• Vinblastine is a vinca alkaloid and a chemical analogue of vincristine. (wikipedia.org)
  • Vinblastine is in a class of medications called vinca alkaloids. (medlineplus.gov)
  • Vinblastine sulfate is the salt of an alkaloid extracted from Vinca rosea Linn. (nih.gov)
  • A vinca alkaloid with a cytotoxic effect (as a result of causing mitotic arrest), vinblastine binds to a specific site on tubulin, prevents polymerization of tubulin dimers, and inhibits microtubule formation. (medscape.com)
  • The rMRP1 transfected cells, like their human ortholog, can confer drug resistance to vinca alkaloid (vinblastine and vincristine) and anthracycline drugs (daunorubcin and doxorubicin), and the resistance conferred by the MRP1 can be partially abolished by the MRP-specific inhibitors. (nih.gov)
  • See WARNINGS for the treatment of patients given intrathecal vinblastine sulfate injection. (nih.gov)
  • Vinblastine paracrystals may be composed of tightly packed unpolymerized tubulin or microtubules. (wikipedia.org)
  • Vinblastine blocks the tubulin monomers from forming microtubules. (cancerquest.org)
  • In this study, we compare the vincristine- or vinorelbine-induced self-association of porcine brain tubulin with our prior vinblastine studies in the presence of 50 microM GDP or 50 microM GTP. (nih.gov)
  • Furthermore, 1 showed a similar Kd to that of vinblastine and also affected assembly of tubulin polymers. (nature.com)
  • Vinblastine (VBL), sold under the brand name Velban among others, is a chemotherapy medication, typically used with other medications, to treat a number of types of cancer. (wikipedia.org)
  • Many plant natural products are highly complex molecules, such as the alkaloids vincristine and vinblastine, which are produced by the Madagascar periwinkle Catharanthus roseus . (mpg.de)
  • The periwinkle plant offers a source for the widely used chemotherapy drugs vincristine and vinblastine. (jic.ac.uk)
  • The drug is comprised of cisplatin and vinblastine co-formulated with a molecule that enables drug dispersion throughout an injected tumor and diffusion into cancer cells. (bmj.com)
  • Doses ranged from 0.14 up to 175mL (87.5 mg of cisplatin, 17.5mg vinblastine - much higher than typical IV doses). (bmj.com)
  • The combination of methotrexate, vinblastine, doxorubicin (Adriamycin), and cisplatin (MVAC) is the standard treatment for metastatic bladder cancer. (medscape.com)
  • The objective of our study was to determine whether BPA at low nanomolar concentrations opposes the action of doxorubicin, cisplatin, and vinblastine in the estrogen receptor-α (ERα)-positive T47D and the ERα-negative MDA-MB-468 breast cancer cells. (nih.gov)
  • Vinblastine may be isolated from the Madagascar Periwinkle (Catharanthus roseus), its only known biological producer, along with several of its precursors, catharanthine and vindoline. (wikipedia.org)
  • The researchers measured the concentrations of several intermediates in the metabolic pathway for vinblastine in single cells and were surprised: 'Two important precursors of vinblastine, catharanthine and vindoline, occur in the idioblast cells at millimolar concentrations, about three orders of magnitude higher than vinblastine itself. (mpg.de)
  • Vinblastine is reported to be an effective component of certain chemotherapy regimens, particularly when used with bleomycin and methotrexate in VBM chemotherapy for Stage IA or IIA Hodgkin lymphomas. (wikipedia.org)
  • The inclusion of vinblastine allows for lower doses of bleomycin and reduced overall toxicity with larger resting periods between chemotherapy cycles. (wikipedia.org)
  • It is important for you to tell your doctor how you are feeling during your treatment with vinblastine injection. (medlineplus.gov)
  • tell your doctor and pharmacist if you are allergic to vinblastine, any other medications, or any of the ingredients in vinblastine injection. (medlineplus.gov)
  • Your doctor will want to treat your infection before you receive vinblastine injection. (medlineplus.gov)
  • You should not become pregnant or breast-feed while you are receiving vinblastine injection. (medlineplus.gov)
  • If you become pregnant while receiving vinblastine injection, call your doctor. (medlineplus.gov)
  • Animals were sacrificed at 40hr (for TEM and benzene), or 30hr (for vinblastine) after the first injection, and maternal bone marrow and fetal liver were sampled randomly for sister chromatid exchanges (SCE) and micronuclei (MN) formation as genetic endpoints. (cdc.gov)
  • The biosynthetic pathway for vinblastine and its precursors, particularly catharanthine, still remains partially unknown. (wikipedia.org)
  • As the analyses showed, the entire biosynthetic pathway for the alkaloid vinblastine is organized in three stages and three discrete cell types. (mpg.de)
  • Vinblastine is a component of a number of chemotherapy regimens, including ABVD for Hodgkin lymphoma. (wikipedia.org)
  • Vinblastine is a component drug in ABVD, given for HL. (cancer.org)
  • But research into the mechanism is still ongoing as recent studies also show vinblastine inducing apoptosis that is phase-independent in certain leukemias. (wikipedia.org)
  • The mechanism of action of vinblastine has been related to the inhibition of microtubule formation in the mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. (nih.gov)
  • Previous sedimentation velocity results with vinblastine have been interpreted by a mechanism involving isodesmic ligand-mediated or ligand-mediated plus ligand-facilitated self-association [Lobert et al. (nih.gov)
  • It is extremely important that the intravenous needle or catheter be properly positioned before any vinblastine sulfate is injected. (nih.gov)
  • Leakage into surrounding tissue during intravenous administration of vinblastine sulfate may cause considerable irritation. (nih.gov)
  • Vinblastine was isolated in 1958. (wikipedia.org)
  • Co-discoverer of vinblastine (from the Madagascar periwinkle plant) with Robert Noble at the University of Western Ontario in 1958. (science.ca)
  • Chemical and physical evidence indicate that vinblastine sulfate is a dimeric alkaloid containing both indole and dihydroindole moieties. (nih.gov)
  • As a vesicant, vinblastine can cause extensive tissue damage and blistering if it escapes from the vein from improper administration. (wikipedia.org)
  • Vinblastine is a moderate vesicant and extravasation should be avoided. (medscape.com)
  • Vinblastine toxicity resulted in MN induction at a level seven times higher in maternal bone marrow than in fetal liver. (cdc.gov)
  • Microtubule-disruptive drugs like vinblastine, colcemid, and nocodazole have been reported to act by two mechanisms. (wikipedia.org)
  • Vinblastine is used in combination with other chemotherapy drugs to treat Hodgkin's lymphoma (Hodgkin's disease) and non-Hodgkin's lymphoma (types of cancer that begin in a type of white blood cell that normally fights infection), and cancer of the testicles. (medlineplus.gov)
  • In addition, glutamic acid and aspartic acid have protected mice from lethal doses of vinblastine sulfate. (nih.gov)
  • Vinblastine treatment causes M phase specific cell cycle arrest by disrupting microtubule assembly and proper formation of the mitotic spindle and the kinetochore, each of which are necessary for the separation of chromosomes during anaphase of mitosis. (wikipedia.org)
  • A number of studies in vitro and in vivo have demonstrated that vinblastine sulfate produces a stathmokinetic effect and various atypical mitotic figures. (nih.gov)
  • Transplacental genotoxicity of triethylenemelamine, benzene, and vinblastine in mice. (cdc.gov)
  • The genotoxicity of triethylenemelamine (51183) (TEM), benzene (71432), and vinblastine (865214) was investigated in transplacentally exposed mice. (cdc.gov)
  • Extraction is costly and yields of vinblastine and its precursors are low, although procedures for rapid isolation with improved yields avoiding auto-oxidation have been developed. (wikipedia.org)
  • Caution: This preparation should be administered by individuals experienced in the administration of vinblastine sulfate. (nih.gov)
  • Enantioselective synthesis has been of considerable interest in recent years, as the natural mixture of isomers is not an economical source for the required C16'S, C14'R stereochemistry of biologically active vinblastine. (wikipedia.org)
  • Other studies indicate that vinblastine sulfate has an effect on cell-energy production required for mitosis and interferes with nucleic acid synthesis. (nih.gov)
  • abametapir will increase the level or effect of vinblastine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
  • apalutamide will decrease the level or effect of vinblastine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
  • chloramphenicol will increase the level or effect of vinblastine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
  • Vinblastine is also sometimes used to treat bladder cancer, certain types of lung cancer, Kaposi's sarcoma, and certain brain tumors. (medlineplus.gov)
  • Although not FDA approved for this indication, vinblastine is often used as a treatment for bladder cancer in combination with a chemotherapy regimen. (medscape.com)
  • An example of a natural herbal remedy that has since been developed into a conventional medicine, vinblastine was originally obtained from the Madagascar periwinkle. (wikipedia.org)
  • Tell your doctor and pharmacist about all the medications you are taking so they can check whether any of your medications may increase the risk that you will develop hearing problems during your treatment with vinblastine. (medlineplus.gov)
  • SCE were absent with vinblastine treatment. (cdc.gov)
  • The most common causes of neuropathy in lympoma treatment are either Vinblastine or Vincristine . (cancer.org)
  • Meloxicam in Combination with Mitoxantrone or Vinblastine as First-Line Treatment for Non-Resectable Urothelial Cell Carcinoma in Dogs. (nih.gov)
  • 3.Makinson A, Martelli N, Peyriere H, Turriere C, Le Moing V, Reynes J. Profound neutropenia resulting from interaction between antiretroviral therapy and vinblastine in a patient with HIV-associated Hodgkin's disease. (webmd.com)
  • Vinblastine should be administered only into a vein. (medlineplus.gov)
  • Vinblastine comes as a powder or solution (liquid) to be injected intravenously (into a vein) by a doctor or nurse in a medical facility. (medlineplus.gov)
  • Vinblastine appears to be a peripherally selective drug due to limited brain uptake caused by binding to P-glycoprotein. (wikipedia.org)
  • Clinically, leukopenia is an expected effect of vinblastine sulfate, and the level of the leukocyte count is an important guide to therapy with this drug. (nih.gov)
  • www.drugguide.com/ddo/view/Davis-Drug-Guide/51788/all/vinBLAStine. (drugguide.com)
  • Vinblastine is a chemotherapy drug used to treat certain types of cancer. (singhealth.com.sg)
  • Vinblastine is a major chemotherapy drug used to treat cancers such. (science.ca)
  • vinblastine decreases effects of adenovirus types 4 and 7 live, oral by pharmacodynamic antagonism. (medscape.com)
  • Reversal of the antitumor effect of vinblastine sulfate by glutamic acid or tryptophan has been observed. (nih.gov)
  • vinblastine will decrease the level or effect of dabigatran by P-glycoprotein (MDR1) efflux transporter. (medscape.com)
  • Vinblastine works by blocking cell division. (wikipedia.org)
  • To determine if any of these transporters is responsible for the secretion of furosemide, we compared directional permeability in the wild-type cell lines, MDCK strains I and II, and LLC-PK1, vs. cell lines that overexpress a single transporter, in both the presence and absence of various inhibitors, for furosemide as compared to vinblastine. (nih.gov)