• There was a statistically significant increase in antibodies to the H3N2 strain when the vaccines were co-administered, suggesting that the MVA-NP+M1 can act as an adjuvant. (bl.uk)
  • For highly variable viruses, such as HCV, isolation and characterization of monoclonal antibodies mediating broad virus neutralization are an important guide for vaccine design. (frontiersin.org)
  • The viral envelope glycoproteins, E1 and E2, are the main targets of these antibodies. (frontiersin.org)
  • Another element in vaccine design is based on information on how the virus escapes from broadly neutralizing antibodies. (frontiersin.org)
  • Immunisation is the process of artificially inducing immunity or protection from disease.19 This may be done either by stimulating the body s immune system with a vaccine or toxoid to produce antibodies, or through the use of an externally produced antibody. (ratbags.com)
  • there is no evidence whatsoever that vaccines of any kind - but especially those against childhood diseases - are effective in preventing the infectious diseases they are supposed to prevent. (ratbags.com)
  • In this open, randomized trial the safety, reactogenicity, and immunogenicity profile of a high-dose combined hepatitis A and B candidate vaccine was compared with that of Twinrix Paediatric in healthy volunteers aged 11-18 years. (curehunter.com)
  • The encouraging results mean the researchers will now test a similar candidate vaccine, this time 'tetravalent' - targeting all of the four types of the virus. (scidev.net)
  • the age-range 2) virus-micronutrient interactions with a particular focus on retinoid-virus interactions and 3) novel adjuvants and immunomodulators to enhance vaccine efficacy and safety. (mcgill.ca)
  • From April 2000 to September 2003 all haemodialysis patients referred to the haemodialysis department in a Babol hospital received 4 microg vaccine intramuscularly at 0, 1, and 6 months. (who.int)
  • From 1978 to 1993 a study of acute viral hepatitis contracted by the Japan Overseas Cooperation Volunteers (JOCV) during their assignments in tropical and subtropical countries was conducted. (ajtmh.org)
  • She has a PhD in micropaleontology and in 1993 published a book - Vaccination 100 Years of Orthodox Research shows that Vaccines Represent a Medical Assault on the Immune System . (ratbags.com)
  • An understanding on the specificities of a protective B cell response, the molecular locations of these epitopes on E1, E2, and E1E2, and the mechanisms, which enable the virus to negatively modulate neutralizing antibody responses to these regions will provide the necessary guidance for vaccine design. (frontiersin.org)
  • Positive responsiveness to the vaccine was defined as an anti-hepatitis B antibody titre above 10 mIU/ml. (bmj.com)
  • I then show that MVA-NP+M1 can be safely co-administered alongside seasonal influenza vaccine. (bl.uk)
  • Such T cell responses can be generated with the use of viral vectored vaccines. (bl.uk)
  • The magnitude of T cell responses to the vaccine immunogen was correlated with the breadth of the T cell responses to different epitopes. (bl.uk)
  • Appropriate vaccination schedules and the responses to vaccines in immunosuppressed children remain to be determined. (bmj.com)
  • Using novel model systems for HCV-host interaction, we have previously defined cellular and viral structures mediating HCV-cell surface interaction and identified targets for antiviral immune responses. (jobvector.com)
  • Having had no new drugs for hepatitis C since ribavirin's approval more than a decade ago, doctors will shortly be spoilt for choice. (blogspot.com)
  • He concluded that despite 'fantastic' new drugs upcoming for hepatitis C, they would have little impact on the global burden of this potentially eradicable disease unless health policies change (up to 170 million people are estimated to be infected with the virus). (blogspot.com)
  • But achieving this goal will require more investments in research and development (R&D). With funding trends distressingly on the decline for TB R&D, political action is critical to bend the curve up toward the development of breakthrough diagnostics, treatments, and vaccines needed to realize the promise of ending TB. (treatmentactiongroup.org)
  • For hepatitis A all subjects had seroconverted at month 7, and geometric mean titres (GMT) were 8,151 mIU/ml in the high-dose group and 6,394 mIU/ml in the Twinrix Paediatric group. (curehunter.com)
  • The autologous neutralizing response tends to be immunodominant, but when mutations occur in the variable epitopes (V1-V5) in the viral envelope due to error prone reverse transcriptase activity, it leads to virus escape from neutralization ( 19 ). (frontiersin.org)
  • Inadequate consideration has been given to the additive or synergistic adverse effects of multiple simultaneous vaccines, although in the case of toxic chemicals, two compounds together may be 10 times more toxic than either separately, or 3 compounds 100 times more toxic. (whale.to)
  • Assessment and Management of Risks Associated With Hepatitis B Effectiveness of Intervention by Hilleman, Maurice R., Dougl. (valorebooks.com)
  • The basic issue to be reviewed here is whether or not in some instances in which a father, family member, or caretaker has been accused of causing the death of an infant or child from the SBS, the true cause of death was a catastrophic vaccine reaction. (whale.to)
  • There were no apparent safety concerns with the vaccine according to investigators, led by Kimberly Page, PhD, MPH , of the University of New Mexico, Albuquerque. (mdedge.com)
  • However, there were significant differences in HCV RNA geometric mean peak at 1 month, which was 193,795 IU/L in the vaccine group and 1,078,092 IU/L in the placebo group, according to investigators. (mdedge.com)
  • Vaccine responsiveness was not influenced by either methotrexate or prednisolone treatment. (bmj.com)
  • 1991. Nucelotide sequence analysis of Urabe mumps vaccine strain that caused meningitis in vaccine recipients. (nvic.org)
  • Health education concerning food and water sanitation, and providing general information on viral hepatitis, was also conducted throughout this period. (ajtmh.org)
  • These results indicate that acute viral hepatitis could be successfully prevented in the JOCV with a combination of ISG, hepatitis B vaccination, and health education. (ajtmh.org)
  • We're also going to be working with agencies such as Health Resources and Services Administration [HRSA] and the Bureau of Primary Health Care to ensure that HRSA-funded grantees and partners are also receiving this additional information on what physicians can actually do to promote better education, better screening, and linkage to care for people living with viral hepatitis," Dr. Fenton said. (acpinternist.org)
  • The two vaccines showed similar safety and reactogenicity profiles. (curehunter.com)
  • Few published studies on vaccine effects include before-and-after studies of immune parameters or brain function studies such as electroencephalograms, or long-term safety monitoring. (whale.to)
  • We are now performing repetition of the experiments and evaluation of the effects of the vaccine in vitro on human dendritic cells,' says Frédéric Tangy, director of research at CNRS and head of the Viral Genomics and Vaccination laboratory at the Pasteur Institute. (scidev.net)
  • Identification and characterization of these bNAbs and understanding their evolution dynamics are critical for obtaining useful clues for the development of an effective HIV vaccine. (frontiersin.org)
  • 1947. Neurologic complications following the administration of pertussis vaccine. (nvic.org)