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  • blood
  • A team of researchers at the National Cancer Institute (NCI), part of the National Institutes of Health (NIH), has uncovered a set of genes that are turned on, or expressed, at high levels only in the blood vessels that feed tumors in mice and humans. (nih.gov)
  • These genes, and the proteins they encode, are important new potential targets for novel drugs that could selectively cut off a tumor's blood supply without affecting the blood vessels of healthy tissues, overcoming one of the major concerns of current anticancer therapies targeted at blood vessel growth. (nih.gov)
  • The growth of blood vessels, a process known as angiogenesis, is a normal process in the body that is essential for organ growth and repair. (nih.gov)
  • In many diseases, including most forms of cancer, this carefully regulated process becomes imbalanced, and normal blood vessel growth is redirected toward supplying nutrients and oxygen to feed diseased tissue, destroy normal tissues, and in the case of cancer, allow tumor cells to escape and travel to distant sites in the body. (nih.gov)
  • Researchers have tried to stop disease-related angiogenesis by identifying the molecules that stimulate blood vessel and developing new drugs to block their action. (nih.gov)
  • However, blocking angiogenesis requires a delicate balance between tumor and normal cells as most angiogenesis-related molecules are also critical for normal blood vessel growth in the body - for example, during menstruation, pregnancy, or tissue repair. (nih.gov)
  • They found that the CD276 protein was overexpressed in tumor-associated blood vessels from colon, lung, breast, esophageal and bladder cancers. (nih.gov)
  • In addition, the protein was also found to be frequently overexpressed by the tumor cells themselves, indicating that a suitable inhibitory molecule might be able to deliver a double blow -- one to the tumor cells themselves and the other to the blood vessels that feed them. (nih.gov)
  • These studies demonstrate that CD276 is overexpressed in the blood vessels of a variety of human cancers," says St. Croix. (nih.gov)
  • Therefore, it may be an important target for the development of new drugs that can selectively home in on blood vessels associated with disease. (nih.gov)
  • Small' blood vessels contributing to angina? (medhelp.org)
  • Follow-up of post of 7/3 on "small" blood vessels. (medhelp.org)
  • What causes the blood vessels to bleed sometimes? (medhelp.org)
  • popped blood vessels. (medhelp.org)
  • Broken blood vessels? (medhelp.org)
  • Broken blood vessel Whenever I was crying (histerically), small red dots suddenly appear. (medhelp.org)
  • The effects may range from a change in blood pressure to an interruption in circulation , depending on the nature and degree of the misplacement and which vessels are involved. (wikipedia.org)
  • The general structure of lymphatics is based on that of blood vessels . (wikipedia.org)
  • Drugs that inhibit a hormone that constricts blood vessels also help improve sodium excretion in blacks who hold onto too much sodium in the face of stress, investigators report. (news-medical.net)
  • In a report in The American Journal of Pathology investigators describe the generation of a successful novel transgenic rat model that accumulates amyloid specifically in brain blood vessels and strongly mimics many of the associated detrimental changes that are observed in humans - a condition known as cerebral amyloid angiopathy, which is also commonly observed in Alzheimer disease. (news-medical.net)
  • Can targeting the red blood cells and blood vessels jointly keep our brains healthy and prevent dementia? (news-medical.net)
  • It can also improve vasodilation -- the widening of blood vessels, -- in the long-term, according to a study by researchers in Japan. (news-medical.net)
  • The blood vessels are the part of the circulatory system , and microcirculation , that transports blood throughout the human body . (wikipedia.org)
  • A few structures (such as cartilage and the lens of the eye) do not contain blood vessels and are labeled. (wikipedia.org)
  • Blood vessels are part of the circulatory system, together with the heart and the blood. (wikipedia.org)
  • Blood vessels function to transport blood . (wikipedia.org)
  • Blood vessels also circulate blood throughout the circulatory system Oxygen (bound to hemoglobin in red blood cells ) is the most critical nutrient carried by the blood. (wikipedia.org)
  • Blood vessels do not actively engage in the transport of blood (they have no appreciable peristalsis ). (wikipedia.org)
  • Three blood-vessels are concerned in the circulation of the liver . (chestofbooks.com)
  • Two carry blood to it - the hepatic artery and the portal vein - while the third, the hepatic vein, returns the blood which has circulated through the gland to the posterior vena cava, which it joins just before that vessel perforates the diaphragm to discharge its blood into the right auricle of the heart. (chestofbooks.com)
  • From these, minute branches are given off which enter the lobules and there form a net- work of capillary vessels ramifying among the cells (2, 2, fig. 90), and then, after uniting and reuniting, form a blood-vessel which runs down the centre of the lobule and is known as the intralobular vein (1, fig. 90). (chestofbooks.com)
  • Great vessels are the large vessels that bring blood to and from the heart. (wikipedia.org)
  • Components
  • Systems that incorporate nuclear components are found almost mostly onboard military vessels due to the regulations limiting distribution and ownership of the radioactive fuels used to power the plants. (wikipedia.org)
  • carry
  • Lymph vessels that carry lymph to a lymph node are called afferent lymph vessels, and those that carry it from a lymph node are called efferent lymph vessels, from where the lymph may travel to another lymph node, may be returned to a vein, or may travel to a larger lymph duct . (wikipedia.org)
  • body
  • Generally, lymph flows away from the tissues to lymph nodes and eventually to either the right lymphatic duct or the largest lymph vessel in the body, the thoracic duct . (wikipedia.org)
  • smaller
  • These were generally smaller vessels, often cutters and luggers, that the Navy used for duties ranging from carrying despatches and passengers to convoy escort, particularly in British coastal waters, and reconnaissance. (wikipedia.org)
  • time
  • He felt that a good officer would be wasting his time in such vessels, while a bad officer should not be allowed to serve in them. (wikipedia.org)
  • cells
  • A vessel element is then a dead cell, but one that still has a function, and is still being protected by surrounding living cells. (wikipedia.org)
  • Vessel-like cells have also been found in the xylem of Equisetum (horsetails), Selaginella (spike-mosses), Pteridium aquilinum (bracken fern), Marsilea and Regnellidium ( aquatic ferns ), and the enigmatic fossil group Gigantopteridales . (wikipedia.org)
  • University
  • In 2007, the University of Oklahoma, through the state's Centennial Celebration, awarded the Vessels Heisman statue to Cleveland, Oklahoma, where it sits across from Cleveland High School in front of the school's gymnasium and event center. (wikipedia.org)
  • container
  • The German-flagged container vessel Hansa Stavanger was captured about 400 miles off the southern Somali port of Kismayu on April 4 with 14 Filipinos, five Germans, three Russians and two Ukranians on board. (ibtimes.com)
  • name
  • Communicating vessels is a name given to a set of containers containing a homogeneous fluid: when the liquid settles, it balances out to the same level in all of the containers regardless of the shape and volume of the containers. (wikipedia.org)