• Thus, the present double-blind, randomized study was designed to test the hypothesis that long-term, 6-month supplementation of L-arginine, the precursor of the endothelium-derived vasodilator NO, reverses coronary endothelial dysfunction to acetylcholine in humans with nonobstructive coronary artery disease. (nih.gov)
  • Thus, the present study was designed to test the hypothesis that long-term oral l -arginine supplementation for 6 months reverses coronary endothelial dysfunction in response to acetylcholine in humans with nonobstructive coronary artery disease. (ahajournals.org)
  • The purpose of this study is to determine whether people infected with HIV have worse blood vessel function than people without HIV infection. (clinicaltrials.gov)
  • H-N ) Increased branching and filopodia extension in E11.5 dll4 +/− hindbrain vessels compared with wild-type. (pnas.org)
  • To exclude the possibility that the defects observed in vessel branching were secondary to other defects in the embryo, e.g., disrupted blood flow, we cultured aortic explants from dll4 +/− and wild-type mice in collagen gels. (pnas.org)
  • The scanning electron micrograph shows pericytes wrapping their processes around a small blood vessel (a post-capillary venule) in the mammary gland of a cat. (nih.gov)
  • Evaluation of a transgenic zebrafish model showed that both Rab4 and Rab11a are functionally required for blood vessel formation and animal viability. (mdpi.com)
  • High-dose endothelial-monocyte activating polypeptide II (EMAP-II), a tumor-derived antiangiogenic cytokine, can sensitize tumor vasculature to the damaging activity of high-dose tumor necrosis factor (TNF)-α. (aacrjournals.org)
  • Coadministration of 0.1 ng of EMAP-II and 0.1 ng of CNGRCG-TNF (NGR-TNF), a peptide-TNF conjugate able to target tumor blood vessels, inhibited lymphoma and melanoma growth in mice, with no evidence of toxicity. (aacrjournals.org)
  • Here we show that Dll4 regulates vessel branching during development by inhibiting endothelial tip cell formation. (pnas.org)
  • Taken together, these data reveal Dll4 as a negative regulator of vascular sprouting and vessel branching that is required for normal vascular network formation during development. (pnas.org)
  • Sprouting from dll4 +/− aortas occurred earlier and more profusely than from wild-type aortas ( Fig. 1 E-G ), indicating that the dll4 +/− vessel defect is intrinsic to ECs and independent of alterations to flow or cardiac output. (pnas.org)
  • Loss of Lama4 leads to increased filopodia formation, tip cell numbers and consequently increased vessel density, resembling the phenotype of disturbed Dll4/Notch signalling. (ucl.ac.uk)
  • For growth factors, we present a mathematical model integrating molecular reactions on blood vessels with tissue-level diffusion. (aimsciences.org)
  • Cancerous tissue is as dependent on a blood supply as is normal tissue, and this has led to a surge of interest in endothelial cell biology. (nih.gov)
  • We show that bifurcated fluid flow (BFF) that arises only at the base of a vessel bifurcation and is characterized by stagnation pressure of ∼38 dyn cm −2 and approximately zero shear stress induces significant decrease in EC permeability compared to the static control condition in a nitric oxide (NO)-dependent manner. (rsc.org)