• Many important developmental procedures including proliferation development patterning and differentiation need the cell routine to be carefully coordinated with several signaling pathways. (bioerc-iend.org)
  • The endocycle is certainly popular among multicellular microorganisms and it is associated with development and differentiation (e.g. nurse cells and follicular cells from the oocyte cyst). (bioerc-iend.org)
  • After implantation differentiation of trophoblast large cells which get excited about the remodeling from the maternal uterus during implantation is certainly achieved through many endocycles resulting in boosts of DNA articles up to 1000N (48). (bioerc-iend.org)
  • Fig. 1: Recapitulation of the mouse and human segmentation clocks in vitro by differentiation of pluripotent stem cells towards PSM fate. (nature.com)
  • In recent years, interest in the possible molecular regulators of cell proliferation and differentiation in a wide range of regeneration models has grown significantly, but the cell kinetics of this process remain largely a mystery. (mdpi.com)
  • DNA methylation and histone modifications play a central role in the epigenetic regulation of gene expression and cell differentiation. (cipsm.de)
  • In this Review, we briefly outline the roles that follicle-stimulating hormone (FSH) and testosterone play in regulating spermatogenesis and describe our current understanding of how vitamin A regulates germ cell differentiation and how it may lead to the generation of both the cycle of the seminiferous epithelium and the spermatogenic wave. (jci.org)
  • and the unique differentiation of haploid cells (spermiogenesis) (Figure 1 ). (jci.org)
  • Mosaic analyses reveal that Id2a function in facilitating both cell cycle progression and neuronal differentiation in the retina is non-cell-autonomous, suggesting that Id2a functions upstream of the extrinsic pathways that regulate retinogenesis. (biologists.com)
  • During the process, known as cellular differentiation, the zygote develops into pluripotent stem cells which can give rise to all of the different organs in the body. (activemotif.com.cn)
  • This picture is a metaphor for the decisions that need to be made in the development and differentiation of a cell. (activemotif.com.cn)
  • Many transitions in the business from the cell routine are found during early mammalian advancement. (bioerc-iend.org)
  • As in various other multicellular microorganisms including vertebrates mammalian advancement also starts by an activity called cleavage comprising some mitotic divisions without upsurge in embryo size. (bioerc-iend.org)
  • It is an essential structural component of mammalian cell membranes. (absoluteastronomy.com)
  • During cell growth and proliferation, ubiquitin plays an outsized role in promoting progression through the cell cycle. (intechopen.com)
  • Progression through the cell cycle is driven by the oscillating activity of Cyclin Dependent Kinases (CDKs). (intechopen.com)
  • As the cell routine machinery continues to be extremely conserved through progression it is today clear the fact that cell routine has been improved in different and novel methods to adapt to brand-new developmental applications elaborated during progression (26). (bioerc-iend.org)
  • For instance, DNA replication and DNA damage checkpoints delay cell cycle progression until each chromosome is fully replicated and physically intact. (rupress.org)
  • The effects of CMTM4 on cellular apoptosis and cell cycle progression were analysed by flow cytometry, and cell cycle hallmarks were detected by western blotting and RT-PCR. (biomedcentral.com)
  • The results demonstrated that JIB extract combined with cisplatin enhanced the inhibition of cell growth, proliferation, and survival through the obstruction of cell cycle progression and AKT/mTOR and MAPK signaling as well as the induction of cell apoptosis. (medsci.org)
  • Id2a-deficient retinas possess increased numbers of cells occupying S phase, at the expense of mitotic cells, and kinetic analyses demonstrate that Id2a is required for S-phase progression and/or the transition from S to M phase. (biologists.com)
  • Preeminent among these proteins are the cyclin dependent kinases, which upon binding to cyclins, phosphorylate numerous targets to trigger cell cycle progression. (smadpathway.com)
  • Within this review, we summarize the functions that all of the Aurora kinases has in cancer biology and mitosis, and discuss the binding modes of Aurora A kinase inhibitors, the spot elements in the binding sites and the fortunate inhibitor components. (survivinpathway.com)
  • Current Opinion in Cell Biology. (elsevierpure.com)
  • Journal of Cell Biology, 83 (2 PART). (cshl.edu)
  • Journal of Cell Biology, 95 (2). (cshl.edu)
  • Molecular Biology of the Cell, 19 (7). (cshl.edu)
  • Nature Cell Biology, 9 (5). (cshl.edu)
  • 1 Section of Molecular Cell and Developmental Biology, Institute for Cell and Molecular Biology, The University of Texas at Austin, Austin, TX 78722, USA. (biologists.com)
  • Invited Perspective in The Journal of Cell Biology . (ucdavis.edu)
  • MARV assembles and buds from the host cell plasma where MARV matrix protein (mVP40) dimers associate with anionic lipids at the plasma membrane inner leaflet and undergo a dynamic and extensive self-oligomerization into the structural matrix layer. (uci.edu)
  • old transporters Activated at the zone of activation and on elucidated authorities are with membrane cycle, splicing to a polymerization of modifications that conducts with the DNA of an national action activation. (evakoch.com)
  • Signals to trigger apoptosis may come from within the cell or from outside, by stimulating suicide receptors in the cell's external membrane. (agemed.org)
  • Within cells, they enable the formation of specialized functional domains at the level of the plasma membrane or intracellular organelles. (unice.fr)
  • Membrane fusion drives pronuclear meeting in the one-cell embryo. (ucdavis.edu)
  • Among all probiotics L. acidophilus NCFM and L. plantarum, Lp-115 showed significant effects on the H. pylori eradication and reduction of inflammation in-vitro and in-vivo. (bvsalud.org)
  • Here we show that human PSM cells derived in vitro-as well as those of the mouse 4 -recapitulate the oscillations of the segmentation clock. (nature.com)
  • Single-cell RNA sequencing reveals that mouse and human PSM cells in vitro follow a developmental trajectory similar to that of mouse PSM in vivo. (nature.com)
  • In this context, cell lines represent alternative experimental models for in vitro studies that complement in vivo assays. (researchgate.net)
  • the influence of the complement (c) system on plasmodial infections in vivo (plasmodium berghei in rats) and in vitro (plasmodium falciparum) has been determined. (liverpool.ac.uk)
  • Near simultaneous fluorescence and DIC light microscopy reveals that the amount of γ-tubulin associated with the centrosome remains relatively constant throughout interphase, suddenly increases during prophase, and then decreases to interphase levels as the cell exits mitosis. (silverchair.com)
  • Additional observations suggest an in vivo role of RanBP2 in interphase microtubule organization. (nih.gov)
  • In interphase cells, GTP-bound Ran (Ran-GTP) is the major form in nucleus while GDP-bound Ran (Ran-GDP) is the predominant form in cytoplasm. (nih.gov)
  • We characterized dCTCF-binding sites according to their occupancy status during the cell cycle, and identified three classes: interphase-mitosis-common (IM), interphase-only (IO) and mitosis-only (MO) sites. (biomedcentral.com)
  • Chromosomes are made of a material called chromatin, which is dispersed throughout the cell nucleus during interphase. (visionlearning.com)
  • While highly conserved through evolution the cell routine continues to be modified to adjust to brand-new developmental applications extensively. (bioerc-iend.org)
  • Recent breakthroughs have uncovered more and more DNA replication licensing machinery proteins (ORC, Cdc6, Cdt1, geminin, etc.) functioning in other cell cycle events, including centrosome replication, mitotic events, transcription and so on. (intechopen.com)
  • The ultimate goals of our studies are to understand how these proteins enable accurate chromosome segregation and to discover how they are coordinated with each other and with other aspects of cell physiology. (nih.gov)
  • Targeted therapy drugs are used to target specific genes and proteins of cancer cells to precisely identify and attack specific types of cancer cells. (medsci.org)
  • Internal signals producing apoptosis depend on interactions of several proteins and may serve to protect the organism from cancer by killing cells that have pre-cancerous changes. (agemed.org)
  • These proteins, including Aurora A and B, are serine/threonine kinases that are essential for cell division activities such as spindle construction, chromosome segregation, and cytokinesis. (smadpathway.com)
  • The single-cell eukaryote Paramecium tetraurelia can undergo both asexual and sexual reproduction. (wikipedia.org)
  • P. tetraurelia is able to replicate asexually for many generations but the dividing cells gradually age and after about 200 cell divisions, if the cells fail to undergo another autogamy or conjugation, they lose vitality and expire. (wikipedia.org)
  • Undifferentiated spermatogonia divide mitotically to both repopulate the testicular stem cell population and provide progenitor cells that undergo spermatogenesis. (jci.org)
  • id2a -overexpressing retinoblasts progress from S to M phase more rapidly and they undergo mitosis more frequently, which results in macrophthalmia. (biologists.com)
  • Cancer A clonal growth (cells all descended from one ancestral cell) that undergo continuing mitotic divisions and are not inhibited in their growth when they come in contact with neighboring cells (contact inhibition). (agemed.org)
  • Identifying the mechanical properties of cells that allow them to undergo shape changes and elucidating the molecular mechanisms that cells use to generate the mechanical forces remains the ultimate challenge of understanding cellular morphogenesis. (biomedcentral.com)
  • A clonal colony would be well exemplified by a bacterial culture colony, or the bacterial films that are more likely to be found in vivo (e.g., in infected multicellular hosts). (wikipedia.org)
  • Whereas, the cells of clones dealt with here are specialized cells of a multicellular organism (usually vertebrates), and reside at quite distant places. (wikipedia.org)
  • JIB extract induced cell cycle arrest at the G 0 /G 1 phase and decreased cyclin and cdk protein expressions. (medsci.org)
  • Along with Cdk1/cyclin N, members of the Aurora/Ipl1 kinase family are also crucial regulators of mitosis. (smadpathway.com)
  • Signal transducer and activator of GSI-IX in vivo transcription 515 (STAT5b) is the main GH-signaling mediator and it is related to IGF1 synthesis and somatic growth. (anti-cancers.com)
  • To determine how this molecule behaves during the cell cycle, we have established several vertebrate somatic cell lines that constitutively express a γ-tubulin/green fluorescent protein fusion protein. (silverchair.com)
  • Although cell shape often predicts spindle orientation, there are numerous examples where this is not the case in somatic cells ( Finegan and Bergstralh, 2019 ). (elifesciences.org)
  • Primary clear cell renal cell carcinoma (ccRCC) and the paired adjacent non-tumour tissues were then collected to examine the expression of CMTM4 by western blotting, immunohistochemistry, and quantitative RT-PCR. (biomedcentral.com)
  • Western blotting then confirmed that CMTM4 was dramatically reduced in 86.9 % (53/61) of ccRCC tissues compared with the paired adjacent non-tumour tissues, as well as in the 786-O and A498 ccRCC cell lines. (biomedcentral.com)
  • The DNA within the nuclei of our cells carries the information to generate the machinery of the cell, the cell itself, our tissues and then the whole human. (birmingham.ac.uk)
  • Mechanochemical Principles of Spatial and Temporal Patterns in Cells and Tissues. (mpi-cbg.de)
  • Patterns are ubiquitous in living systems and underlie the dynamic organization of cells, tissues, and embryos. (mpi-cbg.de)
  • At the level of the organism, they provide interfaces that delimit the organism from the outside world and individual cells within tissues. (unice.fr)
  • Used jointly these total outcomes claim that can be an important regulator from the cell routine in the preimplantation embryo. (bioerc-iend.org)
  • How plastic the normal cell cycle is usually becomes clear when comparing the so-called "embryonic cleavage cycles" and the endoreplication cycle also referred to as the endocycle. (bioerc-iend.org)
  • The embryonic cleavage cycles are maternally powered as nutrition and cell routine factors are kept in the egg cytoplasm during oogenesis. (bioerc-iend.org)
  • Here, we show that cell geometry and polarity domains cooperate, rather than compete, in positioning the cleavage plane during UCDs in early ascidian embryos. (elifesciences.org)
  • We found that the UCDs and their orientation at the ascidian third cleavage rely on the spindle tilting in an anisotropic cell shape, and cortical polarity domains exerting different effects on spindle astral microtubules. (elifesciences.org)
  • An estimate of the minimal amount of this motor needed to produce the required force for cell cleavage fits well with this 10% value. (biomedcentral.com)
  • This process gets rid of unneeded cells and is particularly important for "sculpting" tissue and organ structure during development of the embryo (or larval metamorphosis in insects), but may occur at any time even in adult cells when a tissue needs to be remodeled. (agemed.org)
  • The mechanisms that control how the two parental pronuclei fuse in the first mitosis of the embryo are poorly understood. (ucdavis.edu)
  • Our own bodies start out as a single cell zygote which eventually develops into an embryo and then a fully grown human with about 10 trillion cells . (activemotif.com.cn)
  • Cell Counting Kit-8 (CCK-8) and viable cell counting assays were used to delineate the growth curves of 786-O cells after CMTM4 overexpression or knockdown. (biomedcentral.com)
  • Using loss-of-function and overexpression assays in zebrafish, we demonstrate that Id2a levels modulate retinoblast cell cycle kinetics and thereby influence neuron and glia formation in the retina. (biologists.com)
  • Several common birth defects, such as Down's syndrome, result from aneuploidy arising during meiotic cell divisions. (nih.gov)
  • Human cancer cells are usually seen as a changes in the amount or organization of DNA because of mistakes in mitosis, causing chromosome instability and aneuploidy. (survivinpathway.com)
  • Vertebrate testes are arranged into recurring cellular associations that vary with time and distance along the tubule. (jci.org)
  • cnd-1 expression was first detected in neuroblasts of the AB lineage in 14 cell embryos and maintained in many neuronal descendants of the AB lineage during embryogenesis, diminishing in most terminally differentiated neurons prior to hatching. (biologists.com)
  • or embryos ( Minc and Piel, 2012 ) and is the result of spindle alignment with the longest axis of the cell. (elifesciences.org)
  • The pre-replication complex (pre-RC) assembly or the DNA replication licensing is the first step in DNA replication initiation, characterized by the sequential recruitment of ORCs, Cdc6, Cdt1 and MCMs to the DNA replication origins to form the pre-RC at the end of mitosis ( Bell and Dutta 2002 ). (intechopen.com)
  • During mitosis, metazoan NPCs disassemble, and at least a third of nucleoporins associate with kinetochores, including the RanBP2 complex and the Nup107-160 complex. (nih.gov)
  • Elucidation of the mechanism of this association will not only allow us to test the importance of RanBP2 complex formation in a non-vertebrate system, but also provide a convenient alternative mechanism for formation of this complex that can be used to understand its importance in vertebrate cells. (nih.gov)
  • The process of cell division or mitosis is tightly regulated and complex. (survivinpathway.com)
  • Eukaryotes have evolved complex regulatory systems to ensure the cell cycle continues in a timely and appropriate way. (smadpathway.com)
  • In vertebrates, this drop is mediated partly by Aurora B ubiquitination via the anaphase marketing complex, and subsequent destruction by the proteasome. (smadpathway.com)
  • In this study, we combined in vivo C. elegans genetics and in silico molecular dynamics simulations to understand the relation between the length and amino acid composition of the luminal KASH domain, and the function of the SUN-KASH complex. (ucdavis.edu)
  • These data are the first to characterize the dynamics of centrosome-associated γ-tubulin in vertebrate cells in vivo and to demonstrate the microtubule-independent nature of these dynamics. (silverchair.com)
  • However, this view of cancer onset has been challenged in recent years and many tumors have been argued to have polyclonal origin, i.e. derived from two or more cells or clones, including malignant mesothelioma. (wikipedia.org)
  • It also directly binds to BubR1, a kinetochore-associated kinase implicated in the mitotic checkpoint, the major cell cycle control pathway in which unattached kinetochores prevent anaphase onset. (rupress.org)
  • Studies on the developmental onset of the teleost circadian clock have been carried out in zebrafish and, recently, in rainbow trout and Senegalese sole, where rhythms of clock gene expression entrained by light-dark (LD) cycles have been reported from the first days post fertilization. (researchgate.net)
  • Wound healing and transwell assays were performed to assess the cells' ability to migrate. (biomedcentral.com)
  • Through the development of novel live imaging assays we are now able to visualize this process in vivo, in the context of the development of the zebrafish neural tube. (unice.fr)
  • Brpf1 functions in association with the histone acetyltransferase Moz (Myst3), an interaction mediated by the N-terminal domain of Brpf1, and promotes histone acetylation in vivo. (silverchair.com)
  • The precise regulations of pre-RC protein levels and assembly are effective ways to prevent reassembly of de novo MCM2-7 onto the replicated origins to re-license and re-replicate the genomic DNA in the subsequent phases of the same cell cycle ( Figure 1) . (intechopen.com)
  • However, changes of CTCF-binding sites during the cell cycle, and functions of this protein at different cell cycle phases, remain largely uncharacterized. (biomedcentral.com)
  • We transfected cells with Rap1 targeting or scrambled siRNA and then done protein Retroperitoneal lymph node dissection transfection of the GST fused constitutively active type of Rac1. (survivinpathway.com)
  • DEC-205 (CD205), a member of the macrophage mannose receptor protein family, is the prototypic endocytic receptor of dendritic cells, whose ligands include phosphorothioated cytosine-guanosine (CpG) oligonucleotides, a motif often seen in bacterial or viral DNA. (uci.edu)
  • Preexisting antivector immunity can severely compromise the ability of Salmonella enterica serovar Typhimurium live vaccines to induce protective CD8 T-cell frequencies after type III secretion system-mediated heterologous protein translocation in orally immunized mice. (cipsm.de)
  • Key components supplier CX-4945 of these paths are protein kinases that are critical for the appropriate time of each cell cycle stage. (smadpathway.com)
  • On the two-cell stage transcription from the zygotic genome takes place and is necessary for the next cleavages to occur (11). (bioerc-iend.org)
  • Recently, there has been a growing interest in how the transcription program is re-established during mitosis. (biomedcentral.com)
  • The structure, regulation, and cell types of the mouse testis. (jci.org)
  • Throughout the 19th century, as microscopes developed, scientists had been seeing clues of structures in dividing cells of eukaryotes . (visionlearning.com)
  • But what all these life forms have in common is that their genetic code is copied from cell to cell thanks to the process of mitosis, whereby the nucleus of a cell splits into two before the cell divides. (visionlearning.com)
  • UCD divides the mother cell into two daughter cells of different sizes. (elifesciences.org)
  • Their findings provide a new perspective on the roles of cell polarity and shape in the control of spindle positioning, and are of broad interest to cell and developmental biologists. (elifesciences.org)
  • Our work suggests that another important function of the ESCRT machinery is to promote the virus-like cell surface budding of extracellular vesicles that ensure the transport of developmental signaling molecules such as the major developmental morphogen Hedgehog (Matusek et al, 2014, Juan and Fürthauer, 2018). (unice.fr)
  • Dendrite pruning requires the developmentally regulated degradation of the cell adhesion molecule Neuroglian , and loss of Rab11 causes defects in the developmental degradation of Neuroglian and another target, the ion channel Ppk26 . (sdbonline.org)
  • Development through mitosis depends upon three major regulatory systems, each involving several serine/threonine kinases, referred to as mitotic kinases. (survivinpathway.com)
  • Take-n together, these results suggest that the effect of Rap1 depends o-n Rac1, while the effect of Rac1 is in-dependent of Rap1, hence arguing that Rac1 is located downstream of Rap1 in the spreading inducing signaling in v Abl/3T3/wtCbl cells. (survivinpathway.com)
  • Morphogenesis depends on the interactions of steady state and dynamic physical properties that allow a cell to deform and reform into different shapes, such as neuronal growth cones and columnar epithelia. (biomedcentral.com)
  • However, during course of cell division, one of the cells can get mutated further and acquire new characteristics to diverge as a new clone. (wikipedia.org)
  • Most other cells cannot divide indefinitely as after a few cycles of cell division the cells stop expressing an enzyme telomerase. (wikipedia.org)
  • The genetic material, in the form of deoxyribonucleic acid (DNA), continues to shorten with each cell division, and cells eventually stop dividing when they sense that their DNA is critically shortened. (wikipedia.org)
  • However, this enzyme in "youthful" cells replaces these lost bits (nucleotides) of DNA, thus making almost unlimited cycles of cell division possible. (wikipedia.org)
  • The G 2 gap phase further separates S-phase from mitosis, allowing for continued cell growth and maturation before cell division. (rupress.org)
  • Proper cell division is essential for the health and survival buy Gemcitabine of cells and bacteria. (survivinpathway.com)
  • Cell division orientation is thought to result from a competition between cell geometry and polarity domains controlling the position of the mitotic spindle during mitosis. (elifesciences.org)
  • Whether and how such competition is also at work to determine unequal cell division (UCD), producing daughter cells of different size, remains unclear. (elifesciences.org)
  • Using the early embryonic divisions of the ascidian Phallusia mammillata as a model to investigate mechanisms of unequal cell division, this study convincingly demonstrates that cell shape and cortical domains are cooperating, rather than competing, in order to establish cell size asymmetry, a significant conceptual advance for the field. (elifesciences.org)
  • To achieve this goal, the distribution and flux of the cell division machinery must be quantified. (biomedcentral.com)
  • Cell division can then be thought of as a series of intermediate cell shapes (sphere, cylinder and dumbbell) that are produced along this pathway of cleaving the mother cell. (biomedcentral.com)
  • In addition, AKT/mTOR signaling and MAPK signaling were inhibited by JIB extract to suppress melanoma cell growth and proliferation. (medsci.org)
  • Restoration of CMTM4 significantly suppressed 786-O cell growth by inducing G2/M cell cycle arrest and p21 upregulation, and cell migration was also inhibited. (biomedcentral.com)
  • Interest in ALMS1 is heightened by the recent discovery of its involvement in neonatal cardiomyocyte cell cycle arrest, a process with potential relevance to regenerative medicine. (springer.com)
  • Mechanisms regulating cardiomyocyte cell cycle arrest are of great interest partly because reversing this process could provide a way to stimulate cardiac regeneration after injury [ 17 ]. (springer.com)
  • By systematically varying mitotic cell shape, we could modulate the effect of attractive and repulsive polarity domains and consequently generate predicted daughter cell size asymmetries and position. (elifesciences.org)
  • One appeal of studying cytokinesis as a model for cellular morphogenesis is its relatively simple geometry during normal mitotic cell divisions, which produce equal sized daughter cells. (biomedcentral.com)
  • We sought to identify PKA phosphorylation sites in PLIN5 and assess their functional relevance in cultured cells and the livers of mice. (uci.edu)
  • Expression of phosphorylation-defective PLIN5 S155A in Plin5 null cells resulted in decreased rates of lipolysis and triglyceride-derived fatty acid oxidation. (uci.edu)
  • However, the molecular mechanisms by which particular loci are marked for reactivation after mitosis are only partially understood. (silverchair.com)
  • Our research is defining the normal mechanisms of DNA replication and repair, with the aim of understanding how it is deregulated in cancer cells. (birmingham.ac.uk)
  • B cells are therefore particularly dependent on 'quality control' mechanisms to oversee antibody production. (cipsm.de)
  • It is predicted that MCPH gene mutations may lead to the disease phenotype due to a disturbed mitotic spindle orientation, premature chromosomal condensation, signalling response as a result of damaged DNA, microtubule dynamics, transcriptional control or a few other hidden centrosomal mechanisms that can regulate the number of neurons produced by neuronal precursor cells. (biomedcentral.com)
  • We argue that M. lignano is a suitable model for ageing and rejuvenation research, and especially for the role of stem cells in these processes, due to its accessible stem cell system and regeneration capacity, and the possibility of combining stem cell studies with demographic analyses. (biomedcentral.com)
  • In this chapter, we mainly discuss the coordination regulations between DNA replication initiation and other cell cycle events that ensure genomic integrity. (intechopen.com)
  • Alternatively in endocycles DNA replication (the S stage) and cell development take place lacking any intervening mitosis (M stage) phase resulting in polyploidy. (bioerc-iend.org)
  • It is well known that the products of chromosome replication are paired to ensure that the sisters segregate away from each other during mitosis. (rupress.org)
  • Thus, the products of chromosome replication (sister chromatids) generated during S-phase must be identified over time until mitosis when sisters associate with the mitotic spindle and segregate away from each other into the newly forming daughter cells. (rupress.org)
  • The proper copying and repair of DNA to maintain the correct sequence and structure of genomes is critical to the proper function of cells, and repair and replication is frequently disrupted in cancers and targeted by cancer treatments. (birmingham.ac.uk)
  • Id2a-dependent defects in retinoblast proliferation lead to microphthalmia and to an absence of nearly all differentiated inner and outer nuclear layer cell types. (biologists.com)
  • In agreement with the findings shown in Fig. 3, exhaustion of Rap1 reduced scattering of v Abl/3T3/wtCbl cells. (survivinpathway.com)
  • Recent findings indicate that H3.3 replaces the majority of canonical H3 in non-dividing cells, reaching almost saturation levels in a time-dependent manner. (aging-us.com)
  • In particular, ubiquitin-mediated degradation is critically important at transition points where it provides directionality and irreversibility to the cell cycle, which is essential for maintaining genome integrity. (intechopen.com)
  • However, the role of CTCF in the maintenance and propagation of genome architectures throughout the cell cycle remains elusive. (biomedcentral.com)
  • 13 Genome Plasticity and B Cell, University of Paris-Sud, Centre National de la Recherche Scientifique, Cancer Institute Gustave Roussy, Villejuif, France. (jci.org)
  • We established a novel assay to track endogenous signaling molecules in vivo and identified the asymmetric segregation of Delta-containing endosomes as a novel mechanism to promote directional Notch signaling in asymmetrically dividing neural precursor cells (Coumailleau et al 2009, Kressmann et al, 2015). (unice.fr)
  • Cells become cancerous by accumulating, stepwise, a series of several mutations that alter the function of genes important for cell growth. (agemed.org)
  • Yet, whether and how cell geometry and polarity domains compete with each other not only to determine the orientation but also the centering of the mitotic spindle leading to equal or unequal cell divisions (UCDs) remains unclear. (elifesciences.org)
  • Circadian rhythms are established very early during vertebrate development. (researchgate.net)
  • Some cells replicate faster and others slower, and the entire process can be interrupted. (visionlearning.com)
  • 3 Center for Stem Cell and Regenerative Medicine, USC Keck School of Medicine,Los Angeles, CA 90033, USA. (silverchair.com)
  • Free-living flatworms ("Turbellaria") are appropriate model organisms to gain better insight into the role of stem cells in ageing and rejuvenation. (biomedcentral.com)
  • We used the species Macrostomum lignano , which is an emerging model for studying the reciprocal influence between stem cells, ageing and rejuvenation. (biomedcentral.com)
  • Researchers tended to focus on the role of stem cells and cell renewal during ageing, and the causal effect of regeneration and starvation on rejuvenation [ 2 - 4 ]. (biomedcentral.com)
  • mitotically active cells of intact segments do not significantly contribute to the blastemal cellular sources. (mdpi.com)
  • Malaria parasites must acquire all necessary nutrients from the vertebrate and mosquito hosts to successfully complete their life cycle. (mdpi.com)
  • Consistent with our previous data, CA Rac1 dramatically increased distribution of scrambled siRNA transfected cells. (survivinpathway.com)
  • Aurora B levels peak in early mitosis and then dramatically decline at mitotic exit. (smadpathway.com)