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  • Viral
  • Claverie suggested that the viral factory corresponds to the organism, whereas the virion is used to spread from cell to cell. (virology.ws)
  • Strikingly, although epithelial or neuronal cells express 3-10 viral genomes after infection by free virions, epithelial cells infected by HSV-1 or pseudorabies virus following ADS express fewer than two viral genomes. (pnas.org)
  • Together, these complementary analyses reveal that ADS events are restricted to small numbers of viral particles, most often a single virion, resulting in a single viral genome initiating infection. (pnas.org)
  • HIV-1 Dynamics In Vivo: Virion Clearance Rate, Infected Cell Lifespan, and Viral Generation Time. (psu.edu)
  • ARTICLE{Perelson96hiv-1dynamics, author = {Alan S. Perelson and Avidan U. Neumann and Martin Markowitz and Martin Markowitz John M. Leonardy and David D. Ho}, title = {HIV-1 Dynamics In Vivo: Virion Clearance Rate, Infected Cell Lifespan, and Viral Generation Time. (psu.edu)
  • Using a new mathematical model to analyze a detailed set of viral load data collected from five infected patients after the administration of a potent inhibitor of HIV-1 protease, it was estimated that productively infected cells have, on average, a lifespan of 2.2 days (t 1=2 = 1:6 days) and that plasma virions have a mean lifespan of 0.3 days (t 1=2 = 0:24 days). (psu.edu)
  • Our results also suggest that the minimum duration of the HIV-1 life cycle in vivo is 1.2 days on average, and that the average HIV-1 generation time, defined as the time from release of a virion until it infects another cell and causes the release of a new generation of viral particles, is 2.6 days. (psu.edu)
  • These approaches allow a previously unobserved view of the genesis of individual virions and the determination of parameters of viral assembly that are inaccessible with conventional techniques. (nih.gov)
  • Our results define the LDL-R as a cooperative HCV co-receptor that supports viral entry and infectivity through interaction with apoE ligand present in an infectious HCV/lipoprotein complex comprising the virion. (nih.gov)
  • The RNA product of VSV polymerase activity is present throughout the cytoplasm, and its synthesis is inhibited by the interferon system, as judged by autoradiographs that show the physical distribution, in cells, of RNA produced by virion polymerase in the absence of translation-a demonstration of the transcription product of the viral genome. (sciencemag.org)
  • genome
  • In order to adequately comprehend the scope of laboratory methods, a basic understanding of the structure of the HIV virion and its genome is necessary. (medscape.com)
  • However, radical modifications to the genome size significantly decreases virion stability, suggesting that the virus genome plays a role in maintaining the physical stability of the Ad virion. (mdpi.com)
  • Indeed, a similar relationship between genome size and virion stability has been noted for many viruses. (mdpi.com)
  • This review discusses the impact of the genome size on Ad virion stability and emphasizes the need to consider this aspect of virus biology in Ad-based vector design. (mdpi.com)
  • complex
  • Forms a complex with host APOBEC3F and APOBEC3G thus preventing the entry of these lethally hypermutating enzymes into progeny virions. (uniprot.org)
  • virus
  • A virion is not the same as a virus. (virology.ws)
  • The idea that virus and virion are distinct was first proposed by Bandea in 1983. (virology.ws)
  • If we accept that the virus is the infected cell, then it becomes clear that most virologists have confused the virion and the virus. (virology.ws)
  • But virologists are not the only ones at fault - the media writes about the AIDS virus while showing an illustration of the virion. (virology.ws)
  • To develop a better understanding of virus-host interactions, we performed a comprehensive proteomic analysis of proteinase K treated purified TAdV-3 virions isolated from spleens of infected turkeys, by utilizing one-dimensional liquid chromatography mass spectrometry. (sigmaaldrich.com)
  • individual
  • Here we describe quantitatively the genesis of individual virions in real time, from initiation of assembly to budding and release. (nih.gov)