• A vinca alkaloid with a cytotoxic effect (as a result of causing mitotic arrest), vinblastine binds to a specific site on tubulin, prevents polymerization of tubulin dimers, and inhibits microtubule formation. (medscape.com)
  • A vinca alkaloid derived from vinblastine used for various types of malignancies, but mainly acute lymphocytic leukemia (ALL). (drugbank.com)
  • Vinca alkaloids are a set of anti-mitotic and anti-microtubule alkaloid agents originally derived from the periwinkle plant Catharanthus roseus (basionym Vinca rosea) and other vinca plants. (wikipedia.org)
  • With the botanical name Catharanthus roseus, vinca rosea is also commonly called Madagascar periwinkle, rose periwinkle and cape periwinkle. (gardenguides.com)
  • Native to southeastern and eastern Madagascar, vinca rosea actually prefers poor, unfertile soil. (gardenguides.com)
  • Propagated as both an annual and perennial, vinca rosea has a glossy, deep green, oval leaf and blooms with long-lasting, five-petal pink, lilac or white flowers. (gardenguides.com)
  • The long-lasting blossoms of vinca rosea make it popular as a ground cover or garden border as well as in plantings for containers and hanging baskets. (gardenguides.com)
  • Depending upon the variety, vinca rosea grows to the width and depth of 7 to 24 inches, offering plenty of options for your garden and landscape design. (gardenguides.com)
  • Its success as an antidiabetic in Jamaica led scientists to explore applications for vinca rosea in traditional medicine during the 1950s. (gardenguides.com)
  • Garlands were once fashioned from the flowers to protect the wearer from evil spirits, according to Botanical.com, while the French came to see vinca rosea as an emblem of friendship. (gardenguides.com)
  • Today, many still believe in the spiritual power of vinca rosea. (gardenguides.com)
  • Antitumor alkaloid isolated from periwinkle, Vinca rosea Linn. (drugfuture.com)
  • Alcaloide antitumoral aislado de la Vinca rosea. (bvsalud.org)
  • The vinca alkaloids thus prevent microtubule polymerization, as opposed to the mechanism of action of taxanes. (wikipedia.org)
  • The chemotherapy drugs that most likely cause nerve damage are the vinca alkaloids, platinum drugs and the taxanes. (cancer.org)
  • A majority of validated hits (9/37) are microtubule-targeting agents that are commonly used in clinical oncology, such as taxanes and vinca-alkaloids. (nki.nl)
  • Vinca alkaloid derived from the periwinkle plant. (medscape.com)
  • Vinca alkaloids are a subset of drugs obtained from the Madagascar periwinkle plant. (nih.gov)
  • Despite their cytotoxic activity against cancer cells, the vinca alkaloids have rarely been implicated in causing clinically apparent acute liver injury. (nih.gov)
  • Vinca alkaloids inhibit microtubule formation, which in turn disrupts the formation of mitotic spindle, causing cell proliferation to arrest at metaphase. (medscape.com)
  • Vinca alkaloids act on the M and S phases of mitosis, inhibiting microtubule formation and inhibiting DNA/RNA synthesis. (medscape.com)
  • The National Cancer Institute defines vinca alkaloid as "a type of drug that blocks cell growth by stopping mitosis (cell division). (gardenguides.com)
  • 9. Synthesis and biological evaluation of EC140: a novel folate-targeted vinca alkaloid conjugate. (nih.gov)
  • Alkaloids of Veratrum album subsp. (cas.cz)
  • Veratrum nigrum kan de eerste jaren wat problemen hebben met aanslaan en het duurt vaak een jaar of zeven voordat Veratrum nigrum gaat bloeien. (google.com)
  • Veratrum species contain highly toxic steroidal alkaloids (e.g. veratridine) that activate sodium ion channels and cause rapid cardiac failure and death if ingested. (google.com)
  • 13. EC-145, a folate-targeted Vinca alkaloid conjugate for the potential treatment of folate receptor-expressing cancers. (nih.gov)
  • Vinflunine is also a new synthetic vinca alkaloid, which has been approved in Europe for the treatment of second-line transitional cell carcinoma of the urothelium is being developed for other malignancies. (nih.gov)
  • Normacusine B, a monomeric alkaloid of the corynanthe class, also found in Rauvolfia, Tabernaemontana and Vinca spp. (pfaf.org)
  • Vinca alkaloids are now produced synthetically and used as drugs in cancer therapy and as immunosuppressive drugs. (wikipedia.org)
  • The vinca alkaloids are also important for being cancer fighters. (nih.gov)
  • Effect of Vinca Alkaloids on the Expression Levels of microRNAs Targeting Apoptosis-related Genes in Breast Cancer Cell Lines. (nih.gov)
  • Vinca alkaloids as a potential cancer therapeutics: recent update and future challenges. (nih.gov)
  • 19. Folate-vinca alkaloid conjugates for cancer therapy: a structure-activity relationship. (nih.gov)
  • The Biological Activity of the Novel Vinca Alkaloids 4-chlorochablastine and 4-chlorochacristine. (nih.gov)
  • 7. Comparative preclinical activity of the folate-targeted Vinca alkaloid conjugates EC140 and EC145. (nih.gov)
  • In the winter months, the plant degrades and metabolizes most of its toxic alkaloids. (google.com)