Viral protein adapter proteins. Medical search. Frequent questions

IPS-1, an adaptor molecule linking RIG-I and TBK1, was involved in B-DNA-induced activation of interferon-beta and NF-kappaB. (nih.gov)
Patients with X-linked lymphoproliferative (XLP) disease due to deficiency in the adaptor molecule signaling lymphocytic activation molecule-associated protein (SAP) are highly susceptible to one specific viral pathogen, the Epstein-Barr virus (EBV). (bioxcell.com)
An alternative is always to rely on the actual fact that many proteins phosphorylation events bring about significant conformational adjustments in the proteins, which might develop little molecule binding storage compartments that are absent in the unmodified proteins. (euromedh2020.com)
There is certainly precedent because of this watch in the latest demonstration that little molecule inhibitors can bind selectively to either the energetic or inactive types of proteins kinases. (euromedh2020.com)
provides characterized small-molecule inhibitors that focus on an inactive conformation of proteins kinases4. (euromedh2020.com)
Lately, Filippakopoulous et al discovered a cell-permeable little molecule (JQ1) being a selective and powerful inhibitor of recombinant Brd4 proteins derived from bacterias14. (euromedh2020.com)
The SH2D1A gene provides instructions for making a protein called signaling lymphocyte activation molecule (SLAM) associated protein (SAP). (medlineplus.gov)

Signal transducing adaptor proteins CDC24 Cdc25 PI3 kinase Phospholipase Ras GTPase-activating protein Vav proto-oncogene GRB2 p54 S6 kinase 2 (S6K2) SH3D21 ARMH3 (potentially) STAC3 Some myosins SH3 and multiple ankyrin repeat domains: SHANK1, SHANK2, SHANK3 YAP1 ARHGAP12 vexin (VXN) TANGO1 Integrase Focal Adhesion Kinase (FAK, PTK2) Proline-rich tyrosine kinase (Pyk2, CADTK, PTK2beta) TRIP10 (cip4) Src homology 2 domain-containing Structural domain Pawson T, Schlessingert J (July 1993). (wikipedia.org)

Furthermore, he showed that the difference in signaling pathways among TLRs is due to selective usage of adaptor molecules, such as MyD88 and TRIF. (nih.gov)
The two most common and studied downstream molecular adaptors are the myeloid differentiation factor 88 (MyD88) and Toll-interleukin-1 receptor domain-containing adapter-inducing interferon-β (TRIF). (diabetesjournals.org)
TLR3 is able to recognize double-stranded RNA, which induces a TRIF signaling cascade that results in the activation of the inflammasome and subsequent interleukin-1β-mediated responses as well as the increased expression of type I interferons that aid in the control of viral pathogens ( 3 , 4 ). (diabetesjournals.org)
TLR signaling is certainly mediated through 1 of 2 adapter protein, MyD88 or TRIF. (bio-cavagnou.info)
TLR3 indicators with the adapter proteins TRIF (Kawai and Akira, 2006). (bio-cavagnou.info)

C98's CD4+ T cells declined to nearly 200 cells/ml, and received anti-viral therapy for 16 months before dying of non-AIDS causes. (medscape.com)
Furthermore, he recently demonstrated the role of two DExD/H box RNA helicases --- retinoic acid inducible protein-I (RIG-I) and melanoma differentiation-associated gene 5 (mda-5) --- in anti-viral responses by recognizing RNA in the cytoplasm in a TLR independent manner. (nih.gov)
X-linked lymphoproliferative disease (XLP): a model of impaired anti-viral, anti-tumor and humoral immune responses. (medlineplus.gov)
Elevated creation of inflammatory cytokines such as for example IL-6, type I IFN, an essential component from the anti-viral condition, and secretion of chemokines to attract innate immune system cells, 111902-57-9 manufacture including neutrophils and macrophages, are outcomes of TLR activation (Akira and Takeda, 2004). (bio-cavagnou.info)

TLRs are transmembrane proteins that contain leucine-rich repeat domains capable of binding to conserved pathogen-associated molecular patterns (PAMPs). (diabetesjournals.org)
Jasmine virus H (JaVH) is a newly reported viral pathogen of jasmine in China and USA. (biomedcentral.com)
Understanding the part of TLRs during pathogen contamination as well as the signaling occasions that happen in reaction to activation of TLRs really helps to give a 111902-57-9 manufacture clearer picture from the establishment from the innate immune system reaction to PLCB4 viral infections. (bio-cavagnou.info)
2011). As a result, activation of TLR signaling is frequently countered with the pathogen using viral encoded suppressors of web host immune system protein, some targeted particularly to TLR signaling pathways. (bio-cavagnou.info)
In contrast, Pteropus alecto has a limited type I interferon locus, with only three functional interferon alpha genes, compared to 13 in humans, though the P. alecto interferon mRNAs are constitutively expressed allowing for more rapid protein production upon pathogen detection. (nih.gov)

SH3 domains are found in proteins of signaling pathways regulating the cytoskeleton, the Ras protein, and the Src kinase and many others. (wikipedia.org)
In addition to that, the SH3 domain was responsible for controlling protein-protein interactions in the signal transduction pathways and regulating the interactions of proteins involved in the cytoplasmic signaling. (wikipedia.org)
Thus, modulation of protein clearance pathways is a promising approach for therapeutics. (springer.com)
Misfolded proteins that ensue from external and internal stressors are degraded through two major protein clearance pathways, i.e., the ubiquitin-proteasome system (UPS) and the autophagy-lysosome pathway. (springer.com)
These intracellular proteins are involved in protein synthesis and degradation, biological signal transduction, and negative control of signaling pathways. (biomedcentral.com)
Overall this study implicates the PB2 protein in the regulation of host antiviral innate immune pathways and suggests an important role for the mitochondrial association of the PB2 protein in determining virulence. (ox.ac.uk)
Their findings were further supported by the identification of heightened inflammatory response in those restrained rats where part of the activated inflammatory pathways demonstrated the upregulated expression of key mediators like c-Jun kinase (JNK) and Xbox Binding Protein-1 (XBP-1). (nature.com)
SAP interacts with other proteins called SLAM family receptors to activate signaling pathways that are involved in the control of immune cells (lymphocytes). (medlineplus.gov)
Ligand binding to the extracellular domain of receptor tyrosine kinases induces its dimerization and autophosphorylation, which creates binding sites for cytosolic SH2 adaptor proteins, whose binding and activation triggers signaling pathways leading to the nucleus. (nih.gov)
One of the best-understood pathways is the Mitogen-Activated Protein (MAP) kinase pathway, in which activated MAP kinase moves into the nucleus, where it phosphorylates and activates transcription factors, leading to gene expression. (nih.gov)

a260_a280_ratio a260 a280 ratio A C177536 GDC Property Terminology C139285 Microsatellite Instability Overall Status The state or condition of a subject's microsatellite sequences with respect to the inability of their mismatch repair (MMR) proteins to fix a DNA replication error. (nih.gov)
In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription. (cusabio.com)
This review will concentrate on molecular areas of viral replication in alveolar cells and their response to disease. (bioerc-iend.org)
found that these virally encoded RNAs acted as enhancers for viral replication but they did not function as a primer for replication. (bioerc-iend.org)
These short RNAs were retained in the nucleus throughout the infection and it is postulated that they act to not only stabilize viral RNA genome replication but to also play a role in maintaining the proper stoichiometry of each viral segment (28). (bioerc-iend.org)
Viral proteins also have been shown to regulate viral transcription and genome replication. (bioerc-iend.org)
This serves as a template for viral genome replication which is stabilized by both the newly synthesized polymerase and NP (29). (bioerc-iend.org)
They also identified elements of Nutlin-3 the 3′ and 5′ UTR of the viral segments involved in competition for viral proteins required for replication and also demonstrated that shorter viral segments can out compete larger segments for viral proteins (29). (bioerc-iend.org)
Figure 2 Influenza A viral replication. (bioerc-iend.org)
The monopartite genome consists of 3867 nucleotides (nts), encoding five open reading frames (ORFs) that include replication proteins p27 and p87, movement proteins MP1 and MP2, and coat protein (CP) p37 (Zhuo et al. (biomedcentral.com)

Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) is responsible for the outbreak of a new viral respiratory infection. (hindawi.com)
Furthermore, it has been shown that vaccine efficacy against viral respiratory infection is influenced by probiotics pretreatment. (hindawi.com)
B-DNA signaling by this pathway conferred resistance to viral infection in a way dependent on both TBK1 and IKKi. (nih.gov)
Our approach is to use cutting-edge 'omics' technologies to profile global responses of mosquito cells to viral infection. (surrey.ac.uk)
Bilirubin-IX-alpha inhibited viral infection of Hep-2 and Vero cells when given 2 h before, concomitantly and 2 h after viral infection. (frontiersin.org)
Molecular areas of antiviral response in the cells specifically the proteins kinase RNA reliant response, as well as the oligoadenylate synthetase RNAse L system in relation to influenza infection. (bioerc-iend.org)
Jasmine plants generally exhibit chlorotic mosaicism on their leaves, which is believed to be the consequence of viral infection. (biomedcentral.com)
The bat immune system appears to be uniquely adapted for the control of viral infection without the manifestation of disease or pathology, though the immune mechanisms are not well understood. (nih.gov)

At that time he made the seminal observation that mice lacking the adaptor protein MyD88 were unresponsive to lipopolysaccharide (LPS), a major immunostimulatory component in the cell wall of Gram-negative bacteria, indicating that the LPS receptor uses MyD88 for signaling. (nih.gov)

First identified on the basis of sequence similarity with the Drosophila protein Toll, TLRs are members of an ancient superfamily of proteins, which includes related proteins in invertebrates and plants. (biomedcentral.com)
The PAMPS are comprised of bacterial, parasitic, or viral components, and the binding of these PAMPS to the extracellular domain of TLRs results in the activation of intracellular adaptor molecules. (diabetesjournals.org)
TLRs are 111902-57-9 manufacture type I membrane protein that recognize their ligands via leucine wealthy do it again (LRR) motifs included of their Ig-like ectodomains (Slack et al. (bio-cavagnou.info)

Classical SH3 domains are restricted in humans to intracellular proteins, although the small human MIA family of extracellular proteins also contain a domain with an SH3-like fold. (wikipedia.org)
Among 120 positive clones from the library, 12 intracellular proteins were identified after sequencing and a BLAST search. (biomedcentral.com)
In the present study, using a yeast two-hybrid system, we found that TGEV-S1 interacts with multiple intracellular proteins, including UBX domain-containing protein 1 (UBXN1). (biomedcentral.com)

The SH3 proteins interact with adaptor proteins and tyrosine kinases. (wikipedia.org)
Interacting with tyrosine kinases, SH3 proteins usually bind far away from the active site. (wikipedia.org)
Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. (drugbank.com)
Other retroviral transforming proteins were soon found to be tyrosine kinases, and the epidermal growth factor (EGF) receptor was shown to have tyrosine kinase activity that is stimulated by EGF binding. (nih.gov)
This finding was quickly followed by the demonstration by others that the v-Fps and v-Abl retroviral transforming proteins are tyrosine kinases, and that the EGF receptor also has tyrosine kinase activity that is stimulated by EGF binding. (nih.gov)

2. The Ubiquitin Sensor and Adaptor Protein p62 Mediates Signal Transduction of a Viral Oncogenic Pathway. (nih.gov)
Unwanted, damaged, misfolded and aggregated proteins are degraded by the ubiquitin-proteasome system (UPS) and the autophagy-lysosome pathway. (springer.com)
2014 ). The evolutionary conserved ubiquitin-proteasome system (UPS) and autophagy-lysosome pathway are the two major protein clearance mechanisms in eukaryotes. (springer.com)

The SRC Homology 3 Domain (or SH3 domain) is a small protein domain of about 60 amino acid residues. (wikipedia.org)
Influenza A attaches to its target cell through binding of its hemagglutinin protein to sialic acid linked galactose residues. (bioerc-iend.org)
The phosphorylation of tyrosine residues in proteins was discovered in 1979 during our analysis of the protein kinase activity that phosphorylates the middle T antigen of polyoma virus in vitro. (nih.gov)

Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor. (drugbank.com)

SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. (drugbank.com)
There is a considerable amount of evidence that the insulin-like growth factor (IGF) family is important for cancer development and progression and IGF signalling is known to involve complex regulatory networks with numerous interacting ligands, receptors and binding proteins [ 1 , 2 ]. (biomedcentral.com)

The differential accumulation of JaVH with distinct 3′ UTR suggested that the 3′ UTR of JaVH plays a crucial role in viral RNA accumulation. (biomedcentral.com)

In addition, the up-regulation of HO was shown to play an important role against bacterial and viral infections. (frontiersin.org)

The PB2 subunit of the influenza virus RNA polymerase affects virulence by interacting with the mitochondrial antiviral signaling protein and inhibiting expression of beta interferon. (ox.ac.uk)
Here, we demonstrate that the PB2 protein interacts with the mitochondrial antiviral signaling protein, MAVS (also known as IPS-1, VISA, or Cardif), and inhibits MAVS-mediated beta interferon (IFN-beta) expression. (ox.ac.uk)
Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects. (uchicago.edu)

Approximately 300 SH3 domains are found in proteins encoded in the human genome. (wikipedia.org)
HHV-6 (HHV-6A and HHV-6B) and HHV-7 are unique HHVs that acquire latency by integration of the viral genome into sub-telomeric region of human chromosomes. (frontiersin.org)
However, lack of viral activity in commonly tested biological materials including blood or serum strongly suggests tissue specific localization of active HHV-6 genome. (frontiersin.org)
Analysis of mapped nanopore reads alone, despite an average individual error rate of 24 % (range 8-49 %), permitted identification of the correct viral strain in all four isolates, and 90 % of the genome of CHIKV was recovered with 97-99 % accuracy. (biomedcentral.com)
The genome contains nine open reading frames (ORFs) encoding 16 kinds of nonstructural proteins and four structural proteins, spike (S), envelope (E), membrane (M), and nucleoprotein (N), which are arranged in the order of 5′-replicase-(1a/1b)-S-3a-3b-E-M-N-7-3′ [ 2 ]. (biomedcentral.com)
Phylogenetic analyses and sequence comparisons suggest that the eight virus isolates were close isolates of JaVH-FJ and the isolate from Jilin Province was most closely related to JaVH-FJ with 99.2% nucleotide identity over the entire genome and 99.7% identity of coat protein. (biomedcentral.com)
Interest had centered on a single protein called middle T (or tumor) antigen, which is encoded by one of the three alternatively spliced mRNAs generated from the so-called early region of the polyoma virus genome. (nih.gov)

DNA sequence comparisons of genes encoding Toll-related proteins in Drosophila , reptiles, birds and in mammals have revealed that the genes are well conserved and have evolved independently from a common ancestor gene [ 8 ]. (biomedcentral.com)
Widjaja produced a model whereby transcription of viral genes is accomplished by the associated RNA dependent RNA polymerase. (bioerc-iend.org)

Using a glutathione- S -transferase (GST) pulldown assay and Co-IP, we found that UBXN1 interacts with the S1 protein. (biomedcentral.com)

Condensates separation from the surrounding CYTOPLASM or nucleoplasm or by the concentration of proteins and nucleic acids into droplets as they aggregate on static cellular structures such as CELL MEMBRANES. (nih.gov)

When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN). (drugbank.com)
Proteins phosphorylation is among the most common post-translational adjustments in eukaryotic cells and has a central function in signaling. (euromedh2020.com)
The presence of phosphotyrosine in the middle T antigen was the first indication that tyrosine could be a target for phosphorylation by a protein kinase. (nih.gov)

Examples are the C-terminal SH3 domains of adaptor proteins like Grb2 and Mona (a.k.a. (wikipedia.org)
The loading of GTP onto Ras is stimulated by Sos, a guanine nucleotide exchange factor that is bound to the Grb2 adaptor protein. (nih.gov)

Targets specific host proteins for degradation by the 26S proteasome. (cusabio.com)

This protection increased over time, suggesting that viral shedding or ongoing immune response may persist beyond 90 days and may not represent true reinfection. (contrareport.com)
For example, we use 'proteomics' methods to measure every protein in a given sample, which can tell us how mosquito cells respond when infected with dengue or Zika virus (e.g. does the immune system activate? (surrey.ac.uk)
The response of go for innate immune system cells and their contribution to viral clearance and lung epithelial harm may also be talked about. (bioerc-iend.org)

Here we present nanopore sequencing for metagenomic detection of viral pathogens from clinical samples with a sample-to-answer turnaround time of under 6 hr (Fig. 1a ). (biomedcentral.com)

The C-terminal portion of LEDGF contains a protein binding scaffold known as the Integrase Binding Domain (IBD) because HIV integrase was this domain's first identified binding partner. (eu.org)
The investigators identified IQGAP1, a scaffold protein, as a gasdermin D (GSDMD)-interacting protein through a nonbiased proteomic analysis. (nih.gov)

5. A Screen for Epstein-Barr Virus Proteins That Inhibit the DNA Damage Response Reveals a Novel Histone Binding Protein. (nih.gov)
For every from the infections discussed within this review we may also high light viral proteins recognized to inhibit different facets 111902-57-9 manufacture of TLR signaling. (bio-cavagnou.info)

and distilled L2U), adopted by strenuous tapping for 30?minutes and centrifugation in 15?000 for 5?minutes in 4?C. After identifying the proteins focus of entire cell lysates and nuclear or cytoplasmic components by Bradford reagent (Bio-Rad), equivalent quantities of proteins examples had been separated by salt dodecyl sulfateCpolyacrylamide solution electrophoresis (SDSCPAGE) and moved to polyvinylidene difluoride walls (Millipore, Bedford, MA, USA). (mdm2-inhibitors.com)
Cytoplasmic tails of bunyavirus Gn glycoproteins-Could they act as matrix protein surrogates? (expasy.org)

Shortly thereafter, we found that v-Src, the Rous sarcoma virus (RSV) transforming protein, and c-Src, its cellular progenitor, also have tyrosine kinase activity. (nih.gov)
As soon as Marc Collett and Ray Erikson, then at University of Colorado in Denver, reported in 1978 that the RSV-transforming protein, v-Src, had protein-kinase activity when assayed in an immunoprecipitate, we began to test whether polyoma virus middle T antigen also had such activity. (nih.gov)
We were excited to find that middle T antigen became phosphorylated in immunoprecipitates, and by the middle of 1979, we had shown through the use of viral mutants that the presence of this protein kinase activity correlated well with the ability of middle T antigen to transform mammalian cells. (nih.gov)
In this case, we were able to show that c-Src, the cellular progenitor of v-Src, also had tyrosine kinase activity, suggesting that a normal, vertebrate protein could act as a tyrosine kinase. (nih.gov)

In addition, we show that PB2 proteins of influenza viruses differ in their abilities to associate with the mitochondria. (ox.ac.uk)
In particular, the PB2 proteins of seasonal human influenza viruses localize to the mitochondria while PB2 proteins of avian influenza viruses are nonmitochondrial. (ox.ac.uk)
In order to address the functional significance of the mitochondrial localization of the PB2 protein in vivo, we have generated two recombinant human influenza viruses encoding either mitochondrial or nonmitochondrial PB2 proteins. (ox.ac.uk)
We found that the difference in the mitochondrial localization of the PB2 proteins does not affect the growth of these viruses in cell culture. (ox.ac.uk)

To study the viral gene function and pathogenic mechanism, a full-length infectious clone of JaVH (pXT-JaVH FJ ) was constructed under the control of the cauliflower mosaic virus 35S promoter. (biomedcentral.com)
We were trying to identify the viral gene products responsible for transformation. (nih.gov)

Initially, SH3 was described as a conserved sequence in the viral adaptor protein v-Crk. (wikipedia.org)

Structural features of human members of the TLR protein family and the archetypal Drosophila Toll protein. (biomedcentral.com)
These substrates include enzymes, structural proteins, and proteins called adaptors. (nih.gov)

Although the proteins involved in these diseases are different, they have in common the accumulation of pathological protein inclusions in neurons. (springer.com)

S1 is one of two protein domains in the spike (S) glycoprotein and is responsible for enteric tropism, sialic acid recognition, and host receptor binding. (biomedcentral.com)

Moreover, these ligands usually do not bind to various other phospho-proteins promiscuously. (euromedh2020.com)
We among others possess confirmed that libraries of peptoids5 (oligo-N-substituted glycines) are wealthy resources of protein-binding ligands 6-10. (euromedh2020.com)

SH3 interactomes, revealed that worm SH3 interactome resembles the analogous yeast network because it is significantly enriched for proteins with roles in endocytosis. (wikipedia.org)
Viral attachment to its receptor induces endocytosis of the virus. (bioerc-iend.org)

Due to these limitations, it might be beneficial to develop easy-to-make and inexpensive artificial substances that could become PSSA surrogates, that is certainly, bind and selectively to a specific phospho-form of confirmed proteins tightly. (euromedh2020.com)

The classical SH3 domain is usually found in proteins that interact with other proteins and mediate assembly of specific protein complexes, typically via binding to proline-rich peptides in their respective binding partner. (wikipedia.org)

UBXN1 overexpression significantly increased the viral copy number. (biomedcentral.com)

It binds to chromatin tightly and tethers multiple unrelated protein complexes to the chromatin fibers. (eu.org)

This demonstrated that there was significant selective pressure to express the SIV Nef protein. (medscape.com)

2015 ). With age, post-mitotic cells such as neurons lose extensive control of the proteostasis equilibrium, including deficits in protein degradation machineries (Vilchez et al. (springer.com)
Data indicate that proline residue P109 within the C-terminal poly-proline motif (PPM) of Vpx protein plays a unique role in the regulation of SAM domain and HD domain 1 protein SAMHD1 degradation. (cusabio.com)

Brd4 is certainly a dual bromodomain-containing proteins that is utilized as a mobile adaptor by some pet and individual papillomaviruses (HPV) for anchoring viral genomes to mitotic chromosomes. (euromedh2020.com)

The WD40 repeat is found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing, and cytoskeleton assembly. (team-fancy.de)

In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). (drugbank.com)
SRC is implicated in regulation of pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1. (drugbank.com)

Adaptors are SH2 proteins that lack enzymatic activity but that have other protein-binding domains that bind effector proteins. (nih.gov)

However, the virus encoding the nonmitochondrial PB2 protein induces higher levels of IFN-beta and, in an animal model, is attenuated compared to the isogenic virus encoding a mitochondrial PB2. (ox.ac.uk)

X-linked lymphoproliferative disease is caused by deficiency of a novel SH2 domain-containing signal transduction adaptor protein. (medlineplus.gov)

LEDGF/P75 is a nuclear protein belonging to the family of Hepatoma-derived growth factors (HDGFs). (eu.org)
It is a ubiquitously expressed nuclear transcription factor-type protein with a role in transcriptional regulation, autoimmunity, cell survival, and prevention of apoptosis ( Llano,2009 ). (eu.org)
Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. (cusabio.com)
It was previously shown that the PB2 protein, in addition to its nuclear localization, also accumulates in the mitochondria. (ox.ac.uk)
The vRNP forms a complex in the nucleus between the M1 protein and the nuclear export protein (NEP) formerly known as NS2 (31). (bioerc-iend.org)

Interestingly, the immunogenicity of TGEV S1 is stronger than that of the whole S protein and is the major inducer of TGEV-neutralizing antibodies [ 9 ]. (biomedcentral.com)

This progression can be a combined aftereffect of the sponsor disease fighting capability response to influenza disease as well as the viral disease itself. (bioerc-iend.org)

Inhibition of UBXN1 in IPEC-J2 cells via siRNA interference significantly decreased the viral titer and downregulated the expression of S1. (biomedcentral.com)

Our results show abundant viral miRNA in various regions of the human brain and associated neuronal tissues including the spinal cord that is only detected in ME/CFS patients and not in controls. (frontiersin.org)

Anatomy35

Organisms14

Chemicals and Drugs135

Analytical, Diagnostic and Therapeutic Techniques and Equipment20

Phenomena and Processes52

Information Science3

Molecule7

Signal Transducing1

TRIF5

Anti-viral4

Pathogen5

Pathways10

Replication10

Infection8

MyD881

TLRs3

Intracellular proteins3

Tyrosine kinases5

Pathway3

Residues3

Mitogen-activa1

Receptors2

Role in viral1

Bacterial and viral1

Antiviral3

Genome7

Genes2

Interacts1

Cytoplasm1

Phosphorylation3

GRB22

Host proteins1

Immune3

Pathogens1

Scaffold2

Inhibit2

Cytoplasmic2

Kinase activity4

Viruses4

Gene2

Conserved sequence1

Structural2

Diseases1

Glycoprotein1

Ligands2

Endocytosis2

Surrogates1

Mediate1

Overexpression1

Complexes1

Selective1

Degradation2

Genomes1

Eukaryotic1

Phosphorylates2

Bind1

Induces1

Deficiency1

Nuclear5

Interestingly1

Influenza1

Interference1

Abundant1