Vincristine and vinblastine are most commonly used, and new drugs such as etoposide, teniposide, and vinorelbine are being used in human medicine but have not yet received widespread use in veterinary oncology. (vin.com)
Vinca alkaloids4
The Madagascan periwinkle Catharanthus roseus L. is the source for a number of important natural products, including catharanthine and vindoline and the vinca alkaloids it produces from them: leurosine and the chemotherapy agents vinblastine and vincristine, all of which can be obtained from the plant. (wikipedia.org)
The quest for hostile to cancerous growth compounds from plant sources began vigorously during the 1950s with the disclosure and advancement of the different regular mixtures like vinca alkaloids, vinblastine, vincristine and cytotoxic podophyllotoxins. (researchsquare.com)
Vincristine, doxorubicin, and vinblastine were the only hazardous drugs actually in use during the two NIOSH visits. (cdc.gov)
Chemotherapy3
however, systemic vinblastine (or other chemotherapy) attacks both cutaneous and visceral lesions. (medscape.com)
Localized nodular disease may respond well to surgical excision, radiotherapy, and intralesional and outpatient low-dose vinblastine chemotherapy. (medscape.com)
vincristine and vinblastine which are used in chemotherapy come from a species of the periwinkle found in Madagascar. (womenofgrace.com)
The mitotic spindle in the presence (at different concentrations) and absence of vinblastine (very similar to vincristine). (acsh.org)
Kaposi1
Although the authors prefer intralesional vinblastine, intralesional vincristine as first-line therapy for nodules in classic Kaposi sarcoma has also been recommended. (medscape.com)
Plant1
Left top) Catharanthus roseus, aka the Madagascan Periwinkle, a member of the Vinca plant family, is the source of the cancer drug vincristine (Right top) Nice structure, huh? (acsh.org)
The presence of vincristine contamination is a reminder that the patients themselves can be a source of exposure, even when the drugs are not handled directly by hospital personnel. (cdc.gov)
Evidence of such successes in natural product drug discovery include the isolation of vinca-alkaloids, vinblastine and vincristine from the Madagascar periwinkle Catharanthus roseus , as well as paclitaxel from the bark of the Pacific Yew Taxus brevifolia ( 2 ). (spandidos-publications.com)
The current study quantifies the contribution of cytochromes P450 (P450s), including CYP3A4 and CYP3A5, to vincristine metabolism with a bank of human liver microsomes (HLMs). (aspetjournals.org)
For CYP3A5 high expressers, the contribution of CYP3A5 to the metabolism of vincristine was 54 to 95% of the total activity, and the rate of M1 formation mediated by CYP3A5 correlated with CYP3A5 protein content ( r 2 = 0.95). (aspetjournals.org)
This pattern suggests a genetic contribution to interpatient variability in exposure and prompted our investigation into the role of the genetically polymorphic enzyme CYP3A5 in vincristine metabolism. (aspetjournals.org)
Thus, for individuals that express the enzyme, CYP3A5 may be important in the metabolism of vincristine and a factor in the observed interindividual variation in vincristine exposure and response. (aspetjournals.org)
Periwinkle1
Both vincristine and vinblastine, he pointed out, are highly unstable and probably do not get into the smoke of burning periwinkle leaves in an active form. (weirduniverse.net)
CYP3A42
Vincristine is preferentially metabolized to a secondary amine, M1, by CYP3A5 with a 9- to 14-fold higher intrinsic clearance than CYP3A4 using cDNA-expressed enzymes. (aspetjournals.org)
For each CYP3A5 high expresser ( n = 10), the rate of M1 formation from vincristine due to CYP3A5 was quantified by subtracting the CYP3A4 contribution as determined by linear regression with CYP3A5*3/*3 samples. (aspetjournals.org)
Sedimentation1
Previous sedimentation velocity results with vinblastine have been interpreted by a mechanism involving isodesmic ligand-mediated or ligand-mediated plus ligand-facilitated self-association [Lobert et al. (nih.gov)
Leukemia1
Vincristine is mainly used to treat acute leukemia and other lymphomas. (bris.ac.uk)
Drugs2
The presence of vincristine contamination is a reminder that the patients themselves can be a source of exposure, even when the drugs are not handled directly by hospital personnel. (cdc.gov)
A chemist at Eli Lilly & Co. of Indianapolis, where the drugs vincristine and vinblastine were developed, said last week that the perils may not be as great as Dame suspects. (weirduniverse.net)
Stages1
As the analyses showed, the entire biosynthetic pathway for the alkaloid vinblastine is organized in three stages and three discrete cell types. (mpg.de)
Clinical1
However, despite extensive clinical experience with vincristine, the determinants of the interpatient variability in outcome remain elusive. (aspetjournals.org)
Important1
The researchers measured the concentrations of several intermediates in the metabolic pathway for vinblastine in single cells and were surprised: 'Two important precursors of vinblastine, catharanthine and vindoline, occur in the idioblast cells at millimolar concentrations, about three orders of magnitude higher than vinblastine itself. (mpg.de)
Clearance1
We conclude that polymorphic expression of CYP3A5 may be a major determinant in the P450-mediated clearance of vincristine. (aspetjournals.org)
Therapy1
1] It is probably impractical to resume breastfeeding after vinblastine therapy because of the drug's long half-life. (nih.gov)
Cells1
Efflux ratios across MDR1wt expressing cells were significantly larger for R123 (3.95+/-1.1), Vinblastine (3.75+/-0.26), and Vincristine (2.8+/-0.29). (nih.gov)