• Galls upon plants of species that support infection by virus particles as well as upon non-host plants were analysed by immunoblotting using antisera specific to proteins encoded by viral genes I, IV and VI. (microbiologyresearch.org)
  • The Viral Protein Apoptin Associates with the Anaphase Promoting Complex to Induce G2/M Arrest and Apoptosis in the Absence of p53," Genes Dev. (wpi.edu)
  • The proteins used as marker genes have been previously evaluated for toxicological safety as they are commonly used as marker genes in genetically modified plants. (canada.ca)
  • His research expanded to the mechanism regulating the transcription of cellular and viral genes and characterized the protein SRSF1 as a strong inhibitor of HIV-1 replication. (fau.edu)
  • They include, among others, regulation of interferons and interferon stimulated genes expression. (helsinki.fi)
  • Further, he found that the Human Cytomegalovirus UL26 protein prevents IKKB from inducing the expression of anti-viral interferon stimulated genes. (rochester.edu)
  • Analyzing 5′-upstream non-protein-encoding regions of the human mitochondrial function-associated genes, we speculate that mitochondrial functions could be recovered or improved at a transcriptional level. (intechopen.com)
  • The tool, GASPACHO, captures dynamic changes in gene expression along the innate immune response, allowing researchers to identify genes and molecular pathways associated with disease risk that have previously been too complex to detect or interpret. (sanger.ac.uk)
  • The study, published in Nature Genetics (12 June), helps to unpick the relationship between specific genes, their expression levels, and their potential connection in disease susceptibility. (sanger.ac.uk)
  • Part of this variation may be down to differences in our genes, specifically differences in our genetic regulation of gene expression. (sanger.ac.uk)
  • These are like signposts in our DNA that indicate which genetic variations are linked to changes in the expression of certain genes, affecting how much or how little a gene is dialled up or down, leading to differences in the levels of proteins produced by that gene. (sanger.ac.uk)
  • HBV-X protein: This acts as a transcriptional transactivator for many viral and host genes through interaction with various transcription factors. (medscape.com)
  • The use of viral vectors to deliver foreign genes to the brain is highly logical states in the human brain (Eng et al. (lu.se)
  • Inoculation with a high dose strains of LMP1 transgenic mice vide a powerful tool in mechanistic of EBV caused a B-cell lymphopro- were established that express LMP1 studies on the role of individual viral liferative disorder in these mice, under the control of the immunoglob- genes in cancer. (who.int)
  • A set of viral vectors was thus generated, all of which contained SARS-CoV-2 coding sequences for the spike S1 subunit, the NTD, the RBD, extended RBD, and the S2 core region that contains its fusion domain. (news-medical.net)
  • Gene therapies in the market today use viral vectors to introduce modified genetic material into targeted cells. (sigmaaldrich.com)
  • This means gene therapy manufacturing starts with the upstream production of vectors either through transient transfection or use of stable producer cell line which culminates in the harvesting of the viral vector produced. (sigmaaldrich.com)
  • The production of AAV viral vectors for gene therapy comes with unique upstream challenges. (sigmaaldrich.com)
  • There are a number of hypothesized that regulating the transgene with a GFAP promoter in a different vectors that transduce cells in the brain in a slightly different viral vector would give rise to a high transgenic expression in the manner (for a review see, e.g. (lu.se)
  • These vectors have a number of appealing features including the expression by using the machinery of the host cell instead of depending abilities to ef®ciently transduce cells in the central nervous system, on recombinant regulatory proteins. (lu.se)
  • Up to the present, systematically assessing viral protein antigenicity and/or determining the immunorelevant domain(s) of viral proteins during serological testing for CAV infection has never been performed. (biomedcentral.com)
  • The expression, production and antigenic characterization of CAV viral proteins such as VP1, VP2 and VP3, and their use in the development of diagnostic kit would be useful for CAV infection prevention. (biomedcentral.com)
  • The broad roles eVP24 performs involve the formation of fully functional and infectious viral particles, promotion of filamentous nucleocapsid formation, mediation of host responses to infection, and suppression of the host innate immune system. (wikipedia.org)
  • In 2014, it was found that this mechanism interferes with the cells response to viral infection, which suppressed the innate immune response, allowing the virus to proliferate in the body. (wikipedia.org)
  • The STAT1 protein is phosphorylated by interferons in response to viral infection causing it to express a non-classical nuclear localization signal and bind to the importin protein karyopherin-α (KPNA). (wikipedia.org)
  • Subcellular localization analysis using fluorescently tagged NtREM, ToMV, and viral replication and movement proteins (MPs) indicated that virus infection and transient expression of the viral proteins promoted the formation of NtREM aggregates by altering the subcellular distribution of NtREM, which was localized uniformly on the plasma membrane under normal conditions. (elsevierpure.com)
  • Sasaki, N, Takashima, E & Nyunoya, H 2018, ' Altered subcellular localization of a tobacco membrane raft-associated remorin protein by tobamovirus infection and transient expression of viral replication and movement proteins ', Frontiers in Plant Science , vol. 9, 619. (elsevierpure.com)
  • If chronic infection is established, however, high levels of PD-1 expression can have unfavorable immunological consequences. (frontiersin.org)
  • This line has been developed to express the coat protein of papaya ringspot virus (PRV) which confers resistance to infection by the virus. (canada.ca)
  • Pharmacological reactivation of human immunodeficiency virus (HIV) expression from latent proviruses coupled with fully suppressive antiretroviral therapy (ART) has been suggested as a strategy to eradicate HIV infection. (frontiersin.org)
  • In group A rotaviruses, the segment 7 of the genome encodes NSP3, which is a translation enhancer of viral positive-sense RNAs, expressed moderately in cells following infection. (news-medical.net)
  • These animals showed no clinical signs of FMD, no viremia, and did not develop antibodies against viral nonstructural (NS) proteins, suggesting that complete protection from infection was achieved. (usda.gov)
  • Its activation leads to the production of interferons: a group of cytokines important in overcoming viral infection. (helsinki.fi)
  • During influenza A virus infection, this function is performed by viral non-structural protein 1 (NS1). (helsinki.fi)
  • However, the existing HIV-specific immune response in ART-treated individuals is insufficient to clear persistent infection, even in the presence of latency-reversal agents that induce HIV expression. (sciencedaily.com)
  • Soon after infection, the single stranded positive RNA that constitutes the viral genome is efficiently translated using a cap-independent mechanism driven by the internal ribosome entry site element (IRES). (bionity.com)
  • The arteriviruses are highly species specific, but share many biological and molecular properties, including virion morphology, a unique set of structural proteins, genome organization and replication strategy, and the ability to establish prolonged or true persistent infection in their natural hosts. (bionity.com)
  • Cell macromolecular synthesis may be controlled after CoV infection by locating some virus proteins in the host cell nucleus. (bionity.com)
  • Although current medication can inhibit the infection of cells almost completely, potential side-effects coupled with residual expression and replication of the virus prohibits patients from reaching a normal life expectancy. (europa.eu)
  • The adaptive immune response is thought to be responsible for viral clearance and disease pathogenesis during HBV infection. (medscape.com)
  • genic models are inadequate for number of activated CD8-positive T LMP1 was strongly expressed in the understanding the cancer etiology in cells increased considerably in the lymphoma tissues but was hardly the context of natural viral infection. (who.int)
  • Replication may be categorized into immediate early, delayed early, and late gene expression based on time of synthesis after infection. (medscape.com)
  • NoV) recombinant viral capsid protein (VP) 1. (cdc.gov)
  • Structurally, the EBV genome is enclosed in a nuclear capsid surrounded by a glycoprotein envelope.The EBV genome is a linear DNA molecule that encodes for approximately 100 viral proteins that are expressed during replication. (medscape.com)
  • The Arc gene, which contains remnants of a structural GAG retrotransposon sequence, produces a protein that self-assembles into capsid-like structures harboring Arc mRNA. (lu.se)
  • Both are composed of type-specific HPV L1 protein, the major capsid protein of HPV. (cdc.gov)
  • The OAS1 gene encodes a protein involved in clearing viral RNA from the cell. (sanger.ac.uk)
  • eVP24 was found to have characteristics of typical viral matrix proteins, such as a strong association with lipid bilayers and the ability to oligomerize to form tetramers. (wikipedia.org)
  • Curcumin was chosen for this research due to having low side effects according to Xie, who added that "There are great difficulties in the prevention and control of viral diseases, especially when there are no effective vaccines. (genengnews.com)
  • These compounds might be used in the prevention of viral diseases and in addition to direct-acting antivirals, such as aciclovir. (uni-wuerzburg.de)
  • Pestiviruses account for important diseases in animals such as Classical swine fever (CSF) and Bovine viral diarrhoea / Mucosal disease (BVD/MD). According to the current O.I.E. list CSF and BVD/MD are notifiable diseases and eradication programms are administered in many countries worldwide. (bionity.com)
  • The team identified 1,275 eQTLs within the genome which alter gene expression along the innate immune response between people, relevant for 40 immune-related diseases such as Crohn's disease and diabetes. (sanger.ac.uk)
  • Expression of LMP1 in P3HR1 cells upregulates miR-146a levels. (nih.gov)
  • Based on this, SPF embryos are considered to be free of ASLV viral protein expression, and consequently in developmental research studies RCAS infected cells are routinely identified by immunohistochemistry against the ASLV viral proteins p19 and p27. (johnshopkins.edu)
  • Retrospectively, our observations suggest that studies in which infected cells have been identified simply by pan-ASLV viral protein expression may need to be considered with caution. (johnshopkins.edu)
  • To define the localization of WDFY2 in the endocytic pathway, we transiently transfected hTERT-RPE1 cells with green flourescent protein (GFP)-WDFY2 and performed structured illumination microscopy (SIM) together with APPL1 and EEA1 visualized with antibodies (Fig. 1a ). (nature.com)
  • Programmed cell death protein (PD-1) and its ligands play a fundamental role in the evasion of tumor cells from antitumor immunity. (frontiersin.org)
  • In contrast, PD-L2 expression is more restricted and can be induced on hematopoietic cells such as DCs, B cells, and monocytes/macrophages. (frontiersin.org)
  • The research suggests that curcumin affects TGEV in a number of ways: by directly killing the virus before it is able to infect the cell, by integrating with the viral envelope to inactivate the virus, and by altering the metabolism of cells to prevent viral entry. (genengnews.com)
  • When inducing long-term potentiation (LTP) in the hippocampus, we observed an increase of Arc protein highly correlated with an increase in fluorescent intensity and the number of mCherry-positive cells. (lu.se)
  • In order for this strategy to be effective, latently infected cells must be killed either by the cytopathic effect of reactivated HIV gene expression, or by HIV-specific cytotoxic T lymphocyte (CTL). (frontiersin.org)
  • However, this strategy for the eradication of HIV hinges on the assumption that latently infected cells will be killed by the reactivation of latent proviruses, either as a result of cytopathic effects of HIV gene expression, or through lysis by HIV-specific cytotoxic T lymphocyte (CTL). (frontiersin.org)
  • Protein expression and function of organic anion transporters in short-term and long-term cultures of Huh7 human hepatoma cells. (cancerindex.org)
  • Dr David Courtney is the Principal Investigator in the Courtney Group, and with a talented group of research scientists and students, we aim to answer fundamental questions on the importance of post-transcriptional regulation of RNAs during the viral replication cycle of influenza A RNAs in eukaryotic cells. (google.com)
  • Then, we analysed the number of infected cells and viral infectivity and compared the data to non-treated controls. (uni-wuerzburg.de)
  • Approaches using pharmacological HIV-latency-reversal agents to induce latent virus to express viral protein could make this reservoir vulnerable to T cells. (sciencedaily.com)
  • Interestingly, cells with optimal level of small RNA expression to effectively inhibit viral replication were enriched under the selective pressure of HIV, demonstrating the importance of balancing expression and functionality for successful gene therapy applications. (ca.gov)
  • DAbR1 was subcloned together with green fluorescent protein into an SFG-retroviral vector and used to transduce CD3/CD28-activated primary human T cells and second-generation 1928z (CAR) T cells. (snmjournals.org)
  • Researchers also use cells as biological test tubes to grow viral stocks. (the-scientist.com)
  • Moreover, they infect cells with viruses, or express individual viral proteins, to follow the virus's actions and the host cell response. (the-scientist.com)
  • Unlike previous eQTL mapping attempts that aggregate single-cell data - measuring average gene expression over many cells - GASPACHO enables cell-specific resolution to track changes over time and across individual cells. (sanger.ac.uk)
  • In COVID-19 patients, the team found lower OAS1 expression in nasal epithelial cells as well as monocytes in blood - both viral target cell types - compared to a reference genotype group. (sanger.ac.uk)
  • In these cells, the splicing variant will likely directly influence the efficacy of viral RNA clearance in the individual, explaining the impaired clinical outcome in the COVID-19 patient group. (sanger.ac.uk)
  • The humoral antibody response contributes to the clearance of circulating virus particles and the prevention of viral spread within the host while the cellular immune response eliminates infected cells. (medscape.com)
  • In animals receiving excitotoxic lesions of the striatum we detected an eightfold increase of green ¯uorescent protein (GFP)-expressing cells. (lu.se)
  • Almost all of these genetic changes abnormally activate the protein, which disrupts the tightly regulated RAS/MAPK signaling pathway in cells throughout the body. (medlineplus.gov)
  • Later research indicated that the expression of eVP24 was required to switch from viral transcription and replication to virion assembly. (wikipedia.org)
  • The anti-inflammatory effects of SHE treatment involved blocking of the mitogen-activated protein kinase and signal transducer and activator of transcription 1 signaling pathways. (researchgate.net)
  • His work on RNA binding proteins and SRSF1 has been continuously funded by the NIH and has recently expanded to the study of the role played by multiple RNA binding proteins on cellular gene transcription and T cell development and functions. (fau.edu)
  • The rSA11/NSP3-CoV2/S viruses produced smaller plaques and lower viral titers in cell culture than the wildtype, perhaps because the RNA elongation time required for transcription of the segment 7 dsRNAs is increased during the replication of the virus, or the longer translation time to synthesize proteins encoded from these RNAs. (news-medical.net)
  • The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. (cancerindex.org)
  • Both viral and cellular proteins are required for replication and transcription. (bionity.com)
  • ab27671 has been used to detect recombinant proteins, some of which include transmembrane and secreted proteins, which have been tagged with the V5 epitope. (abcam.com)
  • Once purified by successive purification steps, expression of ASFV recombinant proteins will be tested in vitro using monoclonal and monospecific polyclonal antibodies. (usda.gov)
  • This process occurs concomitantly with the inhibition of cellular protein synthesis, caused by the expression of viral proteases. (bionity.com)
  • CoV N protein is required for coronavirus RNA synthesis, and has RNA chaperone activity that may be involved in template switch. (bionity.com)
  • The tat protein stimulates LONG TERMINAL REPEAT-driven RNA synthesis for both viral regulatory and viral structural proteins. (bvsalud.org)
  • Protein synthesis, folding. (msdmanuals.com)
  • The Courtney lab studies influenza A virus-host interactions with a focus on post-transcriptional regulation of viral RNA by host proteins. (google.com)
  • However, the proteins needed for transcriptional control have been reported to be immunogenic and there is often a substantial leakage in the systems (Clackson, 2000). (lu.se)
  • The nonstructural protein 3 (NSP3) of the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) contains a conserved macrodomain enzyme (Mac1) that is critical for pathogenesis and lethality. (rcsb.org)
  • Expression of Tax, a viral regulatory protein is critical to the pathogenesis. (kegg.jp)
  • Viral RNA as well as viral proteins interact with different components of the host cell, acting as key determinants of viral pathogenesis. (bionity.com)
  • In depth knowledge of the molecular basis of the viral cycle is needed to control viral pathogenesis and disease spreading. (bionity.com)
  • The plasmid construct consisted of the neomycin phosphotransferase II ( nptII), -glucuronidase (gus), and papaya ringspot virus coat protein (PRV CP) gene coding sequences and the regulatory components necessary for expression. (canada.ca)
  • Among the factors that contribute to the progression of HIV is Nef (Negative Regulatory Factor), a protein that promotes viral replication and facilitates immune evasion. (europa.eu)
  • Ebola viral protein 24 (eVP24) is considered a multifunctional secondary matrix protein present in viral particles. (wikipedia.org)
  • Results: We demonstrate that certified SPF chicken embryos have transcriptionally active endogenous ASLV loci (ev loci) capable of expressing ASLV viral proteins, such as p19 and p27, even when those loci are not capable of producing viral particles. (johnshopkins.edu)
  • Expression of the L1 protein using recombinant DNA technology produces noninfectious virus-like particles (VLPs). (cdc.gov)
  • These proteins have very high complementarity in the binding interface, similar to the complementarity shown between antibodies and antigens. (wikipedia.org)
  • In this manuscript, we have developed a recombinant human adenovirus as an expression vector that contains the gene for porcine interferon alpha. (usda.gov)
  • JC virus-iLOV fluorescent strains enable the detection of early and late viral protein expression. (rush.edu)
  • Here, we report the structure-based discovery and development of several different chemical scaffolds exhibiting low- to sub-micromolar affinity for Mac1 through iterations of computer-aided design, structural characterization by ultra-high-resolution protein crystallography, and binding evaluation. (rcsb.org)
  • These encoded sequences for the non-structural protein NSP3 and some parts of the viral spike. (news-medical.net)
  • While the compounds did not interfere with viral entry, it led to lower viral RNA expression after 24 h, indicating that post-entry pathways were inhibited by the compounds. (uni-wuerzburg.de)
  • This mutation leads to production of a BRAF protein that is abnormally active, which disrupts regulation of cell proliferation and may allow histiocytes to grow and divide uncontrollably, leading to the abnormal accumulation of histiocytes that occurs in Erdheim-Chester disease. (medlineplus.gov)
  • This mutation leads to production of a BRAF protein that is abnormally active, which disrupts regulation of cell proliferation. (medlineplus.gov)
  • Notably, in an adsorption assay, curcumin at 40 µM resulted in a reduction in viral titers of 3.55 log TCID50 ml-1, indicating that curcumin possesses excellent inhibitory effects on the adsorption of TGEV. (genengnews.com)
  • Chicken anemia virus (CAV) is an important viral pathogen that causes anemia and severe immunodeficiency syndrome in chickens worldwide. (biomedcentral.com)
  • McNally, MM, Wahlin, KJ & Canto-Soler, MV 2010, ' Endogenous expression of ASLV viral proteins in specific pathogen free chicken embryos: Relevance for the developmental biology research field ', BMC Developmental Biology , vol. 10, 106. (johnshopkins.edu)
  • The PRV virus is a viral pathogen belonging to the potyvirus group of plant viruses and is considered the major limiting factor in commercial papaya production throughout the world. (canada.ca)
  • More recently, Dr. Caputi's research has expanded through collaborative research grants to the development of microfluidic diagnostic devices for the detection of multiple viral species from blood and other bodily fluids. (fau.edu)
  • Abstract Combinational therapy with small RNA inhibitory agents against multiple viral targets allows efficient inhibition of viral production by controlling gene expression at critical time points. (ca.gov)
  • However, data from the macaque simian immunodeficiency virus (SIV) model indicate that in vivo , SIV-specific CTL are only effective during the early stages of the viral replication cycle, and this constitutes an alternative explanation why HIV-specific CTL do not appear to have an impact on HIV reservoirs during ART. (frontiersin.org)
  • To carry out the further antigenic characterization of the immunorelevant domains of the VP2 and VP3 proteins, five recombinant VP2 subunit proteins (VP2-435N, VP2-396N, VP2-345N, VP2-171C and VP2-318C) and three recombinant VP3 subunit proteins (VP3-123N, VP3-246M, VP3-366C), spanning the defined regions of VP2 and VP3 were separately produced by an E. coli expression system. (biomedcentral.com)
  • His disciplinary research focuses on the discovery and characterization of novel virus proteins that have onco-selective toxicity. (wpi.edu)
  • Together with James P. Allison, who worked on another co-inhibitory receptor called cytotoxic T-lymphocyte-associated Protein 4 (CTLA-4), Tasuku Honjo was awarded the Nobel Prize in Physiology or Medicine 2018 for the discovery of cancer therapy by inhibition of negative immune regulation ( Wolchok, 2018 ). (frontiersin.org)
  • For this reason, mitochondrial carrier gene expression needs tight regulation. (cancerindex.org)
  • Based on this information, the corresponding recombinant plasmids will be commercially synthesized placing the selected ASFV proteins under the regulation of specific different promoters already tested in their efficacy in our laboratory. (usda.gov)
  • Here we describe a different method of transgene regulation by the use of the human glial ®brillary acidic protein (GFAP) promoter. (lu.se)
  • We show that the EBV-encoded latent membrane protein 1 (LMP1) induces the expression of miR-146a via NFkappaB. (nih.gov)
  • can reactivate HIV expression from latent proviral genomes. (frontiersin.org)
  • There was also no decrease in the size of the latent reservoir, most likely because of the absence of therapies such as latency-reversal agents, which are designed to perturb the reservoir and induce recognizable expression of HIV proteins that trigger immune responses. (sciencedaily.com)
  • The results of these ELISAs using truncated recombinant VP2 and VP3 subunit proteins as coating antigen showed that VP2-345N, VP2-396N and VP3-246M gave good immunoreactivity with CAV-positive chicken sera compared to the other subunit proteins. (biomedcentral.com)
  • ab27671 recognises a small epitope, termed Pk, present on the P/V proteins of the paramyxovirus, SV5. (abcam.com)
  • Recognizes a 14 aa sequence (GKPIPNPLLGLDST) derived from the P and V proteins of the Paramyxovirus simian virus 5. (enzolifesciences.com)
  • Remorins are plant specific proteins found in plasma membrane microdomains (termed lipid or membrane rafts) and plasmodesmata. (elsevierpure.com)
  • Exhaustion and suppression of antiviral immune responses can result in viral immune evasion. (frontiersin.org)
  • The expression of cauliflower mosaic virus proteins was examined in crown gall tissue transformed by integration of virus genome DNA into plant host chromosomes by Agrobacterium tumefaciens- mediated transfer. (microbiologyresearch.org)
  • Detection of transcripts properties and location of the gene encoding the virus inclusion body protein. (microbiologyresearch.org)
  • Expression of disease symptoms in cauliflower mosaic virus genomic hybrids. (microbiologyresearch.org)
  • The gene III product (p 15) of cauliflower mosaic virus is a DNA-binding protein while an immunologically related pi 1 polypeptide is associated with virions. (microbiologyresearch.org)
  • eVP40 matrix protein which functions in virus budding, and eVP35 which is also associated with immune suppression. (wikipedia.org)
  • This means that eVP24 prevents the activation of an immune response against the Ebola virus without sacrificing its ability to have viral components transported to the nucleus or the target cell. (wikipedia.org)
  • Influenza D virus M2 protein exhibits ion channel activity in Xenopus laevis oocytes. (cdc.gov)
  • To provide a basis for developing novel ion channel-blocking compounds, we investigated the properties of influenza D virus M2 protein (DM2) as a drug target. (cdc.gov)
  • Assuming the same expression level in the Xenopus oocytes, DM2 without tag and influenza C virus M2 protein (CM2) were subjected to the TEVC method. (cdc.gov)
  • Conclusion: The M2 protein from newly isolated influenza D virus showed ion channel activity similar to that of CM2. (cdc.gov)
  • Virus resistant papaya differs from its traditional counterpart in the expression of three novel proteins (PRV CP, NPTII, and GUS). (canada.ca)
  • To enable the tracking of Arc molecules from individual neurons in vivo, we devised an adeno-associated virus (AAV) mediated approach to tag the N-terminal of the mouse Arc protein with a fluorescent reporter using CRISPR/Cas9 homologous. (lu.se)
  • To enable the tracking of Arc molecules from individual neurons in vivo, we devised an adeno-associated virus (AAV) mediated approach to tag the N-terminal of the mouse Arc protein with a fluorescent reporter using CRISPR/Cas9 homologous independent targeted integration (HITI). (lu.se)
  • This includes the S1 N-terminal domain (NTD) or the receptor-binding domain (RBD) and the S2 fusion domains that mediate viral-membrane fusion following virus-host cell attachment at the angiotensin-converting enzyme 2 (ACE2) receptor. (news-medical.net)
  • The most important pathway in influenza virus detection is a retinoic acid-inducible gene I pathway, which recognizes the 5'-triphosphate in viral RNA. (helsinki.fi)
  • The 5-10 most immunogenic African swine fever virus (ASFV) proteins will be selected based in results previously obtained by ARS, PIADC, where these proteins were identified by peptide scanning immune microarray. (usda.gov)
  • We are particularly interested in the role of host proteins in regulating viral gene expression, and how this affects the virus' ability to cause disease. (google.com)
  • These in vitro, and their expression in these human tumour virus. (who.int)
  • SD Bionsensor Inc., submitted documentation in support of safety and performance for ST ND RDTM Q Ebola Zaire Ag as per the "Invitation to Manufacturers of Ebola Virus In Vitro Diagnostics to Submit an Expression of Interest (EOI) for Emergency Assessment by WHO".11 The information submitted in the product application was reviewed by WHO staff and external experts (reviewers) appointed by WHO. (who.int)
  • 1 Invitation to manufacturers of Ebola virus in vitro diagnostics to submit an Expression of Interest (EOI) for emergency assessment by WHO. (who.int)
  • See also Pediatric Hepatitis A, Pediatric Hepatitis C, and Viral Hepatitis. (medscape.com)
  • One class of such RNA agents is small interfering RNAs (siRNAs) that mediate viral message degradation with perfect base pairing to the target. (ca.gov)
  • This was followed-up in his post-doctoral research at UC Santa Cruz (1996-2001) where he was awarded the prestigious Human Frontier Science Program fellowship and published breakthrough work characterizing the key RNA sequences and the cellular proteins that modulate the alternative splicing of the HIV-1 messenger RNA (mRNA). (fau.edu)
  • article{3ef64d42-e741-442e-a1b5-bd0843c8bfaa, abstract = {{The activity-regulated cytoskeleton-associated (Arc) protein is essential for synaptic plasticity and memory formation. (lu.se)
  • The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) macrodomain within the nonstructural protein 3 counteracts host-mediated antiviral adenosine diphosphate-ribosylation signaling. (rcsb.org)
  • Functional studies revealed that some variants increased protein expression, which might increase viral susceptibility and severity, while other variants decreased protein expression, possibly exerting a protective effect. (medpagetoday.com)
  • We demonstrated persistent expression of each anti-HIV RNAs in CEM T cell lines that stably integrate the transgene. (ca.gov)
  • By proximity ligation assay (PLA), we demonstrated that the mCherry-Arc fusion protein retains the Arc function by interacting with the transmembrane protein stargazin in postsynaptic spines. (lu.se)
  • The role of the PD-1/PD-L1 axis during viral infections is further complicated by evidence that PD-L1 also mediates inflammatory effects in the acute phase of an immune response. (frontiersin.org)
  • Naturally occurring infections of papaya result in concentrations of coat proteins at much higher levels than those expressed in papaya line 55-1. (canada.ca)
  • Hough K.P., Rogers A.M., Zelic M., Paris M., Heilman D.W. "Transformed Cell-Specific Induction of Apoptosis by Porcine Circovirus Type 1 Viral Protein 3" J. Gen. Virol. (wpi.edu)
  • The expression of NSP3 along with one or more fluorescent tags allows the expression of a foreign protein, while NSP3 remains a functional, stable dimerizing product. (news-medical.net)
  • The Mayo team used their established deep mutational scanning (DMS) platform to determine the functional implications of 433 human genome variants for ACE2 and TMPRSS2 by analyzing the amount of the encoded proteins. (medpagetoday.com)
  • Overview of Genetics A gene, the basic unit of heredity, is a segment of DNA containing all the information necessary to synthesize a polypeptide (protein) or a functional RNA molecule. (msdmanuals.com)
  • This protein is part of a signaling pathway known as the RAS/MAPK pathway, which controls several important cell functions. (medlineplus.gov)
  • 2000). We of glial cell line-derived neurotrophic factor (GDNF) in models of have recently reported that this vector directs transgene expression to Parkinson's disease (Georgievska et al. (lu.se)
  • Human cellular microRNA hsa-miR-29a interferes with viral nef protein expression and HIV-1 replication. (bvsalud.org)
  • This is the first report to systematically assess the antigenic characteristics of CAV viral proteins for sero-diagnosis purposes. (biomedcentral.com)
  • In our lesioned brain and a substantially less pronounced expression in the laboratory, we have investigated the characteristics of lentiviral vec- normal, intact brain. (lu.se)
  • Develop an ASFV subunit vaccine candidate using racoon pox as a vector with the co-expression of several (6-18) immunogenetic viral proteins. (usda.gov)
  • Scaling up viral vector production using adherent cell culture systems is challenging. (sigmaaldrich.com)
  • We constructed a lentiviral vector that directs transgene expression to astrocytes. (lu.se)
  • These mutations change single protein building blocks (amino acids) in the BRAF protein. (medlineplus.gov)
  • The BRAF gene mutations change single amino acids in the BRAF protein: One mutation replaces the amino acid threonine with the amino acid proline at position 241 (written as Thr241Pro or T241P) and the other mutation replaces the amino acid leucine with the amino acid phenylalanine at position 245 (written as Leu245Phe or L245F). (medlineplus.gov)
  • The BRAF gene provides instructions for making a protein that helps transmit chemical signals from outside the cell to the cell's nucleus. (medlineplus.gov)
  • Currently, the only antiviral drug available targets influenza M2 protein ion channel is not completely effective. (cdc.gov)
  • 2015) SRSF1 inhibition of HIV-1 gene expression. (fau.edu)
  • Furthermore, three of the combinatorial constructs tested potently suppressed viral replication during a 1-month HIV challenge, with greater than 5-log inhibition compared with untransduced, HIV-1-infected CEM T lymphocytes. (ca.gov)
  • This represents the first efficacious example of combining Drosha-processed siRNAs with small nucleolar ribonucleoprotein (snoRNP)-processed nucleolar RNA chimeras from a single intron platform for effective inhibition of viral replication. (ca.gov)
  • The ability to regulate transgene expression will be crucial for development of gene therapy to the brain. (lu.se)
  • Efforts have therefore, designed a study to compare the expression of green ¯uor- been made to develop systems based on different drugs or hormones escent protein (GFP) and GDNF under the control of the hGFAP including tetracycline, rapamycine and progestrone (Clackson, 2000). (lu.se)