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  • amino
  • Vpr-binding protein (VprBP) is a 1,507-amino-acid human protein that contains conserved domains, including YXXY repeats, the Lis homology motif, and WD40 repeats. (wikipedia.org)
  • ubiquitin ligase
  • VprBP acts as a substrate-recognition unit when associated with DNA damage-binding protein 1 (DDB1) as part of a CUL4-DDB1 E3 ubiquitin ligase complex. (wikipedia.org)
  • antigen
  • Nanomedical Diagnostics , a cutting-edge life science company pioneering graphene biosensors that accelerate pharmaceutical and biotherapeutics development, announces a new publication in Biosensors and Bioelectronics demonstrating detection of Zika viral antigen using the label-free Agile R100 biosensor. (prweb.com)
  • The DNA tumor virus simian virus 40 produces the Large T antigen which inactivates two of the cell's most important cancer-preventing proteins, p53 and pRb. (bio-medicine.org)
  • In a study published in the Journal of Biological Chemistry, researchers at the Fred Hutchinson Cancer Research Center report the discovery of an additional target for T antigen--a protein called Fbw7. (bio-medicine.org)
  • T antigen also inactivates some of the most important proteins that protect cells against malignant transformation, including tumor suppressor proteins p53 and pRb. (bio-medicine.org)
  • SV40 T antigen contains a motif that mimics the destruction signal found in these proteins. (bio-medicine.org)
  • 3. Detection of viral antigen in normal murine cells and tissues. (biomedsearch.com)
  • The assay was shown to measure an antigen that is highly related to the virion protein as shown by absorption tests, immunoadsorbent chromatography, and by analysis of linearized dose-response curves. (biomedsearch.com)
  • Cryptotopes are antigenically active only after the dissociation of protein aggregates and virions Some infectious pathogens are known to escape immunological targeting by B-cells by masking antigen-binding sites as cryptotopes. (wikipedia.org)
  • novel
  • Furthermore, because proper trafficking of viral proteins is necessary for their function, discovering the requirements for MAM to mitochondrial trafficking of essential viral proteins may provide novel targets for the rational design of anti-viral drugs. (nih.gov)
  • virally
  • Since HCV does not carry any known oncogene, it is thought that interaction between virally encoded proteins and host proteins is responsible for carcinogenesis. (hindawi.com)
  • The protein, called vFLIP K13, had been thought to protect virally infected cells from attack by the body's own immune system by inhibiting the activity of a cellular protein called caspase 8 that is associated with apoptosis, or programmed cell death. (rxpgnews.com)
  • A third class of virally encoded immunomodulatory proteins consists of proteins that bind directly to cytokines. (wikipedia.org)
  • proteases
  • The genome is then translated into a polyprotein, which is then cleaved at specific cleavage sequences by three proteases, HC-Pro, and P1 and NIa-Pro, which are also encoded in the viral genome. (wikipedia.org)
  • Antibodies
  • Antibodies developed by the Centers for Disease Control (CDC) were used to directly detect the viral protein Zika NS1 at clinically relevant levels of sensitivity. (prweb.com)
  • These proteins have very high complementarity in the binding interface, similar to the complementarity shown between antibodies and antigens. (wikipedia.org)
  • For numerous vaccines that have proven effective against other viral diseases, the primary correlate of protection is the generation of broadly neutralizing antibodies (BnAbs). (fredhutch.org)
  • Antibodies can then bind to these viral proteins. (wikipedia.org)
  • lipid
  • Host cell lipid metabolism plays a major role in the infectious life cycle of HCV and several of the viral proteins are shown to be involved in the recruitment of viral complexes to the lipid droplets, LDs [ 6 , 12 ]. (hindawi.com)
  • eVP24 was found to have characteristics of typical viral matrix proteins, such as a strong association with lipid bilayers and the ability to oligomerize to form tetramers. (wikipedia.org)
  • cell's
  • The ribosome has traditionally been viewed as the cell's molecular machine, automatically chugging along, synthesizing proteins the cell needs to carry out the functions of life. (infectioncontroltoday.com)
  • cells
  • Viral nonstructural proteins are proteins coded for by the genome of the virus and are expressed in infected cells. (wikipedia.org)
  • HIV may be able to affect cells it can't directly infect by packaging a key protein within the host's cellular mail and sending it out into the body, according to a new study out of a University of North Carolina Lineberger Comprehensive Cancer Center laboratory. (unclineberger.org)
  • Researchers are planning to continue to investigate the role of the protein outside of infected immune cells, since they believe it's being sent out for a purpose. (unclineberger.org)
  • What we identified is that the protein is being secreted from infected cells without the viral genetic material. (unclineberger.org)
  • A better understanding is aided by studying the cell fusion activity of cells transiently expressing the relevant proteins. (bio-protocol.org)
  • Called nonstructural protein 1 (NS1), it is the only one of the 10 viral proteins secreted by infected cells to circulate freely in the bloodstream. (berkeley.edu)
  • In a study purifying cancerous liver cells infected with HBV, the level of expression of protein arginine methyltransferase 1 (PRMT1) was found to be associated with changes in transcription due to the methyltransferase function of PRMT1. (wikipedia.org)
  • Much of the early work on virokines involved vaccinia virus, which was discovered to secrete proteins that promote proliferation of neighboring cells and block complement immune activity leading to inflammation. (wikipedia.org)
  • NS1 is the most abundant protein in BTV infected cells. (wikipedia.org)
  • degradation
  • The peptides that are presented in this way are primarily generated by proteasomal degradation of proteins expressed by the target cell. (fredhutch.org)
  • In the first, they fused the entire Gag protein to ubiquitin, a small regulatory protein which tags other proteins for proteasomal degradation. (fredhutch.org)
  • Cdk1 phosphorylation also leads to the activation of the ubiquitin-protein ligase APCCdc20, an activation which allows for chromatid segregation and, furthermore, degradation of M-phase cyclins. (wikipedia.org)
  • cell
  • The findings, published in the Aug. 22 online edition of Proceedings of the National Academy of Sciences (PNAS), demonstrate that a viral protein associated with human herpesvirus 8, or HHV8, may help to cause lymphoma by activating a key pathway involved in the production of lymphocytes, a common cell type found in lymphoid tissue that divide over and over and eventually develop into lymphoma. (rxpgnews.com)
  • This points toward a role for the protein outside of the cell. (unclineberger.org)
  • An E-coli cell-free protein synthesizing system directed by R17 RNA was used to examine the fidelity of translation in vitro. (openthesis.org)
  • This is because the X protein promotes cell cycle progression while binding to and inhibiting tumor suppressor protein p53 from performing their role. (wikipedia.org)
  • The virus exits the host cell by tripartite non-tubule guided viral movement. (wikipedia.org)
  • phosphorylation of these proteins leads to cell cycle progression. (wikipedia.org)
  • Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. (wikipedia.org)