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  • Particle
  • Despite the premature disassociation, the indiscriminate binding of the DNA packing motor still allows the opportunity for a viral particle to be fully assembled. (reasons.org)
  • machinery
  • The interaction of all molecules derived from the cellular and viral transcription and translation machinery results in the generation of infectious influenza A virus. (pnas.org)
  • Now research by scientists at Harvard Medical School's Blavatnik Institute yields a surprising answer: The viral machinery in charge of this survival-ensuring maneuver becomes activated by an RNA from the opposite end of the segment where copying starts. (newswise.com)
  • cDNA
  • In this plasmid-based expression system, viral cDNA is inserted between the RNA polymerase I (pol I) promoter and terminator sequences. (pnas.org)
  • The orientation of the two transcription units allows the synthesis of negative-sense viral RNA and positive-sense mRNA from one viral cDNA template. (pnas.org)
  • binds
  • When the DNA packaging motor binds to a partially filled virus it will add more DNA into the viral head until the full complement of DNA is translocated into the capsid. (reasons.org)
  • gp41
  • Finally, sequences in gp41 trigger the fusion of the viral and cellular lipid bilayers. (cancer.gov)
  • HIV-1 escape from the entry-inhibiting effects of a cholesterol-binding compound via cleavage of gp41 by the viral protease. (cancer.gov)
  • enzyme
  • These changes introduce novel cleavage sites for the viral protease, an enzyme that normally functions to cleave other viral proteins after release of virions from the cell surface. (cancer.gov)
  • recruitment
  • The SCF E3 ubiquitin-ligase complex participates in the recognition and recruitment of target proteins for ubiquitination and degradation by the ubiquitin 26S proteasome system (UPS). (mdpi.com)
  • plasma membrane
  • Sorting of proteins destined for the two plasma membrane domains takes place in the TGN where separate apical and basolateral vesicles form to deliver cargo to the correct destinations ( Griffiths and Simons, 1986 ). (rupress.org)
  • cellular
  • The F-box protein is one of the four components of the SCF (SKp1, Cullin, F-box protein) complex, which mediates ubiquitination of proteins targeted for degradation by the proteasome, playing an essential role in many cellular processes. (mdpi.com)
  • comprises
  • The tail comprises six spikes that mediate primary attachment to the host cell lipopolysaccharides (LPS) and display endorhamnosidase enzymatic activity, hydrolyzing the alpha-1,3-O-glycosidic linkage between rhamnose and galactose of the O-antigen polysaccharide. (uniprot.org)
  • incorporation
  • CT deletion, a matrix mutation affecting Env incorporation or Env expression in the absence of other HIV-1 proteins led to much smaller Env clusters, which were not enriched at viral assembly sites. (nih.gov)
  • structure
  • We identified its host range and determined the gp17 sequences and protein structure using shotgun analysis and bioinformatics technology. (biomedcentral.com)
  • Progress in the knowledge of the structure of many of the main molecular actors of the apoptotic signal transduction pathways has driven the design of synthetic peptides that in some cases can function as simplified versions of their parent proteins. (jove.com)
  • lipid
  • it acts by binding to cholesterol in the viral membrane, which itself is lipid raft like, potently blocking the virus's entry into immune cells. (cancer.gov)
  • functional
  • and small drugs and actin-binding proteins strongly influence the functional properties of monomeric (G) as well as filamentous (F) actin in vitro. (rupress.org)
  • promoter
  • Recent studies demonstrated that the plasmid-driven expression of all eight vRNAs from a pol I promoter and the coexpression of the polymerase complex proteins result in the formation of infectious influenza A virus ( 16 , 17 ). (pnas.org)
  • We study several transcription factors and their complexes with other proteins and DNA promoter regions. (irbbarcelona.org)
  • virus
  • Anti-caveolin-1 antibodies inhibit the apical delivery of influenza virus hemagglutinin without affecting basolateral transport of vesicular stomatitis virus G protein. (rupress.org)
  • Researchers have taken long-term interest in the T4 virus, particularly because of the way the DNA double helix is packed extremely tightly within the viral head. (reasons.org)
  • We employed dual-color super-resolution microscopy visualizing Gag assembly sites and HIV-1 Env proteins in virus-producing and in Env expressing cells. (nih.gov)
  • assembly
  • Involved in the tail assembly. (antibody-antibodies.com)
  • From the extremely d etailed image of the connections between the proteins they discovered that telethonin links the tails in a unique way that may give some clues to sarcomere assembly. (bio-medicine.org)
  • The terminal assembly complex investigated in this work, though, only covers a tiny part of the giant muscle protein titin, which possesses tens of thousands of amino acids in some isoforms. (bio-medicine.org)
  • complex
  • The tail tube first 2 annuli are formed by gp48 and gp54, which are in continuation of the spike complex. (antibody-antibodies.com)
  • Most of the characterized FBPs are components of the SCF (SKp1, Cullin, F-box protein) E3 ubiquitin-ligase complex. (mdpi.com)
  • FBPs are structurally and functionally diverse, and their activity is crucial for selecting proteins that will be targeted by the SCF complex. (mdpi.com)
  • surface
  • B) Differential distribution of cluster size for Env(wt) on the surface of HeLa cells in the presence and absence of other viral proteins. (nih.gov)
  • crucial
  • Scientists at the Hamburg Outstation of the European Molecular Biology Laboratory (EMBL) and collaborators from King's College in London have now discovered that something similar happens to a protein that is crucial in the formation of muscle tissue. (bio-medicine.org)
  • possesses
  • Coliphage LSB-1 possesses a tailspike protein with endosialidase activity which is probably responsible for its specific enteroinvasive E.coli host range within the laboratory. (biomedcentral.com)