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Chromaffin CellsChromaffin SystemChromaffin GranulesAdrenal MedullaCatecholaminesAdrenal GlandsExocytosisCattleSynaptic VesiclesSecretory VesiclesChromograninsPhenylethanolamine N-MethyltransferaseChromogranin ACalciumDopamine beta-HydroxylaseCytoplasmic VesiclesTransport VesiclesVeratridineDigitoninCells, CulturedSeminal VesiclesDimethylphenylpiperazinium IodideNicotineMuscarineCell MembraneTyrosine 3-MonooxygenaseKineticsPara-Aortic BodiesEnterochromaffin CellsNorepinephrineElectric CapacitancePC12 CellsEpinephrineEnkephalin, MethionineCytoplasmic GranulesMicroscopy, ElectronMembrane FusionMembrane PotentialsVesicular Transport ProteinsReceptors, NicotinicCalcium ChannelsNerve Tissue ProteinsBariumIntracellular MembranesPotassiumPheochromocytomaEnkephalinsCell Membrane PermeabilitySynaptosomal-Associated Protein 25Patch-Clamp TechniquesChromogranin BBiological TransportNeuropeptidesEndocytosisSplanchnic NervesProteidaeAcetylcholinePituitary Adenylate Cyclase-Activating PolypeptideSynaptotagminsElectrochemistryNicotinic AntagonistsReserpineSynaptotagmin IAdenosine TriphosphateAnnexin A7Adrenal Gland NeoplasmsCytosolNeurosecretionCOP-Coated VesiclesCell FractionationLiposomesTetanus ToxinTetrabenazineCalcium Channel BlockersElectrophysiologyCalcium RadioisotopesFlunarizineSNARE ProteinsFura-2Qa-SNARE ProteinsMolecular Sequence DataMunc18 ProteinsWasp VenomsEgtazic AcidNeurotransmitter AgentsPyridinium CompoundsAmino Acid SequenceFluorescent Dyesrab3A GTP-Binding ProteinClathrin-Coated VesiclesBotulinum ToxinsAmbystomatidaeHexamethonium CompoundsAdrenal CortexR-SNARE ProteinsCalcium SignalingSyntaxin 1Ganglia, SympatheticNeuronsSpider Venoms
Plasma membraneMembraneGranulesCytoplasmicExocytosis in adrenal chromaffin cellsSecretory vesicleProteinsDenseExtracellularNeuroendocrine cellsAdrenal MedullaCatecholaminesSecretionSingle vesicleNeuronalDocking and exocytosisProteinEndosomesCatecholamine releaseSNAREMorphologicalTissuesRegulateHippocampal NeuronsPathwaysAmperometryCytoplasmSynapseMoleculesFusionIntracellularDynamicsBiologyFissionPARAGANGLIAMitochondriaMammalianReadily releasable poolEndocrineNeurosecretory cellsTumorActinReceptorsReleaseBiophysical
Plasma membrane15
  • Docking to the plasma membrane prepares vesicles for rapid release. (rupress.org)
  • In Caenorhabditis elegans motor neurons, dense core vesicles dock at the plasma membrane but are excluded from active zones at synapses. (rupress.org)
  • Dense core vesicles are usually found in the cytoplasm and these cytoplasmic vesicles must presumably translocate to the plasma membrane before release ( Zupanc, 1996 ). (rupress.org)
  • Our discoveries have led to a deep understanding of how secretory vesicles interact with the cortical actin network prior to fusing with the plasma membrane to release the neurotransmitter. (edu.au)
  • We have identified a critical role of the phospholipid phosphatidylinositol (4,5) bisphosphate in coordinating the actin-mediated recruitment of secretory vesicles to the plasma membrane. (edu.au)
  • This active mechanism allows secretory vesicles to dock with the plasma membrane prior to fusion and is controlled by the effector cdc42. (edu.au)
  • This novel trafficking/chaperoning pathway underpins neurotransmission, as secretory vesicles rely on the zippering of SNARE proteins such as syntaxin-1 to undergo fusion with the plasma membrane. (edu.au)
  • Following exocytosis, the process of endocytosis is required for neurons to replenish their pools of synaptic vesicles by pinching off vesicles from the plasma membrane. (edu.au)
  • We demonstrated that Munc18-1 and syntaxin-1A and are organised in nanodomains on the plasma membrane of neurons and neurosecretory cells that control SNARE-dependent neuroexocytosis through lateral trapping in these nanoclusters. (edu.au)
  • Actin dynamics provides membrane tension to merge fusing vesicles into the plasma membrane. (ki.se)
  • Synaptic transmission is mediated by fusion of synaptic vesicles with presynaptic plasma membrane to release neurotransmitter inside the vesicles. (uic.edu)
  • V-ATPase is ubiquitously expressed and is present in endomembrane organelles such as vacuoles, lysosomes, endosomes, the Golgi apparatus, chromaffin granules and coated vesicles, as well as in the plasma membrane. (nih.gov)
  • Transporters on the plasma membrane of tumor cells are promising molecular "Trojan horses" to deliver drugs and imaging agents into cancer cells. (aspetjournals.org)
  • Sabine Hilfiker Neurosecretion involves fusion of vesicles with the plasma membrane. (biologists.com)
  • N. Morel ABSTRACT Synaptic vesicle docking and exocytosis require the specific interaction of synaptic vesicle proteins (such as VAMP/ synaptobrevin ) with presynaptic plasma membrane proteins (such as syntaxin and SNAP 25). (biologists.com)
Membrane17
  • The neurotransmitter molecules are stored in the first cell in packages known as vesicles, which release their contents by fusing with the cell membrane. (elifesciences.org)
  • Neurons can release small molecule neurotransmitters very rapidly in part because synaptic vesicles are docked to the membrane at active zones. (rupress.org)
  • We have identified a novel mechanism by which dynamin and actin coordinate a series of membrane events that culminate in the formation of bulk endosomes from which new synaptic vesicles emanate at the neuromuscular junction. (edu.au)
  • Liquid-liquid phase separation in cells has emerged as a common principle for the organization of membrane-less compartments. (ki.se)
  • Meeting-Abstract: Loss of Myosin II Function Reduces the Efficiency of Membrane Scission by Making Vesicle Closure Incomplete. (us.es)
  • The stimulus (O2, CO2, PH) depolarizes the cell membrane blocking K channels, this reduction in cell membrane potential opens voltage gated Calcium channels and the increase in Calcium concentration causes exocytosis of vesicles containing neurotransmitters. (khanacademy.org)
  • Gong LW, Alvarez de Toledo G, Lindau M. Exocytotic catecholamine releaae is not associated with cation flux through channels in the vesicle membrane but Na+ influx through the fusion pore. (uic.edu)
  • Gong LW, Hafez I, Alvarez de Toledo G, and Lindau M. Secretory vesicles membrane area is regulated in tandem with quantal size in chromaffin cells. (uic.edu)
  • However, the presence of functional classical nuclear recep-tors on cell membrane has been described (Watson et al. (drugstodaypdf.com)
  • Vesicles formed when cell-membrane coated pits (COATED PITS, CELL-MEMBRANE) invaginate and pinch off. (lookformedical.com)
  • Specialized regions of the cell membrane composed of pits coated with a bristle covering made of the protein CLATHRIN. (lookformedical.com)
  • An adaptor protein complex primarily involved in the formation of clathrin-related endocytotic vesicles (ENDOSOMES) at the CELL MEMBRANE. (lookformedical.com)
  • They perform functions such as binding to the cell membrane, capturing cargo molecules and promoting the assembly of CLATHRIN. (lookformedical.com)
  • A network of membrane compartments, located at the cytoplasmic side of the GOLGI APPARATUS, where proteins and lipids are sorted for transport to various locations in the cell or cell membrane. (lookformedical.com)
  • They play a role in the intracellular transport of molecules contained within membrane vesicles. (lookformedical.com)
  • Such membrane fusion is mediated by the SNARE complex, which is composed of the vesicle-associated protein synaptobrevin (VAMP2), and the plasma. (biologists.com)
  • Squalene bearing 18-crown-6 was synthesized and formed unilamellar vesicles with a membrane thickness of about 6 nm and a diameter of about 0.32 μm. (ebsco.com)
Granules2
Cytoplasmic2
  • However, the addition of NGF to the culture medium induces a phenotypic change in chromaffin cells that results in the extension of neuritic processes and a decrease in the size of their cytoplasmic dense-core vesicles. (elsevierpure.com)
  • Cytoplasmic vesicles formed when COATED VESICLES shed their CLATHRIN coat. (lookformedical.com)
Exocytosis in adrenal chromaffin cells1
Secretory vesicle3
  • Ketotifen is a microglial stabilizer by inhibiting secretory vesicle acidification. (us.es)
  • Mouse chromaffin cells (MCCs) lacking MUNC18-1 show impaired secretory vesicle docking, but also mistargeting of SNARE protein syntaxin1 and an abnormally dense submembrane F-actin network. (amsterdamumc.org)
  • The abnormally dense F-actin network in Munc18-1-deficient cells is not a rate-limiting barrier in secretory vesicle docking or fusion.This article has an associated First Person interview with the first author of the paper. (amsterdamumc.org)
Proteins12
  • More than 90% of extracellular miRNAs are vesicle-free, but form a complex with proteins such as Agonaute2 (AGO2) ( 22 , 23 ). (frontiersin.org)
  • Chromogranins are the main soluble proteins in the large dense core secretory vesicles (LDCVs) found in aminergic neurons and chromaffin cells. (nih.gov)
  • These data demonstrate that although chromogranins regulate the amine concentration in LDCVs, they are not completely essential, and other proteins unrelated to neurosecretion, such as fibrinogen, might compensate for their loss to ensure that vesicles are generated and the secretory pathway conserved. (nih.gov)
  • CAPS function in dense core vesicle docking parallels UNC-13 in synaptic vesicle docking, which suggests that these related proteins act similarly to promote docking of independent vesicle populations. (rupress.org)
  • Hearing depends on faithful synaptic transmission at the inner hair cell (IHC) ribbon synapse, which is orchestrated by active zone proteins. (uni-goettingen.de)
  • Vesicle fusion is thought to be mediated by SNARE proteins, and actin, clathrin and dynamin are believed to be essential for clathrin-mediated endocytosis. (uic.edu)
  • A class of proteins involved in the transport of molecules via TRANSPORT VESICLES. (lookformedical.com)
  • The outer surface of these vesicles are covered with a lattice-like network of coat proteins, such as CLATHRIN, coat protein complex proteins, or CAVEOLINS. (lookformedical.com)
  • A family of proteins that play a role as cofactors in the process of CLATHRIN recycling in cells. (lookformedical.com)
  • A broad category of proteins involved in the formation, transport and dissolution of TRANSPORT VESICLES. (lookformedical.com)
  • Our present understanding of asynchronous exocytosis presents us with an uncertain image, consisting of a wide array of mechanisms, primarily based largely on Ca2+ influx from an external source with vesicle proteins because the target (Smith et al. (nicotinic-receptor.com)
  • In the tumor microenvironment, cell migration and invasion are regulated by many factors such as intracellular signaling pathways, growth factors or onco-proteins [ 2 ]. (oncotarget.com)
Dense10
  • Further work was done in chromaffin cells to investigate catecholamine release from large dense core vesicles. (wikipedia.org)
  • Here, we describe a mechanism for dense core vesicle docking in neurons. (rupress.org)
  • We have found that the calcium-activated protein for secretion (CAPS) protein is required for dense core vesicle docking but not synaptic vesicle docking. (rupress.org)
  • In contrast, we see that UNC-13, a docking factor for synaptic vesicles, is not essential for dense core vesicle docking. (rupress.org)
  • Overexpression of open syntaxin can bypass the requirement for CAPS in dense core vesicle docking. (rupress.org)
  • Thus, CAPS likely promotes the open state of syntaxin, which then docks dense core vesicles. (rupress.org)
  • In addition to synaptic vesicles, neurons also contain secretory vesicles, called dense core vesicles, that release neuropeptides and catecholamines ( Burgoyne and Morgan, 2003 ). (rupress.org)
  • How do neurons differentially regulate synaptic vesicle and dense core vesicle release? (rupress.org)
  • One possible explanation for the bashfulness of dense core vesicles is that they are not docked. (rupress.org)
  • Gong LW, Di Paolo G, Diaz E, Cestra G, Diaz ME, Lindau M, De Camilli P, Toomre D. Phosphatidylinositol phosphate kinase type I gamma regulates dynamics of large dense-core vesicle fusion. (uic.edu)
Extracellular8
  • Extracellular circulating miRNAs are also observed outside the cell, but their origin is poorly understood. (frontiersin.org)
  • miRNAs are transcribed within cells, but are also found outside cells, called extracellular miRNAs. (frontiersin.org)
  • Extracellular miRNAs were observed in cell culture system ( 6 ), in blood plasma and serum ( 7 - 10 ), and in other biological fluids ( 11 ) including cerebrospinal fluid ( 12 ), saliva ( 13 ), breast milk, urine, and tears ( 14 ). (frontiersin.org)
  • The existence of extracellular miRNAs suggests that they participate in cell-to-cell communication. (frontiersin.org)
  • Although extracellular miRNAs are believed to contribute to cell-to-cell communication, the mechanisms by which miRNAs are released are still not understood. (frontiersin.org)
  • Extracellular miRNAs have been considered as byproducts or artifacts caused by cell lysis and cell death. (frontiersin.org)
  • In addition, it also regulated the extracellular secretion of Hsp90α to promote tumor cell migration and invasion. (oncotarget.com)
  • Exosomes, characterized by a size of 30-100 nm in diameter, have been viewed as secreted vesicles that enable extracellular communications [ 4 - 6 ] and have played an important role in tumor progression and metastasis by promoting the extracellular matrix degradation and also by remodeling to establish the metastasis niche [ 7 , 8 ]. (oncotarget.com)
Neuroendocrine cells6
Adrenal Medulla1
Catecholamines1
  • The biosynthesis and storage of catecholamines in chromaffin cell tumors may differ from the biosynthesis and storage in the normal medulla. (medscape.com)
Secretion4
  • Nicotinic receptor-mediated catecholamine secretion from individual chromaffin cells. (wikipedia.org)
  • Because of its potential importance in acinar cell digestive enzyme secretion Rab3 is an important subject for review. (pancreapedia.org)
  • Rab3 isoforms have been identified in different tissues and cell types where it has been suggested to play a role in secretion (Table 1). (pancreapedia.org)
  • echolamine secretion and exocytosis kinetics was studied in perfused rat adrenals and in cultured bovine chromaffin echolamines. (drugstodaypdf.com)
Single vesicle1
  • Dernick G, Gong LW, Tabares L, Alvarez de Toledo G, Lindau M. Patch amperometry: high-resolution measurements of single-vesicle fusion and release. (uic.edu)
Neuronal3
  • Deciphering the intra- and intermolecular steps via which prepare secretory vesicles for fusion is key to understanding neuronal and hormonal communication. (edu.au)
  • Papel del Mastocito en la Activaci n Microglial y Func n Sin ptica Neuronal. (us.es)
  • Because of the presence of multiple forms of Rab3 in neuronal cells, the group of T. Sudhof prepared a mouse model in which all four isoforms of Rab3 were deleted. (pancreapedia.org)
Docking and exocytosis1
Protein9
  • have shown that another protein, synaptotagmin 7, also has a key role in the replenishment of synaptic vesicles, possibly as a sensor for calcium ions. (elifesciences.org)
  • We are aiming at characterizing the signaling mechanisms that regulate the liquid-liquid phase transitions in the synaptic vesicle cycle, mitochondrial functions, and degradation pathways at nerve terminals to clarify how do they become affected at the early stages of neurodegenerative diseases and which molecular steps lead to protein aggregate formation. (ki.se)
  • An Endocytic Scaffolding Protein together with Synapsin Regulates Synaptic Vesicle Clustering in the Drosophila Neuromuscular Junction. (ki.se)
  • RESULTS: Changes were observed in aortic tissue and cultured vascular smooth muscle cells isolated from SHRs relative to WKYs, including more depolarized mitochondria, stronger CCE upon the addition of Ca, larger cytosolic Ca transients (cytosolic Ca concentration) or aortic ring contraction elicited by endoplasmic reticulum depletion and a significant increase in STIM1 protein expression but not of orai1. (bvsalud.org)
  • MUNC18-1 (also known as STXBP1) is an essential protein for docking and fusion of secretory vesicles. (amsterdamumc.org)
  • The main structural coat protein of COATED VESICLES which play a key role in the intracellular transport between membranous organelles. (lookformedical.com)
  • The outer surface of these vesicles is covered with a lattice-like network of the protein CLATHRIN. (lookformedical.com)
  • This acidification process is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. (nih.gov)
  • We detected protein levels of Rab3D in nine cancer cell lines and twelve types of clinical cancer specimens. (oncotarget.com)
Endosomes2
Catecholamine release1
SNARE1
  • 2016 ( Journal of Cell Biology ) we found that the Munc18-1 domain 3a hinge-loop controls syntaxin-1A engagement into the SNARE complex during priming. (edu.au)
Morphological1
  • Extra-Adrenal Chromaffin Cells of the Zuckerkandl Paraganglion: Morphological and Electrophysiological Study. (us.es)
Tissues3
  • 2000). and other molecules with estrogen activity have been widely The sites of action responsible for the rapid action of ste- studied in a variety of tissues including chromaffin cells roids are a source of controversy. (drugstodaypdf.com)
  • Understanding the molecular mechanisms governing mIBG transport in cancer and normal cells is a critical step for developing strategies to optimize the efficacy of 131 I-mIBG while minimizing toxicity in normal tissues. (aspetjournals.org)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Regulate2
  • MicroRNAs (miRNAs) are short non-coding RNAs that posttranscriptionally regulate gene expression inside the cell. (frontiersin.org)
  • in this way, vesicle-free miRNA may regulate cell-to-cell communication including the regulation of gene expression and cellular signaling. (frontiersin.org)
Hippocampal Neurons1
  • Proteoglycans involved in bidirectional communication between mast cells and hippocampal neurons. (us.es)
Pathways1
  • Here, we resolved Ca 2+ -dependent and Ca 2+ -independent synaptic vesicle (SV) replenishment pathways, and found that syt 7 plays a selective and critical role in the Ca 2+ -dependent pathway. (elifesciences.org)
Amperometry3
  • Amperometry is used in electrophysiology to study vesicle release events using a carbon fiber electrode. (wikipedia.org)
  • Unlike patch clamp techniques, the electrode used for amperometry is not inserted into or attached to the cell, but brought in close proximity of the cell. (wikipedia.org)
  • Despite their increased size, single-cell amperometry recordings from chromaffin cells showed that the amine content in these vesicles is reduced by half. (nih.gov)
Cytoplasm1
  • The pits are then internalized into the cytoplasm to form the COATED VESICLES. (lookformedical.com)
Synapse2
  • Kν10.1 opposes activity-dependent increase in Ca²⁺ influx into the presynaptic terminal of the parallel fibre-Purkinje cell synapse. (mpg.de)
  • Vesicle Clustering in a Living Synapse Depends on a Synapsin Region that Mediates Phase Separation. (ki.se)
Molecules2
  • We also developed a new technique sdTIM, Subdiffractional tracking of internalised molecules, to be able to visualise small synaptic vesicles in living hippocampal nerve terminals (Joensuu et al. (edu.au)
  • If chromaffin cell survival augments the trophic action of implant surgery and continues to provide a source of trophic molecules for a host sprouting response, then it might still be important to achieve the maximum amount of chromaffin cell survival possible. (elsevierpure.com)
Fusion4
  • In order to record vesicle fusion, a carbon fiber electrode is brought close to the cell. (wikipedia.org)
  • Following a fusion event, neurons must replenish their vesicle stocks to ensure that they are ready for the arrival of the next action potential. (elifesciences.org)
  • Because of the importance of Munc18-1 in vesicle fusion, human mutations are linked to epilepsy and other neurological symptoms. (edu.au)
  • Exocytosis from chromaffin cells: hydrostatic pressure slows vesicle fusion. (mpg.de)
Intracellular4
  • Mosharov E, Gong LW, Khanna B, Sulzer D, Lindau M. Intracellular patch electrochemistry, a technique to measure intracellular metabolites in single cells: regulation of cytosolic catecholamine in chromaffin cells. (uic.edu)
  • 17␤-Estradiol reduced the intracellular free cells. (drugstodaypdf.com)
  • V-ATPase is an enzyme transporter that functions to acidify intracellular compartments in eukaryotic cells. (nih.gov)
  • 2004), exactly where we discovered quantal, focal Ca2+ release events by means of ryanodine receptors (RyRs) from intracellular Ca2+ shops which were similar to Ca2+ sparks in muscle cells (Cheng et al. (nicotinic-receptor.com)
Dynamics1
  • This super-resolution technique was able to capture, and subsequently analyse, the dynamics of thousands of individual synaptic vesicle trajectories, to uncover the dynamics of synaptic vesicle pool mobility. (edu.au)
Biology1
Fission1
  • A New Role for Myosin II in Vesicle Fission. (us.es)
PARAGANGLIA1
Mitochondria1
Mammalian1
  • Some chromaffin cells do survive when transplanted intraparenchymally into the rat models of Parkinson's disease but exhibit very poor survival in other mammalian species. (elsevierpure.com)
Readily releasable pool1
  • For example, the replenishment of synaptic vesicles (SV) in the readily releasable pool (RRP), which can be exhausted during high frequency stimulation (HFS), plays a critical role in determining the rate and degree of short-term synaptic depression ( Wang and Kaczmarek, 1998 ). (elifesciences.org)
Endocrine2
  • Rab3B and 3 D have been found in exocrine, endocrine, epithelial and adipose cells (60). (pancreapedia.org)
  • Chromaffin cells survive capriciously and continue to exhibit their endocrine phenotype when cultured in the absence of nerve growth factor (NGF). (elsevierpure.com)
Neurosecretory cells3
  • Our lab focuses on the molecular events that govern vesicular trafficking within presynaptic nerve terminals and neurosecretory cells. (edu.au)
  • This has allowed us to probe the nanoscopic environment of neurons and neurosecretory cells undergoing communication. (edu.au)
  • 2006) due within this case for the opening of variety 2 ryanodine receptors (RyR2s), and once again we designated them syntillas as the ACCs are neurosecretory cells. (nicotinic-receptor.com)
Tumor3
  • mIBG enters cancer cells through the norepinephrine transporter (NET) where the radioactive decay of 131 I causes DNA damage, cell death, and tumor necrosis. (aspetjournals.org)
  • Here, we reported that the expression levels of Rab3D were dysregulated in cancer cells and highly correlated with tumor malignancies in the clinical samples. (oncotarget.com)
  • Increased expressions of Rab3D led to tumor invasion in vitro and lung metastasis in vivo , whereas Rab3D knockdown suppressed the tumor cell motility. (oncotarget.com)
Actin3
  • We have recently uncovered a new mechanism that allows secretory vesicles to be recruited on the cortical actin network. (edu.au)
  • We identified a MUNC18-1 mutant (V263T in β-sheet 10) that fully restores syntaxin1 targeting but not F-actin abnormalities in Munc18-1-KO cells. (amsterdamumc.org)
  • MUNC18-2 and -3 (also known as STXBP2 and STXBP3, respectively), which lack the hydrophobic residue at position 263, also did not restore a normal F-actin network in Munc18-1-KO cells. (amsterdamumc.org)
Receptors4
  • These chemicals then diffuse across the gap between the neurons and bind to receptors on the second cell. (elifesciences.org)
  • Dar and Zinder, 1997) assessment of the nongenomic receptors, the so-called Mann- and PC-12 cells (Chen et al. (drugstodaypdf.com)
  • Schwann cells synthesize NGF and express an increase in NGF receptors following transection of a peripheral nerve, a response that facilitates survival and regeneration in the peripheral axons. (elsevierpure.com)
  • These pits are the entry route for macromolecules bound by cell surface receptors. (lookformedical.com)
Release5
  • Another technique used to measure vesicle release is capacitive measurements. (wikipedia.org)
  • This causes a spike, the size of which can be used to estimate the number of vesicles, and the frequency gives information about the release probability. (wikipedia.org)
  • Vesicle Shrinking and Enlargement Play Opposing Roles in the Release of Exocytotic Contents. (ki.se)
  • Intestinal and Peritoneal Mast Cells Differ in Kinetics of Quantal Release. (us.es)
  • To achieve accurate encoding of sounds, inner hair cell (IHC) ribbon-type synapses are highly specialized to release synaptic vesicles (SVs) with high rates and temporal precision. (uni-goettingen.de)
Biophysical2
  • We study the molecular and biophysical mechanisms underlying and regulating vesicle trafficking in neurons and in particular in their axons and presynaptic nerve terminals. (ki.se)
  • In my lab, we combine genetic and cell biological approaches with biophysical methods to investigate the mechanisms of exocytosis and endocytosis. (uic.edu)