• Scholars@Duke publication: Viral and bacterial infections induce expression of multiple NK cell receptors in responding CD8(+) T cells. (duke.edu)
  • To determine how the profile of NK receptor expression changes in murine CD8(+) T cells as they respond to intracellular pathogens, we used class I tetramer reagents to directly examine Ag-specific T cells during lymphocytic choriomeningitis virus and Listeria monocytogenes infections. (duke.edu)
  • Because stem cell transplants destroy and rebuild your immune system, they increase your risk for fungal infections. (cdc.gov)
  • Fungal infections can look like bacterial or viral infections. (cdc.gov)
  • Fungal infections can happen days, weeks, or months after the stem cell transplant. (cdc.gov)
  • Some types of fungal infections are more common than others in stem cell transplant patients. (cdc.gov)
  • Aspergillosis is the most common type of fungal infection in stem cell transplant patients, followed by Candida infection and mucormycosis, but other types of fungal infections are also possible. (cdc.gov)
  • Our data reveal the translational potential of PSA as an immunomodulatory symbiosis factor to orchestrate robust protective anti-inflammatory responses during viral infections. (nature.com)
  • Strep throat and urinary tract infections are common bacterial infections. (medlineplus.gov)
  • Viral infections include HIV and the common cold . (medlineplus.gov)
  • Bacterial vs. Viral Infections: How Do They Differ? (medlineplus.gov)
  • 4]. Neutrophils are involved in the body's infection, cold, fever, chest congestion, defence against microorganisms, especially stomach upset or loose bowel motions were against pyogenic bacterial infections [5]. (who.int)
  • Viruses are thought to facilitate bacterial infections of the respiratory tract, but the mechanisms are poorly understood. (lu.se)
  • Adenovirus (types 1, 2, 3, and 5) commonly causing respiratory tract infections increased the binding of adherent S. pneumoniae strains to the cells. (lu.se)
  • Lymphocytes fight viral infections and some bacterial infections. (answerbag.com)
  • Leukopenia (a white count decreased to less than 4,000/μL) is seen in some viral infections or severe bacterial infections, and conditions that affect the bone marrow such as dietary deficiencies, chemotherapy, radiation therapy , and autoimmune diseases. (answerbag.com)
  • [ 1 , 2 ] The clinical picture is characterized by marked leukocytosis and localized bacterial infections that are difficult to detect until they have progressed to an extensive level secondary to lack of leukocyte recruitment at the site of infection. (medscape.com)
  • Thus, patients with this type of leukocyte adhesion deficiency manifest both severe bacterial infections and bleeding disorder. (medscape.com)
  • Inflammation from viral and bacterial infections cause COPD flare-ups. (nationaljewish.org)
  • It is the most important type of antibacterial agent for fighting bacterial infections , and antibiotic medications are widely used in the treatment and prevention of such infections. (wikipedia.org)
  • Antibiotics are used to treat or prevent bacterial infections, [29] and sometimes protozoan infections . (wikipedia.org)
  • When your body doesn't have enough iron stores, your cells can't respond properly to bacterial and viral infections. (webmd.com)
  • Certain viral or bacterial infections can affect peripheral nerves. (corporatewellnessmagazine.com)
  • Bacterial and viral infections do not seem to be the priming factor, but researchers have been focusing lately on parasites. (abc.net.au)
  • Doctors can tell if you have certain common viral infections based on your symptoms. (msdmanuals.com)
  • How do doctors treat viral infections? (msdmanuals.com)
  • A 2016 study at Yale found that, yes, eating may help fight viral infections and fasting may help combat bacterial infections. (greatist.com)
  • Meningitis is the leading infectious syndrome that affects the central nervous system, and most cases are caused by viral infections, mainly enterovirus. (bvsalud.org)
  • It is noteworthy that the initial clinical infections can present high morbidity and low presentations of viral meningitis and bacterial mortality rates. (bvsalud.org)
  • Viral, fungal and parasitic infections as well as bacterial infections may be problematic. (lu.se)
  • These NK cell receptors are also expressed by certain memory phenotype CD8(+) T cells, and in some cases are up-regulated in T cells responding to viral infection. (duke.edu)
  • A transplant using stem cells from a donor increases your risk for fungal infection more than a transplant that uses stem cells from your own body. (cdc.gov)
  • A recent study reported that oral antibiotic treatment caused dysbiosis of the vaginal microbiota, resulting in increased IL-33 secretion, leading to impaired antiviral T cell responses and enhanced susceptibility to lethal HSV2 infection 23 . (nature.com)
  • Evidence that bacterial small molecules also target viruses provides fresh insights into how bacteria thwart viral infection. (nature.com)
  • Viral and Bacterial Adhesion Network Training (ViBrANT) places adhesion at the heart of virulence: it plays the first and decisive role in the infection process of pathogens. (europa.eu)
  • At a multiplicity of infection of 75 particles per cell, cytopathic effects occurred in 75 to 100% of the cells within 48 h. (lu.se)
  • The virus-infected cells were harvested at various times after infection and analyzed for the ability to bind strains of Haemophilus influenzae and Streptococcus pneumoniae. (lu.se)
  • Adenovirus infection did not change the adherence of cells of poorly adhering strains of S. pneumoniae or H. influenzae. (lu.se)
  • The increased attachment may be one mechanism by which viruses precondition the respiratory mucosa for bacterial infection. (lu.se)
  • White cells protect the body by fighting infection and attacking foreign material. (answerbag.com)
  • Neutrophils increase in response to bacterial infection. (answerbag.com)
  • CMB is comprised of more than 30 independent research groups organized in three themes: Cell Biology, Developmental and Stem Cell Biology and Infection and Cancer. (ki.se)
  • This article is about treatment of bacterial infection. (wikipedia.org)
  • The researchers also measured levels of T helper cells, which recruit other parts of the immune system to fight an infection, and killer T cells, which destroy infected cells. (medicalnewstoday.com)
  • The scientists believe it is a good sign that some antibodies, memory B cells, and T cells remain in a person's blood more than 8 months after infection because the different branches of the adaptive immune system work together. (medicalnewstoday.com)
  • however, an infectious disease workup revealed no evidence of either a bacterial or viral infection. (cancernetwork.com)
  • Dr. Jung leads the Department of Cancer Biology, the Infection Biology Program, and the newly-established Global Center for Pathogen & Human Health Research, which is focused on understanding of viral pathogens and the human immune responses toward preparing and protecting future public health threats. (ccf.org)
  • Broadly defined, transfection is the process of artificially introducing nucleic acids ( DNA or RNA ) into cells , utilizing means other than viral infection. (newworldencyclopedia.org)
  • It also was used in the sense of "infection by transformation," in other words, introduction of DNA (or RNA) from an eukaryote virus or bacteriophage (a virus that infects bacteria) into cells, resulting in an infection. (newworldencyclopedia.org)
  • The transfection process is different from "infection," which is the term used for a viral method of introducing nucleic acids into cells (Promega). (newworldencyclopedia.org)
  • What Is a Viral Infection? (msdmanuals.com)
  • A viral infection is a sickness caused by a virus. (msdmanuals.com)
  • COVID-19 COVID-19 is a potentially severe viral infection that mostly affects your lungs and airways. (msdmanuals.com)
  • Herpes simplex is a viral infection that causes a rash of. (msdmanuals.com)
  • How can doctors tell if I have a viral infection? (msdmanuals.com)
  • however, in most cases the clinical have a viral infection as the most common cause of results are not sufficient to allow a specific etiologic the disease3,5,13. (bvsalud.org)
  • It is the body's first-line defense against many bacterial pathogens. (medscape.com)
  • Treatment of acute sinusitis consists of providing adequate drainage of the involved sinus and appropriate systemic treatment of the likely bacterial pathogens. (medscape.com)
  • New drugs targeting essential viral proteins other than pUL54 are therefore urgently needed. (frontiersin.org)
  • Using this approach, the BALF4 and BNRF1 proteins were identified as targets of the EBV-specific T-helper-cell response, demonstrating that lytic cycle antigens are a relevant component of the EBV-specific TH-cell response. (nih.gov)
  • Adherence was not affected by pretreatment of the cells with virus particles or viral proteins. (lu.se)
  • It is distinguished from serum , the clear cell-free fluid in which fibrinogen, a soluble protein normally found in the plasma, has been converted to fibrin , an insoluble clotting protein, and from which fibrin and other clotting proteins have been removed. (britannica.com)
  • One of the most important functions for iron is to bind with hemoglobin (proteins in the red blood cells) to help carry oxygen throughout the body. (webmd.com)
  • For your skin and hair, iron found in proteins helps to support collagen and follicle cells in the dermis layer. (webmd.com)
  • Isosorbide mononitrate is approximately 5% bound to human plasma proteins and is distributed into blood cells and saliva. (nih.gov)
  • This process allows a variety of important applications, including the study of gene regulation, the analysis of the expression of proteins within eukarotic cells such as those of mammals, the production of transgenic organisms , and the methods of gene therapy. (newworldencyclopedia.org)
  • In practice, the term "cell culture" now refers to the culturing of cells derived from multicellular eukaryotes , especially animal cells, in contrast with other types of culture that also grow cells, such as plant tissue culture , fungal culture, and microbiological culture (of microbes ). (wikipedia.org)
  • These findings show that the presence and ratio of fungal species in cancer cells - the intratumour mycobiome - can, despite their low abundance, promote tumour progression by inducing an immunosuppressive microenvironment. (who.int)
  • Bacteria can use specific protein-based strategies to defend individual cells against viruses. (nature.com)
  • Bacteria can also use general defences to combat their viral predators, in addition to having a plethora of more-specific defences that target particular viruses. (nature.com)
  • This direct antigen identification method is based on the random expression of viral polypeptides fused to chloramphenicol acetyltransferase (CAT) in bacteria, which are subsequently fed to major histocompatibility complex class II+ antigen-presenting cells and probed with antigen-specific T cells. (nih.gov)
  • Bacteria and viruses adhere to different surfaces, to each other, to host molecules or to host cells. (europa.eu)
  • Rockefeller University researchers were already interested in the small molecules that human-associated bacteria produce and their effect on the body's host cells and coinhabiting organisms of the microbiome. (medicalnewstoday.com)
  • The term transformation often is preferred to describe non-viral DNA transfer in bacteria and non-animal eukaryotic cells such as fungi , algae , and plants . (newworldencyclopedia.org)
  • However, transformation also is used in other senses as well, including to the non-viral nucleic acid uptake specifically in bacteria and non-animal eukaryotic cells such as fungi , algae , and plants . (newworldencyclopedia.org)
  • Binding of complement to a foreign substance, or antigen, amplifies and augments the body's innate immune system by means of its role as an opsonin (a factor that enhances phagocytosis of unwanted particles) and as a chemoattractant (a factor that recruits cells to areas of inflammation). (medscape.com)
  • Our researchers found that restoring the cells' ability to produce the protein FABP5 reduced this inflammation. (nationaljewish.org)
  • Stem cells can reduce inflammation, often a culprit in neuropathy. (corporatewellnessmagazine.com)
  • 3) therapeutic/vaccine development and stabilization, and (4) inflammation and immunity (host-pathogen standoff, programmed cell death, immune atlas of pregnancy and inflammation). (ccf.org)
  • MCEMP1 potentiates KIT-mediated mast cell proliferation and chronic lung inflammation. (ccf.org)
  • 2016). Opposing effects of fasting metabolism on tissue tolerance in bacterial and viral inflammation. (greatist.com)
  • Promising new inhibitors that target the viral helicase-primase complex have been reported to block replication of herpes simplex and varicella-zoster viruses, but they have no activity against human cytomegalovirus (HCMV), another herpesvirus. (frontiersin.org)
  • The quantification of live viruses (avian influenza virus, swine influenza virus, avian metapneumovirus, human adenovirus type 1, and transmissible gastroenteritis virus) was accomplished by inoculation of appropriate cell culture systems. (cdc.gov)
  • Viral diseases of potato are a group of diseases caused by different types of viruses that affect potato crops worldwide and, although they do not affect human or animal health since they are viruses that only infect vegetables, they are a source of great economic losses annually. (wikipedia.org)
  • The magnitude of economic losses associated with this synergistic effect depends on the types of viruses that are interacting, their respective races, their interaction with the host potato cultivar, the viral vectors involved, and the environment. (wikipedia.org)
  • Viral culture is also related, with cells as hosts for the viruses. (wikipedia.org)
  • Growing viruses in cell cultures allowed preparation of purified viruses for the manufacture of vaccines . (wikipedia.org)
  • Viruses 14: v14040792 (2022)), and mapped 59 host protein interactions to the viral surface. (europa.eu)
  • However, some viruses can stay inside cells for a long time without killing them. (msdmanuals.com)
  • Certain viruses change how your cells work, which can lead to cancer. (msdmanuals.com)
  • Because the term transformation had another sense in animal cell biology (a genetic change allowing long-term propagation in culture, or acquisition of properties typical of cancer cells), the term transfection acquired, for animal cells, its present meaning of a change in cell properties caused by introduction of nucleic acids by non-viral methods. (newworldencyclopedia.org)
  • index in the 1st trimester, the increases were bacterial, viral or parasitic) of Vidyasagar statistically significant (Table 1). (who.int)
  • Ampicillin and puromycin antibiotic resistance genes provide selection in bacterial or mammalian cells respectively. (sigmaaldrich.com)
  • Originally, the term was used for the artificial insertion of viral nucleic acid into bacterial cells, resulting in multiplication of mature viral particles (Dorland 2007). (newworldencyclopedia.org)
  • In addition, self-inactivating replication incompetent viral particles can be produced in packaging cells (HEK293T) by co-transfection with compatible packaging plasmids. (sigmaaldrich.com)
  • MISSION ® pLKO.1-puro Non-Target shRNA Control Transduction Particles have been used to generate 3T3-L1 (pre-adipocytes) control cell lines. (sigmaaldrich.com)
  • Innate immunity resides in the skin, mucous membranes, polymorphonuclear (PMN) cells, complement system, and a select group of cells that possess cytotoxic capabilities. (medscape.com)
  • NK cells are specialized effectors of the innate immune system that destroy their targets by antibody-dependent cell-mediated cytotoxicity, have prominent antitumor effects, and are potent killers of virally infected cells. (medscape.com)
  • Other cellular components of the innate immune system include mononuclear phagocytes, dendritic cells, and NK cells. (medscape.com)
  • Importantly, PSA binding by B cells is essential for induction of regulatory CD4 + and CD8 + T cells secreting IL-10 to control innate inflammatory responses, consistent with the lack of PSA mediated protection in Rag −/− , B cell- and IL-10-deficient mice. (nature.com)
  • Introduction: Acute Bacterial meningitis is still a major cause of death in under-five children. (bvsalud.org)
  • Absolute other hand, another study reported that the neutrophil count was calculated as fol- phagocytic activity of neutrophils was simi- lows: absolute value (neutrophils/mm3) = lar in women in the 1st and 2nd trimesters total leukocyte count (cells/mm3) × relative of pregnancy and non-pregnant women, but value (%) obtained from the differential significantly decreased during the 3rd tri- count [10]. (who.int)
  • When many neutrophils are needed, they are released from the bone marrow as immature cells, called bands or stab cells. (answerbag.com)
  • The HCMV helicase-primase complex (pUL105-pUL102-pUL70) is essential for viral DNA replication and could thus be a relevant antiviral target. (frontiersin.org)
  • 1 report their analysis of an antiviral defence system that can protect more than one bacterial species. (nature.com)
  • They did this by isolating bacterial compounds and testing their antiviral proprieties in laboratory cultures of cells. (medicalnewstoday.com)
  • Bacterial species belonging to the phyla Bacteroidetes and Firmicutes dominate the microbiota. (nature.com)
  • It adds to existing knowledge of similar mechanisms by specific viral and bacterial species. (who.int)
  • Globally, HCMV represents the first viral cause of birth defect, leading to severe congenital malformations ( Leruez-Ville and Ville, 2017 ). (frontiersin.org)
  • The generation of receptors specific for antigens is a unique and complex process that generates 10 12 specific receptors for each cell type of the adaptive immune system, including T and B cells. (medscape.com)
  • Various cell types can process and present these antigens to T cells, or antigens may be soluble and bound to B-cell receptors. (medscape.com)
  • Epstein-Barr virus (EBV)-specific T cells have been successfully used to treat or prevent EBV-positive lymphoproliferative disease in hematopoietic stem cell transplant recipients, but the antigens recognized by the infused CD4+ T cells have remained unknown. (nih.gov)
  • Here, we describe a simple procedure that permits the identification of viral T-helper (TH)-cell antigens and epitopes. (nih.gov)
  • In addition, certain tests are used to classify blood according to specific red blood cell antigens , or blood groups ( see blood typing ). (britannica.com)
  • The specificity of a virus for infecting a particular type of cell or tissue . (online-medical-dictionary.org)
  • Cell culture or tissue culture is the process by which cells are grown under controlled conditions, generally outside of their natural environment. (wikipedia.org)
  • After the cells of interest have been isolated from living tissue , they can subsequently be maintained under carefully controlled conditions. (wikipedia.org)
  • Tissue culture commonly refers to the culture of animal cells and tissues, with the more specific term plant tissue culture being used for plants. (wikipedia.org)
  • The historical development and methods of cell culture are closely interrelated to those of tissue culture and organ culture . (wikipedia.org)
  • The laboratory technique of maintaining live cell lines (a population of cells descended from a single cell and containing the same genetic makeup) separated from their original tissue source became more robust in the middle 20th century. (wikipedia.org)
  • [12] He suggested that the potentialities of individual cells via tissue culture as well as that the reciprocal influences of tissues on one another could be determined by this method. (wikipedia.org)
  • Since Haberlandt's original assertions, methods for tissue and cell culture have been realized, leading to significant discoveries in biology and medicine. (wikipedia.org)
  • The stem cell and developmental biology program at CMB is engaged in a broad range of basic research aimed at understanding the molecular mechanisms underlying diverse aspects of embryonic development and tissue regeneration. (ki.se)
  • TRI Reagent ® performs well with large or small amounts of tissue or cells and works with many samples including human, plant, yeast, bacterial and viral samples. (sigmaaldrich.com)
  • The whole process of RNA extraction starting with fresh tissue or cells can be completed in less than one hour. (sigmaaldrich.com)
  • Transformation of eukaryotic cells in tissue culture is usually called transfection. (newworldencyclopedia.org)
  • Especially common in gram-negative sepsis where endotoxin stimulates monocytes and endothelial cells to express tissue factor. (vin.com)
  • Malignant cells cause endothelial damage and allow the expression of tissue factor as well as other procoagulant materials. (vin.com)
  • Burns, hypo- and hyperthermia, rhabdomyolysis, and hypoxia damage endothelial cells and allow for the exposure of tissue factor. (vin.com)
  • Commonly seen in hemangiosarcomas because of damaged endothelial cells, release of tissue factor. (vin.com)
  • Endothelial cells can be damaged and tissue factor released. (vin.com)
  • Differing functions, including binding of diverse protein epitopes, viral neutralization, impact on RBD-hACE2 binding, and immunohistochemical staining of infected lung tissue, were correlated with variable gene usage and sequence. (cdc.gov)
  • NK cells express several families of receptors that play central roles in target cell recognition. (duke.edu)
  • These subtle effects suggest that CD94/NKG2A-mediated inhibition of T cells may be limited to particular circumstances or may synergize with other receptors that are similarly up-regulated. (duke.edu)
  • These 2 members mediate leukocyte adhesions to endothelial cells but they also serve as receptors for iC3b (inactivated C3b). (medscape.com)
  • They found higher levels of viral shedding in those receiving antibiotic treatment prior to vaccination compared with controls receiving no antibiotic treatment prior to vaccination. (sciencedaily.com)
  • After antibiotic treatment and vaccination, subjects were assessed for antibody response and viral shedding. (sciencedaily.com)
  • No differences were found in antibody levels between the three treatment arms except a slight increase in early vaccine boosting in the narrow-spectrum arm, but higher viral shedding was noted in the antibiotic-treated groups compared with the control arm. (sciencedaily.com)
  • The adaptive immune system consists of 2 types of lymphocytes: T cells (70-75% of the adaptive immune force) and B cells (10-20% of the adaptive immune force). (medscape.com)
  • Conditions or medications that weaken the immune system, such as AIDS or chemotherapy , cause a decrease in white cells. (answerbag.com)
  • Iron is also important for your immune system because it supports the development of lymphocytes (white blood cells) and other immune cells, and it helps them mobilize the best response. (webmd.com)
  • The idea is that if the immune system is not properly primed in childhood, immune cells can improperly react to harmless triggers such as pollen. (abc.net.au)
  • Stem cells can potentially differentiate into nerve cells or support the environment to facilitate the body's inherent repair mechanisms. (corporatewellnessmagazine.com)
  • Usually, it's used to permeabilize cells and make cell extracts in order to isolate protein, DNA, RNA, or other cell constituents. (scienceblogs.com)
  • The key interests lie within the field of genome integrity and variation, cell division, regulation of gene expression, protein turnover and signal transduction. (ki.se)
  • They found that levels of antibodies targeted at the spike protein, which the virus uses to gain entry to its host cells, remained relatively stable for at least 6 months. (medicalnewstoday.com)
  • Differential diagnoses include cryoglobulinemia, warfarin-induced necrosis, purpura fulminans, emboli to the skin, thrombocythemia, protein C deficiency, Sneddon syndrome, and skin ulcers in patients with sickle cell anemia or hemolytic anemia. (medscape.com)
  • The analysis of polymerase chain reaction (PCR), white blood cells, red blood cells, glucose, protein, and lactate in the cerebrospinal fluid (CSF) provides the first clues to the diagnosis. (bvsalud.org)
  • Of greatest interest is the~300 amino acid receptor binding domain (RBD) within the S1 subunit of the spike protein because of its key interaction with the human angiotensin converting enzyme 2 (hACE2) receptor present on many cell types, especially lung epithelial cells. (cdc.gov)
  • Given a collection of viral genome sequences, we can use our models of sequence evolution to predict the virus's history, and we can use this to answer questions like, "How fast do mutations occur? (livescience.com)
  • Basic genetic and molecular biology methodologies are combined with complementary bioinformatic and genome-wide approaches, allowing investigation global molecular changes in cells in various differentiation processes. (ki.se)
  • Since the DNA introduced in the transfection process is usually not inserted into the nuclear genome, the foreign DNA is lost at the later stage when the cells undergo mitosis . (newworldencyclopedia.org)
  • If it is desired that the transfected gene actually remains in the genome of the cell and its daughter cells, a stable transfection must occur. (newworldencyclopedia.org)
  • The present study analyzed the effect of adenovirus on bacterial adherence to human respiratory tract epithelial cells. (lu.se)
  • When extra white cells are needed, the bone marrow increases production. (answerbag.com)
  • in some cases, the blood cells of the bone marrow may also be examined. (britannica.com)
  • Mutational analysis of several of these amino acids both in pUL105 and pUL70, proved that they are crucial for viral replication. (frontiersin.org)
  • The Early Detection group is one of the constituent groups of the US National Institutes of Health National Institute of Allergy and Infectious Diseases SARS-CoV-2 Assessment of Viral Evolution program. (cdc.gov)
  • As part of the US National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) SARS-CoV-2 Assessment of Viral Evolution (SAVE) effort to combat the SARS-CoV-2 pandemic, the NIH NIAID SAVE Early Detection Group regularly prioritizes SARS-CoV-2 variants. (cdc.gov)
  • The following is a description of several of the viral diseases of potato crops, their symptoms and management possibilities. (wikipedia.org)
  • DNA sequencing is largely used to study human diseases and genetics, but in recent years, sequencing has become a routine part of viral point of care , and as sequencing becomes cheaper and cheaper , viral sequencing will become even more frequent as time progresses. (livescience.com)
  • Through detailed characterization of fundamental molecular mechanisms of normal and perturbed cells, the theme strives to unravel information that increases the understanding of various diseases such as cancer and neurodegenerative, cardiovascular and inflammatory disorders. (ki.se)
  • Here, he developed expertise in the testing of blood derivatives, viral and bacterial vaccines. (1888pressrelease.com)
  • In molecular biology, the term transformation has been used in the related sense to refer to the genetic alteration of a cell resulting from the uptake, genomic incorporation, and expression of foreign genetic material ( DNA ). (newworldencyclopedia.org)
  • Cell culture techniques were advanced significantly in the 1940s and 1950s to support research in virology . (wikipedia.org)
  • Key areas of investigation are the identification and functional characterization of stem cell niches in developing tissues and adult organs. (ki.se)
  • All tissues and organs are made of billions of different cells. (msdmanuals.com)
  • Histopathology and localization of SARS-CoV-2 and its host cell entry receptor ACE2 in tissues from naturally infected US-farmed mink (Neovison vison). (cdc.gov)
  • The study demonstrates that altering the bacterial intestinal microbiome can affect a vaccine's immunogenicity. (sciencedaily.com)
  • While checkpoint immunotherapy has revolutionized the treatment of patients with non-small cell lung cancer (NSCLC), a subset of patients develop hyperprogressive disease, yet the pathological features or underlying mechanisms for this association have yet to be fully understood. (aacr.org)
  • Other findings include the presence of fragmented red cells and low specific clotting factor assays for Factors II, V, VII, VIII, and IX. (vin.com)
  • CD11a/CD18 (LFA-1) expressed on lymphocytes is known to play an important role in lymphocyte trafficking (adhesion to vascular endothelium), as well as interactions to antigen presenting cells (APC). (medscape.com)
  • More surprisingly, perhaps, the memory B cells that produce these antibodies were more abundant 6 months after the onset of symptoms than they had been at 1 month. (medicalnewstoday.com)
  • They found that 3-5 months after the onset of symptoms, the number of these two types of T cells that targeted the virus had roughly halved. (medicalnewstoday.com)
  • Viral meningitis can occur in people of all present nonspecific symptoms, such as headache, ages, but it is more common in children5,6. (bvsalud.org)
  • His original idea, presented in 1902, was called totipotentiality: "Theoretically all plant cells are able to give rise to a complete plant. (wikipedia.org)
  • The purpse of this study is to identify the target Non-Small Cell Lung Cancer (NSCLC) population(s) that over express c-Met (c-Met+) best suited for Telisotuzumab Vedotin therapy in the second line or third line setting (Stage 1) and then to expand the group(s) to further evaluate effectiveness in the selected population(s) (Stage 2). (mayo.edu)
  • In preclinical models utilizing human lung cancer cells and specific NSCLC mutational subsets, the researchers found that tumor growth was enhanced by anti-PD-1 treatment but not by anti-PD-1 F(ab) 2 fragments, which lack the Fc portion of the antibody. (aacr.org)
  • Natural-killer (NK) cells are specialized lymphocytes that have cytotoxic properties in addition to their ability to produce cytokines that assist in the orchestration of adaptive immunity. (medscape.com)
  • In this study we described the epidemiological data on Bacterial meningitis in under-five children at Gondar University Hospital from 2012-2021. (bvsalud.org)
  • Results: In this study, a total of 4311 under-five admitted with suspected bacterial meningitis from 2012 to 2021 were enrolled. (bvsalud.org)
  • This disease is a defect in fucose metabolism (lack of fucosylation of the carbohydrate selectin ligands) that results in failure to express the ligand for E and P selectin, sialyl Lewis-X (CD15s) expressed on leukocytes and endothelial cells. (medscape.com)
  • During treatment with decitabine, the patient used hematopoietic stem cell transplantation, depending on the levofloxacin 500 mg once daily, micafungin 100 mg once daily, risk stratification. (bvsalud.org)
  • enterovirus, cerebrospinal fluid, viral meningitis. (bvsalud.org)
  • There are more than 100 into bacterial meningitis and aseptic meningitis1,2. (bvsalud.org)
  • viral meningitis are caused by enterovirus. (bvsalud.org)
  • Surveillance on Pediatric Bacterial Meningitis has been set up by the World Health Organization to generate data on vaccine preventable causes of Meningitis in under-five children. (bvsalud.org)
  • All under-five children with suspected meningitis over the 10-years period were included and descriptive statistics like frequency, percentage, mean, median and standard deviations were used for the characteristics of under-five Children with Suspected Bacterial Meningitis. (bvsalud.org)
  • I am a bioinformatician who studies the relationships between epidemics and viral evolution, and I am among the many researchers now studying the evolution of SARS-CoV-2 because it can help researchers and public health officials track the spread of the virus over time. (livescience.com)
  • This research aims at characterizing molecules and signals involved in controlling the undifferentiated state and self-renewal capacity of stem cells, and to develop methods to direct the differentiation of stem cells into clinically relevant cell types. (ki.se)
  • Binding of the CD94/NKG2A receptor by its ligand (Qa-1(b)) did not significantly inhibit CD8(+) T cell effector functions. (duke.edu)
  • LFA-1 also plays a role of cytotoxic killing by T cells. (medscape.com)
  • these studies indicate that reciprocal interactions between tumor cells and brain stromal cells facilitate metastatic growth. (aacr.org)
  • The expression of CD94/NKG2A was rapidly initiated in naive CD8(+) T cells responding to peptide Ags in vitro and on many of the naive T cells that proliferate when transferred into lymphopenic (Rag-1(-/-)) hosts. (duke.edu)
  • The white blood cell count and differential determine the number of white blood cells and the percentage of each type of white blood cell in a person's blood. (answerbag.com)
  • Cell-to-cell interactions set off a cascade of events that may result in T- or B-cell activation and, ultimately, host defense. (medscape.com)
  • 2020 Cell Host & Microbe 27:704. (ccf.org)
  • The results appear August 8 in the journal Cell Host & Microbe . (sciencedaily.com)
  • Thus, CD94/NKG2A expression is a common consequence of CD8(+) T cell activation. (duke.edu)
  • Abnormalities in T cell numbers or function are common. (lu.se)
  • Most cells require a surface or an artificial substrate to form an adherent culture as a monolayer (one single-cell thick), whereas others can be grown free floating in a medium as a suspension culture . (wikipedia.org)
  • Both the white blood cell count (also called white count or leukocyte count) and the differential (also called diff) are covered by insurance. (answerbag.com)
  • We conducted a study by aerosolizing MS-2 suspended in human saliva and found that actual human saliva was much less protective than cell culture media or artificial saliva. (cdc.gov)
  • Human cells vary in size, but all are quite small. (msdmanuals.com)
  • Laboratory analysis of biopsied samples showed immunostaining and molecular evidence of BK virus DNA in the cancer cells. (cdc.gov)
  • 2023 Nature Cell Biology 25:92. (ccf.org)
  • The central aim of the research within the Cell Biology theme is to gain a deeper understanding of the biology of the eukaryotic cell. (ki.se)
  • Commonly, the term transfection is used in the sense of non-viral introductions of nucleic acid specifically into eukaryotic cells, or even more specifically into animal cells. (newworldencyclopedia.org)
  • It now includes any means of artificial introduction of foreign DNA into cells, or more specifically cultured eukaryotic cells. (newworldencyclopedia.org)