Vertebral fractures in postmenopausal women osteoporosis postmenopausal. Medical search. Frequent questions

Alendronate Prevalent vertebral fractures Post-menopausal Nonvertebral fractures Among postmenopausal women Incidence Spine Raloxifene Risedronate Osteoporotic vertebral fractures Treatment of osteoporosis Increases Clinical vertebral fractures Reduce risk of vertebral Parathyroid hormone Vertebra Glucocorticoid-induced oste Methods Compression Prediction Denosumab Risk of fractures Cochrane Database of Systematic Reviews Prevalence Placebo Spinal Prevention of Osteoporotic Fractures Treatments Decrease Distal radius Prevent osteoporotic fractures Estrogen Body fractures Secondary osteoporosis Intra-articular fractures Turnover markers Menopause Bisphosphonate Patients Prolia Reduction Femoral-neck Occur Premenopausal women Efficacy Diagnosis of osteoporosis Hormonal Vertebrae Common fracture Wrist Antiresorptive Radiographs Bone loss and fractures Clinically recognized osteoporosis Increase in fracture

Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. (nih.gov)
Previous studies have shown that alendronate can increase bone mineral density (BMD) and prevent radiographically defined (morphometric) vertebral fractures. (nih.gov)
The Fracture Intervention Trial aimed to investigate the effect of alendronate on the risk of morphometric as well as clinically evident fractures in postmenopausal women with low bone mass. (nih.gov)
2027 women were randomly assigned placebo (1005) or alendronate (1022) and followed up for 36 months. (nih.gov)
The relative hazards for hip fracture and wrist fracture for alendronate versus placebo were 0.49 (0.23-0.99) and 0.52 (0.31-0.87). (nih.gov)
We conclude that among women with low bone mass and existing vertebral fractures, alendronate is well tolerated and substantially reduces the frequency of morphometric and clinical vertebral fractures, as well as other clinical fractures. (nih.gov)
In postmenopausal women, a decrease in the number of vertebral 5 and hip fractures 6 has been found with the use of alendronate. (bmj.com)
Alendronate sodium tablets, USP are indicated for the treatment of osteoporosis in postmenopausal women. (nih.gov)
In postmenopausal women, alendronate sodium tablets, USP increases bone mass and reduces the incidence of fractures, including those of the hip and spine (vertebral compression fractures). (nih.gov)
Clinicians should offer pharmacologic treatment with alendronate, risedronate, zoledronic acid, or denosumab to reduce the risk for hip and vertebral fractures in women who have known osteoporosis. (medscape.com)
Drug therapies for osteoporosis include bisphosphonates, such as alendronate and risedronate. (naturalmedicinejournal.com)
For those who screen positive for osteoporosis, there is fair evidence to recommend using alendronate, risedronate, or raloxifene to treat. (canadiantaskforce.ca)
For postmenopausal women with osteoporosis but no prevalent fractures, there is good evidence to recommend alendronate (A Recommendation) and fair evidence to recommend risedronate or raloxifene (B Recommendation) for the secondary prevention of vertebral fractures. (canadiantaskforce.ca)
There is fair evidence to recommend alendronate or risedronate for secondary prevention of hip and nonvertebral fractures. (canadiantaskforce.ca)
RESULTS: For women with high bone turnover, the cost per QALY gained with alendronate compared to no drug therapy among women aged 70 years with T-scores of -2.0 or -1.5 were $58,000 and $80,000 (U.S. 2004 dollars), respectively. (healthpartners.com)
Two systematic reviews involving postmenopausal women found that alendronate reduced vertebral and nonvertebral fractures compared with placebo after one to four years. (aafp.org)
In a randomized controlled trial in postmenopausal women, there was a higher rate of major adverse cardiac events (MACE), a composite endpoint of cardiovascular death, nonfatal myocardial infarction and nonfatal stroke, in patients treated with EVENITY ® compared to those treated with alendronate. (evenityproliahcp.com)

or=-2.5 SD) or with prevalent vertebral fractures (PVF). (unboundmedicine.com)
Thus, the aim of the current study was to number and severity of prevalent vertebral fractures [3]. (sagepub.com)

Originally it was described in elderly and/or post-menopausal women. (wikipedia.org)
Prolia was originally approved in the USA in 2010 to treat osteoporosis in post-menopausal women at increased risk of fractures. (pharmatimes.com)
Not believing a post-menopausal woman should replace hormones is a prejudice from earlier days when it was considered unnatural. (gynob.com)
ABSTRACT The study aimed to determine hospital-based prevalence of vertebral fractures in post- menopausal Saudi Arabian women. (who.int)
INTRODUCTION AND HYPOTHESIS: Over half of all fractures among post-menopausal women occur in those who do not have osteoporosis by bone density criteria. (healthpartners.com)
METHODS: Using a Markov model, we estimated the cost per quality adjusted life year (QALY) for five years of oral bisphosphonate compared to no drug therapy for osteopenic post-menopausal women aged 60 to 80 years with a high (top quartile) or low (bottom 3 quartiles) level of a bone turnover marker. (healthpartners.com)
CONCLUSION: Measurement of bone turnover markers has the potential to identify a subset of post-menopausal women without osteoporosis by bone density criteria for whom bisphosphonate therapy to prevent fracture is cost-effective. (healthpartners.com)
Another small RCT involving post-menopausal women found no significant difference between calcium plus vitamin D 3 and placebo in hip fractures after two years. (aafp.org)
However, another systematic review and two subsequent RCTs involving post-menopausal women found no significant difference in vertebral fractures. (aafp.org)
Both oestrogen and testosterone help maintain bone, making post-menopausal women and elderly people more prone to osteoporosis. (cochrane.org)
Osteoporosis is a common disease, with higher incidence in post-menopausal women. (labiotech.eu)

Raloxifene has not been shown to prevent nonvertebral fractures. (aafp.org)
One systematic review involving postmenopausal women found that compared with control (i.e, placebo, calcium, or calcium plus vitamin D) risedronate reduced vertebral and nonvertebral fractures after four years. (aafp.org)
One randomized controlled trial (RCT) involving women with prior vertebral fractures found that parathyroid hormone reduced the proportion of women with vertebral and nonvertebral fractures compared with placebo. (aafp.org)
One large RCT involving postmenopausal women with osteoporosis found that raloxifene reduced vertebral fractures compared with placebo, but no significant difference was found in nonvertebral fractures. (aafp.org)
One systematic review involving postmenopausal women found that etidronate reduced vertebral fractures compared with control (placebo, calcium, or calcium plus vitamin D) over two years but found no significant difference in nonvertebral fractures. (aafp.org)
Calcium Plus Vitamin D . One large RCT involving women 69 to 106 years of age living in nursing homes found that calcium plus vitamin D 3 reduced hip fractures and all nonvertebral fractures after 18 months to three years compared with placebo. (aafp.org)
One smaller RCT involving women and men 65 years or older found that calcium plus vitamin D 3 reduced nonvertebral fractures after three years compared with placebo but found no significant difference in hip fractures. (aafp.org)
One systematic review involving postmenopausal women found that calcitonin reduced vertebral fractures compared with placebo one to five years after treatment but found no significant difference between calcitonin and placebo in nonvertebral fractures. (aafp.org)
One systematic review involving postmenopausal women found no significant difference between calcium supplementation and placebo in vertebral or nonvertebral fractures after one and one half to four years. (aafp.org)
One large RCT involving postmenopausal women and two large RCTs involving postmenopausal women and older men provided no evidence of a difference between vitamin D 3 and placebo in hip, vertebral, and nonvertebral fractures after two to five years. (aafp.org)
Two systematic reviews and two subsequent RCTs provided insufficient evidence about the effects of hormone therapy on nonvertebral fractures. (aafp.org)

Efficacy and Safety of Romosozumab Among Postmenopausal Women With Osteoporosis and Mild-to-Moderate Chronic Kidney Disease. (nih.gov)
The objectives of this study were to elicit self-reported health status, quantify osteoporosis-related burden, and understand preferences for treatment attributes among postmenopausal women with severe osteoporosis in Greece. (dovepress.com)
It was reported that the performance of ANN models for the prediction of BMD values using several parameters among postmenopausal women was superior to the conventional regression methods [ 6 ]. (biomedcentral.com)
However, no study has investigated the ability of ANN to predict future BMD and bone loss rate (BLR) values among postmenopausal women. (biomedcentral.com)
These findings demonstrate that high plasma S1P level at baseline and at years 1 to 5 is a strong and independent risk factor for future [ORFs] among postmenopausal women and could be a useful biomarker for fracture risk assessment in this population. (e-jbm.org)
Bone turnover markers (BTMs), particularly those of bone resorption, can predict fracture risk among postmenopausal women. (e-jbm.org)

The incidence of spine fracture is estimated to be 20% in postmenopausal women [ 4 ]. (hindawi.com)
In postmenopausal women with osteoporosis, Prolia reduces the incidence of vertebral, nonvertebral, and hip fractures [see Clinical Studies ]. (rxlist.com)
Also the incidence of new vertebral fractures was 62% lower for Prolia-treated men. (pharmatimes.com)
c) fracture incidence. (bmj.com)
Beyond issues of race, age, and gender, incidence varies widely from society to society, suggesting that osteoporosis is largely preventable. (peacehealth.org)
Osteoporotic vertebral compression fractures (OVCFs) have a high incidence, which have attracted wide attention from society. (researchsquare.com)
Thoraco-lumbar osteoporotic vertebral fractures (TLOVF) affect millions of people worldwide each year, with the incidence rising with the increasing aging of the world's population ( 1 ). (amegroups.org)
Read More osteoporosis, Prolia ® reduces the incidence of vertebral, nonvertebral, and hip fractures. (evenityproliahcp.com)

Non-spine clinical fractures were confirmed by radiographic reports. (nih.gov)
The weakness of paraspinal extensor muscles noticed in osteoporosis accompanied by repetitive vertebral microfracture results in progressive change in alignment of the spine, mainly hyperkyphosis, in osteoporotic patients [ 2 , 8 - 10 ]. (hindawi.com)
Osteoporosis is a disease characterized by low bone mass and structural deterioration of bone tissue, leading to bone fragility and an increased risk of fractures of the hip, spine, and wrist. (daviddarling.info)
People with osteoporosis have brittle bones, which increases the risk of bone fracture, particularly in the hip, spine, and wrist. (peacehealth.org)
In a double-blind trial, postmenopausal women who supplemented with 40 grams of soy protein powder (containing 90 mg of isoflavones) per day were protected against bone mineral loss in the spine, although lower amounts were not protective. (peacehealth.org)
In a double-blind study, administration of the soy isoflavone genistein (54 mg per day) to postmenopausal women for one year reduced bone breakdown, increased bone formation, and increased bone mineral density of the hip and spine. (peacehealth.org)
Osteoporosis can affect any bone in the body, although the most common sites are the wrist, spine, and hips. (naturalmedicinejournal.com)
Collapse of the vertebrae of the spine is the most common fracture in postmenopausal women and people on steroids. (cochrane.org)
The results from small studies show a trend towards a decrease in spine (vertebral) fractures with calcium supplements and a smaller trend for non-spinal fractures, such as of the hip and wrist. (cochrane.org)
These fractures occur most often in the middle of the back (the thoracic spine). (regendoctors.com)
Although fractures are often painful, some fractures of the spine do not cause pain but can cause deformities. (msdmanuals.com)
A diagnostic approach integrated multimodal radiomics with machine learning models based on lumbar spine CT and X-ray for osteoporosis. (cdc.gov)

In postmenopausal women, estrogen or estrogen plus progestogen or raloxifene should not be used for the treatment of osteoporosis. (medscape.com)
Raloxifene (60 mg daily for three years) will prevent one vertebral fracture, including asymptomatic fractures, for every 46 postmenopausal women with osteoporosis or presence of previous vertebral fractures. (aafp.org)
Recommend against using menopausal estrogen therapy or menopausal estrogen plus progestogen therapy or raloxifene for the treatment of osteoporosis in women. (medscape.com)
There is insufficient evidence to recommend for or against exercise, raloxifene, bisphosphonates, calcitonin, parathyroid hormone, fluoride or combination therapy to prevent osteoporotic fractures in this population. (canadiantaskforce.ca)

Strontium ranelate was dominant (i.e. more effective and less costly) versus risedronate for women with osteoporosis aged over 75 years and for women with PVF aged 80 years. (unboundmedicine.com)
The cost per QALY gained of strontium ranelate compared with risedronate at 75 years of age was euro 11,435 for women with PVF. (unboundmedicine.com)

Conclusion: serum OPN levels might be used as a biomarker of the early diagnosis of osteoporosis in postmenopausal women, with or without osteoporotic vertebral fractures. (acta-endo.ro)

7-10 In addition, the ACR has recently developed recommendations for the prevention and treatment of osteoporosis in corticosteroid treated patients. (bmj.com)
11 In contrast, no consensus or guidelines exist for the prevention and treatment of osteoporosis in patients with rheumatoid arthritis (RA), although osteoporosis frequently occurs in patients with RA. (bmj.com)
Harrison P. New ACP guidelines on the treatment of osteoporosis. (medscape.com)
The safety and effectiveness of ACTONEL for the treatment of osteoporosis are based on clinical data of three years duration. (guidelinecentral.com)
High age or clinical risk factors for fracture alone are not reasons to initiate treatment of osteoporosis with a bisphosphonate. (medthority.com)

The flexed posturing in kyphotic patients caused by osteoporosis places their center of gravity closer to its limits of stability and increases the risk of falling [ 16 , 17 ]. (hindawi.com)
With the onset of menopause, bone loss in women increases considerably: in the first 5-10 years the loss is 25-30% of trabecular bone and 10-15% of cortical bone. (who.int)
2 , 4 The prevalence of primary osteoporosis (i.e., osteoporosis without underlying disease) increases with age and differs by race/ethnicity. (uspreventiveservicestaskforce.org)
More than 10 million Americans are afflicted, and 34 million more may already be exhibiting signs of low bone mass, which increases the risk of developing osteoporosis. (naturalmedicinejournal.com)
Low bone mass increases the risk of developing osteoporosis and fractures. (naturalmedicinejournal.com)
It increases fracture risk, causing a huge amount of personal suffering and loss of quality of life. (naturalmedicinejournal.com)
The 3,591 postmenopausal women in the study who were given placebo treatment were five times likelier to experience fractures than the 3,589 administered romosozumab, an antibody given as an injection which inhibits a protein called sclerostin and increases bone density and formation. (creakyjoints.org)
One example is osteoporosis that increases the chances of fractures in our vertebra - the small rectangular bones that make up our backs. (mwmc.com)
The risk of new vertebral fractures increases with the at follow-up. (sagepub.com)
This mainly occurs via secondary hyperparathyroidism, leading to excessive bone remodelling and ultimately to bone weakening, which in turn increases fragility fracture risk. (hindawi.com)
In women, bone density (or mass) progressively increases until about age 30, when bones are at their strongest. (msdmanuals.com)

Although arzoxifene met the main goal of reducing the risk of vertebral fracture and invasive breast cancer in postmenopausal women, the drug did not prove to be effective against secondary efficacy endpoints, such as non-vertebral fractures, clinical vertebral fractures, cardiovascular events and cognitive function, compared to placebo. (pharmaceutical-technology.com)

The primary endpoint of the study was to reduce risk of vertebral fractures, with a 75% reduction in treated patients. (labiotech.eu)

There is fair evidence to recommend using etidronate, oral pamidronate, and limited duration of parathyroid hormone (PTH) for women with severe osteoporosis. (canadiantaskforce.ca)
All postmenopausal women are recommended to have adequate calcium and vitamin D, since participants in these clinical trials were all supplemented with calcium and vitamin D. There is insufficient evidence to recommend for or against calcium and vitamin D alone, HRT, exercise, calcitonin, parathyroid hormone, fluoride or combination therapy to prevent fractures in this population. (canadiantaskforce.ca)
Another RCT involving women with osteoporosis found that parathyroid hormone plus estrogen reduced vertebral fractures compared with estrogen alone after three years. (aafp.org)

People may not know that they have osteoporosis until their bones become so weak that a sudden strain, bump, or fall causes a hip to fracture or a vertebra to collapse. (daviddarling.info)
Vertebral body fracture is a fracture of the thick oval bone (the vertebral body) that forms the front of each vertebra. (regendoctors.com)
Balloon kyphoplasty, however, achieved less progression of wedging angle of the fractured vertebra. (amegroups.org)
Specifically, the wedging angle of fractured vertebra at 1 and 2 years following the procedures was significantly higher than that of immediately post-operative assessment for percutaneous vertebroplasty, whereas there was no difference between early and later timepoints following balloon kyphoplasty. (amegroups.org)

ACTONEL is indicated for the treatment and prevention of glucocorticoid-induced osteoporosis in men and women who are either initiating or continuing systemic glucocorticoid treatment (daily dosage of greater than or equal to 7.5 mg of prednisone or equivalent) for chronic diseases. (guidelinecentral.com)

At present, there are two main surgical methods for vertebral compression fractures, namely percutaneous kyphoplasty (PKP) and percutaneous pedicle screw fixation (PPSF). (researchsquare.com)
METHODS: Radiographs and clinical information from 115 Japanese patients (female/male: 81/34, mean age at onset: 48.7 years) diagnosed with SAPHO syndrome between January 2007 and December 2020 were retrospectively reviewed. (bvsalud.org)
Applications of Artificial Intelligence Methods for the Prediction of Osteoporotic Fractures. (cdc.gov)
COCs, the patch, and the ring do not protect against sexually transmitted diseases (STDs), including human immunodeficiency virus (HIV), and women using these methods should be counseled that consistent and correct use of the male latex condom reduces the risk for transmission of HIV and other STDs. (cdc.gov)

Prevalence of Osteoporosis and Low Bone Mass in Postmenopausal Women with Vertebral Compression Fractures. (tmu.edu.tw)
Spinal compression fractures can be extremely painful and can cause short- and long-term morbidity. (medscape.com)
Calcitonin may rarely help acute pain associated with acute osteoporotic vertebral compression fractures. (medscape.com)
About 25 percent of postmenopausal women will have vertebral compression fractures. (mwmc.com)
Fortunately, a minimally invasive technique called kyphoplasty offers relief for many people who suffer pain or have spinal deformities because of vertebral compression fractures. (mwmc.com)
People with vertebral compression fractures also are at greater risk for breathing problems, loss of appetite and difficulty with walking. (mwmc.com)
Another cause of vertebral compression fractures is trauma to the vertebrae (e.g., blunt trauma, a fall, or motor vehicle accident). (regendoctors.com)
However, few scholars have conducted researches on osteopenic vertebral compression fractures (osteopenic VCFs). (researchsquare.com)
Our research has compared the clinical and imaging effects of percutaneous kyphoplasty (PKP) and percutaneous pedicle screw fixation (PPSF) in the treatment of Osteopenic thoracolumbar vertebral compression fractures (Osteopenic VCFs). (researchsquare.com)
In the course of clinical diagnosis and treatment, there are still some patients with thoracolumbar compression fractures whose bone mineral density has not yet reached the diagnostic criteria of osteoporosis and is only in a state of osteopenia. (researchsquare.com)
Generalizability of Deep Learning Classification of Spinal Osteoporotic Compression Fractures on Radiographs Using an Adaptation of the Modified-2 Algorithm-Based Qualitative Criteria. (cdc.gov)
Differential diagnosis of benign and malignant vertebral compression fractures: Comparison and correlation of radiomics and deep learning frameworks based on spinal CT and clinical characteristics. (cdc.gov)
Deep Learning Classification of Spinal Osteoporotic Compression Fractures on Radiographs using an Adaptation of the Genant Semiquantitative Criteria. (cdc.gov)

The prediction of future bone mineral density values estimated by artificial neural networks was considered to be useful as a tool to tailor medicine for the early diagnosis of and intervention for women osteoporosis with women. (biomedcentral.com)
This is expected to be useful in combination with the use of FRAX (fracture risk assessment tool), an additional tool for the future prediction of bone fractures [ 8 ]. (biomedcentral.com)
There is fair evidence to recommend using history of previous fracture for the prediction of osteoporotic fractures. (canadiantaskforce.ca)
2 ] Identifying new biomarker(s) independent of BMD to improve fracture prediction is needed. (e-jbm.org)
It does not, however, give an accurate prediction of the likelihood of bone fracture. (cochrane.org)
Osteoporosis Prediction Using Machine-Learned Optical Bone Densitometry Data. (cdc.gov)
Prediction of osteoporosis using MRI and CT scans with unimodal and multimodal deep-learning models. (cdc.gov)
Development and validation of sex-specific hip fracture prediction models using electronic health records: a retrospective, population-based cohort study. (cdc.gov)
Conceptual design of the dual X-ray absorptiometry health informatics prediction system for osteoporosis care. (cdc.gov)

Prolia (denosumab) is a monoclonal antibody used to treat bone loss ( osteoporosis ) in women who are at high risk for bone fracture after menopause . (rxlist.com)
Dose-response study of denosumab on bone mineral density and bone turnover markers in Japanese postmenopausal women with osteoporosis. (druglib.com)
The efficacy and safety of denosumab were evaluated in Japanese postmenopausal women with osteoporosis. (druglib.com)
Denosumab was well tolerated in Japanese subjects.INTRODUCTION: The efficacy and safety of three doses of denosumab were compared with a placebo over 12 months in Japanese postmenopausal women with osteoporosis. (druglib.com)
CONCLUSIONS: Denosumab 60 mg could be an effective dose for Japanese postmenopausal women with osteoporosis as was shown in the Caucasian population. (druglib.com)
VANCOUVER, Canada - With treatment with a bisphosphonate following sequential use of teriparatide (Forteo) and denosumab (Prolia) for premenopausal women with idiopathic osteoporosis, bone mineral density (BMD) was maintained over the first year following denosumab cessation, according to results from a small, nonrandomized extension of a phase 2 study. (medscape.com)
Bisphosphonates are recommended for patients after they have completed a course of denosumab because cessation of the bone resorption blocker is known to increase bone turnover markers, decrease BMD, and raise the risk of vertebral fractures. (medscape.com)
There was a 2% decline in BMD in the forearm (distal radius [DR]). A group of 32 of the women participated in an extension study and took denosumab for 12 months. (medscape.com)
This is developed in partnership with Amgen (US), which already has the first ever FDA approved antibody drug for osteoporosis ( denosumab ). (labiotech.eu)

There has also been progress in identifying women at the highest risk of fractures. (elsevierpure.com)

Data on the effect of both treatments on fracture risk were taken from the Cochrane Database of Systematic Reviews. (unboundmedicine.com)

Postmenopausal osteoporosis is considered a serious public health concern due to its high prevalence worldwide," it added. (creakyjoints.org)
As the vitamin D status of Algerian postmenopausal women was poorly described, this cross-sectional study investigated the prevalence of low vitamin D status in a sample population. (hindawi.com)
However, data obtained from various populations of community-living postmenopausal women with or without osteoporosis highlight a wide disparity of prevalence rates of 25(OH)D concentration ≤ 20 ng/mL depending on the considered geographical areas [ 7 , 8 ]. (hindawi.com)
For instance, in a European study involving more than 8500 postmenopausal women, the prevalence of 25(OH)D deficiency reached 32.1% when considering the cutoff value of 20 ng/mL [ 9 ], while in Indian, Chinese, and US populations of postmenopausal women, the estimated prevalence rates were 53.3%, 72.1%, and 53%, respectively [ 10 - 12 ]. (hindawi.com)

Postmenopausal women with osteoporosis who took romosozumab for a year experienced "rapid and large reductions" in risk of fracturing vertebrae compared to placebo, notes research presented in Madrid at the 2017 Annual European Congress of Rheumatology. (creakyjoints.org)
Clinical vertebral fracture risk was 83 percent lower in the romosozumab group versus placebo at 12 months," the release stated. (creakyjoints.org)
One systematic review found limited evidence from two small RCTs involving postmenopausal women that calcitriol reduced vertebral fractures after three years compared with placebo. (aafp.org)
One large RCT, which focused on estrogen plus progestin versus placebo for primary prevention of coronary heart disease in healthy postmenopausal women, was stopped because hormonal treatment increased risks of invasive breast cancer, coronary events, stroke, and pulmonary embolism. (aafp.org)
The bone mineral density test, which measures how dense bones are, showed that the amount of bone lost in women taking calcium supplements for two or more years was less than that in women who took a non-active supplement (placebo). (cochrane.org)
A total of 1806 postmenopausal women were randomly assigned to receive 500 to 2000 mg of calcium supplements daily (including calcium gluconate, calcium carbonate, calcium citrate with or without vitamin D) or a non-active supplement (placebo). (cochrane.org)
Very few fractures occurred, making it difficult to determine any benefit of taking calcium compared with placebo. (cochrane.org)
However, generally there was no improvement in romozomab vs. placebo for non-vertebral fractures during this period - one of the measured secondary endpoints. (labiotech.eu)

Vertebral fractures are the main clinical consequences of spinal osteoporosis and constitute a major public health burden. (hindawi.com)
No new vertebral fracture was observed on spinal radiographs in either group. (druglib.com)
It is not recommended for younger, otherwise healthy people, or for patients whose spinal curvature is caused by conditions other than osteoporosis (such as scoliosis), who suffer from a herniated disk or severe arthritis. (mwmc.com)
Balloon kyphoplasty is generally thought to be more effective in normalizing spinal biomechanics by optimizing recovery of vertebral body height and kyphosis, and it is perhaps the preferred modality for vertebral fractures associated with vertebral with heigh loss greater than 30% ( 3 , 4 ). (amegroups.org)
Can this Positive Phase III Immunotherapy End Spinal Fractures due to Osteoporosis? (labiotech.eu)

These foods are not recommended as calcium sources for the prevention of osteoporotic fractures. (peacehealth.org)

They also rated a series of treatments attributes and stated their preference for one out of two unlabeled osteoporosis treatments. (dovepress.com)
Treatment of postmenopausal osteoporosis when alternative treatments are not suitable. (drugs.com)
Despite the fact that a number of treatments for osteoporosis have become available over the last few years, physicians still believe that lifestyle and diet are the first line in the prevention of bone loss. (womens-health.co.uk)
What are the effects of treatments for uncomplicated infections in men and nonpregnant women? (aafp.org)
What are the effects of treatments for uncomplicated infections in pregnant women? (aafp.org)
What are the effects of treatments to prevent fractures in postmenopausal women? (aafp.org)
What are vertebral body fracture treatments? (regendoctors.com)
There are six common vertebral body fracture treatments. (regendoctors.com)

New vertebral fractures, the primary endpoint, were defined by morphometry as a decrease of 20% (and at least 4 mm) in at least one vertebral height between the baseline and latest follow-up radiograph. (nih.gov)
Orthotics may be used to decrease the flexion forces to prevent the worsening of kyphosis and to reduce the pressure on the fracture site in the acute phase of disease. (medscape.com)
Patients attached the greatest value to a treatment that would decrease probability of future fractures, followed by increase in bone density, safety, and mode and frequency of administration. (dovepress.com)
When asked about treatment preferences, patients valued a treatment that would decrease probability of future fractures, followed by increase in bone density, safety, mode of administration, and frequency of administration. (dovepress.com)
These fractures decrease quality of life, was not good enough for evaluation and adding to age-related complications with they were discarded. (who.int)
Osteoporosis is a disease of the skeletal system that is characterized by deterioration of bone tissue, along with a decrease in bone mass. (naturalmedicinejournal.com)
Notably, though, the use of percutaneous pedicle screw (PPS) placement in combination with balloon kyphoplasty may alleviate the decrease in kyphosis and vertebral body height in the late setting after surgery ( 7 ). (amegroups.org)
Osteoporosis is a condition in which a decrease in the density of bones weakens the bones, making breaks (fractures) likely. (msdmanuals.com)
Although it does not cause death, menopause can decrease quality of life and lead to degenerative diseases especially bone loss or osteoporosis [2]. (bvsalud.org)

However, the term now tends to be used loosely to describe any fracture of the distal radius, with or without involvement of the ulna, that has dorsal displacement of the fracture fragments. (wikipedia.org)
Computed tomography (CT) and direct CT arthrography have become important tools in the treatment of intra-articular distal radius fractures. (medscape.com)

While several bone measurement tests similarly predict risk of fracture, DXA directly measures bone mineral density (BMD), and most treatment guidelines use central DXA to define osteoporosis and the treatment threshold to prevent osteoporotic fractures. (uspreventiveservicestaskforce.org)

Women who smoke have lower levels of estrogen compared to nonsmokers, and they often go through menopause earlier. (daviddarling.info)
or 10 mg daily in postmenopausal women not receiving estrogen. (nih.gov)
Premenopausal women are partially protected against bone loss by the hormone called estrogen. (peacehealth.org)
Both the estrogen and calcium will hinder osteoporosis which can thwart a nasty hip fracture later on (usually a death sentence in itself) and prevent vertebral fractures. (gynob.com)
Whether a woman isn't quite at the menopause and needs some supplementation, or she's past it and needs full replacement, estrogen replacement therapy is not just a good idea, it is the standard of care! (gynob.com)
Many women experience this change before or after this age, and it would be simple if this were like a light bulb going out, signaling the end of estrogen production. (gynob.com)
Even though controlled studies with only progesterone have not been performed, progesterone may be responsible for the heightened risk of breast cancer associated with estrogen-progesterone use (hormone replacement) in postmenopausal women. (medscape.com)
The amount of fat tissue a woman has correlates with the amount of estrogen produced [4,5]. (bvsalud.org)

In some cases, vertebral body fractures can stop us in our tracks. (regendoctors.com)
All patients over the age of 50 who present with a sudden and acute onset of lower back pain should be evaluated for vertebral body fractures. (regendoctors.com)
Exercise and physical therapy, especially bodyweight exercises, are invaluable tools for healing (and preventing) vertebral body fractures. (regendoctors.com)
This Message From the Editor-in-Chief focuses on one of those Original Articles and one of those Editorials, each pertaining to the management of thoraco-lumbar osteoporotic vertebral body fractures. (amegroups.org)
However, cement migration may occur with balloon kyphoplasty, as may adjacent vertebral body fractures, occurring in up to 29% of patients post-procedurally ( 5 , 6 ). (amegroups.org)

If secondary osteoporosis is present, treatment for the primary disorder should be provided. (medscape.com)
Patients who were diagnosed as secondary osteoporosis by clinical and laboratory examinations were excluded. (who.int)
Women with secondary osteoporosis were excluded, except in studies of glucocorticoid use. (elsevierpure.com)

Younger individuals tend to require a higher energy force to cause the fracture and tend to have more complex intra-articular fractures. (wikipedia.org)
therefore, forearm fractures are considered intra-articular fractures. (medscape.com)

There is insufficient evidence to recommend using bone turnover markers to predict fractures in individual postmenopausal woman. (canadiantaskforce.ca)

Prolia is usually used in women after menopause. (rxlist.com)
The North American Menopause Society has updated its position on postmenopausal osteoporosis management, last issued in 2006. (womens-health.co.uk)
Breast cancer risk assessment, hormone therapy, menopause and related medical problems, menstrual disorders and interdisciplinary women's health, osteoporosis, menopause, women's health, bioidentical hormone therapy, pelvic electrical stimulation device therapy for urinary leakage and female sexual dysfunction. (clevelandclinic.org)
So it is actually a new phenomenon that so many women are leading half their lives past the menopause. (gynob.com)
Although the source of the hormone is artificial, a woman having her hormones is as natural in later years as before the menopause. (gynob.com)
Although a woman may have enough hormone to cause a cyclic sloughing of the lining of her womb each month (the period), the decreasing levels may not be what her body has been used to all those years to keep away the other symptoms of menopause. (gynob.com)
A 52-year-old woman who just started menopause and has no other risk factors for osteoporosis. (clevelandclinicmeded.com)
A 57-year-old woman who went through natural menopause in her late 40s. (clevelandclinicmeded.com)
A 66-year-old woman who went through natural menopause in her early 50s and has no other risk factors for osteoporosis. (clevelandclinicmeded.com)
There are few studies that measure whether calcium supplements prevent fractures yet calcium supplements provide a simple and inexpensive way to prevent bone loss after menopause, as measured by bone mineral density. (cochrane.org)
To analyze the relationship between age, body mass index (BMI), bone mineral density (BMD), and alveolar bone resorption with menopause duration in postmenopausal women. (bvsalud.org)

The bisphosphonate phase of the extension study included 24 women (mean age, 43 years). (medscape.com)
The optimal duration of bisphosphonate treatment for osteoporosis has not been established. (medthority.com)

A 2008 literature review suggested that the use of "reminders plus education targeted to physicians and patients" can lead to increased BMD testing and greater use of osteoporosis medications. (medscape.com)
The authors concluded that multicomponent tools aimed at doctors and patients may support clinical decision making in the management of osteoporosis. (medscape.com)
A 2009 study indicated that the use of a case manager for the treatment of patients with hip fractures can lead to more frequent use of appropriate osteoporosis treatment and may result in fewer fractures, increased life expectancy, and significant health-care cost savings. (medscape.com)
In patients who have experienced an osteoporotic fracture, the first goal of rehabilitation is to control pain. (medscape.com)
For patients with established osteoporosis, medical intervention can halt its progression. (medscape.com)
Patients identified as at risk for osteoporosis (including children and adolescents) should undergo preventive measures, including adequate calcium intake, vitamin D intake, and exercise. (medscape.com)
Many patients who sustain these fractures have poor bone health and are at increased risk for subsequent fractures. (medscape.com)
Bone mineral density testing is underused nationwide in patients sustaining distal forearm fractures despite current guidelines. (medscape.com)
Patients usually have localized pain, tenderness, and swelling at the fracture site. (medscape.com)
Tenderness or prominence of the radial head may be the only physical finding in patients with reduced Monteggia lesion or radial head fracture. (medscape.com)
In this nonrandomized controlled clinical trial, 31 patients with osteoporosis were included. (hindawi.com)
In fact, falls are responsible for 90% of the growing increase in hip fractures [ 11 ] and are the sixth cause of death among patients aged over sixty. (hindawi.com)
conducted a study to evaluate the effects of WKO on gait disturbances and risk of falls in patients with osteoporosis [ 18 ]. (hindawi.com)
Patients reported valuing treatment efficacy, measured through reduction in future fractures and increase in bone density, and safety, as key treatment attributes. (dovepress.com)
or patients who have failed or are intolerant to other available osteoporosis therapy. (rxlist.com)
Since the organization last issued a statement, the 10-year fracture risk calculator, known as FRAX, has been made available, thanks to a World Health Organization meta-analysis of over 60,000 patients and more than 5,000 fractures. (womens-health.co.uk)
Should we look for osteoporosis in patients with rheumatoid arthritis? (bmj.com)
Moreover, successful prevention of further bone loss in patients with primary osteoporosis can be offered now with the introduction of new and more potent anti-osteoporotic drugs. (bmj.com)
2 Osteoporosis in RA patients is often related to the use of corticosteroids, but rheumatologists are increasingly aware that bone loss in RA patients may also occur in RA patients without (previous) use of corticosteroids. (bmj.com)
The patients had experienced a mean of 3.0 fractures in adulthood, and 38% of patients had a history of vertebral fracture. (medscape.com)
For patients at low- risk for fracture, consider drug discontinuation after 3 to 5 years of use. (nih.gov)
Patients with new thigh or groin pain should be evaluated to rule out an incomplete femoral fracture. (nih.gov)
abstract = 'Early prognosis of osteoporosis risk is not only important to individual patients but is also a key factor when screening for osteoporosis drug trial populations. (ku.dk)
Cancer patients, people with circulatory disorders like thrombophlebitis, and some women with fibrocystic breasts will not be candidates. (gynob.com)
Patients who discontinue therapy should have their risk for fracture re-evaluated periodically. (guidelinecentral.com)
1 Osteoporotic fractures, particularly hip fractures, are associated with limitation of ambulation, chronic pain and disability, loss of independence, and decreased quality of life, and 21% to 30% of patients die within 1 year of a hip fracture. (uspreventiveservicestaskforce.org)
Of 785 radiographs analysed 159 (20.3%) patients had 198 vertebral fractures. (who.int)
Patients who underwent which decreases the bone quantity and quali- standard posterior-anterior and lateral chest ty causing fragility fractures. (who.int)
A total of 71 patients were treat complications of osteoporosis rather excluded from the study: 21 had malignant than osteoporosis itself [ 6 ]. (who.int)
Especially, fractures of the proximal femur (femoral) often have a markedly negative impact on the quality of life of affected patients [ 1 ]. (biomedcentral.com)
One systematic review involving older community-dwelling patients or nursing home residents found no significant difference in hip fractures after six months to two years between hip protectors and no protectors in RCTs where individuals were randomized. (aafp.org)
Vertebral body fracture is most often diagnosed in patients with pre-existing osteoporosis. (regendoctors.com)
For osteopenic patients between the ages of 55 and 65, the probability of fracture was 4.6% ~10.4% for men and 6.7%~19.3% for women. (researchsquare.com)
They provide insightful suggested management strategies, including treatment approaches for patients with recent osteoporotic fractures that are immediately symptomatic and for patients in whom osteoporotic fractures are initial asymptomatic and later become symptomatic due to kyphosis. (amegroups.org)
Development of Machine Learning Models for Predicting Osteoporosis in Patients with Type 2 Diabetes Mellitus-A Preliminary Study. (cdc.gov)
A Computed Tomography-Based Radiomics Analysis of Low-Energy Proximal Femur Fractures in the Elderly Patients. (cdc.gov)
CNN-based evaluation of bone density improves diagnostic performance to detect osteopenia and osteoporosis in patients with non-contrast chest CT examinations. (cdc.gov)

The green light has also been given for Prolia as a treatment to increase bone mass in men at high risk for fracture receiving androgen-deprivation therapy (ADT) for non-metastatic prostate cancer. (pharmatimes.com)
Prolia ® is contraindicated in women who are pregnant and may cause fetal harm. (evenityproliahcp.com)

A fracture with mild angulation and displacement may require closed reduction. (wikipedia.org)
[ 147 ] In addition, a physician reminder in conjunction with a patient risk assessment strategy can result in a reduction in patient fractures and an increase in osteoporosis therapy. (medscape.com)
Muscle reeducations and resistance exercises for strengthening and reduction of kyphosis are key elements for reducing the risk of falls and subsequent fractures [ 2 , 13 - 15 ]. (hindawi.com)
The rapid and large reduction in clinical vertebral fracture risk is an important and highly relevant clinical outcome," he said in the release. (creakyjoints.org)
Many randomized controlled trials (RCTs) have investigated drug treatment for women at high risk of fracture, with a reduction in fracture risk as their end point. (elsevierpure.com)

Women aged 55-81 with low femoral-neck BMD were enrolled in two study groups based on presence or absence of an existing vertebral fracture. (nih.gov)
Application of intelligent X-ray image analysis in risk assessment of osteoporotic fracture of femoral neck in the elderly. (cdc.gov)

Colles fractures occur in all age groups, although certain patterns follow an age distribution. (wikipedia.org)
Fractures can occur with little or no force and may occur after a minor fall. (msdmanuals.com)

Although there is evidence to support this treatment sequence for postmenopausal women, there was no evidence regarding premenopausal women with idiopathic osteoporosis, said Adi Cohen, MD, who presented the results of the study at the American Society for Bone and Mineral Research (ASBMR) 2023 Annual Meeting. (medscape.com)
It is too early to call the results practice changing, said Cohen, professor of medicine and endocrinology at Columbia University Irving Medical Center (CUIMC), but she noted, "It's important just to provide information about how sequences of osteoporosis medications might be used in a rare but certainly understudied group of premenopausal women with osteoporosis who need treatment, and these data hopefully will help make some treatment decisions. (medscape.com)
In the early 2000s, researchers initially believed that premenopausal women with low BMD had experienced some kind of temporary event and that they would likely improve on their own over time. (medscape.com)
However, there are no practice guidelines for the management of osteoporosis in premenopausal women, according to Shane. (medscape.com)
For premenopausal women, exercise is also important, but taken to extreme, it may lead to cessation of the menstrual cycle, which contributes to osteoporosis. (peacehealth.org)
The International Society for Clinical Densitometry (ISCD) recommends that T scores not be used in premenopausal women or in younger men, and certainly not in children. (clevelandclinicmeded.com)
CHC use has little to no effect on BMD in premenopausal women ( 60 - 74 ) and might preserve bone mass in those who are perimenopausal ( 75 - 83 ). (cdc.gov)
BMD is a surrogate marker for fracture risk that might not be valid for premenopausal women and therefore might not accurately predict current or future (postmenopausal) fracture risk ( 84 - 86 ). (cdc.gov)

In the absence of head-to-head RCTs with fracture risk as the end point, however, the efficacy of antifracture drugs cannot be directly compared. (elsevierpure.com)

The diagnosis of osteoporosis is based on the presence of fragile bone fractures or low bone mineral densities (BMD), which are usually measured by dual energy X-ray absorptiometry (DXA). (biomedcentral.com)
For the latter, values of no more than 70% YAM (young adult mean values), the same as a T-score (the bone density compared with what is normally expected in a healthy young adult of your sex in terms of standard deviations) ≤ − 2.5, were designated as cut-off values for the diagnosis of osteoporosis [ 3 ]. (biomedcentral.com)

For hormonal reasons, significant osteoporosis is much more common in women than in men. (daviddarling.info)
Many women experience symptoms and complaints due to these hormonal changes. (bvsalud.org)
Limited information is available about the safety of the combined hormonal patch and combined vaginal ring among women with specific medical conditions. (cdc.gov)

Postmenopausal women with osteoporosis who took romosozumab for a year experienced "rapid and large reductions" in risk of fracturing vertebrae. (creakyjoints.org)
However, if the force put on the vertebrae exceed the threshold they can tolerate, or the threshold is lowered due to problems, the vertebrae can fracture and collapse. (regendoctors.com)

Colles fracture is a common fracture in people with osteoporosis, second only to vertebral fractures. (wikipedia.org)

The classic Colles fracture has the following characteristics: Transverse fracture of the radius 2.5 cm (0.98 inches) proximal to the radio-carpal joint dorsal displacement and dorsal angulation, together with radial tilt Other characteristics: Radial shortening Loss of ulnar inclination≤ Radial angulation of the wrist Comminution at the fracture site Associated fracture of the ulnar styloid process in more than 60% of cases. (wikipedia.org)
The volar forearm splint is best for temporary immobilization of forearm, wrist and hand fractures, including Colles fracture. (wikipedia.org)
Proper management of such fractures is necessary to restore forearm functions, including supination and pronation, elbow and wrist movements, and handgrip strength. (medscape.com)
The upper extremity is involved in nearly half of all fractures seen, and wrist fractures account for about one third of these. (medscape.com)
Anteroposterior and lateral radiographic views of the wrist, forearm, and elbow are required when forearm fracture is suspected from clinical findings. (medscape.com)
18% were of wrist fractures and more than twice that in females above the age of 50 years. (who.int)

In only 37.8% of the radiographs with fractures was a vertebral fracture highlighted in the radiologist's report, and only 13.2% of the women with vertebral fractures were on antiresorptive therapy for osteoporosis. (who.int)
If osteoporosis therapy remains warranted, continued therapy with an antiresorptive agent should be considered. (evenityproliahcp.com)

Follow-up radiographs were obtained for 1946 women (98% of surviving participants). (nih.gov)
Forearm fractures are less identifiable on radiographs in children than in adults. (medscape.com)
Chest radiographs from consecutive Saudi women over the age of 50 years visiting the emergency room at King Fahd Hospital of the University were evaluated. (who.int)
A.H.G. and H.S.). The radiographs were white women in the USA have osteoporosis, then jointly reviewed with the principle au- of whom 25% have a vertebral fracture [ 3 ]. (who.int)
17 ]. Radiographs fractures are missed by clinicians [ 8-10 ] were scored as normal (0), mild (1), moder- and more remain undetected by radiologists ate (2) or severe (3). (who.int)
I am happy to let the radiologists use it to describe washed out bones seen on standard radiographs, but I realize that someone with washed-out bones has probably lost 30% of her or his young adult bone mass and therefore has osteoporosis. (clevelandclinicmeded.com)

Those who drink heavily are more prone to bone loss and fractures, because of both poor nutrition and increased risk of falling. (daviddarling.info)

Clinicians should offer pharmacologic treatment with bisphosphonates to reduce the risk for vertebral fracture in men who have clinically recognized osteoporosis. (medscape.com)

It is characterized by low bone mass and microarchitectural deterioration of bone tissue, leading to increased bone fragility and a consequent increase in fracture risk [ 1 , 2 , 7 ]. (hindawi.com)

Anatomy19

Organisms1

Diseases47

Chemicals and Drugs77

Analytical, Diagnostic and Therapeutic Techniques and Equipment71

Psychiatry and Psychology2

Phenomena and Processes34

Anthropology, Education, Sociology and Social Phenomena3

Technology, Industry, Agriculture6

Humanities1

Information Science4

Named Groups3

Health Care40

Geographicals5

Alendronate17

Prevalent vertebral fractures2

Post-menopausal11

Nonvertebral fractures11

Among postmenopausal women6

Incidence8

Spine12

Raloxifene4

Risedronate2

Osteoporotic vertebral fractures1

Treatment of osteoporosis5

Increases11

Clinical vertebral fractures1

Reduce risk of vertebral1

Parathyroid hormone3

Vertebra4

Glucocorticoid-induced oste1

Methods4

Compression13

Prediction9

Denosumab9

Risk of fractures1

Cochrane Database of Systematic Reviews1

Prevalence4

Placebo8

Spinal5

Prevention of Osteoporotic Fractures1

Treatments8

Decrease9

Distal radius2

Prevent osteoporotic fractures1

Estrogen8

Body fractures5

Secondary osteoporosis3

Intra-articular fractures2

Turnover markers1

Menopause11

Bisphosphonate2

Patients37

Prolia2

Reduction5

Femoral-neck2

Occur2

Premenopausal women8

Efficacy1

Diagnosis of osteoporosis2

Hormonal3

Vertebrae2

Common fracture1

Wrist6

Antiresorptive2

Radiographs6

Bone loss and fractures1

Clinically recognized osteoporosis1

Increase in fracture1