• Vincristine, also known as leurocristine and marketed under the brand name Oncovin among others, is a chemotherapy medication used to treat a number of types of cancer. (wikipedia.org)
  • If you are having vincristine in combination with another chemotherapy drug called doxorubicin , the infusion may be given over a few days using a pump that you take home. (macmillan.org.uk)
  • One dog died after the third dose of vincristine, and in one case the tumor was vincristine resistant, and the doxorubicin treatment was required. (vin.com)
  • In patients with renal failure or highly aggressive disease, therapy with vincristine, Adriamycin (doxorubicin), and dexamethasone (VAD) may be preferred. (medscape.com)
  • The U.S. Food and Drug Administration today approved Marqibo (vincristine sulfate liposome injection) to treat adults with a rare type of leukemia called Philadelphia chromosome negative (Ph-) acute lymphoblastic leukemia (ALL). (news-medical.net)
  • 1.Marqibo (vincristine sulfate) US prescribing information. (webmd.com)
  • The combination of cytostatic vincristine and steroid-like prednisone pulses (vincristine-steroid pulses) are commonly used as a maintenance treatment in paediatric B-cell ALL. (bjh.be)
  • We describe three families with autosomal dominant CMT1, among whom a family member with a neoplastic disease suffered rapid onset, severe neuropathy after receiving initial doses of vincristine as a part of a routine chemotherapy protocol. (nih.gov)
  • With repeated doses of vincristine, you may feel symptoms of peripheral neuropathy (tingling sensation and numbness in the fingers and toes). (medicap.com)
  • Vincristine sulphate belongs to a group of medications known as vinca alkaloids and is obtained from the plant Vinca rosea Linn. (vin.com)
  • The purpose of this work was to document the efficacy and side effects of vincristine sulphate treatment on TVTc. (vin.com)
  • Vincristine sulphate, at the dose of 0.5 mg/m 2 of body surface (IV), on 7-14 days intervals, reveal high efficiency (86.6%) for TVTc treatment. (vin.com)
  • Vinlon - Vincristine Sulphate is supplied for Tenders/ Emergency imports/ Un - licensed, Specials, Orphan drug/ Name patient line/ RLD supplies/ Reference listed drugs/ Comparator Drug/ Bio-Similar/ Innovator samples For Clinical trials. (gnhindia.com)
  • tell your doctor and pharmacist if you are allergic to vincristine, any other medications, or any of the ingredients in vincristine lipid complex injection. (medlineplus.gov)
  • Your doctor may not want you to receive vincristine lipid complex or may need to change your dose of vincristine lipid complex injection. (medlineplus.gov)
  • Vincristine liposome injection is used to treat Philadelphia chromosome-negative acute lymphoblastic leukemia (Ph- ALL) that has worsen or come back or in patients who have received at least 2 previous cancer treatments that did not work well. (mayoclinic.org)
  • You will be given vincristine in the chemotherapy day unit or during a stay in hospital. (macmillan.org.uk)
  • People with Charcot-Marie-Tooth syndrome should not be given vincristine. (medicap.com)
  • If you miss an appointment to receive vincristine, contact your doctor as soon as possible to reschedule your appointment. (medbroadcast.com)
  • The liposome encapsulation of vincristine enhances the efficacy of the vincristine drug while simultaneously decreasing the neurotoxicity associated with it. (wikipedia.org)
  • In a retrospective case series, we investigated the possible association between the DNA rearrangement found in patients with Charcot-Marie-Tooth Disease Type 1A (CMT1A) and susceptibility to the neurotoxicity of vincristine. (nih.gov)
  • These cases show that 17p11.2-12 duplication predisposes patients to severe neurotoxicity from vincristine and that this drug should be avoided with patients with CMT1A. (nih.gov)
  • 7.Pana ZD, Roilides E. Risk of azole-enhanced vincristine neurotoxicity in pediatric patients with hematological malignancies: old problem - new dilemma. (webmd.com)
  • 8.Jain S, Kapoor G. Severe life threatening neurotoxicity in a child with acute lymphoblastic leukemia receiving posaconazole and vincristine. (webmd.com)
  • 12.Ariffin H, Omar KZ, Ang EL, Shekhar K. Severe vincristine neurotoxicity with concomitant use of itraconazole. (webmd.com)
  • 13.Sathiapalan RK, El-Solh H. Enhanced vincristine neurotoxicity from drug interactions: case report and review of literature. (webmd.com)
  • 14.Jeng MR, Feusner J. Itraconazole-enhanced vincristine neurotoxicity in a child with acute lymphoblastic leukemia. (webmd.com)
  • Vincristine is used alone or in combination with other antineoplastic medications to treat many different types of cancer , including leukemia (cancer of white blood cells), lymphoma (cancer of the lymph cells), breast cancer, lung cancer, malignant melanoma, cancer of the cervix, colorectal cancer, and Wilms' tumor. (medbroadcast.com)
  • I. Determine the maximum tolerated dose of bryostatin 1 when administered with vincristine in patients with recurrent or refractory HIV-related B-cell lymphoma. (knowcancer.com)
  • The National Comprehensive Cancer Network (NCCN) has launched the "Just Bag It" campaign for the safe handling of vincristine, a chemotherapeutic agent used primarily in the treatment of patients with leukemia and lymphoma. (oncologynurseadvisor.com)
  • Vincristine has been use in combination with other medicines to treat the following cancers: non-Hodgkin's lymphoma, Hodgkin's lymphoma, acute lymphoblastic leukemia (ALL), Wilms' tumor (a form of pediatric kidney cancer), rhabdomyosarcoma, and neuroblastoma. (medicap.com)
  • Vincristine was an effective chemotherapeutic agent for genital TVTc, showing tumours totally regression in 13 dogs, among them the therapy was also efficient for one case of diffuse cutaneous TVTc. (vin.com)
  • Synthetic lethal hubs associated with vincristine resistant neuroblastoma. (kent.ac.uk)
  • This fact also holds true for neuroblastoma utilizing chemotherapeutics as vincristine. (kent.ac.uk)
  • No consensus profile for vincristine resistance could be derived, but resistance-associated changes on the level of individual neuroblastoma cell lines as well as individual patient profiles became clearly evident. (kent.ac.uk)
  • Verification of such synthetic lethal hub candidates in human neuroblastoma tissue expression profiles indicated the feasibility of this screening approach for addressing vincristine resistance in neuroblastoma. (kent.ac.uk)
  • The main side effects of vincristine are chemotherapy-induced peripheral neuropathy, hyponatremia, constipation, and hair loss. (wikipedia.org)
  • Chemotherapy-induced peripheral neuropathy can be severe, and may be a reason to reduce or avoid using vincristine. (wikipedia.org)
  • One of the first symptoms of peripheral neuropathy is foot drop: A person with a family history of foot drop and/or Charcot-Marie-Tooth disease (CMT) should avoid vincristine. (wikipedia.org)
  • Vincristine induced peripheral neuropathy potentiated by voriconazole in a patient with previously undiagnosed CMT1X. (webmd.com)
  • Vincristine-induced neuropathy is the main dose-limiting side effect. (wikipedia.org)
  • The recommended dose and dosing schedule of vincristine varies according to the specific type of cancer being treated, the response to therapy, and the other drugs or treatments being used. (medbroadcast.com)
  • The vincristine administrations, at the dose of 0.5 mg/m 2 of body surface (IV), were done considering all the manufacturers' warnings recommendations. (vin.com)
  • Vincristine works partly by binding to the tubulin protein, stopping the tubulin dimers from polymerizing to form microtubules, causing the cell to be unable to separate its chromosomes during the metaphase. (wikipedia.org)
  • Vincristine inhibits cellular mitosis by inhibition of intracellular tubulin function, binding to microtubules, and synthesis of spindle proteins in the S phase. (medscape.com)
  • Vincristine is delivered via intravenous infusion for use in various types of chemotherapy regimens. (wikipedia.org)
  • VINCRISTINE SULFATE is an Oncology drug manufactured by Pfizer and administered via the Intravenous route of administration. (buyandbill.com)
  • It is extremely important that the intravenous needle delivering vincristine be properly positioned in the vein. (medicap.com)
  • VINCRISTINE (vin KRIS teen) treats some types of cancer. (chemocare.com)
  • A significant series of inadvertent intrathecal vincristine administration occurred in China in 2007 when batches of cytarabine and methotrexate (both often used intrathecally) manufactured by the company Shanghai Hualian were found to be contaminated with vincristine. (wikipedia.org)
  • 15.Gillies J, Hung KA, Fitzsimons E, Soutar R. Severe vincristine toxicity in combination with itraconazole. (webmd.com)
  • Vincristine toxicity in five children with acute lymphoblastic leukaemia. (webmd.com)
  • This systematic review suggests that the previous benefit assumed by frequent pulses of vincristine-steroids in maintenance therapy for paediatric B-cell ALL in historical trials no longer applies in contemporary trials but is associated with toxicity. (bjh.be)
  • The vincristine molecule inhibits leukocyte production and maturation. (wikipedia.org)
  • During a simulated vincristine shortage, a strategy that allocated by both greater efficacy per volume and worse alternatives improved survival compared to either alone, younger age, or the default of first-come, first-served. (confex.com)
  • One tumor (6.6%) was refractory to vincristine, while at the treatment beginning we observed a mass reduction. (vin.com)
  • To prevent fatal instances when vincristine is administered intrathecally, the NCCN developed the "Just Bag It" campaign to ensure the proper administration of vincristine and to render it impossible to accidentally administer the medication into the spinal fluid. (oncologynurseadvisor.com)
  • 2023. https://www.drugguide.com/ddo/view/Davis-Drug-Guide/51789/all/vinCRIStine. (drugguide.com)
  • Vincristine-steroid pulses are commonly used during maintenance therapy for paediatric B-cell acute lymphoblastic leukaemia (ALL), but the impact of this treatment on the outcomes has not been well established. (bjh.be)
  • Vincristine lipid complex should be given only under the supervision of a doctor with experience in the use of chemotherapy medications. (medlineplus.gov)
  • Vincristine belongs to the group of cancer-fighting medications known as antineoplastics . (medbroadcast.com)
  • A downside, however, to Vincristine is that it does not only affect the division of cancer cells. (wikipedia.org)
  • Vincristine is also being studied in the treatment of other types of cancer. (news-medical.net)
  • Vincristine is a chemotherapy drug used to treat many types of cancer. (macmillan.org.uk)
  • Vincristine can be given in combination with other cancer drugs. (macmillan.org.uk)
  • Vincristine interferes with the growth of cancer cells, which are eventually destroyed. (mayoclinic.org)
  • As well as interfering with the genetic material DNA of cancer cells, vincristine can interfere with some of your normal cells. (medbroadcast.com)
  • To e valuate the impact of these allocation strategies on patient survival during a chemotherapy shortage, we developed a simulation model through the use-case of vincristine, a widely prescribed blood cancer chemotherapeutic recently in shortage. (confex.com)
  • Vincristine treats certain types of cancer. (medicap.com)
  • Vincristine has been use in combination with other medicines to treat certain types of cancer. (medicap.com)
  • Vincristine lipid complex should be administered only into a vein. (medlineplus.gov)
  • Vincristine lipid complex comes as a liquid to be injected intravenously (into a vein) over 1 hour by a doctor or nurse in a medical facility. (medlineplus.gov)
  • Vincristine is injected into a vein through a specially prepared site on your skin that has been prepared for this purpose. (medbroadcast.com)
  • [3] If vincristine is used alone, it is given once a week strictly into a vein. (mdwiki.org)
  • The campaign encourages health care providers to implement a policy to always dilute and administer vincristine in a mini IV-drip bag, rather than a syringe, in order to avoid potentially deadly medication errors. (oncologynurseadvisor.com)
  • Vincristine is the active ingredient in a drug used to treat acute leukemia. (news-medical.net)
  • Repurposing Mebendazole as a Replacement for Vincristine for the Treat" by M. De Witt, A. Gamble et al. (hofstra.edu)
  • Plasma and vincristine were given as adjuvant ther- exchange was started on the first day with apy. (who.int)
  • Your doctor may tell you to take a stool softener or laxative to help prevent constipation during your treatment with vincristine lipid complex. (medlineplus.gov)
  • you should know that vincristine may interfere with the normal menstrual cycle (period) in women and may temporarily or permanently stop sperm production in men. (medlineplus.gov)
  • Most people experience some side effects from vincristine treatment. (wikipedia.org)
  • It is important for you to tell your doctor how you are feeling during your treatment with vincristine lipid complex. (medlineplus.gov)
  • Vincristine is usually given once a week, but your nurse or doctor will discuss your treatment plan with you. (macmillan.org.uk)
  • Before you begin treatment with vincristine, you and your doctor should talk about the good this medicine will do as well as the risks of using it. (mayoclinic.org)
  • In patients with unexplained or preexisting familial neuropathy, testing for 17p11.2-12 duplication should be carried out prior to initiating vincristine therapy. (nih.gov)
  • Patients receive bryostatin 1 IV continuously on days 1 and 15 and vincristine IV over 5 minutes on days 2 and 16. (knowcancer.com)
  • Vincristine is safe for most patients, but potential side effects can occur, as gastrointestinal alterations, myelosuppression and extravasation injury. (vin.com)
  • 10.Harnicar S, Adel N, Jurcic J. Modification of vincristine dosing during concomitant azole therapy in adult acute lymphoblastic leukemia patients. (webmd.com)
  • The current study aimed to evaluate the influence of various frequencies of vincristine-steroid pulses on event-free survival (EFS), overall survival (OS), relapse rate, and adverse effects in paediatric B-cell ALL patients during maintenance therapy. (bjh.be)
  • 1 This systematic review and meta-analysis examined the impact of the frequency of vincristine-steroid pulses during maintenance therapy for paediatric patients with newly diagnosed B-cell ALL. (bjh.be)
  • However, high-frequency vincristine-steroid pulses were associated with a significantly higher risk of adverse effects. (bjh.be)
  • Before the therapy sections it is necessary to execute the clinical evaluation, the cytological exam and the complete blood count for monitoring the side effects related to vincristine. (vin.com)
  • For this reason, alternate methods to produce synthetic vincristine are being used. (wikipedia.org)
  • Vincristine is created through the semi-synthesis coupling of indole alkaloids vindoline and catharanthine in the vinca plant. (wikipedia.org)
  • Your nurse will give you vincristine as a drip (infusion) over 5 to 10 minutes. (macmillan.org.uk)