Viability cardiac ischemia reperfusion. Medical search. Frequent questions

Cell viability, total cell count and oxidative stress, i.e., total reactive oxygen species (ROS) and superoxide level were measured by fluorescent assays. (nih.gov)
Viability of hiChol adult cardiac myocytes was significantly decreased and superoxide level was increased in normoxia and these changes were further aggravated by SI/R. HiChol combined with hyperglycemia further aggravated cell death, however level of oxidative stress increased only in normoxic condition. (nih.gov)
HiChol rat cardiac myocytes showed reduction of cell viability and increased oxidative stress, which were further aggravated by SI/R and with additional hyperglycemia. (nih.gov)
induced cardiac toxicity such as oxidative stress and deteriorated mitochondrial function, a disturbance in iron regulatory protein [(IRP)-1], the release of nitric oxide, autophagy and dysregulation of Ca 2+ level. (mosuljournals.com)
However, harmful stimuli (such as ischemia-reperfusion, oxidative stress, and toxic chemicals) can change the direction and efficiency of intercellular mitochondrial transfer. (frontiersin.org)
As the heart contains a high amount of mitochondria, cardiac mitochondrial dysfunction can lead to cardiac oxidative stress which aggravates the development of DCM. (encyclopedia.pub)
Cardiac ischemia is modelled in vitro through the application of hypoxic and oxidative stress. (biomedcentral.com)
Ischemia/reperfusion (I/R) in mouse hearts and hypoxia/oxidative stress in neonatal rat cardiomyocytes have been associated with a downregulation of MG53. (biomedcentral.com)

HPC protected neonatal rat cardiomyocytes against H/R injury by increasing cell viability, while reducing LDH release and cell apoptosis. (spandidos-publications.com)
Since cardiomyocytes are terminally differentiated cells with limited self-renewal capacity, and membrane rupture is a major cause of cardiomyocyte cell death following injury, membrane repair is a necessary process for preserving cardiomyocyte viability [ 6 ]. (biomedcentral.com)
The initial ischemia in AMI causes biochemical and metabolic alterations in cardiomyocytes. (springeropen.com)
Cardiomyocytes were isolated and subjected to 6 h hypoxia followed by 18 h reperfusion. (biomedcentral.com)

Stem cell-derived cardiac myocytes are potential sources for testing cardiocytoprotective molecules against ischemia/reperfusion injury in vitro. (nih.gov)
Here we performed a systematic analysis of two different induced pluripotent stem cell lines (iPSC 3.4 and 4.1) and an embryonic stem cell (ESC) line-derived cardiac myocytes at two different developmental stages. (nih.gov)
Cardiac myocytes isolated from neonatal or adult rat hearts were cultured in control or in three different hypercholesterolemic media with increasing cholesterol content (hiChol) or hiChol + hyperglycemic medium, respectively. (nih.gov)
Cholesterol uptake was tested by Filipin staining in neonatal cardiac myocytes. (nih.gov)
Neonatal cardiac myocytes took up cholesterol from the different hiChol media at a concentration-dependent manner. (nih.gov)
In normoxia, viability of hiChol neonatal cardiac myocytes was not significantly changed, however, superoxide levels were increased as compared to vehicle. (nih.gov)
After SI/R, the viability of hiChol neonatal cardiac myocytes was decreased and total ROS level was increased as compared to vehicle. (nih.gov)
This is the first demonstration that the combination of the current hypercholesterolemic medium and SI/R in cardiac myocytes mimics the cardiac pathology of the comorbid heart with I/R and hypercholesterolemia. (nih.gov)
MGF-2 is a growth factor that is naturally present in the heart as well as cardiac myocytes and possesses growth promoting and cardioprotective properties, which make it an important therapeutic tool for reducing or preventing damage by ischemia and/or improving cardiac prognosis subsequent to cardiac injury. (umanitoba.ca)
In addition, my results also demonstrate that endogenous production of FGF-2 can be targeted and is significantly increased in adult mouse cardiac myocytes using the natural catecholamine, norepinephrine. (umanitoba.ca)
Overexpression of FGFR-1 resulted in FGF-2 mediated mitogenic response in FGFR-1 deficient cardiac H9c2 cells as well as primary neonatal cardiac myocytes. (umanitoba.ca)
In cases of less severe ischemia, some myocytes remain viable but have depressed contractile function. (medscape.com)
When ischemia is prolonged, myocytes have depressed contractile function but remain viable. (medscape.com)
Chronic hypoxia in the presence of high glucose leads to progressive acidosis of cardiac myocytes in culture. (biologists.com)

Midiv-1 has been demonstrated to attenuate the effects of ischemia reperfusion injury after cardiac arrest. (wikipedia.org)
Cell viability in simulated ischemia/reperfusion (SI/R)-induced injury and a known cardiocytoprotective NO-donor, S-nitroso-n-acetylpenicillamine (SNAP) was tested. (nih.gov)
After analysis of full embryoid bodies (EBs) and cardiac marker (VCAM and cardiac troponin I) positive cells of three lines at 6 conditions (32 different conditions altogether), we found significant SI/R injury-induced cell death in both full EBs and VCAM+ cardiac cells at later stage of their differentiation. (nih.gov)
Hypercholesterolemia causes endothelial and myocardial dysfunction, as well as aggravates ischemia/reperfusion (I/R)-induced myocardial injury. (nih.gov)
ischemia/reperfusion injury (I/R injury). (nih.gov)
Lung transplantation is the last effective treatment for end-stage respiratory failure, however, with ischemia-reperfusion injury (IRI) inevitably occurring in postoperative period. (bvsalud.org)
Adult rats were subjected to myocardial ischemia/reperfusion (I/R) injury with or without ischemic preconditioning (IPC), and the level of miR‑133b‑5p in myocardium was measured. (spandidos-publications.com)
Cellular injury was evaluated by detecting cell viability, lactate dehydrogenase (LDH) activity and apoptotic rate. (spandidos-publications.com)
Reperfusion after cardiac ischemia increases cell death and infarct size (IS), called myocardial ischemia/reperfusion (I/R) injury, which is the main cause of myocardial injury during the cardiac surgery particularly in coronary artery bypass graft surgery ( 1 , 2 ). (spandidos-publications.com)
This likely contributed to the increased cardiac myocyte viability observed after ischemia-reperfusion injury in isolated FGF-2 transgenic mouse hearts, representing the first account of the cardioprotective potential of endogenous FGF-2. (umanitoba.ca)
has been demonstrated to attenuate renal ischemia‑reperfusion (I/R) injury. (spandidos-publications.com)
However, reperfusion following a period of prolonged ischemia can often cause myocardial ischemia-reperfusion (I/R) injury, leading to damage of cardiac tissues ( 5 ). (spandidos-publications.com)
Cardiac ischemia/reperfusion (I/R) injury is a serious disease and threatens human health [ 1 ]. (hindawi.com)
Despite the recent surge about miRNA discoveries for cardiac I/R injury, there is still very little known about the mechanism details because of the complexity of cellular events and the interference of other risk factors. (hindawi.com)
Activated fibroblasts during cardiac injury can alter the composition and activity of these ECM proteins. (beaumont.org)
Here, we initially confirmed our big dataset analysis through cells, mice, and clinical atrial biopsy samples to demonstrate increased Aspn expression after pressure overload or cardiac ischemia/reperfusion injury. (beaumont.org)
We tested the hypothesis that Aspn, being a TGFβ1 inhibitor, can attenuate fibrosis in mouse models of cardiac injury. (beaumont.org)
Increased infarct size after ischemia/reperfusion injury in Aspn-/- mice confirmed Aspn's contribution to cardiomyocyte viability. (beaumont.org)
Pharmacologically-induced pre- and post-conditioning represent attractive therapeutic strategies to reduce ischaemia/reperfusion injury during cardiac surgery and following myocardial infarction. (ntu.ac.uk)
Cold ischemia and subsequent reperfusion injury are non-immunologic cornerstones in the development of graft injury after heart transplantation. (frontierspartnerships.org)
The nitric oxide donor S-nitroso-human-serum-albumin (S-NO-HSA) is known to attenuate myocardial ischemia-reperfusion (I/R)-injury. (frontierspartnerships.org)
There is substantial evidence that endothelial injury during organ procurement and preservation, caused by ischemia and subsequent reperfusion, results in endothelial dysfunction. (frontierspartnerships.org)
Ischemia-reperfusion injury is common in critically ill patients, and directed therapies are lacking. (hydrogenstudies.com)
Inhaled hydrogen gas diminishes ischemia-reperfusion injury in models of shock, stroke, and cardiac arrest. (hydrogenstudies.com)
Here we explored the mechanism underlying the actions of a mimetic peptide on GJ channels, Cx protein levels, and CxHC activity in fibroblast cells under normal conditions and following ischemia-reperfusion injury. (monthion.com)
However, accumulating evidence suggests that MG53 has a potentially protective role in heart tissue, including in ischemia/reperfusion injury of the heart, cardiomyocyte membrane injury repair, and atrial fibrosis. (biomedcentral.com)
In addition to its function in skeletal muscle, MG53 has been shown to have protective effects on various forms of cardiac muscle injury. (biomedcentral.com)
IPC activates the reperfusion injury salvage kinase (RISK) and survivor activating factor enhancement (SAFE) pathways to protect the heart against IR injury. (biomedcentral.com)
Tao Q, Tianyu W, Jiangqiao Z, Zhongbao C, Xiaoxiong M, Long Z, Jilin Z. Tripartite Motif 8 Deficiency Relieves Hepatic Ischaemia/reperfusion Injury via TAK1-dependent Signalling Pathways. (ijbs.com)
However, the function of Trim8 in hepatic ischaemia/reperfusion (I/R) injury remains largely unknown. (ijbs.com)
Hepatic I/R injury can result in loss of viability of a liver graft, which is directly correlated with the recipient's survival [ 2 ]. (ijbs.com)
Despite extensive research, our understanding of the precise role of different subsets of macrophages in ischemia/reperfusion injury remains incomplete. (elifesciences.org)
Specific absence of homeostatic, monocyte-independent macrophages altered the immune cell crosstalk in response to injury and induced proinflammatory neutrophil polarization, resulting in impaired cardiac remodelling without influencing infarct size. (elifesciences.org)
In summary, resident macrophages orchestrate inflammatory responses improving cardiac remodelling, while recruited macrophages determine infarct size after I/R injury. (elifesciences.org)
Current methods of cold static storage have reached their limits in storage time due to the extent of ischemia-reperfusion (I/R) injury induced during static cold storage. (gotomydoctor.com)
The extent of reperfusion injury is directly proportional to preservation time in cold storage, and research has shown that with static storage methods, heart storage time will not exceed six hours. (gotomydoctor.com)
Additionally, machine reperfusion induces the production of ROS, which results in I/R injury to the heart. (gotomydoctor.com)
In patient suffering an ischemic event, most of the myocardial damage incurred happens once blood flow is restored - a phenomena known as reperfusion injury. (sun.ac.za)
Mitochondrial ROS production is implicated as one of the major contributors to cell death in the reperfused heart and the importance of mitophagic processes (mitochondrial housekeeping) could be a potential therapeutic target to prevent ischemia/reperfusion injury (I/R-I). Aspalathus linearis (commonly known as rooibos) is an indigenous South African plant grown exclusively in the Western Cape fynbos region. (sun.ac.za)
Acute myocardial infarct (MI), commonly known as a heart attack, is a condition characterized by ischemic injury and necrosis of the cardiac muscle. (medscape.com)
Pluripotent cardiac progenitor cells resident in myocardium offer a potentially promising role in promoting recovery from injury. (stanford.edu)
The uncoupling of glycolysis and glucose oxidation induces lactate accumulation during myocardial ischemia/reperfusion (I/R) injury. (biomedcentral.com)
A therapeutic drug that targets ischemia reperfusion (I/R) injury is needed and has yet to be developed. (biomedcentral.com)

Restoration of blood supply, termed reperfusion, has been used to treat ischemic myocardium and prevent further tissue damage. (spandidos-publications.com)
Stunned myocardium is myocardium that suffers transient reversible myocardial contractile dysfunction that is caused by acute ischemia during which the blood supply is almost completely restored by reperfusion, with no metabolic deterioration. (medscape.com)
The term hibernating myocardium is also used to indicate chronic myocardial contractile dysfunction due to ischemia, in which there is reduced coronary blood flow at rest and increased myocardial demand results in impaired contractility. (medscape.com)
Schematic representation of infarction (cell death), chronic ischemia with contractile dysfunction (hibernating myocardium), and transient ischemia (stunned myocardium) with restored blood flow with transient contractile dysfunction. (medscape.com)
Clinically, discerning the etiology of depressed myocardial contractile function is difficult, whether due to stunned myocardium, silent ischemia, or hibernating myocardium. (medscape.com)
and is an intrinsic process through which repeated short episodes of ischemia are instituted to protect the myocardium against subsequent ischemic insults [ 7 ]. (biomedcentral.com)
Coronary thrombolysis and mechanical revascularization have revolutionized the primary treatment of acute MI, largely because they allow salvage of the myocardium when implemented early after the onset of ischemia. (medscape.com)
9. Sasayama S, Nonogi H , Fujita M, Sakurai T, Wakabayashi A, Kawai C, Eiho S, Kuwahara M: Changes in diastolic properties of the regional myocardium during pacing-induced ischemia in human subjects. (fiercecert.com)
CABG may be performed as an emergency procedure in the context of an ST-segment elevation MI (STEMI) in cases where it has not been possible to perform percutaneous coronary intervention (PCI) or where PCI has failed and there is persistent pain and ischemia threatening a significant area of myocardium despite medical therapy. (medscape.com)

2012). Cardiac security continues to be observed in rat types of myocardial infarction also, where Cx mimetic peptides resulting in a significant reduced amount of infarct size by over 60% (Hawat et al. (monthion.com)

This augmented adverse remodelling after I/R and led to an increased infarct size and deterioration of cardiac function. (elifesciences.org)
The accumulation of cardiac lactate was attenuated by PLCA during myocardial I/R, and infarct size was smaller in rats treated with PLCA (1 mg/kg) than in those treated with caffeic acid (1 mg/kg). (biomedcentral.com)

H9c2 cells were exposed to 8 h hypoxia (1% O2) followed by 18 h reoxygenation, after which cell viability was assessed by monitoring mitochondrial reduction of MTT, lactate dehydrogenase release and caspase-3 activation. (ntu.ac.uk)
Regarding cardiac and mitochondrial signaling, prior to ischemia HCD heart had a decreased dependence on insulin-dependent AMPK and increased inflammation via upregulated p38, whereas GRT treatment presented with decreased insulindependent PKB and AS160 signaling (together with increased FA OxPhos compared to carbohydrates, however showed more mitochondrial uncoupling, decreasing basal metabolic rate and thereby potentially less ROS production), inhibited GSK3β and conferred an anti-inflammatory effect by significantly reducing p38 activation. (sun.ac.za)

Redox Regulation of Cardiac ASK1 (Apoptosis Signal-Regulating Kinase 1) Controls p38-MAPK (Mitogen-Activated Protein Kinase) and Orchestrates Cardiac Remodeling to Hypertension. (ox.ac.uk)
PLCA at 1 μM and metformin at 30 μM exerted similar effects on the improvement of cell viability and the alleviation of cell apoptosis in NRVM after H/R. PLCA promoted p-AMPK, p-AKT, and GLUT4 upregulation to induce a cardioprotective effect in both cell and animal model. (biomedcentral.com)

Building upon this intensive analysis, using a style of cerebral ischemia in foetal sheep, Davidson and co-workers confirmed that Cx mimetic peptide could raise the success price of cells during ischemia reperfusion and decrease seizure activity (Davidson et al. (monthion.com)
Repeated routine of comfort and pressure causes serious tissues ischemia reperfusion harm in your skin, like the harm observed in cardiac and cerebral ischemia reperfusion. (monthion.com)

Myocardial ischemia, also called cardiac ischemia or hypoxia/reoxygenation (H/R)-induced heart damage, is caused by decreased blood flow [ 1 ]. (biomedcentral.com)
Cardiac glutathione peroxidase (GSH-px), malondialdehyde (MDA), hypoxia-inducible factor 1 alpha (HIF-1α), autophagy proteins (P62 & LC3IIB) and gene expression of PI3K, Akt, FOXO-1, and eNOS were assessed. (springeropen.com)
The downstream regulator of PI3K/Akt is hypoxia-inducible factor-1α (HIF-1α) which is a master regulator of gene expression in hypoxia, and it has the ability to influence cellular adaptive responses to hypoxia or ischemia. (springeropen.com)

The treatment prevented both mitochondria fragmentation and increased cell viability. (wikipedia.org)

This review summarizes the regulatory role of MG53 in cardiac tissues, current debates regarding MG53 in diabetes and diabetic cardiomyopathy, as well as highlights potential clinical applications of MG53 in treating cardiac pathologies. (biomedcentral.com)
At the end of the experiment, serum and cardiac tissues were collected. (springeropen.com)
1. The objective is to evaluate the relationship between concentration of NaHS and its effect on viability by performing a dose-response test in order to evaluate the concentration of NaHS with the most beneficial results to tissues. (gotomydoctor.com)
Polymorphonuclear neutrophils (PMNs) contribute to postischemic reperfusion damage in many organs and tissues, a prerequisite being adhesion of PMNs to vascular endothelial cells. (silverchair.com)

Systolic wall thickening after coronary artery occlusion and subsequent reperfusion in normal and ischemic zones. (medscape.com)

FGF-2 signaling also plays a major role in embryonic and neonatal cardiac myocyte proliferation 'in vitro' and as a result, is implicated in cardiac regeneration. (umanitoba.ca)

The concomitant presence of myocardial necrosis with myocardial ischemia, stunning, or hibernation may complicate appraisal of left ventricular (LV) function and patient management. (medscape.com)
15. Nakamura Y, Sasayama S, Nonogi H , Miyazaki S, Fujita M, Kihara Y, Konishi T, Kawai C: Effects of pacing-induced ischemia on early left ventricular filling and regional myocardial dynamics and their modification by nifedipine. (fiercecert.com)

Systemic hypertension increases cardiac workload causing cardiomyocyte hypertrophy and increased cardiac fibrosis. (ox.ac.uk)
However, it suppressed hypertension-induced cardiac hypertrophy resulting from angiotensin II (0.8 mg/[kg·d], 7d), with inhibition of Nppa/Nppb mRNA upregulation, reduced cardiomyocyte hypertrophy and, notably, significant reductions in interstitial and perivascular fibrosis. (ox.ac.uk)

Several imaging modalities have been proposed for accurate assessment of myocardial necrosis, viability, stunning, and hibernation, with mixed results. (medscape.com)
MI may also manifest itself as sudden cardiac death, which may not be apparent on autopsy (because necrosis takes time to develop). (medscape.com)

We received a call that a middle aged male in cardiac arrest was 5 minutes out. (blogspot.com)
He arrived in PEA arrest with a slow and wide cardiac waveform during initial rhythm check, with faint cardiac activity on US but no palpable or visible femoral pulse on US of the femoral artery. (blogspot.com)
Press-News.org) Around 50,000 people suffer sudden cardiac arrest in Germany every year. (press-news.org)
One of the first persons treated with CARL therapy successfully survived a cardiac arrest after about 120 minutes of resuscitation. (press-news.org)
After decades of research, we were able to develop a new treatment method to reduce the physical damage that would otherwise occur after cardiac arrest and resuscitation. (press-news.org)
This raises the prospect of people surviving much longer and better after cardiac arrest than was previously thought," Beyersdorf said. (press-news.org)
As a result of cardiac arrest, blood vessels in the brain swell, making them less permeable to gas exchange. (press-news.org)
With CARL we can treat the damage caused by cardiac arrest and the associated lack of oxygen. (press-news.org)
In another case, a patient suffered cardiac arrest at home and was brought to the Medical Center - University of Freiburg by helicopter after first responder resuscitation. (press-news.org)
These pump systems more recently have allowed the use of cardiac grafts retrieved from donors after cardiac arrest. (msdmanuals.com)

Neutral impact on systolic and diastolic cardiac function of 2 years of intensified multi-intervention in type 2 diabetes: The randomized controlled Asker and Bærum Cardiovascular Diabetes (ABCD) study. (uib.no)

Reperfusion treatment has a potential risk of worsening tissue damage after ischemia, which can accelerate the deterioration of cardiac function [ 2 ]. (hindawi.com)

Moreover, Aspn-/- mice displayed increased fibrosis and decreased cardiac function after pressure overload by transverse aortic constriction (TAC) in mice. (beaumont.org)
Donor pre-treatment with S-NO-HSA lead to reduced fibrosis and preservation of myocardial miR-126-3p and GATA2 levels in murine cardiac isografts 60 days after transplantation. (frontierspartnerships.org)

DCM is a cardiac pathological condition in patients with DM characterized by the appearance of aberrant myocardial morphology and cardiac functions in the truancy of other factors, such as coronary artery disease, hypertension, and prominent valvular disease [ 3 ] . (encyclopedia.pub)
Our data identify a specific reactive oxygen species→ASK1→p38-MAPK pathway in the heart and establish that ASK1 inhibitors protect the heart from hypertension-induced cardiac remodeling. (ox.ac.uk)

When ischemia is severe and prolonged, it causes myocyte death and results in loss of contractile function and tissue infarction. (medscape.com)
Cells Lesinurad sodium ischemia is a major medical problem that may occur in a number of organs such as the heart (e.g. cardiac infarction), mind (e.g. ischemic stroke), and pores and skin (e.g. pressure ulcer). (monthion.com)

Thus, targeting the ASK1→p38-MAPK nexus has potential therapeutic viability as a treatment for hypertensive heart disease. (ox.ac.uk)

Multicenter cohort study of patients with acute ischemic stroke who underwent a brain computed tomography perfusion and were scheduled to undergo reperfusion therapy. (medscape.com)
Migraine is likely to increase individual vulnerability to ischemic stroke during the process of acute brain ischemia and might represent, therefore, a potential new therapeutic target against occurrence and progression of the ischemic damage. (medscape.com)
Based on these premises, taking advantage of the reliability of computed tomography perfusion (CTP) imaging in the estimation of cerebral tissue viability in both clinical and research settings, [ 4 ] we conducted a case-control study comparing CTP maps of migraineurs and nonmigraineurs patients with acute ischemic stroke aimed at investigating whether a personal history of migraine is associated with vulnerability to brain ischemia. (medscape.com)

After thrombolytic therapy, reperfusion arrhythmias, such as an accelerated idioventricular rhythm (AIVR), may occur. (medscape.com)

Potential sequelae of ischemia. (medscape.com)

Cell survival during ischemia/reperfusion is governed by HIF-1α-dependent genes such as heme oxygenase-1, inducible nitric oxide synthase, cyclooxygnease-2, and vascular endothelial growth factor. (springeropen.com)

STA reversed the decrease in cell viability and increased LDH release in H9c2 cells with the H/R insult. (biomedcentral.com)
SIRT1 and Nrf2 involved the protective effect of STA in H/R-exposed H9c2 cells, as the changes in cell viability and caspase-3 activity by STA can be reversed by SIRT1 inhibitor EX-527 or Nrf2 siRNA. (biomedcentral.com)

Serum cardiac troponin I (cTnI), and creatine kinase MB (CK-MB) were measured. (springeropen.com)

miR-21 was found to be highly deregulated in mouse cardiac tissue after cardiac ischemic preconditioning [ 12 ]. (hindawi.com)

The profound damage, however, occurs during the reperfusion phase. (monthion.com)
Ischaemic reperfusion (I/R) occurs during surgical procedures, including hepatic resection and liver transplantation (LT) [ 1 ]. (ijbs.com)

Evaluation of a multi-view autostereoscopic real-time 3D ultrasound system for minimally invasive cardiac surgery guidance. (uib.no)
Aortic valve (AV) disease presents critical situations requiring surgery in over 2% of the US population and is increasingly the reason for cardiac surgery. (stanford.edu)

Heart failure is accompanied by adverse cardiac remodeling involving extracellular matrix (ECM). (beaumont.org)
Thus, we establish the role of ASPN as a critical ECM molecule that regulates cardiac remodeling to preserve heart function. (beaumont.org)
2004) whilst unwanted effects of Lesinurad sodium CxHC activity on cell viability have already been reported in types of heart stroke (Cotrina et al. (monthion.com)
In this review, we summarize the biological function of MG53 with its potential mechanisms in cardiac tissue (Fig. 1 ), discuss current debates regarding the role of MG53 in diabetic cardiomyopathy (Table 1 ), and potential clinical applications of recombinant MG53 protein in the management and treatment of heart diseases (Table 2 ). (biomedcentral.com)
Adult stem cells remain of particular interest as therapeutic agents for cardiac regeneration in ischemic heart disease [ 1 - 4 ]. (biomedcentral.com)
Therefore, we propose to investigate the effect of varying NaHS concentrations on heart cell viability. (gotomydoctor.com)
Although the mechanism of action of volatile anesthetics remains unclear in these preliminary studies, their inhibitory effect on ischemia-induced adhesion of PMNs may be beneficial for the heart during general anesthesia. (silverchair.com)
Although a recent joint society scientific statement (the American Association of Cardiovascular Pulmonary Rehabilitation, the American Heart Association, and the American College of Cardiology) suggests home-based cardiac rehab (CR) is appropriate for low- and moderate-risk patients, there are no paradigms to define such individuals with coronary heart disease. (journaltocs.ac.uk)
With ischemia in coronary heart disease, impairment of the oxygen supply and metabolic disorder both occur [ 2 ]. (biomedcentral.com)
60 years and have normal cardiac and pulmonary function and no history of coronary artery disease or other heart disorders. (msdmanuals.com)

Myocardial ischemia is a clinical syndrome manifesting a variety of tissue effects and global cardiac effects that impair cardiac function. (medscape.com)
In vivo (C57Bl/6J mice with osmotic minipumps for drug delivery), selonsertib (4 mg/[kg·d]) alone did not affect cardiac function/dimensions (assessed by echocardiography). (ox.ac.uk)
Short periods of myocardial ischemia are often associated with incomplete recovery of contractile function during reperfusion, despite complete preservation of cellular integrity. (silverchair.com)
10. Sasayama S, Nonogi H , Asanoi H, Yamanishi K, Kawai C: Effects of nifedipine on pacing-induced ischemia:modification of regional myocardial function and coronary hemodynamics. (fiercecert.com)

Overexpression of the kinase-deficient TGF-B receptors (TGF-BRII) resulted in serum-induced cardiac myocyte cell cycle entry as well as an amplification of FGF-2 induced S phase entry (13 fold versus 3 fold with FGF-2 alone). (umanitoba.ca)

It is very important to lower the body temperature of the patients as quickly as possible in order to slow down metabolic processes," explains the Freiburg cardiac surgeon, who published the study together with colleagues from Yale University, USA, and Max Planck Institute for Metabolic Research, Germany. (press-news.org)

The research described in this thesis is focussed on developing and testing multiple strategies to regulate cardiac myocyte protection and regeneration in an effort to provide the basis for novel treatments and/or prevention of cardiac disease. (umanitoba.ca)
In conclusion, my doctoral studies have provided substantial evidence that regulating the FGF-2 axis can be used as a means to exploit the effects of FGF-2 on cardioprotection and cardiac myocyte regeneration in an effort to provide the basis for novel treatments and prevention strategies for cardiac disease. (umanitoba.ca)
Moreover, the automatically generated CP shows equal cardiac regeneration potential in vivo. (biomedcentral.com)
To create an experimental model of associated comorbidities, for healing and regeneration studies, protocols for induction of nephropathy by ischemia and reperfusion (I/R) and induction of DM by injection of streptozotocin (STZ) were associated. (scielo.br)

05) and an identical reduction resulted when sevoflurane (1 MAC) was applied only with the onset of reperfusion. (silverchair.com)

Patients' demographics, perioperative clinical factors, and pre- and intraoperative PaCO2 data after reperfusion were collected and analyzed. (bvsalud.org)

ASK1 was activated during ischemia in adult rat hearts, but not on reperfusion, consistent with activation by moderate (not high) reactive oxygen species levels. (ox.ac.uk)

this change was not completely reversible during the 10-minute reperfusion period. (curehunter.com)

Anatomy26

Organisms14

Diseases40

Chemicals and Drugs86

Analytical, Diagnostic and Therapeutic Techniques and Equipment50

Phenomena and Processes43

Disciplines and Occupations1

Health Care6

Oxidative Stress8

Cardiomyocytes4

Myocytes14

Injury43

Myocardium9

Myocardial infarction1

Infarct size2

Mitochondrial2

Apoptosis2

Cerebral ischemia2

Hypoxia3

Mitochondria1

Tissues4

Coronary artery occlusion1

Vitro1

Left ventricular2

Cardiomyocyte2

Necrosis2

Arrest10

Systolic1

Deterioration1

Fibrosis2

Hypertension2

Infarction2

Potential therapeutic1

Acute3

Arrhythmias1

Sequelae1

Endothelial1

H9c22

Troponin1

Mouse cardiac1

Occurs2

Surgery2

Heart10

Function4

Kinase1

Metabolic1

Regeneration4

Reduction1

Clinical1

Adult rat hearts1

Reversible1