• The virus was recovered from acute-phase serum samples from both case-patients and identified with cardiovirus-specific reverse transcription-PCR and sequencing. (cdc.gov)
  • family Picornaviridae , genus Cardiovirus ) is a group of closely related virus strains belonging to 1 serotype with a wide host range ( 1 ). (cdc.gov)
  • Mengovirus, also known as Columbia SK virus, mouse Elberfield virus, and Encephalomyocarditisvirus (EMCV), belongs to the genus Cardiovirus which is a member of the Picornaviridae. (wikipedia.org)
  • Cardiovirus (type species, encephalomyocarditis virus) is a classic infection in mice, although it has been observed to cause disease in humans. (medscape.com)
  • Detection of virus in serum strongly supports a role for EMCV in human infection and febrile illness. (cdc.gov)
  • Enteroviruses are common human viruses associated with various clinical syndromes, from minor febrile illness to severe, potentially fatal conditions (e.g., aseptic meningitis, paralysis, myocarditis, and neonatal enteroviral sepsis). (cdc.gov)
  • Virus isolated in Vero E6 cells was identified as encephalomyocarditis virus (EMCV) by electron microscopy and by subsequent molecular diagnostic testing of samples from 2 febrile patients with nausea, headache, and dyspnea. (cdc.gov)
  • Virus isolation and serologic studies indicate EMCV is distributed worldwide, but clinical disease in humans or domestic animals is relatively infrequent. (cdc.gov)
  • Human EMCV infection and disease have been documented by virus isolation from several specimen types, including serum, stool samples, cerebral spinal fluid, and throat washings ( 10 - 12 ). (cdc.gov)
  • Serologic studies also indicate that humans have been infected by EMCV or immunologically related viruses ( 17 - 22 ). (cdc.gov)
  • The proof of concept and effectiveness of this system was demonstrated using three different types of viruses: vesicular stomatitis virus (VSV), herpes simplex virus type-1 (HSV-1), and encephalomyocarditis virus (EMCV). (daitime.com)
  • The Picornaviridae family (picornaviruses) causes a wider range of illnesses than most other, if not all, virus families. (medscape.com)
  • In addition to the major human enteroviral pathogens (poliovirus, enterovirus, coxsackievirus , echovirus), rhinoviruses (approximately 105 serotypes), the human hepatitis A virus (HAV), and several parechoviruses, Picornaviridae contains several other genera of viruses that infect nonhuman vertebrate hosts. (medscape.com)
  • Enteroviruses (genus Enterovirus, family Picornaviridae ) are among the most common viruses infecting humans worldwide. (cdc.gov)
  • P1 encodes the virus capsid proteins, P2 and P3 encode genes required for genome replication to occur. (wikipedia.org)
  • Here we investigated the role of PI4KIII in foot-and-mouth disease virus (FMDV) replication. (microbiologyresearch.org)
  • Cholesterol shuttling is important for RNA replication of coxsackievirus B3 and encephalomyocarditis virus. (microbiologyresearch.org)
  • RNA viruses rewire cellular pathways to build replication organelles. (microbiologyresearch.org)
  • Replication-defective vectors of reticuloendotheliosis virus transduce exogenous genes into somatic stem cells of the unincubated chicken embryo. (org.ua)
  • Viruses have been divided into seven groups in the Baltimore classification, which is based on the nature of their genome and the replication hereof [2]. (fortunejournals.com)
  • Virus neutralization assays were used to evaluate potential antigenic differences between this strain and a vaccine strain and mixed ANOVA test was used to compare the titers. (biomedcentral.com)
  • Our results and analysis highlight the transformative potential of this AI-powered viral plaque detection system for use with a variety of plaque assays in virology, which can help accelerate vaccine and drug development research by significantly reducing the detection time required for traditional viral plaque assays. (daitime.com)
  • The genomes of two unrelated viruses from a dog and fox each from a different state were sequenced and aligned with previously published genomes. (biomedcentral.com)
  • Common for these viruses is that their genomes resemble mRNA and act directly as a template for translation upon infection. (fortunejournals.com)
  • However, most of these RVAs have been identified via dsRNA viral genomes and not from infectious viruses, and their virological properties, such as cell/host tropisms, transmissibility, and pathogenicity, are unclear and remain to be clarified. (bvsalud.org)
  • Vaccination may be with attenuated or inactivated virus, or with viral proteins produced by genetic engineering techniques. (justia.com)
  • The inactivated vaccines consist of purified viral particle without or with only minor contaminants of NSP and thus induce antibody mainly against structural proteins of virus. (ncl.edu.tw)
  • Virus particles have a nucleic acid genome and may also carry a few viral proteins, which are enclosed in a capsid of viral proteins or an envelope comprised of a small part of the host cell membrane. (fortunejournals.com)
  • Its genome is a single stranded positive-sense RNA molecule, making the Mengoviruses a class IV virus under the Baltimore classification system. (wikipedia.org)
  • The genome is approximately 8400nt in length, and has 5' VG protein (Virus genome protein) and a 3' polyadenine tail. (wikipedia.org)
  • These protein subunits can assemble into virus particles without viral RNA genome in mammalian cells to study virus-cell entry 2 and to develop vaccines 3 . (nature.com)
  • Zika virus (ZIKV), a mosquito-borne transplacentally transmissible flavivirus, is an enveloped virus with an ~10.8 kb plus-strand RNA genome that can cause neurological disease. (mdpi.com)
  • The infection of the virus induces vesicular lesions in animals. (ncl.edu.tw)
  • In the fight against this viral infection, various techniques have been established to detect and quantify viruses, making a significant contribution to the development of critical vaccines and antiviral treatments. (daitime.com)
  • Studies of the mechanism of Qβ infection can increase our general understanding of the single-stranded (+)-RNA viruses, which can be exploited in the pursuit to treat and prevent diseases caused by pathogenic (+)-RNA viruses. (fortunejournals.com)
  • Since a plant-derived antibody cocktail to Ebola virus in 2014 had been shown to be effective 5 , more studies and cases have been reported. (nature.com)
  • Virus-like particles (VLPs) enable the construction of promising platforms in the field of vaccine development. (nature.com)
  • The single-stranded (+)-RNA viruses comprise the largest group of viruses, which includes pathogens such as Dengue virus, Corona virus and West Nile virus. (fortunejournals.com)
  • The group of (+)-RNA viruses includes a number of pathogenic viruses such as Polio virus, Hepatitis A and C, Dengue virus and Severe Acute Respiratory Syndrome coronavirus [3]. (fortunejournals.com)
  • Over one hundred vaccines using varied approaches including protein subunit, viral vector, RNA, DNA, inactivated virus, attenuated virus, and virus like particles (VLPs) platforms are in clinical trials. (nature.com)
  • Aphthovirus (type species, foot-and-mouth disease virus [FMDV]) creates a major worldwide economic problem, particularly in South America and Australia. (medscape.com)
  • Canine distemper virus (CDV) is an enveloped negative-sense, single-stranded RNA virus that produces multi-systemic disease in dogs and other terrestrial carnivores [ 1 ]. (biomedcentral.com)
  • The largest group is the single-stranded, positive sense (+)-RNA viruses, which comprises more than a third of all viruses. (fortunejournals.com)
  • Viruses are intracellular parasites that infect all three domains of life. (fortunejournals.com)
  • The prophylactic vaccines are against the hepatitis B virus, which can cause liver cancer, and against human papillomavirus types 16 and 18, which are responsible for about 70 percent of cervical cancer cases. (biomedcentral.com)
  • These anti-viral vaccines are highly effective in curbing virus infections and onset of cancer. (biomedcentral.com)
  • Viruses are grouped according to pathogenicity, host range, and serotype, which is based on serum neutralization. (medscape.com)
  • Arthropod-infecting viruses, including Cricket paralysis virus, Drosophila C virus, and Tussock moth virus, are additional unclassified picornaviruses. (medscape.com)
  • Recent outbreaks of canine distemper have prompted examination of strains from clinical samples submitted to the University of Tennessee College of Veterinary Medicine (UTCVM) Clinical Virology Lab. (biomedcentral.com)
  • [ 9 ] Certain strains of this virus are associated with the development of diabetes in certain strains of mice and are used as a model for virus-associated insulin-requiring diabetes in humans. (medscape.com)
  • Here, we performed virus isolation-based screening for RVA in animal specimens and isolated RVAs (representative strains: 16-06 and MpR12) from Egyptian fruit bat and Natal multimammate mouse collected in Zambia. (bvsalud.org)
  • The invited scientists reviewed the pathfinding role of PV in virology, evaluated the progress made in eradicating this devastating human pathogen and discussed strategies to achieve the goal of a polio-free world. (springer.com)
  • [19] Benchaibi M, Mallet F, Thoraval P, Savatier P, Xiao JH, Verdier G, Samarut J, Nigon V. Avian retroviral vectors derived from avian defective leukemia virus: role of the translational context of the inserted gene on efficiency of the vectors. (org.ua)
  • One method of providing virus resistance is by use of vaccines. (justia.com)
  • The (+)-RNA viruses have been used in the development of vaccines, as imaging tools and in virus inactivation studies [4, 5]. (fortunejournals.com)
  • They rely on their target cell for molecular building blocks, energy sources and host factors to replicate, since viruses are gene poor compared to their host [1]. (fortunejournals.com)
  • [6] Katz RA, Terry RW, Skalka AM. A conserved cis-acting sequence in the 5' leader of avian sarcoma virus RNA is required for packaging. (org.ua)
  • [7] Knight JB, Si ZH, Stoltzfus CM. A base-paired structure in the avian sarcoma virus 5' leader is required for efficient encapsidation of RNA. (org.ua)
  • Expression of Rous sarcoma virus-derived retroviral vectors in the avian blastoderm: potential as stable genetic markers. (org.ua)
  • [18] Cosset FL, Legras C, Thomas JL, Molina RM, Chebloune Y, Faure C, Nigon VM, Verdier G. Improvement of avian leukosis virus (ALV)-based retrovirus vectors by using different cis-acting sequences from ALVs. (org.ua)
  • February 12, 1987) observed inhibition of influenza virus in NIH 3T3 mouse cells genetically modified to express the mouse protein Mx. (justia.com)
  • Orlando: Academic Press, Inc., 1986, Vol. 119(C). The interferons do not act directly against the virus, rather, they stimulate the antiviral response of the immune system. (justia.com)
  • Patients' clinical signs and symptoms were recorded, and acute- and convalescent-phase serum samples were obtained for serologic examination and virus isolation in Vero E6 and C6/36 cells. (cdc.gov)
  • Further, VLPs have the advantage that, contrary to inactivated or attenuated viruses that must be prepared in mammalian cell lines, they can be produced in heterologous systems, such as bacteria, yeasts, insect cells, or plants. (nature.com)
  • The system incorporates a cost-effective, high-throughput holographic imaging device that continuously monitors unstained virus-infected cells throughout their incubation process. (daitime.com)
  • The first is the direct oncolysis of cancer cells by the virus, which is, in most cases a mixture of apoptosis, necrosis, pyroptosis and autophagic cell death, often with one as predominant for a particular OV. (biomedcentral.com)
  • The molecular biology of RNA tumor virus. (org.ua)
  • researchers could not unequivocally establish that the virus did not originate from the mice used for isolation and passage rather than from human clinical specimens ( 12 ). (cdc.gov)
  • To celebrate 100 years of this seminal discovery, one of the first to show that a virus could cause a human disease, an international symposium was held on the 20 November 2009, in Vienna, Austria ( http://www.meduniwien.ac.at/100yearspolio ). (springer.com)
  • ECHO virus is a misnomer based on the acronym enteric cytopathic human orphan virus. (medscape.com)
  • The virus therefore requires a mechanism for transporting incompletely spliced and unspliced mRNAs from the nucleus to the cytoplasm for either protein expression or for encapsidation of the full-length or genomic mRNA. (peerj.com)
  • At the University of Wisconsin-Madison, Vincent meets up with one of his virology heroes, Roland R. Rueckert, to talk about his research and his second career as a forest manager. (microbe.tv)
  • We have seen an increase in overall CDV positive samples submitted to University of Tennessee College of Veterinary Medicine (UTCVM) Clinical Virology Lab from 5 % in 2010 to 27 % in 2013 [ 7 ]. (biomedcentral.com)
  • Viruses infect all kingdoms of life, and new species are continuously being discovered. (fortunejournals.com)
  • Mengovirus is a non-enveloped virus which has a nucleocapsid made up of 12 subunits. (wikipedia.org)
  • Lassa virus (LASV), a Risk Group-4 zoonotic haemorrhagic fever virus, affects sub-Saharan African countries. (bvsalud.org)