Vinca alkaloidIndolePaclitaxelCatharanthusVinblastine and vincristineOncovinChemotherapyDose of vincristineLiposomePlantMicrotubuleCompoundsIntravenousLeurocristineBelongs to a groupBiosyntheticBiosynthesisRoseusMedicinalTubulinInjectionConstipationStemsEfficacyPotentMorphinePeripheral neuropathyMedicationsBindIncludeTreatmentConcentrationsMedicinesSide effectsExtensivelyDerivativesTreatmentsSymptomsNumbnessLeavesCancerChemicalFoundVeinTreatDrug
Vinca alkaloid2
- It is a vinca alkaloid that can be obtained from the Madagascar periwinkle Catharanthus roseus. (wikipedia.org)
- It is a type of vinca alkaloid and a type of antimitotic agent. (news-medical.net)
Indole3
- Vincristine is created through the semi-synthesis coupling of indole alkaloids vindoline and catharanthine in the vinca plant. (wikipedia.org)
- Plant yields more than 100 monoterpenoid indole alkaloids in different organs. (stuartxchange.org)
- the sole source of chemotherapy agents, vincristine and vinblastine (specialized metabolites, terpenoid indole alkaloids/TIAs). (bvsalud.org)
Paclitaxel1
- Taxol - paclitaxel, Taxotere - docetaxel, and Abraxane - albumin-bound paclitaxel) and vinca alkaloids (e.g. (shu.edu)
Catharanthus6
- The research team studied the biosynthesis of two alkaloids from the plant Catharanthus roseus that are used in human medicine as anti-cancer agents. (analytica-world.com)
- Many plant natural products are highly complex molecules, such as the alkaloids vincristine and vinblastine, which are produced by the Madagascar periwinkle Catharanthus roseus . (analytica-world.com)
- The chemo drugs vincristine and vinblastine, vinca alkaloids, although they come from a different plant, Catharanthus roseus, aka the Madagascan Periwinkle, work in the same manner - inhibiting cell division. (acsh.org)
- Left top) Catharanthus roseus, aka the Madagascan Periwinkle, a member of the Vinca plant family, is the source of the cancer drug vincristine (Right top) Nice structure, huh? (acsh.org)
- Led by Chenxin Li of UGA's Center for Applied Genetic Technologies in the College of Agricultural and Environmental Sciences, the research team studied the biosynthesis of two alkaloids from the Madagascar periwinkle (Catharanthus roseus) that are used as anti-cancer agents in human medicine. (hortidaily.com)
- The research team is confident that the organization of biosynthetic pathways for medicinally relevant alkaloids in Catharanthus roseus is not an isolated phenomenon. (hortidaily.com)
Vinblastine and vincristine1
- Vinca alkaloids, such as vinblastine and vincristine, have also been shown to have antifungal activity. (selfgrowth.com)
Oncovin2
- Vincristine, also known as leurocristine and marketed under the brand name Oncovin among others, is a chemotherapy medication used to treat a number of types of cancer. (wikipedia.org)
- Vinblastine and Oncovin - vincristine) have been reported to be highly effective against breast cancer as well as many other types of cancer. (shu.edu)
Chemotherapy4
- Vincristine is delivered via intravenous infusion for use in various types of chemotherapy regimens. (wikipedia.org)
- The main side effects of vincristine are chemotherapy-induced peripheral neuropathy, hyponatremia, constipation, and hair loss. (wikipedia.org)
- Chemotherapy-induced peripheral neuropathy can be severe, and may be a reason to reduce or avoid using vincristine. (wikipedia.org)
- Vincristine lipid complex should be given only under the supervision of a doctor with experience in the use of chemotherapy medications. (medlineplus.gov)
Dose of vincristine2
- Your doctor may not want you to receive vincristine lipid complex or may need to change your dose of vincristine lipid complex injection. (medlineplus.gov)
- One dog died after the third dose of vincristine, and in one case the tumor was vincristine resistant, and the doxorubicin treatment was required. (vin.com)
Liposome2
- The liposome encapsulation of vincristine enhances the efficacy of the vincristine drug while simultaneously decreasing the neurotoxicity associated with it. (wikipedia.org)
- The U.S. Food and Drug Administration today approved Marqibo (vincristine sulfate liposome injection) to treat adults with a rare type of leukemia called Philadelphia chromosome negative (Ph-) acute lymphoblastic leukemia (ALL). (news-medical.net)
Plant6
- Plant alkaloids are plant-based substances that prevent cancerous cells from dividing and growing into more cells. (medicalnewstoday.com)
- Plant yields an amorphous alkaloid, vincarosin. (stuartxchange.org)
- Isoquinoline alkaloids - Isoquinoline alkaloids 1-Benzyl isoquinoline type: Papaverine: An opiate alkaloid isolated from the plant Papaver somniferum and produced synthetically. (powershow.com)
- These two alkaloids were the first plant-derived anticancer agents deployed for clinical use. (thisisafrica.me)
- Vincristine sulphate belongs to a group of medications known as vinca alkaloids and is obtained from the plant Vinca rosea Linn. (vin.com)
- The contents of active components of vinblastine and Leurocristine (vincristine) make the plant has efficacy and benefits as anticancer in leukemia 1210, leukemia 1534, Ehrlich ascitic liver carcinoma, AKR leukemia, and Carcinoma Walker 256. (theboegis.com)
Microtubule1
- Vinca alkaloids (vincristine, vinblastine, etc.) bind to microtubule plus ends and the outer surface of microtubules, inhibiting microtubule lengthening (polymerization) as well as shortening (depolymerization) (Figure 2B). (shu.edu)
Compounds4
- In the realm of organic chemistry, one class of compounds has captured the scientific community's attention for decades - alkaloids. (selfgrowth.com)
- Alkaloids represent a large and diverse group of organic compounds characterized by the presence of a nitrogen-containing heterocyclic ring. (selfgrowth.com)
- Alkaloids are a fascinating group of naturally occurring chemical compounds found in various plants, fungi, and some animals. (selfgrowth.com)
- Natural products from food sources, such as polyphenols, saponins, alkaloids, and polysaccharides, are classified as antiaging compounds that promote health and prolong life via various mechanisms. (frontiersin.org)
Intravenous1
- It is extremely important that the intravenous needle delivering vincristine be properly positioned in the vein. (medicap.com)
Leurocristine1
- Active components of vinblastine and Leurocristine (vincristine), alkaloids found in the roots. (theboegis.com)
Belongs to a group1
- Vincristine belongs to a group of drugs called vinca alkaloids. (medicap.com)
Biosynthetic2
- As the analyses showed, the entire biosynthetic pathway for the alkaloid vinblastine is organized in three stages and three discrete cell types. (analytica-world.com)
- As the analyses showed, the entire biosynthetic pathway for the alkaloid vinblastine is organized into three stages and three discrete cell types. (hortidaily.com)
Biosynthesis1
- The term omics refers to the fact that an entire collection of genes or metabolites is quantified and analyzed," says Lorenzo Caputi, head of the Alkaloid Biosynthesis Project Group in the Department of Natural Product Biosynthesis in Jena and one of the lead authors, explaining the methodological approach. (analytica-world.com)
Roseus1
- Due to the high market value and its effectiveness in different medical treatments, this chapter deals with the pharmacological application of the C. roseus alkaloids. (intechopen.com)
Medicinal2
- Alkaloids possess significant medicinal, pharmaceutical, and ecological importance, making them a subject of extensive research by leading companies. (selfgrowth.com)
- In this article, we will delve into the intriguing world of alkaloids, exploring their sources, structures, and attractive medicinal value. (selfgrowth.com)
Tubulin1
- Vincristine works partly by binding to the tubulin protein, stopping the tubulin dimers from polymerizing to form microtubules, causing the cell to be unable to separate its chromosomes during the metaphase. (wikipedia.org)
Injection2
- Accidental injection of vinca alkaloids into the spinal canal (intrathecal administration) is highly dangerous, with a mortality rate approaching 100 percent. (wikipedia.org)
- tell your doctor and pharmacist if you are allergic to vincristine, any other medications, or any of the ingredients in vincristine lipid complex injection. (medlineplus.gov)
Constipation1
- Your doctor may tell you to take a stool softener or laxative to help prevent constipation during your treatment with vincristine lipid complex. (medlineplus.gov)
Stems1
- Leaves and stems yield dimeric alkaloids vincristine and vinblastine. (stuartxchange.org)
Efficacy1
- The purpose of this work was to document the efficacy and side effects of vincristine sulphate treatment on TVTc. (vin.com)
Potent2
- Alkaloids have emerged as promising candidates in the fight against malaria, displaying potent antimalarial effects. (selfgrowth.com)
- Rosy Periwinkle contains two potent anti-cancer alkaloids which are vincristine and vinblastine. (fasting.ws)
Morphine1
- Alkaloids such as morphine and codeine have been widely used as painkillers due to their powerful analgesic properties. (selfgrowth.com)
Peripheral neuropathy2
- One of the first symptoms of peripheral neuropathy is foot drop: A person with a family history of foot drop and/or Charcot-Marie-Tooth disease (CMT) should avoid vincristine. (wikipedia.org)
- With repeated doses of vincristine, you may feel symptoms of peripheral neuropathy (tingling sensation and numbness in the fingers and toes). (medicap.com)
Medications1
- Vincristine lipid complex is in a class of medications called vinca alkaloids. (medlineplus.gov)
Bind1
- These alkaloids bind to specific receptors in the central nervous system, effectively alleviating severe pain and inducing sedation. (selfgrowth.com)
Include1
- Other therapies include azathioprine, mycophenolate mofetil, dapsone and vinca alkaloids. (mja.com.au)
Treatment7
- Most people experience some side effects from vincristine treatment. (wikipedia.org)
- It is important for you to tell your doctor how you are feeling during your treatment with vincristine lipid complex. (medlineplus.gov)
- Artemisinin, an alkaloid extracted from Artemisia annua, revolutionized malaria treatment. (selfgrowth.com)
- Alkaloids have demonstrated considerable potential in combatting various fungal pathogens, providing alternative treatment options for these debilitating infections. (selfgrowth.com)
- Vincristine is also being studied in the treatment of other types of cancer. (news-medical.net)
- Vincristine sulphate, at the dose of 0.5 mg/m 2 of body surface (IV), on 7-14 days intervals, reveal high efficiency (86.6%) for TVTc treatment. (vin.com)
- One tumor (6.6%) was refractory to vincristine, while at the treatment beginning we observed a mass reduction. (vin.com)
Concentrations1
- The mitotic spindle in the presence (at different concentrations) and absence of vinblastine (very similar to vincristine). (acsh.org)
Medicines2
- Vincristine has been use in combination with other medicines to treat certain types of cancer. (medicap.com)
- Vincristine has been use in combination with other medicines to treat the following cancers: non-Hodgkin's lymphoma, Hodgkin's lymphoma, acute lymphoblastic leukemia (ALL), Wilms' tumor (a form of pediatric kidney cancer), rhabdomyosarcoma, and neuroblastoma. (medicap.com)
Side effects3
- Vincristine lipid complex may cause side effects. (medlineplus.gov)
- Vincristine is safe for most patients, but potential side effects can occur, as gastrointestinal alterations, myelosuppression and extravasation injury. (vin.com)
- Before the therapy sections it is necessary to execute the clinical evaluation, the cytological exam and the complete blood count for monitoring the side effects related to vincristine. (vin.com)
Extensively2
- Many alkaloids have been discovered and studied extensively over the years, with more than 20,000 known alkaloids identified to date. (selfgrowth.com)
- Two of its alkaloids , vincristine and vinblastine, have been extensively explored by the pharmaceutical industry. (thisisafrica.me)
Derivatives1
- There is an attempt to overcome resistance by the addition of derivatives and substituents to the vincristine molecule. (wikipedia.org)
Treatments1
- Use a reliable method of birth control while receiving vincristine treatments. (medicap.com)
Symptoms1
- Vincristine has been proven hazardous and should be avoided by all CMT patients, including those with no symptoms. (asociatiacmt.ro)
Numbness1
- Vincristine can cause tingling sensation and numbness in the fingers and toes. (medicap.com)
Leaves1
- Therefore, 530 kg of dry leaves are necessary to produce 1 kg of vincristine and half a ton for getting 1 g of vinblastine. (intechopen.com)
Cancer2
- A downside, however, to Vincristine is that it does not only affect the division of cancer cells. (wikipedia.org)
- Vincristine treats certain types of cancer. (medicap.com)
Chemical1
- Alkaloids can be classified into several subclasses based on their chemical structures and origin. (selfgrowth.com)
Found2
- A significant series of inadvertent intrathecal vincristine administration occurred in China in 2007 when batches of cytarabine and methotrexate (both often used intrathecally) manufactured by the company Shanghai Hualian were found to be contaminated with vincristine. (wikipedia.org)
- Quinine, an alkaloid found in the bark of the cinchona tree, has been traditionally used as a natural remedy for malaria by interfering with the parasite's protein synthesis. (selfgrowth.com)
Vein2
- Vincristine lipid complex should be administered only into a vein. (medlineplus.gov)
- Vincristine lipid complex comes as a liquid to be injected intravenously (into a vein) over 1 hour by a doctor or nurse in a medical facility. (medlineplus.gov)
Treat2
- Vincristine is the active ingredient in a drug used to treat acute leukemia. (news-medical.net)
- Vincristine is used to treat acute lymphocytic leukemia, lymphosarcoma, lympho-granulomatosis and in solid infant tumors. (intechopen.com)
Drug2
- The overuse of vincristine may also lead to drug resistance by overexpression of the p-glycoprotein pump (Pgp). (wikipedia.org)
- This is not a complete list of vincristine drug interactions. (medicap.com)