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  • mice
  • We report in this study that a stable, lyophilized, modified vaccinia virus Ankara (MVA) vaccine can be directly applied to the nostrils of mice without previous reconstitution. (jimmunol.org)
  • subsequent
  • For this to occur, the virus first recognizes and binds to specific receptors on the cell surface, resulting in fusion of the viral envelope with the cell membrane and subsequent endocytosis. (genscript.com)
  • development
  • One of the advances in preventing cervical cancer has been the development of a vaccine against the human papillomavirus. (sharecare.com)
  • Drug Development & Delivery recently interviewed Dave Backer, Head of Virus & Gene Therapy Strategic Initiatives at MilliporeSigma, to discuss its expanding GMP capacity to speed development and manufacture of gene therapies, immunotherapies, and viral vaccines. (drug-dev.com)
  • There are real opportunities to improve production yield as well as viral vector purity through the combination of cell line and media development, bioreactor-based expansion, and downstream processing improvements. (drug-dev.com)
  • After reviewing the list of vaccines in development, I decided to explore a handful of interesting viral vaccines that are in late stage development. (cellculturedish.com)
  • While there are several other Dengue Fever vaccines candidates in various phases of development, Sanofi's is the furthest along. (cellculturedish.com)
  • The reasons behind vaccine-induced augmentation are only partially understood, and fear of augmentation continues to hold back vaccine development. (pnas.org)
  • The past decade has witnessed a significant progress in elucidating mechanisms of vaccine-induced immune response (2, 3), providing data necessary for rational development and design of 'smart' vaccines. (uniri.hr)
  • Novel approaches of vaccine development include delivery of the gene of interest and expression of antigens within a host. (uniri.hr)
  • Tumors
  • Therefore, clinical studies using MVA as a viral vector system against HIV and tumors have been conducted ( 4 , 5 ). (jimmunol.org)
  • infectious
  • Cellular substrates are one critical component that can have an enormous impact on reactogenicity of the final preparation, level of attenuation of a live virus, yield of infectious units or antigens, and cost per vaccine dose. (duhnnae.com)
  • Furthermore, to fully control or even eradicate an infectious disease, vaccines must be stable to be broadly distributed, which is often a difficult task in developing countries. (jimmunol.org)
  • H1N1
  • Evidence of an earlier outbreak of pandemic H1N1 may necessitate earlier administration of vaccine. (scielo.org.za)
  • Another Reuters article, Narcolepsy link to Glaxo vaccine poses challenge for FDA, describes how recent studies conducted in England, Sweden, Finland and Ireland have found a heightened risk of developing narcolepsy for those who received GSK's Pandemrix vaccine during the H1N1 swine flu pandemic. (cellculturedish.com)
  • hepatitis
  • To induce T cell responses to hepatitis C virus, I used the vaccines ChAd3-NSmut and MVA-NSmut in a prime-boost regimen. (bl.uk)
  • viruses
  • Of note, the quality of antibody responses of GTi virus was superior to that with FAi virus, in terms of the magnitude of antibody titer, cross-reactivity to hetero-subtypes of influenza viruses, and the avidity to viral antigens. (frontiersin.org)
  • However, most licensed viral vaccines have been produced by chemical inactivation of the viruses to eliminate the infectivity and to ensure vaccine safety. (frontiersin.org)
  • Would a permissive vaccine lead to the emergence of more virulent viruses? (virology.ws)
  • The more serious flaw lies in making anthropomorphic assessments of what we think viruses require, such as concluding that increased viral transmission is a desired trait. (virology.ws)
  • This long preamble is an introduction to a series of findings which are purported to support the idea that permissive vaccines (the authors call them 'leaky' and 'imperfect' vaccines but I dislike both names because they imply defects) can lead to the selection of more virulent viruses. (virology.ws)
  • The authors wonder if the use of permissive Marek's vaccines has lead to the selection of more virulent viruses. (virology.ws)
  • Nor do the results prove in general that leaky vaccines lead to selection of more virulent viruses. (virology.ws)
  • gene
  • The clinical manufacturing of intermediates and final products used in viral vaccines and gene therapies requires dedicated facilities, and there is significant demand for these services in the growing cell and gene therapy market. (drug-dev.com)
  • The Carlsbad campus features segregated fill/finish capacity for gene therapy, viral vaccine, and immunotherapy products. (drug-dev.com)
  • A comparison of the functional analysis of gene lists from both vaccines showed that similar pathways were being activated and repressed. (bl.uk)
  • human
  • What are the benefits of the human papillomavirus (HPV) vaccine? (sharecare.com)
  • Human papillomavirus (HPV) is a virus that can cause conditions like cervical cancer and genital warts, and the vaccine can protect against common strains. (sharecare.com)
  • For women, the human papilloma virus (HPV) vaccine protects against cervical cancer, and for both men and women it protects against genital warts and several oral and anal cancers. (sharecare.com)
  • This behavior has been well documented in human populations, yet the virulence of poliovirus has not increased for the 60 years during which the Salk vaccine has been used. (virology.ws)
  • This review summarizes the diversity of cellular substrates for propagation of viral vaccines from primary tissue explants and embryonated chicken eggs to designed continuous cell lines of human and avian origin. (duhnnae.com)
  • History Vaccine types How they work Recommended Schedule Specific Vaccines Flu HIV/AIDS Human Papillomavirus (HPV) To stick or not to stick? (slideserve.com)
  • Despite this enormous disease burden, there is still no vaccine for human use. (pnas.org)
  • adjuvant
  • Cytheris SA has announced publication of data showing that following a vaccine-induced immune response, adjuvant interleukin-7 (IL-7) improves anti-tumor responses and survival in an animal model. (technologynetworks.com)
  • The Pandemrix vaccine contains the same AS03 adjuvant and there is concern that it is the adjuvant causing the increased risk. (cellculturedish.com)
  • novel
  • These findings reveal an unexpected mechanism of vaccine-induced disease augmentation and indicate that selective chemoattraction of Tregs into diseased sites may offer a novel approach to the modulation of tissue-specific inflammation. (pnas.org)
  • cells
  • However, delivery of chemokine ligands (CCL) 17/22 via the airway selectively recruited airway Tregs and attenuated vaccine-augmented disease, reducing weight loss and inhibiting local recruitment of pathogenic CD4 + T cells. (pnas.org)
  • Products
  • Abstract Vaccines are complex products that are manufactured in highly dynamic processes. (duhnnae.com)
  • Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. (hirepurpose.com)
  • approaches
  • Although the majority of concepts of the new vaccine approaches stem from in vitro data, major insights still have to come from in vivo analysis. (uniri.hr)
  • combination
  • We are certainly focused on this through the combination of our Carlsbad viral manufacturing experience and our MilliporeSigma product and process knowledge. (drug-dev.com)
  • cell
  • Through brands you trust - Gibco TM cell culture media and feeds , POROS TM chromatography resins , Thermo Scientific TM single-use technologies , and Applied Biosystems TM SEQ rapid contaminant tests - we are helping to set new manufacturing standards in product quality, safety and fast-to-market efficiency for viral vaccine production. (thermofisher.com)
  • Such T cell responses can be generated with the use of viral vectored vaccines. (bl.uk)
  • Re-administration of the same two vaccines after a short time interval (8 weeks) did not improve upon previous peaks in T cell response. (bl.uk)
  • results
  • But these results do not prove that more virulent MDV arose because of permissive vaccines. (virology.ws)
  • A September 2012 New York Times article, In a Setback, Sanofi's Dengue Fever Vaccine Falls Short of Its Goal , describes the disappointing results in more detail. (cellculturedish.com)