• We propose that such proteins generally regulate virion attachment both by binding to cells and by covering another receptor-binding protein until they are displaced. (asm.org)
  • Structural, antigenic, and evolutionary characterizations of the envelope protein of newly emerging Duck Tembusu Virus. (nih.gov)
  • In this study, we examined in detail structural, antigenic, and evolutionary properties of envelope (E) proteins of six DTMUV isolates spanning 2010-2012, each being isolated from individual farms with different geographical locations where disease outbreaks were documented. (nih.gov)
  • Structural analysis showed that E proteins of DTMUV and its closely related flavivirus (Japanese Encephalitis Virus) shared a conserved array of predicted functional domains and motifs. (nih.gov)
  • There are two large ORFs (ORF1a and ORF1b) that encode non-structural proteins. (wikipedia.org)
  • The remaining eight ORFs create the six main structural proteins for the virus. (wikipedia.org)
  • Furthermore, phylogenetic analysis of the nucleotide sequences of the E proteins showed that viruses evolved into two distinct genotypes, termed as DTMUV.I and DTMUV.II, with II emerging as the dominant genotype. (nih.gov)
  • A phylogenetic tree was inferred from the nucleotide sequences of E proteins (Fig. 5). (nih.gov)
  • 11 . The isolated nucleic acid of any one of claims 3 - 10 , wherein the transmembrane protein is gp41 or a modified form of gp41, wherein the modification alters the immunogenicity of the molecule relative to wildtype gp41. (google.com)
  • 12 . The isolated nucleic acid of claim 11 , wherein the transmembrane protein is the gp41 ectodomain. (google.com)
  • p53/58 is a transmembrane protein that continuously recycles between the ER and pre-Golgi intermediates composed of vesicular-tubular clusters (VTCs) found in the cell periphery and at the cis face of the Golgi complex. (nih.gov)
  • Molecular chaperones bind nonnative protein conformations, sequestering misfolded protein or aggregation-prone folding intermediates from the cytosol, thereby reducing the likelihood of aggregate formation ( Hartl, 1996 ). (rupress.org)
  • We found that 57.70% of differentially-expressed proteins were functionally related, and through bioinformatics analysis, we were able to construct a network mainly in complement and coagulation cascades. (bireme.br)
  • Most herpesviruses also encode at least one additional receptor-binding protein that is more specific for a given virus subfamily. (asm.org)
  • Interestingly, these genetic polymorphisms resulted in no detectable change in viral neutralization properties as demonstrated in a serum neutralization assay. (nih.gov)
  • Thus, they regulate viral tropism both positively and negatively depending upon the presence or absence of their receptor. (asm.org)
  • Viral progeny assemble in the nucleus and are released from their host cell by a process that appears to involve the activity of a newly identified later-expressed protein, VP4 ( 16 ). (asm.org)
  • There is a newly discovered protein encoded in ORF5a that overlaps ORF5. (wikipedia.org)
  • Given the potentially pathogenic consequences of intracellular protein aggregation, it is not surprising that eukaryotic cells have evolved mechanisms to prevent their formation or accumulation. (rupress.org)
  • Membrane disruption observed at the end of the viral life cycle is a highly tuned and temporally controlled step that maximizes viral dissemination ( 57 ). (asm.org)
  • 14 . The isolated nucleic acid of any one of claims 1 - 13 , wherein the stabilization of the complex is achieved by one or more cysteine-cysteine bonds that are formed between the surface and transmembrane proteins and that are not present in the corresponding wildtype complex. (google.com)
  • This effort has included biochemical and biological characterizations of the interaction between cell surface receptors and the HIV envelope. (grantome.com)
  • Three murine mammary tumor virus (MuMTV)-producing epithelial cell lines derived from murine mammary tumors were examined in order to identify the MuMTV-specific cell surface antigens and their distribution on the cell surface, to study the kinetics of the MuMTV envelope precursor processing, virus assembly, and release, and to characterize the soluble MuMTV antigens that are shed into culture medium. (biomedsearch.com)
  • P rotein folding is the process by which a linear polymer of amino acids is converted to a unique three-dimensional structure that comprises a functional protein molecule. (rupress.org)
  • A gene or gene product (protein) that small molecule drugs will be screened and developed against. (sigmaaldrich.com)
  • Entry occurs after receptor binding by fusion of virion envelope and cellular plasma membrane followed by microtubuli-assisted transport of capsids to the nuclear pore. (nih.gov)
  • These data lead us to propose that aggresome formation is a general response of cells which occurs when the capacity of the proteasome is exceeded by the production of aggregation-prone misfolded proteins. (rupress.org)
  • p>This section provides any useful information about the protein, mostly biological knowledge. (uniprot.org)
  • The analysis of the activity of viroporins is crucial for understanding of the viral release process. (asm.org)
  • pim-1 proto-oncogene expression in anti-CD3-mediated T cell activation is associated with protein kinase C activation and is independent of Raf-1. (jimmunol.org)
  • Represents the average number of viral particles per single cell. (sigmaaldrich.com)
  • Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest. (uniprot.org)
  • section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. (uniprot.org)
  • p>This indicates the type of evidence that supports the existence of the protein. (uniprot.org)
  • Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)
  • a href='/help/protein_existence' target='_top'>More. (uniprot.org)
  • However, both processes can be distinguished by involvement of additional viral components. (nih.gov)
  • Lentiviral particles that are incapable of producing additional viral particles, due to the elimination of wild-type enhancers in the long terminal repeat region. (sigmaaldrich.com)
  • Three proteins-gB, gH, and gL-form a core fusion machinery conserved in the Alpha -, Beta -, and Gammaherpesvirinae subfamilies ( 21 ). (asm.org)
  • Activation of type I protein kinase A during receptor-mediated human T lymphocyte activation. (jimmunol.org)
  • To increase the number of the infectious disease specialist with the proper knowledge of viral hemorrhagic fever including EVD is a common problem for infectious disease physicians working in Japan, the academic society, and the government. (bireme.br)
  • G protein-coupled receptors are essential for intercellular communication in multicellular organisms and they are also the targets for many drugs already in use or under development, for the treatment of, for example, cardiovascular disease, asthma, cancer, neurological dysfunction and metabolic disorders. (keystonesymposia.org)
  • A gene or its product (protein) which plays a critical role in disease. (sigmaaldrich.com)
  • The field of GPCR biology has undergone a radical transformation with the structure determination of over 15 different GPCRs, including the first complex of an activated GPCR bound to a heterotrimeric G protein. (keystonesymposia.org)
  • Aggresome formation is accompanied by redistribution of the intermediate filament protein vimentin to form a cage surrounding a pericentriolar core of aggregated, ubiquitinated protein. (rupress.org)
  • to learn more about the safety of the combination use of the two HIV envelope vaccines utilized in the study. (clinicaltrials.gov)