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  • isolates
  • Viral isolates are represented by dashed lines, and genotype means are represented by solid lines. (nih.gov)
  • To determine whether the WN02 displacement of the East Coast genotype was the result of viral adaptation to North American avian hosts, groups of HOSPs collected in 2012 and 2013 were inoculated with 12 WNV isolates representing the three North American genotypes: East Coast, WN02, and SW03 (Table 1). (nih.gov)
  • Porcine circovirus type 2 (PCV2) vaccination of conventional pigs prevents viremia against PCV2 isolates of different genotypes and geographic origins, 2008, Vaccine, 26:1063-1071. (freepatentsonline.com)
  • fewer viral
  • In adjusted models, the rate of uncontrolled viremia was lower in those with fewer viral rebounds before baseline (IRR per additional prior rebound = 1.12 (95% CI: 1.04-1.20), and with increasing time fully suppressed on cART prior to baseline (IRR per additional 10% suppressed = 0.86 (0.83-0.90). (biomedcentral.com)
  • Since reduced levels of viral protein were synthesized in the absence of σ1s, the maturation of viral factories was impaired, and significantly fewer viral progeny were produced. (nih.gov)
  • peak
  • While the peak viral titer was generally observed on day 3 for HOSPs inoculated with any WNV genotype, peak viremias of individual birds occurred on different days. (nih.gov)
  • To determine the overall peak titer for each virus, the peak viral titer for individual HOSPs was determined irrespective of the day post-inoculation and then averaged. (nih.gov)
  • SW03 viruses produced a similar 10-fold increase in mean peak viral titer over East Coast viruses, though this difference was not significant (p = 0.09). (nih.gov)
  • Median
  • Median viral load and CD4 count was 98 copies/mL and 542 cells/mm3, and at baseline (pre-ART) was 189,000 copies/mL and 212 cells/mm3, respectively. (thebodypro.com)
  • patients
  • 530 patients experienced uncontrolled viremia (400 whilst on cART) after starting a new ARV. (biomedcentral.com)
  • Hence, the history of patterns of viral response to cART regimens should be an integrated component in deciding monitoring strategies and adherence counseling for patients whenever a change in cART is made. (biomedcentral.com)
  • This phase I trial studies the side effects and the best dose of viral therapy in treating patients with squamous cell carcinoma of the head and neck that has returned (come back) after a period of improvement or has spread to other parts of the body or breast cancer that has spread to other parts of the body. (clinicaltrials.gov)
  • immune activation
  • African green monkeys (AGMs) infected with the AGM type of SIV (SIVagm) do not develop chronic immune activation and AIDS, despite viral loads similar to those detected in humans infected with HIV-1 and rhesus macaques (RMs) infected with the RM type of SIV (SIVmac). (jci.org)
  • cells
  • Viral reproduction rates upon discontinuation of PMPA treatment after 2 weeks were approximately twofold greater than those obtained just prior to initiation of treatment in the same animals, likely reflecting accumulation of susceptible target cells during treatment. (pubmedcentralcanada.ca)
  • CSFR1 antagonism reduced B7 co-stimulatory signals on peripheral and CNS antigen-presenting cells (APCs) by depleting CNS cellular sources, which limited local reactivation of CNS-infiltrating virus-specific T cells and reduced viral clearance. (springer.com)
  • These resting cells likely integrate HIV-DNA upon activation and then contribute to HIV viremia and viral spread. (clinicaltrials.gov)
  • In these cells, wild-type virus produced substantially higher levels of viral protein than a σ1s-deficient mutant. (nih.gov)
  • spread
  • For reovirus, nonstructural protein σ1s is required for viral spread via the blood. (nih.gov)
  • plasma
  • The study used single-genome sequencing on plasma RNA, cell-associated DNA, and p24+ culture supernatants from quantitative viral outgrowth assays (qVOA). (thebodypro.com)
  • study
  • In this study, we identified σ1s as a viral mediator of reovirus protein expression. (nih.gov)
  • show
  • Figure 1 show the crude incidence of uncontrolled viremia after stratification by the number of rebounds and the proportion of time fully suppressed while on cART prior to baseline. (biomedcentral.com)