Virulence factor on streptococci. Medical search. Frequent questions

Pneumococcal infections are caused by Streptococcus pneumoniae, a lancet-shaped, gram-positive, catalase-negative facultative anaerobe commonly referred to as pneumococcus. (medscape.com)
Empyema caused by Streptococcus pneumoniae. (medscape.com)
Streptococcus pneumoniae remains a major public health hazard. (mdpi.com)
Streptococcus pneumoniae is a human pathogen that is responsible for causing pneumonia, otitis media, meningitis, and other infectious diseases. (mdpi.com)
Genetic transformation in Streptococcus pneumoniae, Streptococcus mitis and Streptococcus oralis is regulated by secreted peptide pheromones named the competence-stimulating peptide (CSP). (anaspec.com)
Designed reduction of Streptococcus pneumoniae pathogenicity via synthetic changes in virulence factor codon-pair bias. (anaspec.com)
Streptococcus pneumoniae possesses large zinc metalloproteinases on its surface. (biomedcentral.com)
Streptococcus pneumoniae is an important human pathogen responsible for community acquired pneumonia, as well as meningitis, sepsis and milder infections like otitis media [ 1 ]. (biomedcentral.com)
A characteristic feature of S. pneumoniae and other oral streptococci is the presence of large proteases (1800-2001 amino acids) on the cell surface. (biomedcentral.com)
Except for one serine protease, these enzymes are zinc metalloproteinases and are thought of contributing to the virulence of S. pneumoniae . (biomedcentral.com)
Large scale studies, carried out to identify virulence genes in S. pneumoniae , report different results concerning surface zinc metalloproteinases. (biomedcentral.com)
The second series was created to detect PCR products from seven of the most common bacterial species or groups that cause meningitis: Neisseria meningitidis, Haemophilus influenzae, Streptococcus pneumoniae, S. agalactiae, Escherichia coli and other enteric bacteria, Listeria monocytogenes, and Staphylococcus aureus. (alliedacademies.org)
Pneumolysin (PLY) is a major virulence factor released by Streptococcus pneumoniae and has been implicated in the pathogenesis of pneumococcal pneumonia. (aai.org)
Streptococcus pneumoniae (SPN) is the agent responsible for causing respiratory diseases, including pneumonia, which causes severe health hazards and child deaths globally. (springeropen.com)
BACKGROUND: Streptococcus pneumoniae infections cause morbidity and mortality worldwide. (cdc.gov)
Important bacterial pathogens include Staphylococcus aureus, Streptococcus pneumoniae, and Escherichia coli. (lu.se)
Пневмококові інфекції Streptococcus pneumoniae (pneumococci) are gram-positive, alpha-hemolytic, aerobic, encapsulated diplococci. (msdmanuals.com)
Typical bacterial pathogens that cause CAP include Streptococcus pneumoniae , Haemophilus influenzae , and Moraxella catarrhalis . (medscape.com)
Gram stain showing Streptococcus pneumoniae. (medscape.com)

Antimicrobial peptide temporin derivatives inhibit biofilm formation and virulence factor expression of Streptococcus mutans . (bvsalud.org)
Temporin-GHa obtained from the frog Hylarana guentheri showed bactericidal efficacy against Streptococcus mutans . (bvsalud.org)
The gene expression level of virulence factors of S. mutans was detected by qRT- PCR . (bvsalud.org)
Rainey K, Wilson L, Barnes S, Wu H . Quantitative Proteomics Uncovers the Interaction between a Virulence Factor and Mutanobactin Synthetases in Streptococcus mutans . (ohsu.edu)
On the one hand, the ability of green tea polyphenols to inhibit Streptococcus mutans growth, biofilm formation, and acid production may contribute to its beneficial effects for dental caries [ 9 - 11 ]. (biomedcentral.com)
Aim: The aim of this study was to investigate the metabolic activity of Streptococcus mutans biofilms after treatment with mouthwashes with different compositions. (bvsalud.org)
The Gram positive bacteria Streptococcus mutans are a substantial part of the oral microbiota and their importance in the dental caries etiology is unquestionable 3 . (bvsalud.org)
This adherence is mediated mainly by the action of the GTF enzymes, which are considered fundamental to the virulence of S. mutans in the pathogenesis of dental caries 5-7 . (bvsalud.org)

S. pseudintermedius is an opportunistic pathogen that secretes immune modulating virulence factors, has many adhesion factors, and the potential to create biofilms, all of which help to determine the pathogenicity of the bacterium. (wikipedia.org)
How does the virulence factor hyaluronidase benefit a pathogen? (swirlzcupcakes.com)
The Group A Streptococcus (GAS), or Streptococcus pyogenes, is a strict human pathogen that colonizes a variety of sites within the host. (umd.edu)
In this study, we discovered the strep genes responsible for the biosynthesis and assembly of GAC, the very molecule that defines the pathogen in clinical diagnosis," said first author Nina van Sorge, PharmD, PhD, a former postdoctoral fellow at UC San Diego who now leads her own laboratory at Utrecht University Medical Center in the Netherlands. (science20.com)
We showed that antibodies produced against mutant GAC antigen helped human white blood cells kill the pathogen and protected mice from lethal strep infection," said Jason Cole, PhD, a visiting project scientist from the University of Queensland, Australia, and co-lead author of the paper. (science20.com)
It is satisfying to find that a fundamental observation regarding the genetics and biochemistry of the pathogen can have implications not only for strep disease pathogenesis, but also for vaccine design," Nizet said. (science20.com)
When genes encoding virulence factors are inactivated, virulence in the pathogen is diminished. (pressbooks.pub)
Streptococcus suis (S. suis) is an important zoonotic pathogen, which can cause serious diseases such as meningitis, pneumonia, endocarditis, polyserositis, arthritis, septicemia and abortion in pigs. (snaubulletin.com.ua)
Enhanced understanding of pathogen derived virulence attributes can facilitate development of novel anti-infectives aimed at distinct virulence factors. (lu.se)
The most significant streptococcal pathogen is S. pyogenes , which is beta-hemolytic and in Lancefield group A and is thus denoted as group A beta-hemolytic streptococci (GABHS). (msdmanuals.com)
Streptococcus suis, a bacterium that affects pigs, is a neglected pathogen that causes systemic disease in humans. (cdc.gov)
Streptococcus suis is a neglected zoonotic pathogen that has caused large outbreaks of sepsis in China ( 1 , 2 ) and has been identified as the most common and the third leading cause of bacterial meningitis in adults in Vietnam and Hong Kong, respectively ( 3 - 5 ). (cdc.gov)

Scoffield JA, Duan D, Zhu F, Wu H . A commensal streptococcus hijacks a Pseudomonas aeruginosa exopolysaccharide to promote biofilm formation. (ohsu.edu)
Therapeutic failures of antibiotics used to treat macrolide-susceptible Streptococcus pyogenes infections may be due to biofilm formation. (microbiologyresearch.org)
Fibrinogen induces biofilm formation by Streptococcus suis and enhances its antibiotic resistance. (microbiologyresearch.org)

In this section, we examine various types and specific examples of virulence factors and how they contribute to each step of pathogenesis. (pressbooks.pub)
Contribution of fibronectinbinding protein to pathogenesis of Streptococcus suis serotype 2. (snaubulletin.com.ua)

Porpyhromonas gingivalis W50 ATCC 25611 and Streptococcus intermedius were placed in Tripticaseine sodium broth and grown in four flasks: ratio of 1:1 (1 ml of the two bacteria), and finally 1:9 (1ml S.intermedius P.gingivalis and 9) after 48 hours. (umich.edu)
Although most investigations of stress hormones induction of growth and virulence have been carried out with gut-associated bacteria, a few studies have shown that stress hormones have a significant effect on the growth of periodontal pathogens. (nature.com)
The findings, published online in the June 11 issue of Cell Host&Microbe , shed new light on how strep bacteria resists the human immune system and provides a new strategy for developing a safe and broadly effective vaccine against strep throat, necrotizing fasciitis (flesh-eating disease) and rheumatic heart disease. (science20.com)
This is an electron micrograph, in false color, of group A Streptococcus bacteria. (science20.com)
The toxins of group A streptococcus, the flesh eating bacteria. (medscape.com)
Pyodermitis are primary skin infections mainly caused by pyogenic bacteria of the Staphylococcus and Streptococcus genera. (scielo.br)
Streptococcus is a highly diverse genus of gram positive bacteria. (am-online.org)
ii) to evaluate the virulence factors expressed by these cariogenic bacteria in the presence of Terpinen-4-ol by real-time PCR. (fapesp.br)
The genus Streptococcus are gram-positive spherical bacteria which are divided into 49 species and eight subspecies. (poultrydvm.com)
It suggests that these bacteria are able to adapt to diffwrent environments in infected individual and proper expression of virulence factors, in response to diverse niches, makes their survival possible. (am-online.org)
The infamous gram-negative pathogenic bacteria Vibrio cholerae uses quorum sensing for virulence during a cholera infection. (asm.org)
As a result, 40 isolates were identified as hemolytic bacteria and only 6 of them were identified as Streptococcus. (rjptonline.org)

Which of the following virulence factors would be found in Staphylococcus aureus? (swirlzcupcakes.com)
Not surprisingly, TAs have been directly implicated in the virulence of Listeria monocytogenes , Group B strep, Staphylococcus aureus , and others. (asmblog.org)
As piodermites são infecções cutâneas primárias originadas principalmente por bactérias piogênicas dos gêneros Staphylococcus e Streptococcus. (scielo.br)
The aim of this studi is to examine the antibacterial activity of aloe vera leaf infuse (Aloe barbadensis Miller) against human pathogens such as Pseudomonas aeroginosa, Salmonella typhi, Staphylococcus aureus, dan Streptococcus pneumonia. (uny.ac.id)
Pseudomonas aeroginosa, Salmonella typhi, Staphylococcus aureus, but did not show antibacterial activity against Streptococcus pneumonia. (uny.ac.id)
For example, in chronic skin wounds, Pseudomonas aeruginosa virulence is activated by Gram-positive organisms, such as Staphylococcus aureus . (asmblog.org)

Group C and G Streptococcus (GCGS) are quickly becoming a major public health concern as the incidence of invasive infection and severe disease is increasing ( 1 - 6 ). (cdc.gov)
Viral and Bacterial Adhesion Network Training (ViBrANT) places adhesion at the heart of virulence: it plays the first and decisive role in the infection process of pathogens. (europa.eu)
This is likely important for the rare, but deadly, complications of strep infection such as pneumonia, necrotizing fasciitis and toxic shock syndrome. (science20.com)
The Listeria 471 -- Epidemiology and Clinical Manifestations of Listeria monocytogenes Infection / Walter F. Schlech III 473 -- Immune and Inflammatory Responses to Listeria monocytogenes Infection / Alyce Finelli, Eric G. Pamer 480 -- Genetic Tools for Use with Listeria monocytogenes / Nancy E. Freitag 488 -- Regulation of Virulence Genes in Pathogenic Listeria spp. (epa.gov)
Over the last four decades multiple virulence factors produced by pathogenic streptococci responsible for infection dynamics were identified and characterized. (am-online.org)
Epidemiology of Streptococcus suis serotype 5 infection in a pig herd with and without clinical disease. (snaubulletin.com.ua)
Distinct pathogens use a diverse arsenal of molecular weapons to establish infection, designated virulence factors. (lu.se)
Many streptococci elaborate virulence factors, including streptolysins, DNAases, and hyaluronidase, which contribute to tissue destruction and spread of infection. (msdmanuals.com)
The host response to this infection is an important factor in determining the extent and severity of the disease. (medscape.com)
Our analysis identified gaps in the literature, particularly in assessing risk factors and sequelae of this infection. (cdc.gov)
Although substantial new data on the incidence, clinical and microbiological characteristics, and risk factors for S. suis infection have accumulated during recent years, the prevalence of this infection has not measurably decreased. (cdc.gov)

An international team of scientists, led by researchers at the University of California, San Diego School of Medicine, have identified the genes encoding a molecule that famously defines Group A Streptococcus (strep), a pathogenic bacterial species responsible for more than 700 million infections worldwide each year. (science20.com)
A pathogen's virulence factors are encoded by genes that can be identified using molecular Koch's postulates. (pressbooks.pub)
A cluster of virulence genes encoded on a pathogenicity island is responsible for the pathogenicity of L. monocytogenes . (pressbooks.pub)
These genes are regulated by a transcriptional factor known as peptide chain release factor 1 (PrfA). (pressbooks.pub)
These genes help to foil predators, but they're also "virulence factors" that allow E.coli to successfully infect mammal cells. (nationalgeographic.com)

The most studied BHS is the group A Streptococcus (GAS), which concurs with the species Streptococcus pyogenes (SP). (lu.se)
The vast majority of clinical isolates associated with human infections, that are identified as GCS and GGS belong to the species Streptococcus dysgalactiae (SD). (lu.se)
Earlier this year, I described how the normally harmless nose bacterium Streptococcus pneumonia normally harmless nose bacterium Streptococcus pneumonia becomes infectious when it battles against another species called Haemophilius influenzae . (nationalgeographic.com)
Lancefield groups K through V are streptococcal species of limited virulence that can cause infections in people who are immunocompromised. (msdmanuals.com)
Streptococcus dysgalactiae is a bacterial species, and it's just one of many bacterial species belonging to the larger family of Streptococcus . (cdc.gov)
Cultures grew Streptococcus milleri and anaerobes (Prevotella species). (medscape.com)

Kaplan EL, Chhatwal GS, Rohde M. Reduced ability of penicillin to eradicate ingested group A streptococci from epithelial cells: clinical and pathogenetic implications. (medscape.com)
The involvement of aberrant AID expression in human gingival epithelial cells with Streptococcus anginosus antigen on the mechanisms of oral cancer. (nii.ac.jp)
Non-encapsulated strains reveal novel insights in invasion and survival of Streptococcus suis in epithelial cells. (snaubulletin.com.ua)
These factors can contribute to adherence and multiplication at an epithelial surface, evasion of immune defense mechanisms or invasion into host cells and tissue. (lu.se)

citation needed] CoPS strains typically express more virulence factors. (wikipedia.org)
This discovery allowed us to generate mutant bacterial strains and study the contribution of GAC to strep disease. (science20.com)
Because GAC is present in all strep strains, this may represent a safer antigen for inclusion in a universal strep vaccine. (science20.com)
To analyse the importance in virulence of three of these metalloproteinases, intranasal challenge of MF1 outbred mice was carried out using a range of infecting doses of wild type and knock-out pneumococcal mutant strains, in order to compare mice survival. (biomedcentral.com)
ii) ZmpC, only present in about 25% of pneumococcal strains, has a lower influence on virulence in mice. (biomedcentral.com)
Virulence and mutation rates of Salmonella typhimurium strains with increased mutagenic strength in a mouse model. (microbiologyresearch.org)
To the most important virulence factors belong: capsule, C5a peptidase, which inhibits the action of neutrophils, α-C protein, laminin binding protein, and β hemolysin typical for invasive strains. (am-online.org)
2. Virulence factors S. agalactiae strains. (am-online.org)
A few strains release exotoxins that activate certain T cells, triggering release of cytokines, including tumor necrosis factor-alpha, interleukins, and other immunomodulators. (msdmanuals.com)

14 (2004) studied the effects of mouthwashes containing essential oils, triclosan, cetylpyridinium chloride and chlorhexidine against Streptococcus gordonii biofilms. (bvsalud.org)
The ability to form biofilms within its host ensures the success of the bacteria's reproduction cycle and eventual secretion of cholera toxin, 1 of 2 virulence factors that contribute to 21,000 to 143,000 cholera deaths worldwide each year. (asm.org)

RsmA up regulates virulence factors used in colonizing hosts. (bepress.com)

This is due to the unique virulence factor s produced by individual pathogens, which determine the extent and severity of disease they may cause. (pressbooks.pub)
The goal of this work is to present the current knowledge concerning the virulence factors of S. agalactiae and, at the same time, possible reasons why these pathogens are still causing life threatening infections, especially in neonates. (am-online.org)

In this study, pneumococcal surface protein A (PspA), one of the major virulence factors of SPN, is used to design a multi-epitope vaccine. (springeropen.com)

From there, they performed a series of follow-up analyses on one of these candidates - a surface polysaccharide known as poly-beta-(1,6)-N-acetyl glucosamine, or PNAG - demonstrating that the virulence factor may be vulnerable to vaccine targeting in E. coli K1 and in Group B Streptococcus that can also cause neonatal meningitis. (genomeweb.com)
But this armour also allows Streptococcus to evade our own immune system, resulting in pneumonia, meningitis and other diseases. (nationalgeographic.com)
Meningitis caused by streptococcus suis can no longer be treated with conventional antibiotics. (snaubulletin.com.ua)
Meningitis caused by Streptococcus suis in humans. (snaubulletin.com.ua)

M protein mediated adhesion of M type 24 Streptococcus pyogenes stimulates release of interleukin-6 by HEp-2 tissue culture cells. (medscape.com)
Decrease of the adhesion of Streptococcus suis serotype 2 mutants to embryonic bovine tracheal cells and porcine tracheal rings. (snaubulletin.com.ua)

In humans, S. zooepidemicus may cause glomerulonephritis and rheumatic fever, which are known sequelae of Streptococcus pyogenes infections. (cdc.gov)

Research efforts to date have focused on identifying how either components of the phosphoenolpyruvate-phosphotransferase system (PTS) or global transcriptional networks affect the regulation of virulence factors, but not the synergistic relationship between the two. (umd.edu)
7. Huish S. Thelwell C. Longstaff C. Activity Regulation by Fibrinogen and Fibrin of Streptokinase from Streptococcus Pyogenes. (rjptonline.org)

Most people experience one or more painful strep throat infections as a child or young adult," said senior author Victor Nizet, MD, professor of pediatrics and pharmacy. (science20.com)
Researchers plan to assess the new modified antigen against other candidates in advanced strep throat vaccine tests in nonhuman primates beginning later this year in Atlanta, Georgia, funded by the National Health and Medical Research Council of Australia. (science20.com)
Tonsillitis which is commonly referred to a strep throat is caused by group A ß-hemolytic streptococci (GABHS) or Streptococcus pyogenes. (rjptonline.org)
10. Rijal K. Dhakal N. Shah R. Timilsina S. Mahato P. Thapa S. Ghimire P. Antibiotic susceptibility of Group A Streptococcus isolated from throat swab culture of school children in Pokhara, Nepal. (rjptonline.org)
It produces the strep throat, and it's also a notable cause of school sores or impetigo. (cdc.gov)

Once intracellular concentration increases, autoinducers bind to their receptors, triggering signaling cascades that alter transcription factor activity and therefore, gene expression. (asm.org)

We'll be discussing Streptococcus dysgalactiae bloodstream infections in Norway. (cdc.gov)
Sarah Gregory] What is Streptococcus dysgalactiae and how is it different from other streps? (cdc.gov)
I'm guessing that many of the listeners may not have heard about dysgalactiae , but they might be familiar with its closest sibling, the group A strep, or Streptococcus pyogenes in Latin. (cdc.gov)
Now, dysgalactiae is genetically very similar to the group A strep, and the range of diseases they can produce is also highly overlapping. (cdc.gov)
Oddvar Oppegaard] Well, looking back at history, Streptococcus dysgalactiae was initially considered to be a commensal microbe, meaning a microbe that co-resides with us in harmony, for instance as part of the microbial community living in our gut. (cdc.gov)

ESR12 studied the interactions of M-protein, the main virulence factor and adhesin of Streptococcus pyogenes. (europa.eu)

Pseudomonas aeruginosa , a Gram-negative bacillus, commonly infects immunocompromised individuals and uses a variety of virulence factors to persist in these hosts. (bepress.com)

Bacterial cell wall components and toxins, for example, are well-known virulence factors for sepsis that directly contribute to the profound dysregulation of the immune response. (lu.se)

This CoPS characteristic is a contributing factor to its biochemical similarities to S.aureus. (wikipedia.org)

Background The Concept of Emergence Emerging infectious diseases are diseases of infectious origin whose incidence in humans has increased within the past two decades or threatens to increase in the near future.1 Many factors, or combinations of factors, can contribute to disease emergence (Table1). (cdc.gov)

The VraSR regulatory system contributes to virulence in Streptococcus suis via resistance to innate immune defenses. (snaubulletin.com.ua)
Streptococcus suis synthesizes deoxyadenosine and adenosine by 5'-nucleotidase to dampen host immune responses. (snaubulletin.com.ua)

Serotypes, Virulence-Associated Factors, and Antimicrobial Resistance of Streptococcus suis Isolates Recovered From Sick and Healthy Pigs Determined by Whole-Genome Sequencing. (uoguelph.ca)
Among GCS causing human infections, isolates of Streptococcus equi (SE) have been found. (lu.se)
Antibacterial susceptibility should be performed on bacterial isolates in any clinical cases of Streptococcus . (poultrydvm.com)

Sequelae of infections due to group A beta-hemolytic streptococci may include rheumatic fever and glomerulonephritis. (msdmanuals.com)

Hyaluronidase in snake and insect venom is thought to function as a "spreading factor" by degrading host hyaluronic acid, thus allowing spread of toxin (13). (swirlzcupcakes.com)
1. Hyaluronidase - This is also called the spreading factor because it catalyzes the breakdown of hyaluronic acid, the. (swirlzcupcakes.com)
Detection of Hyaluronidase and Streptokinase Virulence Factors from Streptococcus pyogenes. (rjptonline.org)

Borek AL, Wilemska J, Izdebski R, Hryniewicz W, Sitkiewicz I. A new rapid and cost-effective method for detection of phages, ICEs and virulence factors encoded by Streptococcus pyogenes. (medscape.com)

While it is known that the PTS can affect activity of the Mga virulence regulator, further characterization of the mechanism by which sugars and its protein domains affect activity have not been studied. (umd.edu)
12. Bhardwaj S. Angayarkanni J. Bhattacharya S. Das A. Palaniswamy M. Isolation, screening and characterization of β-haemolytic streptococci with potential of streptokinase production. (rjptonline.org)

Among the environmental factors that may alter the equilibrium in host-microbiome homeostasis, host-stress is a known risk factor for a variety of diseases. (nature.com)
Streptococcus pyogenes causing toxic-shock-like syndrome and other invasive diseases: clonal diversity and pyrogenic exotoxin expression. (medscape.com)

Biosecurity here encompasses genetic research to reduce bacterial colonisation in animals and internal measures to curb transmissions and coinfections (e.g., with PRRSV, Swine Influenza virus, Bordetella bronchiseptic a, or E. coli ), which constitute a significant virulence factor for S. suis infections. (pigprogress.net)

The course of the disease caused by S. agalactiae seems to depend greatly on the presence of its diverse virulence factors. (am-online.org)

Gialeli C., Tuysuz E., Staaf J., Guleed S., Paciorek V., Mörgelin M., Papadakos K.S. and Blom A.M. (2021) Complement inhibitor CSMD1 modulates epidermal growth factor receptor oncogenic signaling and sensitizes breast cancer to chemotherapy. (lu.se)

were initially included among the group D streptococci but are now classified as a separate genus even though they do express Lancefield group D antigens. (msdmanuals.com)

Identify clinical features of patients with group C and G Streptococcus (GCGS) bacteremia, based on a retrospective study in Manitoba, Canada. (cdc.gov)
In addition, no specific emm -types or other clinical factors were significantly associated with recurrences. (lu.se)

Streptococcus have potential to cause opportunistic infections in poultry. (poultrydvm.com)

GCS and GGS exhibit the M-protein, a known virulence factor in GAS infections. (lu.se)

β-hemolytic streptococci are usually classified as pyogenic and anginosus groups, while others (with α-hemolysis) are commonly called viridans streptococci. (am-online.org)

15. Spellerberg B. Brandt C. Laboratory diagnosis of Streptococcus pyogenes (group A streptococci). (rjptonline.org)

The expression of these factors is tightly regulated during growth. (swirlzcupcakes.com)
In order to adapt to niches, GAS utilizes environmental cues, such as carbohydrates, to coordinate the expression of virulence factors. (umd.edu)
The THP-1 DCs had significantly increased expression of cluster of differentiation 11c (CD11c), CD40, CD80, CD83, and CD86, as well as secretion of tumor necrosis factor-alpha. (hindawi.com)
The posttranscriptional regulator, RsmA, plays a role in the expression of many virulence factors in P. aeruginosa . (bepress.com)
6. Molaee N. Abtahi H. Mosayebi G. Expression of recombinant streptokinase from streptococcus pyogenes and its reaction with infected human and murine sera. (rjptonline.org)

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