AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
ArenavirusArenaviridae InfectionsArenaviridaeArenaviruses, New WorldVirionLassa virusJunin virusArenaviruses, Old WorldPichinde virusLymphocytic choriomeningitis virusHemorrhagic Fever, AmericanHemorrhagic Fevers, ViralLassa FeverVero CellsMurinaeReverse GeneticsCercopithecus aethiopsVirus InternalizationViral ProteinsSigmodontinaeVirus ReleaseNucleoproteinsRNA, ViralViral Envelope ProteinsVirus ReplicationLymphocytic ChoriomeningitisCell LineGenome, ViralRING Finger DomainsVirus AssemblyDystroglycansMolecular Sequence DataProprotein ConvertasesCricetinaeVirus AttachmentGlycoproteinsRNA VirusesRodent DiseasesAmino Acid SequenceViral VaccinesAntibodies, Viral
MorphologyLassaJuninViralVirusesParticlesLymphocyticPleomorphicSpeciesSingle-strandedStructuralVaccineRodentsLatinGenomeFeversVirusCellularCellsFormationImageSpreadPropertiesLCMVFatal arenavirusTractable experimental model systemsInfectionsHemorrhagic feversGlycoproteinProteinsInfectionMatrix proteinDiameterDiseaseCell
Morphology1
  • The image shows typical arenavirus morphology with pleomorphic virions containing ribosomes. (cdc.gov)
Lassa6
  • The most familiar of the arenaviruses include lymphocytic choriomeningitis virus (LCMV) and hemorrhagic fevers caused by Lassa virus, Machupo virus, and Junin virus. (medscape.com)
  • Among the Old World Arenaviruses, Lassa virus, Lujo virus and Lymphocytic Choriomeningitis virus are considered the most worthy of disease detectives' attention, largely because of their ability to cause severe disease in people. (gavi.org)
  • Lassa fever is an acute viral zoonotic illness caused by Lassa virus, an arenavirus known to be responsible for a severe haemorrhagic fever characterised by fever, muscle aches, sore throat, nausea, vomiting and, chest and abdominal pain. (folkhalsomyndigheten.se)
  • Lassa fe- Lassa virus in many more districts and states in en- ver is endemic in West Africa and has been reported demic countries of the West African sub-region and from Sierra Leone, Guinea, Liberia, and Nigeria4-7. (folkhalsomyndigheten.se)
  • Like other arenaviruses, Lassa virus lacks a ogy and clinical presentation, treatment, prevention conventional negative-strand coding arrangement and control as well as the current theories of its patho- and the isolates of the virus differ in their genetic, genesis and efforts in vaccine development. (folkhalsomyndigheten.se)
  • We show that GP determines the apical release of Lassa computer virus from epithelial cells, presumably by recruiting the matrix protein Z to the site of computer virus assembly, which is usually in turn essential for nucleocapsid incorporation into virions. (esbiomech2012.org)
Junin4
  • The prime suspects among the New World Arenaviruses are Junin virus, Machupo virus, Guanarito virus and Sabia virus. (gavi.org)
  • What is known, however, is that the New World Arenaviruses such as Junin and Machupo virus enter human cells after binding to a particular type of molecule known as transferrin receptor 1, or TfR1, and perhaps other types of cell surface receptors too. (gavi.org)
  • Monoclonal antibodies prepared against Tacaribe and Junin viruses have been used to define further the serological relationships between arenaviruses of the Tacaribe complex. (microbiologyresearch.org)
  • Various polyoxometalates proved inhibitory to the replication of a number of enveloped DNA and RNA viruses, i.e., herpesviruses (herpes simplex and cytomegalo), togaviruses (Sindbis), paramyxoviruses (respiratory syncytial), rhabdoviruses (vesicular stomatitis), arenaviruses (Junin and Tacaribe), and retroviruses [human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2), simian immunodeficiency virus, and murine sarcoma virus]. (neb.com)
Viral7
  • The genus Arenavirus includes 22 viral species and 9 additional arenaviruses that have been recently discovered, for which taxonomic status remains pending. (medscape.com)
  • Other arenaviruses from South America and Africa are classic causes of viral hemorrhagic fever syndrome, whereas others have been identified but not found to cause disease or even infection in humans. (medscape.com)
  • This confirms the temporal separation of viral gene expression expected due to the ambisense coding strategy of arenaviruses and also suggests that antigenomic RNA contained in virions is not transcriptionally active upon entry. (hal.science)
  • Thus, our data support a model of LCMV persistence whereby infected cells can spontaneously clear infection and become reinfected by viral reservoir cells that remain in the population.IMPORTANCE Arenaviruses are human pathogens that can establish asymptomatic, lifelong infections in their rodent reservoirs. (hal.science)
  • Several models have been proposed to explain how arenavirus spread is restricted within host rodents, including the periodic accumulation and loss of replication-competent, but transcriptionally incompetent, viral genomes. (hal.science)
  • Other segmented viral genomes include those of reoviruses, arenaviruses, and bunyaviruses. (virology.ws)
  • Besides the virus inhibiting effect, the increased synthesis of mutant virions under the action of FPV possess a threat of the emergence of novel threatening viral strains with high pathogenicity for humans and animals and acquired resistance to chemotherapeutic compound. (crie.ru)
Viruses8
  • The arenaviruses are a large group of viruses that typically affect rodents. (medscape.com)
  • Arenaviruses are single-stranded ribonucleic acid (RNA) viruses that cause chronic asymptomatic infections in rodents and zoonotically acquired disease in humans through rodent excreta, especially urine. (medscape.com)
  • The Arenavirus family has scores of viruses in it, several of which are known to infect and cause disease in people as well as animals. (gavi.org)
  • While the family's human pathogenic viruses are fairly closely related, they are divided into two groups-the Old World Arenaviruses and the New World Arenaviruses. (gavi.org)
  • Rats, mice, hamsters, voles and other rodents are the primary carriers of Arenaviruses and are the main route of transmission of the viruses from animals to people. (gavi.org)
  • Monoclonal antibodies to lymphocytic choriomeningitis virus and Pichinde viruses: generation, characterization and cross-reactivity with other arenaviruses. (microbiologyresearch.org)
  • The highly conserved N-linked glycosylation profiles of arenavirus glycoproteins could therefore be viable targets for designing attenuating viruses for vaccine development against other arenavirus-associated illnesses. (bvsalud.org)
  • The matrix Z proteins of arenaviruses are related to cellular RING domain proteins, and the matrix proteins of some negative strand RNA viruses are related to cellular cyclophilin. (virology.ws)
Particles4
  • The name describes the sandy grain-like appearance of Arenavirus particles, or virions, under a microscope. (gavi.org)
  • We also provide evidence that virion-associated cholesterol contributes to the interaction between HCV particles and apolipoprotein E. The molecular basis for the effects of different sterols on HCV infectivity is discussed. (microbiologyresearch.org)
  • It has been shown for LASV, as well as for other arenaviruses, Rabbit polyclonal to IFIH1 that during the course of contamination, infectious computer virus particles are released from epithelia into body fluids and urine (32, 45, 71). (esbiomech2012.org)
  • Paramyxoviruses are tiny, spherical or irregular spherical enveloped virus particles, or virions, of about 150 to 300 nanometres in diameter. (hexdigital.com)
Lymphocytic2
Pleomorphic1
  • Arenaviruses are either spherical, oval, or pleomorphic and vary between 110 and 130 nanometers in diameter. (gavi.org)
Species1
  • Overview of Arbovirus, Arenavirus, and Filovirus Infections Arbovirus (arthropod-borne virus) is defined as any virus that is transmitted to humans and/or other vertebrates by certain species of blood-feeding arthropods, mostly insects (flies and mosquitoes). (msdmanuals.com)
Single-stranded1
  • Different models have been proposed to describe how arenaviruses regulate the replication and transcription of their bisegmented, single-stranded RNA genomes, particularly during persistent infection. (hal.science)
Structural2
  • I. Relationship of soluble antigens derived from infected BHK-21 cells to the structural components of the virion. (microbiologyresearch.org)
  • Then the structural proteins are translated, assembled into mature virions, and released via vesicles by exocytosis. (medchemexpress.com)
Vaccine1
  • Bharat Biotech BBV87 vaccine candidate is an inactivated whole virion vaccine based on a strain derived from an East, Central, South African (ECSA) genotype. (precisionvaccinations.com)
Rodents1
  • Arenaviruses have been divided into 2 groups based on whether the virus is found to infect Old World (ie, Eastern Hemisphere) rodents (family Muridae, subfamily Murinae) or New World (ie, Western Hemisphere) rodents (family Muridae, subfamily Sigmodontinae). (medscape.com)
Latin1
  • Arenavirus comes from the Latin arena (sand) for the sandy appearance of the virions. (wikipedia.org)
Genome1
  • This was possible in the lab because the molecular biology of replication is well characterised and that measles virus is polyploid allowing the engineering of a tri-segmented genome that can replicate and be packaged into virions. (virology.ws)
Fevers1
  • The Arenavirus family includes some of the most lethal haemorrhagic fevers known. (gavi.org)
Virus1
  • The New World arenaviruses are further divided into 3 lineages designated clades: A, B, C. LCMV is the only arenavirus to exist in both areas but is classified as an Old World virus. (medscape.com)
Cellular1
  • An analysis of the sequence an structure of major virion proteins has identified likely ancestors in cellular proteins. (virology.ws)
Cells3
  • Despite multiple intensive studies by disease investigators, the way in which Arenaviruses enter host cells is still something of a mystery. (gavi.org)
  • The new generation of virions exits the cell and spreads to new cells. (transmissible.eu)
  • The polyoxometalates also proved inhibitory to the binding of HIV-1 virions to the cells. (neb.com)
Formation1
  • The 5′- and 3′-ends of all segments (are complementary at their termini, likely promoting the formation of circular ribonucleoprotein (RNP) complexes within the virion. (ictv.global)
Image1
Spread1
  • Zanamivir blocks the action of neuraminidase, which prevents the cleavage of sialic acid on the cell receptors, thus preventing release and spread of the newly formed virions. (xcessbio.com)
Properties1
LCMV2
  • The New World arenaviruses are further divided into 3 lineages designated clades: A, B, C. LCMV is the only arenavirus to exist in both areas but is classified as an Old World virus. (medscape.com)
  • In today's study, we examined a recently created cell-permeable, peptide-based S1P inhibitor merging a chloromethylketone (CMK) moiety with peptides produced from the RRLL reputation LAMNA theme of S1P, decanoyl (december)-RRLL-CMK (30), in the framework of successful arenavirus infections 52286-74-5 IC50 using the prototypic arenavirus LCMV. (molecularcircuit.com)
Fatal arenavirus2
  • A hallmark of fatal arenavirus contamination is quick multiplication from the computer virus that overwhelms the patient's disease fighting capability, leading to uncontrolled infection. (molecularcircuit.com)
  • Having less effective disease control procedures aswell as the breakthrough of brand-new fatal arenavirus types A-484954 that cause a threat of epidemic potential [16] [17] emphasize the necessity for book healing interventions. (biodiversityhotspot.org)
Tractable experimental model systems1
  • Arenaviruses merit significant interest as tractable experimental model systems and medically important human being pathogens (6). (molecularcircuit.com)
Infections4
  • Arenaviruses are single-stranded ribonucleic acid (RNA) viruses that cause chronic asymptomatic infections in rodents and zoonotically acquired disease in humans through rodent excreta, especially urine. (medscape.com)
  • treatment of individual arenavirus infections, led to additive drug results. (molecularcircuit.com)
  • Arenavirus infections are relatively common in humans in some areas of the world and can cause severe illnesses. (unt.edu)
  • Overview of Arbovirus, Arenavirus, and Filovirus Infections Arbovirus (arthropod-borne virus) is defined as any virus that is transmitted to humans and/or other vertebrates by certain species of blood-feeding arthropods, mostly insects (flies and mosquitoes). (msdmanuals.com)
Hemorrhagic fevers1
  • As yet there is absolutely no effective and particular treatment open to fight hemorrhagic fevers due to arenaviruses. (biodiversityhotspot.org)
Glycoprotein1
  • An essential step in the life span routine of arenaviruses may be the biosynthesis from the mature envelope glycoprotein (GP) in charge of receptor connection and cell admittance (6). (molecularcircuit.com)
Proteins1
  • Primarily synthesized as an individual polypeptide, arenavirus GP precursor (GPC) goes through proteolytic processing with the mobile proprotein convertase site 1 protease (S1P), also called subtilisin-kexin-isozyme 1 (SKI-1), yielding the peripheral virion connection proteins GP1 as well as the fusion-active transmembrane proteins GP2 (2, 17, 21, 37). (molecularcircuit.com)
Infection1
  • While of great worth for proof process, protein-based S1P inhibitors aren't cell permeable, producing their make use of as antiviral medications for treatment of individual arenavirus infection challenging. (molecularcircuit.com)
Matrix protein1
  • and how the Ebola matrix protein assembles into one structure to bud new virions and into a different conformation to bind RNA and control transcription inside infected cells. (nih.gov)
Diameter1
  • Virions have a mean diameter of 110-130 nm but can vary in size. (medscape.com)
Disease3
  • Despite multiple intensive studies by disease investigators, the way in which Arenaviruses enter host cells is still something of a mystery. (cepi.net)
  • These results claim that antiviral medicines targeted at reducing arenavirus multiplication and spread might provide the contaminated individual using a home window of possibility to develop a highly effective antiviral protection response to avoid or reduce arenavirus-associated disease. (molecularcircuit.com)
  • A number of arenaviruses cause hemorrhagic disease. (unt.edu)
Cell1