envelope Gn glycoprotein, which contains a C-terminal cytoplasmic tail. (nih.gov)
  • Here we report the NMR structure of the CCHF virus Gn cytoplasmic tail, residues 729-805. (nih.gov)
  • Although many cytoplasmic foci contain multiple vRNA segments, not all vRNA species are present in every focus, indicating that assembly of all eight vRNA segments does not occur prior to export from the nucleus. (ox.ac.uk)
  • During virus cell exit, the assembly of different viral components seems to be established by interaction of Gn and Gc cytoplasmic tails CT with internal viral ribonucleocapsids. (duhnnae.com)
  • Here, we show that a region of basic residues in the capsid protein of the betaretrovirus Mason-Pfizer monkey virus (M-PMV) contributes to interaction of Gag with nucleic acid. (asm.org)
  • We have investigated several families of small molecules with assembly enhancing activity, in particular heteroaryldihydro- pyrimidines (HAPs). (grantome.com)
  • To extend the observations made in fixed cells, we used a virus that encodes GFP fused to the viral polymerase acidic (PA) protein (WSN PA-GFP) to explore the dynamics of vRNA assembly in live cells during a productive infection. (ox.ac.uk)
  • They've found that a genetically engineered version of a virus called M13, which normally infects bacteria, can be used to control the arrangement of the nanotubes on a surface. (tgdaily.com)
  • My laboratory uses cryo-electron microscopy (cryo-EM) and correlative microscopy approaches to explore the structure and function of bacteria, viruses and human cells. (researchschool.nl)
  • Although several systems have been developed to study HBV capsid assembly, including heterologous overexpression systems like bacteria and insect cells, in vitro assembly using purified protein, and mammalian cell culture systems, the requirement for non-physiological concentrations of HBc and salts and the difficulty in manipulating host regulators of assembly presents major limitations for detailed studies on capsid assembly under physiologically relevant conditions. (bio-protocol.org)
  • In contrast, excluding CD317/tetherin from HIV-1 assembly sites depended on Vpu motifs for interaction with AP-1 and CD317/tetherin and correlated with antagonism of the particle release restriction. (uni-hd.de)
  • The recruitment of caveolae occurred just prior to the initiation of RSV filament assembly, and was dependent upon an intact actin network as well as a direct physical interaction between caveolin-1 and the viral G protein. (biologists.org)
  • In other Bunyaviridae viruses, the Gn tail has been implicated in host-pathogen interaction and viral assembly. (nih.gov)
  • Structural characterization of the Crimean-Congo hemorrhagic fever virus Gn tail provides insight into virus assembly. (nih.gov)
  • Shortly after the first purification of virus by Stanley (1935), structural studies were begun using the methods of biochemistry (Bawden and Pirie, 1937) and X-ray diffraction (Bernal and Fankuchen, 1941). (springer.com)
  • Our data indicate that RSV exploits caveolae for its assembly, and we propose that the incorporation of caveolae into the virus contributes to defining the biological properties of the RSV envelope. (biologists.org)
  • The models provide complementary information in support of a common conclusion that the ability of simple pathway models to adequately explain capsid assembly kinetics varies considerably across the space of biologically meaningful assembly parameters. (hindawi.com)
  • You will develop and apply computational models and simulation for protein structure prediction, folding and assembly to help optimize the processing of the vaccine and optimize its function. (ccl.net)
  • CCHF virus Gn zinc finger domain (residues 729-805) relies on Zn 2+ for proper folding. (nih.gov)
  • Core contains 183 to 185 amino acids with an N-terminal assembly domain and a C-terminal arginine-rich domain that interacts with nucleic acids. (asm.org)
  • It is of fundamental importance in virology, with a broad spectrum of applications ranging from the image analysis and classification of experimental data to the construction of assembly models. (royalsocietypublishing.org)
  • Unlike Hantavirus zinc fingers, however, the CCHF virus zinc fingers bind viral RNA and contain contiguous clusters of conserved surface electrostatics. (nih.gov)
  • Our results provide insight into a likely role of the CCHF virus Gn zinc fingers in Nairovirus assembly. (nih.gov)
  • These data indicate that, surprisingly, interactions between the capsid domain and RNA play an important role in the assembly of M-PMV. (asm.org)
  • The PI will investigate the role of RNA in the assembly of spherical, cylindrical and conical viral shells. (ucr.edu)
  • Our results define displacement from HIV-1 assembly sites as active principle of CD317/tetherin antagonism by Vpu and support a role of tripartite complexes between Vpu, AP-1, and CD317/tetherin in this process. (uni-hd.de)
  • During virus cell entry, the role of Gn and Gc in receptor binding has not yet been determined. (duhnnae.com)
  • 2015). Whether CTD, and its state of phosphorylation, play a role in capsid assembly under physiological conditions remained unclear. (bio-protocol.org)
  • Their main role is to aid virus assembly. (wikipedia.org)
  • The PS ensemble controls assembly efficiency and accounts for the packaging specificity seen in vivo. (whiterose.ac.uk)
  • If the addition of carbon nanotubes via the virus process can improve their efficiency, the industry is likely to adopt such processes. (tgdaily.com)
  • In this review, we discuss FV assembly, with special emphasis on Pol incorporation. (mdpi.com)