• Earlier adoptive-T-cell-therapy approaches for HIV had limited efficacy as a result of multiple factors. (sciencedaily.com)
  • Randomized controlled studies in different cancers resulting in significant increase in survival and disease free period have been reported and its efficacy is enhanced by 20-30% when cell-based immunotherapy is combined with conventional treatment methods. (wikipedia.org)
  • Continued clinical efficacy demonstrations of cell-based immunotherapies (iTx) such as chimeric antigen receptor T cell (CAR-T) therapies has made the prospect increasingly likely of an immunotherapy product achieving conditional market authorization in the short term. (bioprocessintl.com)
  • NK cell adoptive immunotherapy in humans has shown modest efficacy. (bvsalud.org)
  • Given recent advances in efficacy in numerous pilot trials, the next steps in clinical development will require multicenter trials to establish adoptive immunotherapy as a mainstream technology. (sagepub.com)
  • Monitoring HAdV-specific T-cell immunity may improve risk assessment in HSCT recipients and enhance treatment efficacy by determining the optimal time point for adoptive T-cell transfer. (biomedcentral.com)
  • These findings indicate that a concise understanding of antigens and T cells in NSCLC is needed to improve therapeutic efficacy and reduce toxicity with immunotherapy, particularly adoptive T cell therapy. (researchwithrutgers.com)
  • According to current challenges, there is a need to explore innovative immunotherapies, maximize the tumor-killing efficacy of γδ T cells, and attenuate or eliminate tumor immunosuppression. (explorationpub.com)
  • The antigen specificity, life span and effector functions of the resultant T cells from immunotherapies may determine their efficacy. (nhri.org.tw)
  • Moreover, the inhibitory mechanisms in tumor microenvironment may also influence the efficacy of the cancer immunotherapy. (nhri.org.tw)
  • Combination with other immunotherapy regimens improve overall therapeutic efficacy. (biomedcentral.com)
  • For example, the relative inefficiency of delivering OVs to tumor nodules, selective viral replication inside tumor nodules and spread to distant micrometastases limits its overall efficacy. (biomedcentral.com)
  • Researchers must ensure reproducibility, efficacy and potency of cancer immunotherapy treatments before these reach the clinic. (technologynetworks.com)
  • While different methods exist to evaluate the efficacy of immunotherapy products, more efficient and robust in vitro assays are still required to ensure their safety and consistency. (technologynetworks.com)
  • The need for a novel cancer immunotherapy assay The most significant challenge faced by cancer immunotherapy researchers is the inability to predict treatment efficacy and response. (technologynetworks.com)
  • TILs represent the most developed strategy for neoantigen-targeting immunotherapy, and it is well known that this therapy has shown efficacy in infiltrating tumors, Svane said. (targetedonc.com)
  • Recommendation B. Create a translational science network devoted exclusively to immunotherapy approaches to treat and prevent adult cancers. (nih.gov)
  • Cell-based immunotherapies are effective for some cancers. (wikipedia.org)
  • Adoptive cell transfer has been tested on lung and other cancers, with greatest success achieved in melanoma. (wikipedia.org)
  • Newswise - NEW YORK, July 22, 2021-The Cancer Research Institute (CRI), a U.S. nonprofit organization dedicated to saving more lives through the discovery and development of powerful immunotherapies for all cancers, announced today that it has awarded more than $28.5 million in research grants and fellowships during the 2021 fiscal year ending June 30, 2021. (newswise.com)
  • These grants total $10.7 million for the launch, expansion, or ongoing support of platform studies including the AMADEUS biomarker study as well as the IPROC (ovarian cancer), PORTER (prostate cancer), and REVOLUTION (pancreatic cancer) studies testing novel immunotherapy combinations in these hard-to-treat cancers. (newswise.com)
  • Investigators are saving lives and improving care through innovative studies in adoptive T-cell immunotherapy, precision medicine, and de-escalation of treatment of breast and other cancers. (cancer.gov)
  • In principle, immunotherapy aims to generate effective T cell response for direct killing of tumor cells and induce long-term immune surveillance against cancers. (nhri.org.tw)
  • Dr. Huang has profound experiences working on immune cell interactions in the liver microenvironment and also on T-cell engineering and currently is developing immunotherapies for treatment of cancers based on these well-established immunological knowledge and technologies in the laboratory. (nhri.org.tw)
  • Studies by researchers at Roswell Park, the University of Chicago, and others have identified critical factors which make immunotherapy less effective in ovarian cancer than other cancers. (roswellpark.org)
  • The second generation of immunotherapies for treatment of cancer, called CAR-T therapies, showed huge remission rates in severe blood cancers (i.e. lymphoma and leukemia). (musicbeatscancer.org)
  • Since virtually all undifferentiated NPCs are associated with Epstein-Barr virus (EBV), this tumor is an attractive candidate for cellular immunotherapy targeted against tumor-associated viral antigens. (nih.gov)
  • The class I and class II Human Leucocyte Antigens (HLA) are an integral part of the host adaptive immune system against viral infections. (bvsalud.org)
  • The characterization of HLA allele frequency in the population can play an important role in determining whether HLA antigens contribute to viral susceptibility. (bvsalud.org)
  • Self antigens expressed by solid tumors Do not efficiently stimulate naive or activated T cells: implications for immunotherapy. (ox.ac.uk)
  • In addition, the data suggest that the risk for induction of chronic autoimmune diseases is limited, which may encourage immunotherapy against antigens selectively but not exclusively expressed by the tumor. (ox.ac.uk)
  • In this subpopulation of tumor-reactive T cells, we find neoantigen-specific T cells as well as tumor-associated antigen-specific T cells and T cells reactive toward viral antigens [such as] human papillomavirus [HPV]. (targetedonc.com)
  • Our current and planned early clinical trials include phase I Epstein-Barr virus (EBV) vaccines and monoclonal antibodies, as well as collaborations with CNH CETI for viral-specific T cell therapies for the treatment and prevention of chronic norovirus infection and COVID-19. (nih.gov)
  • She is passionate about her work in the clinic caring for patients with primary immunodeficiencies, as well as seeking new therapies and vaccines against viral diseases. (nih.gov)
  • These methods and results can help us to better understand immune reconstitution following hematopoietic cell transplantation, leading to future studies on the clinical application of adoptive T-cell therapies. (nature.com)
  • A better and deeper understanding of immune reconstitution following allo-HCT is required for further clinical application of these adoptive T-cell therapies. (nature.com)
  • Cancer immunotherapies can be divided into four major categories: - Cytokines/immunomodulation agents - Monoclonal antibodies - Cell‑based therapies - Oncolytic viruses Though monoclonal antibodies currently represent the largest class of commercialized cancer immunotherapies, cell‑based therapies are rapidly making headway. (technologynetworks.com)
  • The clinical program within the Medical Virology Section has 2 main foci: the natural history of viral infections and their intersection with immune defects and early phase therapeutics and vaccines for herpesvirus infections. (nih.gov)
  • Our natural history protocols allow for the clinical, laboratory and genetic assessment of patients with viral infections with particular emphasis on unusual or severe viral infections. (nih.gov)
  • In addition, the MVS clinical team collaborates with referring physicians to manage underlying immunodeficiency and/or refractory viral infections. (nih.gov)
  • During her fellowship, she joined the Cell Enhancement and Technologies for Immunotherapy Program (CETI) at Children's National Hospital (CNH) under the mentorship of Dr. Catherine Bollard and Dr. Michael Keller with an emphasis on adoptive T cell therapy for viral infections in immunocompromised hosts including SARS-CoV-2 and chronic Norovirus. (nih.gov)
  • However, T-cell depletion is associated with higher rates of graft rejection and increased vulnerability to viral and fungal infections while the T-cell population is diminished. (medscape.com)
  • June, Carl H. 2014-03-21 00:00:00 Adoptive immunotherapy, or the infusion of lymphocytes, is a promising approach for the treatment of cancer and certain chronic viral infections. (sagepub.com)
  • A considerable proportion of the most prevalent T cells in tumors are also prevalent in the uninvolved tumor-adjacent lungs and appear specific to shared background mutations or viral infections. (researchwithrutgers.com)
  • Patients posttransplant are at high risk for several potentially lethal viral infections. (cancer.gov)
  • During chronic viral infections or malignancies, there are usually monoclonal T cell response detected and most of the Ag-specific T cells undergo exhaustion or apoptosis rapidly after activation. (nhri.org.tw)
  • These anti-viral vaccines are highly effective in curbing virus infections and onset of cancer. (biomedcentral.com)
  • An immunotherapy treatment that effectively kills cancer AND viral infections without toxic side effects. (musicbeatscancer.org)
  • In these times of pandemic, Geneius has adapted its immunotherapy to fight several viral infections including Covid-19. (musicbeatscancer.org)
  • Nowadays, immunotherapy has become an important alternative to fight cancer. (mdpi.com)
  • Shares of ZIOPHARM Oncology Inc. (ZIOPHARM) skyrocketed 54.5% in trade to end at $8.87 , a day after the Company and Intrexon Corporation announced a broad exclusive licensing agreement with The University of Texas MD Anderson Cancer Center, for the development of non-viral adoptive cellular cancer immunotherapies. (prnewswire.com)
  • Projects proposed should focus on establishing an efficient infrastructure to collect and analyze outcomes data of cellular immunotherapy trials (NCI-sponsored, investigator-initiated, or pharmaceutical company-sponsored) or with an FDA-approved agent and facilitating analysis of the observational data for the design of pre-clinical research in the Cancer Immunotherapy Consortium (CIC) and elsewhere, as well as inform design of future trials. (nih.gov)
  • The CIC will be composed of organ site-specific Cancer Immunotherapy Research Projects (U01, supported by RFA-CA-17-045 ) and Cancer Immunoprevention Research Projects (U01, supported by RFA-CA-17-046 ). (nih.gov)
  • Immunotherapy is under preliminary research for its potential to treat various forms of cancer. (wikipedia.org)
  • Cancer immunotherapy attempts to stimulate the immune system to destroy tumours. (wikipedia.org)
  • One of the oldest forms of cancer immunotherapy is the use of BCG vaccine, which was originally to vaccinate against tuberculosis and later was found to be useful in the treatment of bladder cancer. (wikipedia.org)
  • Topical immunotherapy utilizes an immune enhancement cream (imiquimod) which produces interferon, causing the recipient's killer T cells to destroy warts, actinic keratoses, basal cell cancer, vaginal intraepithelial neoplasia, squamous cell cancer, cutaneous lymphoma, and superficial malignant melanoma. (wikipedia.org)
  • The first FDA-approved cell-based immunotherapy, the cancer vaccine Sipuleucel-T is one example of this approach. (wikipedia.org)
  • One example is adoptive cell therapy with T cells that were genetically modified with gamma-retroviral and lentiviral (LV) delivery vectors to express a CD19-specific chimeric antigen receptor (CAR) for cancer treatment. (uni-wuerzburg.de)
  • As the field of cancer immunotherapy advances rapidly, it is now crucial to understand how the dissemination and maintenance of tumor-specific T cells can be optimally achieved. (frontiersin.org)
  • Thus, they might hold great potential for cancer immunotherapy. (bvsalud.org)
  • Therefore, NK cells must be reversed from their dysfunctional status and increased in their effector roles in order to improve the efficiency of cancer immunotherapy. (bvsalud.org)
  • Rosenberg, S.A. & Restifo, N.P. Adoptive cell transfer as personalized immunotherapy for human cancer. (nature.com)
  • Advances in adoptive immunotherapy, which concentrates on the growth and infusion of particular illness-combating white blood cells in sufferers, have boosted this science to peak performance when it comes to being an efficient therapy for viral diseases, colon cancer, and even stage 4 cancer varieties. (biousing.com)
  • Immunotherapy targeting T cells is increasingly utilized to treat solid tumors including non-small cell lung cancer (NSCLC). (researchwithrutgers.com)
  • In total, CRI gave 79 awards that will support immunology and cancer immunotherapy research at 43 institutions in 8 countries. (newswise.com)
  • Advances in immunology and cancer immunotherapy are being made at an accelerating pace thanks in part to new technologies and techniques that are opening up exciting new ways to explore the complex relationship between cancer and the immune system," said Jill O'Donnell-Tormey, Ph.D., CEO and director of scientific affairs at the Cancer Research Institute. (newswise.com)
  • HOUSTON, Nov. 09, 2021 (GLOBE NEWSWIRE) - Ziopharm Oncology, Inc. ("Ziopharm" or the "Company") (Nasdaq: ZIOP), today announced the presentation of preclinical data highlighting the potential of neoantigen-specific TCR-T cells for the treatment of solid tumors at the Society for Immunotherapy of Cancer 2021 Annual Meeting. (archiebronsonoutfit.net)
  • In the study presented at SITC, Ziopharm's non-viral gene transfer technology, Sleeping Beauty, was used to develop TCR-T cells targeting EGFR, KRAS and p53 neoantigens, which are present in cancer cells but not in normal tissue, and are presented by a variety of human leukocyte antigen (HLA) molecules on the cancer cell surface. (archiebronsonoutfit.net)
  • Both papers indicated that diversity of bacteria and the abundance of certain types of bacteria can affect patients' response to anti-PD-1 immunotherapy for some cancer types. (acir.org)
  • As an emerging cancer immunotherapy, oncolytic virotherapies (OVTs) can not only selectively lyse cancer cells, but also induce a systemic antitumor immune response. (frontiersin.org)
  • During the past two decades, due to the better understanding of cancer pathogenesis, targeted therapy and immunotherapy have been extensively developed and utilized in cancer treatment. (nhri.org.tw)
  • Though immunotherapies such as immune checkpoint blockade, adoptive T cell therapy, and oncolytic viruses have led to remarkable advances in the treatment of other tumor types (e.g. melanoma, lung, and kidney cancer), these strategies have been less successful in ovarian cancer. (roswellpark.org)
  • Cancer Immunotherapy Agilent xCELLigence RTCA handbook 2 Table of contents What is cancer immunotherapy? (technologynetworks.com)
  • 4 xCELLigence real-time cell analysis 6 Diverse cancer immunotherapy applications 6 How does the xCELLigence real-time cell analysis assay work? (technologynetworks.com)
  • Cancer immunotherapy consists of multiple approaches that harness and enhance the innate powers of the immune system to fight the disease. (technologynetworks.com)
  • It is currently viewed as one of the most promising forms of cancer treatment with 12 cancer immunotherapies approved in recent years. (technologynetworks.com)
  • Few of us understand the cancer-fighting paradigm of "immunotherapy" that recently entered the clinic. (musicbeatscancer.org)
  • We are developing a new immunotherapy approach that will democratize treatment so that patients with all cancer types can access immunotherapy at an affordable cost without having to recover from immuno-related side effects in the ICU. (musicbeatscancer.org)
  • The Geneius immunotherapy is an "adoptive T- cell therapy," a form of treatment that uses the cells of our immune system to eliminate cancer. (musicbeatscancer.org)
  • Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer. (ukw.de)
  • Last week, the ACIR team attended the AACR Tumor Immunology and Immunotherapy conference in Boston, MA. (acir.org)
  • The purpose of this specific FOA is to establish a Data Resource associated with clinical trials in cellular immunotherapy as a component of the Immuno-Oncology Translation Network (IOTN). (nih.gov)
  • Among tumor immunotherapies, neoantigen vaccines are in early human clinical trials and have demonstrated substantial efficiency. (wjgnet.com)
  • He has successfully translated his findings from the laboratory to the clinics and has conducted and led several large national immunotherapy clinical trials for brain tumors. (stanfordhealthcare.org)
  • One way in which biologists and medics use immunotherapy is by injecting antigen-incubated Dendritic Cells (DCs) into mice to stimulate an immune response. (mdpi.com)
  • Injection immunotherapy ("intralesional" or "intratumoural") uses mumps, candida, the HPV vaccine or trichophytin antigen injections to treat warts (HPV induced tumours). (wikipedia.org)
  • Dendritic cells, a type of antigen-presenting cell, are harvested from the person needing the immunotherapy. (wikipedia.org)
  • These cells are then either pulsed with an antigen or tumour lysate or transfected with a viral vector, causing them to display the antigen. (wikipedia.org)
  • His main scientific contributions in the last 10 years relate to antigen presentation in dendritic cells and immunotherapy. (euroacadti.eu)
  • Subsequent adoptive transfer of virus activated spleen cells into RIP(GP x Tag2) mice further prolonged survival (168 +/- 11 d), demonstrating continued expression of the LCMV-GP tumor antigen and MHC class I. The data show that the tumor did not spontaneously induce or maintain an activated CTL response, revealing a profound lack of immunogenicity in vivo. (ox.ac.uk)
  • Dr. Vile's research includes the study of oncolytic viruses, adoptive cell therapy, and chimeric antigen receptor (CAR)-T cell therapy. (mayo.edu)
  • Due to their efficient gene delivery, viral vectors have been successfully used in T-cell engineering to provide gene transfer medicinal products for the treatment of human disease. (uni-wuerzburg.de)
  • One example is adoptive cell therapy with T cells that were genetically modified with gamma-retroviral and lentiviral (LV) delivery vectors to express a CD19-specific chimeric The advances in genetic engineering have enabled us to confer T cells new desired functions or delete their specific undesired endogenous properties for improving their antitumor function. (uni-wuerzburg.de)
  • However, there are persistent concerns and limitations with the use of viral vectors for CAR T cell generation with regard to safety, cost and scale of vector production. (uni-wuerzburg.de)
  • In the first part of the study, we engineered CAR T cells through non-viral Sleeping Beauty (SB) transposition of CAR genes from minimalistic DNA vectors called minicircles rather than conventional SB plasmids. (uni-wuerzburg.de)
  • The high level of gene transfer rate and efficient genome editing, superior safety profile as well as ease-of-handling and production of non-viral MC vectors and Cas9 RNP position our developed non-viral strategies to become preferred approaches in advanced cellular and gene-therapy. (uni-wuerzburg.de)
  • With the application of such viral vectors as clinical therapeutics growing, scalable commercial processes (particularly for purification) are being investigated and optimized to best ensure that critical quality attributes (CQAs) are retained. (bioprocessintl.com)
  • Current methodologies for reprogramming, however, face a number of translational hurdles, including heavy reliance on viral vectors, and the highly stochastic nature of current transfection methodologies. (osu.edu)
  • Since these earlier attempts, the adoptive-T-cell-therapy field has made significant advances, largely in the oncology field, that could help to overcome some of the pitfalls encountered with earlier T-cell-therapy approaches for HIV. (sciencedaily.com)
  • Approaches using pharmacological HIV-latency-reversal agents to induce latent virus to express viral protein could make this reservoir vulnerable to T cells. (sciencedaily.com)
  • Natural killer (NK) cells are unique innate immune cells that mediate anti-viral and anti-tumor responses. (bvsalud.org)
  • Once packaged into a E1-complementing cell line, which provides the E1 products in trans, such as QBI 293A Cells, recombinant viral will be easily propagated. (genemedi.com)
  • It also exhaustively introduces the concrete mechanism of invading GC cells and the viral genome composition of adenovirus and herpes simplex virus type 1 (HSV-1). (frontiersin.org)
  • Adoptive T-cell therapy is established by taking tumor tissue from the patient and driving out the T cells from the tumor lesion, followed by initial TIL expansion. (targetedonc.com)
  • Dr. Lim is a world leader in immunotherapy for brain tumors. (stanfordhealthcare.org)
  • In addition to being invited world-wide to give lectures and seminars, he has given platform presentations on the topics of immunotherapy for brain tumors, neurosurgical techniques and management of brain tumors at the American Society of Clinical Oncologists, American Academy of Neurological Surgeons, Radiological Society of North America, Annual Symposium on Brain and Spine Metastases, Congress of Neurological Surgeons, and other meetings. (stanfordhealthcare.org)
  • Recently, the lab of Dr. P. Agostinis documented that immunogenic cell death mediated by ER stress can be harnessed to develop novel and clinically relevant, next-generation dendritic cell-based immunotherapies for brain tumors. (euroacadti.eu)
  • In order to address these concerns, we aimed to improve non-viral gene transfer and genome editing tools as an effective, safe and broadly applicable alternative to viral delivery methods for T-cell engineering. (uni-wuerzburg.de)
  • After the synthesis of viral genome and capsid, they are assembled into viral products, releasing out of cell, and the infected cell starts lysis [45]. (genemedi.com)
  • We showed that, for all five viral variants, mutations cause a significant reduction in the number of tightly binding peptides for HLA-B*07:02 and HLA-C*01:02 molecules. (bvsalud.org)
  • Interestingly, mutations caused multidirectional effect on the binding affinities of the viral peptides and HLA-DRB1*03:01. (bvsalud.org)
  • New technologies capable of mediating nuclear reprogramming through non-viral deterministic approaches are needed in order to facilitate the transition from lab bench to bedside. (osu.edu)
  • This was accomplished using non-viral CRISPR/Cas9 via pre-assemble Cas9 protein and in vitro-transcribed sgRNA (Cas9 RNP). (uni-wuerzburg.de)
  • One safe avenue for harnessing T cell responses to fight HIV is adoptive cellular therapy. (sciencedaily.com)
  • BCG immunotherapy induces both local and systemic immune responses. (wikipedia.org)
  • Responses to immunotherapy vary due to a number of factors, and according to two recent papers published in Science, the gut microbiome is definitely one of them. (acir.org)
  • Dr. Lim's bibliography contains well over 200 articles on topics such as immunotherapy for glioblastoma, long-term survival of glioma patients treated with stereotactic radiation, and treatment of neuropathic pain. (stanfordhealthcare.org)
  • Radiotherapy, chemotherapy, targeted therapy, and immunotherapy are basically intended to provide another choice for patients with post- or non-operative conditions. (frontiersin.org)
  • The current immunotherapies are therefore too toxic and economically out of reach for the millions of patients who could potentially benefit. (musicbeatscancer.org)
  • Importantly, the Geneius immunotherapy would be available to patients through their community oncologist as an out-patient procedure. (musicbeatscancer.org)
  • Geneius needs to achieve several important steps before its immunotherapy approach can be considered for use in patients. (musicbeatscancer.org)
  • In another phase 1/2 study (NCT00937625), adoptive cell therapy with TILs was examined in patients with metastatic melanoma who had progressed on prior treatment with high-dose IL-2 and ipilimumab (Yervoy). (targetedonc.com)
  • Anti-PD-1 therapy is a main treatment strategy for patients with metastatic melanoma, according to Svane, and, as such, it was important for investigators to examine whether adoptive cell therapy with TILs can be utilized in patients who had progressed on this therapy. (targetedonc.com)
  • The late transcribed genes are L1-L5, encoding viral capsid components (Fig. 7B). (genemedi.com)
  • Our investigators have pioneered first-in-human testing of different viral platforms that they developed as oncolytic agents, including measles virus strains encoding the sodium iodide symporter gene, vesicular stomatitis virus strains encoding the human interferon beta and NIS genes, and measles virus strains encoding the TLR-2 agonist neutrophil activating protein. (mayo.edu)
  • At monthly faculty meetings, basic and clinical immunologists discuss ongoing research in their labs in order to foster translation of immunological principles into clinical immunotherapy trials. (dana-farber.org)
  • Before we can combine this approach with treatments meant to bring HIV out from hiding so the improved immune response can clear it from the body, we need to first establish that this immunotherapy approach is safe on its own," says co-senior study author Catherine Bollard of the Children's National Health System. (sciencedaily.com)
  • Clinical use of a combination of radiotherapy and chemotherapy continues to increase, while the development of immunotherapy, such as checkpoint inhibitors, offers hope in improving treatment outcome. (hkmj.org)
  • Immunotherapies designed to elicit or amplify an immune response are classified as activation immunotherapies, while immunotherapies that reduce or suppress are classified as suppression immunotherapies. (wikipedia.org)
  • Therapeutic DNA is largely delivered using viral vector systems based on adenoviruses (Ad), adenoassociated viruses (AAV), and lentiviruses (LV). (bioprocessintl.com)
  • For most serotypes, adenovirus infection is mediated by the high-affinity binding of the fiber-knob region to a receptor of target cell, named as the coxsackie-Ad receptor (CAR), which mainly determines the viral tropism [44]. (genemedi.com)
  • The Company's non-viral Sleeping Beauty gene transfer platform has enabled the development of a unique TCR-T Library. (archiebronsonoutfit.net)
  • Adenovirus transcription is a two-phase event, early and late, occurring before and after viral DNA replication, respectively (Figure. (genemedi.com)
  • Life cycle of adenovirus is separated by DNA replication process into two distinct phases: the early and late, occurring before and after viral DNA replication, respectively. (genemedi.com)
  • Additionally, results from a meta-analysis that examined studies that administered adoptive cell therapy with TILs at treatment centers worldwide showed that durability of response can be experienced with this treatment if a CR is achieved. (targetedonc.com)