Versus leukemia effect graft vs leukemia effect. Medical search. Frequent questions

These T cells are not alloreactive and do not induce GVHD but can exhibit potent anti-leukemia and anti-infectious activities. (bethematchclinical.org)
Although new techniques are being developed to extend CAR T cell therapy to the allogeneic setting, the risk of graft-versus-host disease (GVHD) remains. (bethematchclinical.org)
Graft versus host disease (GVHD) is an immune-mediated condition resulting from a complex interaction between donor and recipient adaptive immunity. (medscape.com)
Autologous graft versus host disease (GVHD) involving the skin of a patient's arm appeared shortly after signs of engraftment appeared. (medscape.com)
A new Phase 3 clinical trial at Winship is enrolling participants after extremely encouraging results in the study's first two phases indicate the first-in-class high-precision cell therapy retains the benefits of stem cell transplant without such serious complications as graft versus host disease (GvHD) and disease relapse in patients with certain blood cancers. (emory.edu)
GvHD is an immune reaction of donor T cells against normal tissues in the transplant recipient," he says. (emory.edu)
Orca-T combines purified cells from a matched donor to replace a patient's diseased blood and immune system with a healthy one while lowering their risk of developing GvHD and other life-threatening transplant-related side effects. (emory.edu)
These cells expand and help prevent both rejection of the graft and GvHD. (emory.edu)
BACKGROUND: Preventing graft-versus-host disease (GVHD) by depletion of T lymphocytes from the stem cell graft for transplantation remains controversial, mainly because of the perceived increase in disease recurrence. (ox.ac.uk)
CONCLUSION: T-cell depletion with CAMPATH-1 effectively prevents GVHD, particularly the severe acute forms, without leading to excessive risk of relapse in acute leukemia. (ox.ac.uk)
While bone marrow transplants (BMTs) are sometimes the only hope for patients with diseases like leukemia and other blood disorders, they come with the significant risk of the patient developing graft-vs-host disease (GVHD). (genengnews.com)
We were able to identify two ligands and two receptors that account for all the effects of Notch signaling in GVHD, with a dominant role for just one ligand-receptor pair," Dr. Maillard explains. (genengnews.com)
When the researchers used antibodies to inhibit the target Notch ligands, mice had none of the gastrointestinal side effects that came with global inhibition of Notch-and they did not develop GVHD. (genengnews.com)
The effects of Notch blockade could be traced to decreased inflammation as well as increased expansion of regulatory T cells that suppress GVHD, Dr. Maillard says. (genengnews.com)
GvHD: uncoupling immunopathology from the graft-vs-leukemia effect. (ncri.org.uk)
The possibility exists that there could be a little "Graft vs. Host Disease" (GVHD) going on but, it could also be the prophylactic drugs I take every day causing havoc with my digestive tract. (johnbugay.com)
At the same time, the so-called graft versus host disease (GvHD) often develops when the donor's lymphocytes are transplanted. (uni-mainz.de)
[ 20 ] Hosokawa et al reported two cases of APL associated with HSCT in children who manifested graft-versus-host disease (GVHD) following treatment for leukemia. (medscape.com)
GVHD disease is the most common consequence of allogeneic BMT and the skin is the most commonly affected organ [5, 13]. (bvsalud.org)

Can Graft vs. Leukemia Effect Be Uncoupled From Graft vs. Host Disease? (vcu.edu)
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is applied successfully to the treatment of many hematopoietic malignancies, but remains limited by severe acute graft-versus-host-disease (aGvHD). (frontiersin.org)
Joshua Brody, MD, Director of the CLL/Lymphoma Immunotherapy Program, Icahn School of Medicine at Mount Sinai, New York, who was not involved in these trials, commented: "CLL is an extremely prevalent disease affecting nearly 200,000 patients in the United States. (ascopost.com)
Leukemia remission is when there is no evidence of the disease during treatment. (medicalnewstoday.com)
In other words, it is a period when leukemia is in a state of minimal or undetectable disease activity. (medicalnewstoday.com)
Refractory ALL is a type of leukemia characterized by the failure to achieve complete remission or the recurrence of the disease after initial treatment. (medicalnewstoday.com)
The transplantation of stem cells from a healthy donor (allogeneic) offers the chance of cure for patients with an aggressive form of chronic lymphocytic leukemia (CLL), irrespective of genetic prognostic factors and the prior course of the disease. (disabled-world.com)
Allogeneic stem cell transplantation provides durable disease control in poor-risk chronic lymphocytic leukemia: long-term clinical and MRD results of the GCLLSG CLL3X Trial. (disabled-world.com)
Principal investigator Edmund K. Waller, MD, PhD, FACP, says the net result of giving the patient a precise number of donor T cells with specific functions "leads to better elimination of cancer with less graft versus host disease and less toxicity from the transplant. (emory.edu)
Graft versus host disease can cause severe damage to the skin, liver, intestines and lungs," Waller says. (emory.edu)
Chronic graft- versus -host disease (cGvHD) is a major cause of morbidity after hematopoietic stem cell transplantation (HSCT). (haematologica.org)
As a result, HSCT is often attributed to an increased risk of health complications, the most severe being chronic graft- versus -host disease (cGvHD). (haematologica.org)
Ex vivo depletion of T cells from bone marrow grafts with CAMPATH-1 in acute leukemia: graft-versus-host disease and graft-versus-leukemia effect. (ox.ac.uk)
Antibodies inhibiting specific elements of the Notch pathway can prevent the disease in mice, without serious side effects and without substantially compromising the cancer-fighting ability of the transplanted cells, the team reports. (genengnews.com)
Conventional methods for preventing the disease include removing T cells from the donor graft and treating the patient with global immunosuppressive drugs. (genengnews.com)
These findings open perspectives for studying Notch inhibition in the treatment of T cell-mediated disorders including graft-versus-host disease in patients. (genengnews.com)
Only five out of 72 patients (6.9%) developed graft versus host disease. (arizona.edu)
Use of donor-derived CAR T cell for relapse prophylaxis, minimal residual disease clearance or salvage from relapse is therefore highly effective, and risk of graft versus host disease flare is very low. (arizona.edu)
Graft vs leukemia (GVL) effects independent of graft vs host disease were investigated in allogeneic bone marrow chimeras tolerant of host and donor alloantigens. (ox.ac.uk)
The data suggest that T cells may mediate GVL effects in the absence of graft vs host disease and in circumstances where tolerance to conventional alloantigens is elicited. (ox.ac.uk)
Induction of GVL effects by allogeneic cells tolerant of host MHC suggests that these effects may be independent of graft vs host disease. (ox.ac.uk)
The clinical use of this agent in prevention and treatment of graft-versus-host disease will be examined. (johnshopkins.edu)
The types of leukemia are grouped based on how quickly the disease develops. (cancersupportcommunity.org)
She's still got "a touch of chronic GHVD" (graft vs host disease). (johnbugay.com)
These patients typically require immune suppression treatment to suppress graft versus host disease. (scitechdaily.com)
What we need is the graft-versus-leukemia effect without the graft-versus-host disease. (blogspot.com)
High incidence of extensive chronic graft-versus-host disease in patients with the REG3A rs7588571 non-GG genotype. (cdc.gov)
Characteristics and risk of chronic graft-versus-host disease of liver in allogeneic hematopoietic stem cell transplant recipients. (cdc.gov)
Donor-recipient killer immunoglobulin like receptor (KIR) genotype matching has a protective effect on chronic graft versus host disease and relapse incidence following HLA-identical sibling hematopoietic stem cell transplantation. (cdc.gov)
Chain Predicts Risk of Graft-versus-Host Disease and Cytomegalovirus Infection after Allogeneic Hematopoietic Stem Cell Transplantation. (cdc.gov)
Chronic graft-versus-host disease could ameliorate the impact of adverse somatic mutations in patients with myelodysplastic syndromes and hematopoietic stem cell transplantation. (cdc.gov)
Chronic graft versus host disease (cGVHD) is the most common consequence of allogeneic bone marrow transplantation, and it is associated with morbidity and mortality. (bvsalud.org)
Chronic graft-vs-host disease (cGVHD) is the most common complication following allogeneic BMT [10]. (bvsalud.org)
Many other clinical conditions present substantial skin fibrosis and may be potentially confused with Scleroderma, sometimes leading to a wrong diagnosis (eosinophilic fasciitis, systemic amyloidosis, scleromyxedema, graft-versus-host disease, progeroid disorders, stiff skin syndrome). (bvsalud.org)
During the current outbreak, CDC has received reports of people with monkeypox who have severe manifestations of disease, including but not limited to · Atypical or persistent rash with coalescing or necrotic lesions, or both, some which have required extensive surgical debridement or amputation of an affected extremity. (cdc.gov)

Successful treatment of therapy-resistant chronic leukemia using allogeneic stem cell transplantation. (disabled-world.com)
Our study is the largest so far for this patient population and proved that allogeneic stem cell transplantation is a promising therapy option for high-risk CLL and has the potential to cure for this otherwise incurable kind of leukemia," says Professor Dreger, head of the study. (disabled-world.com)
Allogeneic stem cell transplantation is a very stressful and risky form of therapy, which could previously not be carried out on the generally older patients affected by CLL. (disabled-world.com)
Survival after allogeneic transplantation depends on donor-recipient matching, the graft-versus-host response and the development of a graft versus leukemia effect. (emory.edu)
The platform technology used in this study can be applied to include additional populations of cells that may further improve survival and decrease complications for patients with leukemia and MDS undergoing allogeneic stem cell transplantation," he says. (emory.edu)
Characterization of effector cells of graft vs leukemia following allogeneic bone marrow transplantation in mice inoculated with murine B-cell leukemia. (ox.ac.uk)
It is now widely accepted that immunocompetent lymphocytes in allogeneic bone marrow grafts exert an antileukemic effect that contributes to the cure of leukemia. (ox.ac.uk)
Poor graft function (PGF), manifested by multilineage cytopenias and complete donor chimerism post-allogeneic stem cell transplantation (alloSCT), and acquired aplastic anaemia (AA) are immune-mediated acquired bone marrow (BM) failure syndromes with a similar clinical presentation. (bvsalud.org)
Allogeneic hematopoietic stem cell transplantation is currently the only available treatment that offers patients a realistic chance of recovery from chemotherapy-resistant leukemias. (uni-mainz.de)
In the allogeneic stem cell technique, what happens is that the leukemia patient's own hematopoietic cells are first destroyed by chemotherapy and radiation therapy. (uni-mainz.de)
Kinetics and Risk Factors of Relapse after Allogeneic Stem Cell Transplantation in Children with Leukemia: A Long-Term Follow-Up Single-Center Study. (cdc.gov)

chronic leukemias are composed of more mature cells. (curehunter.com)
See Chronic Leukemias: 4 Cancers to Differentiate, a Critical Images slideshow, to help detect chronic leukemias and determine the specific type present. (medscape.com)

Stem cell transplantation, or bone marrow transplantation, is a treatment option for leukemia and other blood cancers. (medicalnewstoday.com)
The German CLL Study Group proved this in a multi-centric clinical phase II study led by Professor Dr. Peter Dreger, senior consultant and head of the division of stem cell transplantation at the Department of Internal Medicine V at Heidelberg University Hospital. (disabled-world.com)
For a large percentage of patients, highly sensitive tests were conducted regularly to detect any remaining leukemia cells after the transplantation. (disabled-world.com)
Some medical treatments may affect transplantation. (clevelandclinic.org)
Autologous hematopoietic cell transplantation for adult acute myeloid leukemia: An obsolete or resurfacing concept? (umn.edu)
Dive into the research topics of 'Autologous hematopoietic cell transplantation for adult acute myeloid leukemia: An obsolete or resurfacing concept? (umn.edu)
The curative effect of stem cell transplantation relies on alloreactivity of donor T cells against cancer cells, which is known as Graft-versus-Leukaemia (GvL). (ox.ac.uk)
Ideally, the donor's lymphocytes, received during the transplantation will destroy any remaining leukemia cells. (uni-mainz.de)
When a donor's lymphocytes are transferred during stem cell transplantation, this is often accompanied by a so-called graft versus leukemia (GvL) effect. (uni-mainz.de)
10 Data from the European Society for Blood and Marrow Transplantation (EBMT) megafile database indicates that the graft-versus-tumour effect achieved with allo-SCT is weaker and PFS rates lower in MM than in other types of haematological cancers. (medicalupdateonline.com)
69 Years with Acute Myelogenous Leukemia: On Behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation. (cdc.gov)
Another form of lipodystrophy that fits the classification of "acquired partial" not involving the complement pathway is associated with hematopoietic stem cell transplantation (HSCT) to treat leukemia or neuroblastoma. (medscape.com)
Bone marrow transplantation (BMT) is the treatment of choice for lymphoma, aplastic anemia, various types of leukemia and immunodeficiency disorders [5]. (bvsalud.org)

T-replete mismatched cord blood transplant (TRCB) offers an augmented graft versus leukemia (GVL) effect mediated by alloreactive donor T cells and thereby presents a potential for long term remission and cure in high risk and relapsed refractory AML in children. (ebmt.org)

To create the precision-engineered donor graft, Waller explains that different cellular subsets in the graft are selectively purified and then infused into the transplant recipient in a timed fashion. (emory.edu)

In the last decade, multiple novel cellular therapies have been developed to enhance graft-versus-leukemia (GVL) effects, and these advances have the potential to change the standard of care in preventing or treating post-transplant relapse. (bethematchclinical.org)
Broader use has been hampered for a long time mainly by high non-relapse mortality, offsetting the advantage of a graft-vs-lymphoma effect. (nih.gov)

Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. (curehunter.com)

The main risk still remains the "graft-versus-host reaction", in which donor cells attack the patient's own cells, which are foreign to them. (disabled-world.com)
The efficacy of allo-SCT in MM relies on the transplanted immune system having an anti-tumour effect on the host bone marrow, the so-called graft-versus-myeloma (GvM) effect. (medicalupdateonline.com)

However, some side effects may last longer or become severe or bothersome. (healthgrades.com)
When used at high doses in doseranging studies in patients with acute leukemia , FLUDARA (fludarabine) FOR INJECTION was associated with severe neurologic effects, including blindness, coma, and death. (rxlist.com)
Similar severe central nervous system toxicity, including coma, seizures, agitation and confusion, has been reported in patients treated at doses in the range of the dose recommended for chronic lymphocytic leukemia. (rxlist.com)

Healthcare providers call this "graft-versus-tumor" effect (GVT). (clevelandclinic.org)
The optimization of graft composition should not only enable a sufficient IR but also improve graft vs. leukemia/tumor effects, overcome infectious complications and, finally, improve patient survival. (uni-wuerzburg.de)
Side effects include cytokine release syndrome, tumor lysis syndrome, B-cell aplasia along with CNS toxicity. (arizona.edu)

Learn about remission from acute myeloid leukemia (AML). (medicalnewstoday.com)
Therefore, we analyzed the influence of graft manipulation on IR in 40 patients with acute leukemia in remission. (uni-wuerzburg.de)
Early T-cell expansion post T-replete mismatched cord transplant with granulocytes is associated with induction of remission and sustenance in relapsed-refractory high risk acute myeloid leukemia. (ebmt.org)

providing evidence for an immunological graft-versus-leukemia effect (GvL). (frontiersin.org)
This review will cover the basic pharmacology and immunological effects of pentostatin. (johnshopkins.edu)

He led the initial clinical trials of the drug that resulted from the team's research, later known as rituximab, which demonstrated its safety and activity against CD20-positive B cells in patients with lymphoma. (wikipedia.org)
Clinical treatment currently involves the use of corticosteroids, other immunosuppressive drugs and newly developed biologics, the long term application of which are limited by serious systemic side effects and the local risk of cataracts and glaucoma 24 , 25 . (nature.com)
In a study reported in the Journal of Clinical Oncology, Elsayed et al developed a risk score based on single nucleotide polymorphisms (SNPs) associated with cytarabine pharmacodynamics or clinical outcomes that identified pediatric patients with acute myeloid leukemia (AML) who could benefit from. (ascopost.com)
Winship is one of several clinical trial sites for the Precision-T study evaluating the safety and efficacy of Orca-T, a cell therapy that combines purified cells from a matched donor, in patients with acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL) and high-risk myelodysplastic sydromes (MDS). (emory.edu)
Some of the more common side effects of Imbruvica that occurred during clinical studies are listed below. (healthgrades.com)
Pre-clinical and clinical data support a beneficial synergistic effect of ibrutinib on apheresis product fitness, CAR-T expansion and toxicity. (bvsalud.org)
The Chief Scientific Director of the Mainz University Medical Center, Professor Reinhard Urban, is convinced that the team led by Professor Wolfgang Herr will be able to achieve significant progress in the field of leukemia treatment: 'I share the view of the German Research Foundation that it will be readily possible to apply the highly relevant research results to clinical practice. (uni-mainz.de)
What started as a personal journey of a doctor turned patient morphed into a way to share what's universal in dealing with cancer, in my case a nasty leukemia (CLL), a failed transplant and a successful clinical trial. (blogspot.com)

It is crucial to control the transplanted donor immune cells so that the effect is strong enough to eliminate the leukemia cells but not strong enough to lead to complications in other tissues and organs. (disabled-world.com)

This development could make these cells available to more people, and be more readily accepted in those who undergo adult stem cell treatments for conditions such as leukemia, blood disorders, immune system diseases, and other types of cancers, but who do not have an appropriate available bone marrow match. (scitechdaily.com)

The role of Thy1.2, L3T4 and Lyt2 T lymphocytes as effector cells of GVL were investigated in (BALB/c x C57BL/6)F1 mice inoculated with murine B-cell leukemia and subsequently conditioned with total lymphoid irradiation and cyclophosphamide (200 mg/kg). (ox.ac.uk)
The lymphocytes produced by the donor's immune system then recognize and destroy the leukemia cells still present in the patient's body. (uni-mainz.de)
This effect means that the donor's lymphocytes attack the healthy tissues of the patient's weakened body. (uni-mainz.de)
Chronic lymphocytic leukemia (chronic lymphoid leukemia, CLL) is a monoclonal disorder characterized by a progressive accumulation of functionally incompetent lymphocytes (see the image below). (medscape.com)

Furthermore, the chemoattractive effects of CCL2 and CCL21 on inflammatory cells were inhibited by MSC-Exo. (nature.com)
Refractory ALL is a more challenging form of leukemia because the cancer cells have become resistant to standard treatments. (medicalnewstoday.com)
However, this is also the mechanism by which the leukemia cells are eliminated. (disabled-world.com)
This blood disorder affects your body's ability to produce red blood cells. (clevelandclinic.org)
This disorder affects white blood cells. (clevelandclinic.org)
The conventional T cells help eliminate the cancer in the patient through a process called "graft-versus-leukemia. (emory.edu)
Haplo-CAR T cells could effectively proliferate in vivo and had a clinically significant antitumor activity without serious side effects. (bmj.com)
Leukemia is cancer of the blood cells. (cancersupportcommunity.org)
The Vidaza she is taking is a form of chemotherapy that has two functions: a cytotoxic effect, which just simply kills bad (and good) cells, and a genetic component, which is supposed to allow some of the "undifferentiated" blast cells (baby blood cells) to "grow up" and differentiate into the kinds of cells they are supposed to be. (johnbugay.com)
The first effect continues to work - she feels terrible - but I think that, because her brand of leukemia is so rare, the Vidaza doesn't quite touch on the genes that enable these blast cells to differentiate normally. (johnbugay.com)
Since the Ythdf2 protein is present in different kinds of adult stem cells, targeting it and how it affects hematopoietic stem cells seemed a safer approach and, if it worked, broadly applicable. (scitechdaily.com)
What if there was some way to temporarily replace the stem cells with the donor, and then have those fade away once they've killed the leukemia, to be replaced by the patient's own cells again. (blogspot.com)

The in vitro effects of MSC-Exo on immune cell migration and responder T cell proliferation were examined by chemotactic assays and lymphocyte proliferation assays, respectively. (nature.com)
Unexpectedly, analysis of samples from patients with good graft function post-alloSCT demonstrated significant changes in the immune microenvironment compared to normal controls, with downregulation of CD44, STING, VISTA, and ARG1, suggesting that recovery of multilineage haematopoiesis post-alloSCT does not reflect recovery of immune function and may prime patients for the development of PGF upon further inflammatory insult. (bvsalud.org)

In patients with newly diagnosed acute myeloid leukemia (AML) with an IDH1 mutation who were ineligible for intensive chemotherapy, the addition of the IDH1 inhibitor ivosidenib to azacitidine significantly improved survival vs azacitidine alone, according to data presented at the 2021 American. (ascopost.com)

The latest research in cellular therapies, antibody-based treatments, and tyrosine kinase inhibitor (TKI)-based approaches to enhance GVL effects are outlined in articles published in a special edition of Blood . (bethematchclinical.org)

Treatments for leukemia include chemotherapy, radiation therapy, and stem cell transplants. (medicalnewstoday.com)
Chemotherapy, radiation therapy, targeted therapy, and stem cell or bone marrow transplant are common treatment options for leukemia. (medicalnewstoday.com)
Chemotherapy for leukemia can cause various side effects, depending on the specific drugs, the dosage, and the person. (medicalnewstoday.com)
Some supportive therapies, such as anti-nausea medications or growth factors to boost blood cell production, may help manage side effects and improve quality of life during chemotherapy. (medicalnewstoday.com)
Learn more about chemotherapy side effects here. (medicalnewstoday.com)
People who are exposed to high levels of radiation and the chemical benzene are more likely to get certain types of leukemia, as are smokers, people who have had chemotherapy and people with certain inherited diseases and blood disorders. (cancersupportcommunity.org)
So the net effect is that she is receiving a light version of a chemotherapy (which is working), but with none of the good effects. (johnbugay.com)

In addition to his research, he treats patients with chronic lymphocytic leukemia, non-Hodgkin lymphoma and multiple myeloma at Seattle Cancer Care Alliance. (wikipedia.org)
More than 170,000 people in the US are expected to be diagnosed in 2018 with blood cancer (leukemia, lymphoma, or myeloma) according to the American Cancer Society. (scitechdaily.com)

CLL is the most frequent form of leukemia in western countries. (disabled-world.com)
It is the most common form of leukemia found in adults in Western countries. (medscape.com)

This effect is crucial for reducing the risk of the recurrence of leukemia. (uni-mainz.de)
During the pretravel consult for an immunocompromised traveler, consider additional issues (e.g., the patient's increased risk for travel-associated infections and diseases, the effects travel can have on the patient's underlying condition, and the patient's response or adverse reactions to pretravel vaccines and travel medications). (cdc.gov)

Scientists at St. Jude Children's Research Hospital are studying the impact of genetic ancestry on childhood acute lymphoblastic leukemia (ALL). (ascopost.com)

Each treatment option can have side effects that vary for different people. (medicalnewstoday.com)
The healthcare team will work closely with the person to manage side effects and provide supportive care throughout treatment. (medicalnewstoday.com)
According to the researchers, the treatment was only necessary short-term, although its beneficial effects were long lasting. (genengnews.com)
Treatment of the primary marrow inoculum with monoclonal anti-Thy1.2 or anti-Lyt2 abolished the GVL effects and all secondary BALB/c recipients developed leukemia within 60 days. (ox.ac.uk)
On the other hand, the treatment with monoclonal anti-L3T4 did not influence the effect of GVL and all treated recipients remained without leukemia. (ox.ac.uk)

12 however, the finding in the Myeloma XI study that lenalidomide maintenance therapy was associated with a significant improvement in PFS but with little further improvement in depth of response 13 suggests that the graft is providing an adjunct to highly effective maintenance therapy rather than the other way around. (medicalupdateonline.com)

A woman with human immunodeficiency virus (HIV) who received a cord blood stem cell transplant to treat acute myeloid leukemia has had no detectable levels of HIV for 14 months, despite cessation of antiretroviral therapy, according to research presented at the Conference on Retroviruses and. (ascopost.com)
A 27-year-old female was admitted, in a Hematology Center, in 1997, with previous diagnosis of chronic myeloid leukemia since 1994. (bvsalud.org)

We examined the cell recovery post haploidentical SCT in patients receiving a CD34(+)-selected or CD3/CD19-depleted graft, considering the applied conditioning regimen. (uni-wuerzburg.de)
In conclusion, cell reconstitution dynamics showed complex diversity with regard to the graft manufacturing procedure and conditioning regimen. (uni-wuerzburg.de)

Treatments may cause side effects that vary for different people. (medicalnewstoday.com)
This article outlines the main leukemia treatments. (medicalnewstoday.com)

CPI brings together patient advocates and policy experts to effect policymaking. (cancersupportcommunity.org)
Peripheral smear from a patient with chronic lymphocytic leukemia, small lymphocytic variety. (medscape.com)
The patient reported that the lesions caused considerable discomfort and affected her normal oral function. (bvsalud.org)

Especially in haploidentical SCT, the optimization of graft composition is controversial. (uni-wuerzburg.de)

Following device implantation, patients may experience stent ring enlargement beyond design specification, stent fractures, holes in the graft fabric (type III endoleaks), life-threatening bleeding, aortic rupture, or death. (acpinternist.org)

If you're using it to treat cancer, you'll take it until it's no longer effective or until you can't tolerate its side effects. (healthgrades.com)
Fludara (fludarabine) is a cancer medication used to treat B-cell chronic lymphocytic leukemia (CLL). (rxlist.com)
Those kinds of genetic mutations could lead to the re-genesis of leukemia or cancer, Zhenrui Li explains. (scitechdaily.com)

Anatomy1

Organisms5

Diseases18

Chemicals and Drugs2

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Phenomena and Processes5

Named Groups1

Health Care3

Geographicals3

GVHD19

Disease35

Allogeneic11

Chronic leukemias2

Transplantation13

Cord Blood Transplant1

Donor graft1

Relapse2

Acute or chronic1

Host2

Severe3

Tumor3

Remission3

Immunological2

Clinical8

Complications1

Cancers1

Lymphocytes4

Cells12

Immune2

Survival1

Tyrosine kinase in1

Chemotherapy7

Lymphoma2

Form of leukemia2

Risk2

Lymphoblastic1

Treatment5

Suggests1

Myeloid2

Regimen2

Treatments2

Patient3

Controversial1

Type1

Cancer3