As Type C retroviruses, replicating murine leukemia viruses produce a virion containing a spherical nucleocapsid (the viral genome in complex with viral proteins) surrounded by a lipid bilayer derived from the host cell membrane. (wikipedia.org)
The lipid bilayer contains integrated host and viral proteins studded with carbohydrate molecules. (wikipedia.org)
Proteins associated with the inner surface of the lipid bilayer of the viral envelope. (lookformedical.com)
Endogenous4
MLVs include both exogenous and endogenous viruses. (wikipedia.org)
citation needed] The MLVs include both exogenous and endogenous viruses. (wikipedia.org)
Different strains of mice may have different numbers of endogenous retroviruses, and new viruses may arise as the result of recombination of endogenous sequences. (wikipedia.org)
The genomes of exogenous and endogenous murine leukemia viruses have been fully sequenced. (wikipedia.org)
Proteins3
The encoded proteins are trafficked to the plasma membrane, where they assemble into progeny virus particles. (wikipedia.org)
These proteins have been implicated in control of viral transcription and may possibly serve as the "glue" that binds the nucleocapsid to the appropriate membrane site during viral budding from the host cell. (lookformedical.com)
Membrane2
The viral glycoproteins are expressed on the membrane as trimer of a precursor Env, which is cleaved into SU and TM by host furin or furin-like proprotein convertases. (wikipedia.org)
As a result, the fusion of the viral membrane and the plasma membrane occurs. (wikipedia.org)
Tumor2
A highly immunogenic tumor transfected with a murine transforming growth factor type beta 1 cDNA escapes immune surveillance. (academicinfluence.com)
The mechanism by which latent viruses, such as genetically transmitted tumor viruses ( PROVIRUSES ) or PROPHAGES of lysogenic bacteria, are induced to replicate and then released as infectious viruses. (lookformedical.com)
Transcription1
In eukaryotes, subsequent activation and viral replication is thought to be caused by extracellular stimulation of cellular transcription factors. (lookformedical.com)
Particles4
The viral particles of replicating MLVs have C-type morphology as determined by electron microscopy. (wikipedia.org)
This cleavage is essential for the Env incorporation into virus particles. (wikipedia.org)
Immature particles are released from the cell with the help of cellular "ESCRT" machinery and then they undergo maturation as the viral protease cleaves the polyproteins. (wikipedia.org)
The murine leukemia viruses are group/type VI retroviruses belonging to the gammaretroviral genus of the Retroviridae family. (wikipedia.org)
The type species of ORTHOPOXVIRUS, related to COWPOX VIRUS , but whose true origin is unknown. (lookformedical.com)
Process1
Process of growing viruses in live animals, plants, or cultured cells. (lookformedical.com)
Found2
Thus, divergent viral sequences may be found in a single host organism. (wikipedia.org)
Nuclear antigens encoded by VIRAL GENES found in HUMAN HERPESVIRUS 4. (lookformedical.com)
Ability2
The murine leukemia viruses (MLVs or MuLVs) are retroviruses named for their ability to cause cancer in murine (mouse) hosts. (wikipedia.org)
The ability of a pathogenic virus to lie dormant within a cell (latent infection). (lookformedical.com)
Family1
A genus of the family HERPESVIRIDAE, subfamily ALPHAHERPESVIRINAE, consisting of herpes simplex-like viruses. (lookformedical.com)
Cells3
Among the latter MLVs are amphotropic viruses (Gr. amphos, "both") that can infect both mouse cells and cells of other animal species. (wikipedia.org)
Here, we use a BCR light chain neoepitope defined by a characteristic point mutation (IGLV3-21R110) for selective targeting of a poor-risk subset of chronic lymphocytic leukemia (CLL) with chimeric antigen receptor (CAR) T cells. (bvsalud.org)
We develop murine and humanized CAR constructs expressed in T cells from healthy donors and CLL patients that eradicate IGLV3-21R110 expressing cell lines and primary CLL cells, but neither cells expressing the non-pathogenic IGLV3-21G110 light chain nor polyclonal healthy B cells. (bvsalud.org)
Highly1
The viral genome is a single stranded, positive-sense RNA highly folded, molecule of around 8000 nucleotides. (wikipedia.org)
HUMAN1
B virus (HBV), hepatitis C virus (HCV), or human immunodeficiency virus (HIV). (cdc.gov)
Endogenous retroviruses2
Different strains of mice may have different numbers of endogenous retroviruses, and new viruses may arise as the result of recombination of endogenous sequences. (wikipedia.org)
Radiation-induced murine leukemias and endogenous retroviruses: the time course of viral expression. (microbiologyresearch.org)
Recombination of endogenous1
Serological characterization of B-tropic viruses of C57BL mice: possible origin by recombination of endogenous N-tropic and xenotropic viruses. (microbiologyresearch.org)
Glycoproteins1
The viral glycoproteins are expressed on the membrane as trimer of a precursor Env, which is cleaved into SU and TM by host furin or furin-like proprotein convertases. (wikipedia.org)
Mice4
Antibody-induced loss of Friend virus leukemia cell surface antigens occurs during progression of erythroleukemia in F1 mice. (microbiologyresearch.org)
And then we progressed, or moved, from there to studying indigenous viruses of mice, because we were beginning to use mice a lot for experimental purposes, and it became very clear that there were a lot of viruses already in the mice that weren't recognized, hadn't been classified, or tests worked out for their characterization. (nih.gov)
And when Sarah Stewart and Bernice Eddy isolated Polyoma virus, we got involved in seeing how it could be handled in the laboratory and began a whole series of experiments that had to do with studying the natural history of Polyoma virus infection in lab mice, and Bob Huebner's particular interest in mice in the wild. (nih.gov)
And Ludwig Gross's induction of leukemia in mice with AKR thymic lymphomas met the same sort of reaction. (nih.gov)
Immature particles are released from the cell with the help of cellular "ESCRT" machinery and then they undergo maturation as the viral protease cleaves the polyproteins. (wikipedia.org)
Specific motifs in viral proteins called late assembly domains (L-domains) are responsible for recruiting the host ESCRT machinery directly or via ESCRT-associated proteins like ALIX. (expasy.org)
Antigens1
Antibody-induced modulation of Friend virus cell surface antigens decreases virus production by persistent erythroleukemia cells: influence of the Rfv-3 gene. (microbiologyresearch.org)
Characterization2
PMID- 214398 TI - Characterization of an adenosine triphosphatase of the avian myeloblastosis virus and the virus-infected myeloblast. (nih.gov)
Serological characterization of C-type retroviruses endogenous to the C57BL/6 mouse and isolated in tumours induced by radiation leukaemia virus (RadLV-Rs). (microbiologyresearch.org)
Cellular1
We examined whether specific antigenicities, viral or cellular, were expressed by tumour cells that could be recognized by antibodies from the irradiated animals. (microbiologyresearch.org)
Vitro2
AB - Peripheral blood mononuclear cells from donors of known serological status with respect to EB virus were exposed to the virus in vitro and then cultured at various cell concentrations. (nih.gov)
The results strongly suggest that the regression phenomenon is an in vitro expression of long-term T-cell-mediated immunity to EB virus which the large majority, if not all, infected individuals possess. (nih.gov)
Herpes2
PMID- 214407 TI - Antibodies to Herpes simplex virus types 1 and 2 in patients with squamous-cell carcinoma of uterine cervix in India. (nih.gov)
AB - Antibody activity to Herpes simplex virus type-1 (HSV-1) and type-2 (HSV-2) was measured by the indirect hemagglutination (IHA) test in sera from 124 women with squamous-cell carcinoma of the uterine cervix, 46 women with non-cervical cancer and 116 matched normal women. (nih.gov)
Virology1
But I've always felt that one of the key things to sort of opening up tumor virology was the isolation of a virus that you could work with in the lab that produced changes in tissue culture. (nih.gov)
Cell1
PMID- 214405 TI - Long-term T-cell-mediated immunity to Epstein-Barr virus in man. (nih.gov)
Cancer3
The murine leukemia viruses (MLVs or MuLVs) are retroviruses named for their ability to cause cancer in murine (mouse) hosts. (wikipedia.org)
Baker: Dr. Hartley, before we get into looking at the Viruses Cancer Program itself, could you give us a little bit about your background, where you went to school, and what experiences you've had? (nih.gov)
Baker: It became quite a change because, as you know, before 1955 nobody thought viruses had anything to do with cancer. (nih.gov)
Core1
Structural markers on core protein p30 of murine leukemia virus: functional correlation with Fv-1 tropism. (microbiologyresearch.org)
Transmission2
PMID- 214400 TI - Transmission of Japanese encephalitis virus by Culex bitaeniorhynchus Giles. (nih.gov)
Avoiding occupational blood exposures is the primary way to prevent transmission of hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV) in health-care settings ( 1 ). (cdc.gov)
Host2
The lipid bilayer contains integrated host and viral proteins studded with carbohydrate molecules. (wikipedia.org)
Thus, divergent viral sequences may be found in a single host organism. (wikipedia.org)
Mouse2
Among the latter MLVs are amphotropic viruses (Gr. amphos, "both") that can infect both mouse cells and cells of other animal species. (wikipedia.org)
So, we got rather deeply into mouse viruses. (nih.gov)
Human2
The first isolations had been made from cultivated tonsils and adenoids, and the work was just beginning to try to understand what a broad spectrum of viruses was involved and what they had to do with human disease, with respiratory disease in the military, and with Trachoma and with pink eye and all the things that are now known to be associated with Adenovirus infection. (nih.gov)
This report updates and consolidates all previous U.S. Public Health Service recommendations for the management of health-care personnel (HCP) who have occupational exposure to blood and other body fluids that might contain hepatitis B virus (HBV), hepatitis C virus (HCV), or human immunodeficiency virus (HIV). (cdc.gov)
Include2
MLVs include both exogenous and endogenous viruses. (wikipedia.org)
citation needed] The MLVs include both exogenous and endogenous viruses. (wikipedia.org)