SulfonesPurinesPiperazinesErectile DysfunctionPhosphodiesterase InhibitorsPhosphodiesterase 5 Inhibitors3',5'-Cyclic-GMP PhosphodiesterasesCyclic Nucleotide Phosphodiesterases, Type 5Penile ErectionVasodilator AgentsHomosexuality, MaleMethamphetamineVentricular Dysfunction, LeftCyclic GMPGeorgiaUnsafe SexRisk-TakingSexual BehaviorVentricular DysfunctionSexual Dysfunction, PhysiologicalSexual Dysfunctions, PsychologicalEndothelium, VascularVentricular Dysfunction, RightDisease Models, AnimalOxidative StressPrimary Graft DysfunctionVasodilationDiastoleAutonomic Nervous System DiseasesMitochondriaTime FactorsMyocardiumHeart FailureMyocardial ContractionEchocardiographyMultiple Organ FailureCardiomyopathiesImpotence, VasculogenicMitochondrial DiseasesMice, Inbred C57BLNitric OxideCognition DisordersSystoleBiological MarkersVentricular Function, LeftPenisStroke VolumeReactive Oxygen SpeciesHeartRats, Sprague-DawleyHeart Failure, DiastolicNitric Oxide Synthase Type IIIKidney DiseasesHemodynamicsTreatment OutcomeSeverity of Illness IndexRisk FactorsBlood PressureProspective StudiesVascular DiseasesMice, KnockoutVentricular RemodelingAcetylcholineEchocardiography, DopplerCase-Control StudiesAgingMice, TransgenicAnalysis of VarianceBrainRats, WistarMyocytes, CardiacCells, CulturedSphincter of Oddi DysfunctionNeuropsychological TestsHeart DiseasesEndothelial CellsMicrocirculationFollow-Up StudiesHypertensionChronic DiseaseKidneyDose-Response Relationship, DrugSignal TransductionBrachial ArteryNatriuretic Peptide, BrainMagnetic Resonance ImagingDiabetes Mellitus, ExperimentalSepsis