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  • patients
  • RATIONALE: Giving different schedules of mycophenolate mofetil and cyclosporine may be effective in reducing graft-versus-host disease in patients undergoing donor peripheral stem cell tra. (bioportfolio.com)
  • This pilot phase II trial studies how well high dose cyclophosphamide, tacrolimus, and mycophenolate mofetil work in preventing graft versus host disease in patients with hematological mal. (bioportfolio.com)
  • Mesoblast said they were in the process of completing an Investigational New Drug (IND) submission to the United States FDA to commence Phase 2 clinical trials in patients with low back pain due to disc degenerative disease. (wikipedia.org)
  • In patients with multiple sclerosis (MS), disease-associated myelin-specific T cells from the blood are predominantly co-stimulation-independent effector-memory T cells that express high numbers of Kv1.3 channels. (wikipedia.org)
  • In children with type-1 diabetes mellitus, the disease-associated insulin- and GAD65-specific T cells isolated from the blood are effector-memory T cells that express high numbers of Kv1.3 channels, and the same is true of T cells from the synovial joint fluid of patients with rheumatoid arthritis. (wikipedia.org)
  • Kv1.3 is also considered a therapeutic target for the treatment of obesity, for enhancing peripheral insulin sensitivity in patients with type-2 diabetes mellitus, and for preventing bone resorption in periodontal disease. (wikipedia.org)
  • Thymoma-associated multiorgan autoimmunity (TAMA) is a severe often fatal disease that presents in some patients with thymoma. (wikipedia.org)
  • Patients often have a refractory disease course but some patients may respond to phototherapy. (wikipedia.org)
  • Treatment
  • The information should not be used for either diagnosis or treatment or both for any health related problem or disease. (medindia.net)
  • A 45-year-old man received growth factor-mobilized blood cells from an HLA-matched unrelated male donor after conditioning with 12 Gy total body irradiation and cyclophosphamide for treatment of acute myeloid leukemia with persistent disease. (bloodjournal.org)
  • RATIONALE: Mycophenolate mofetil added to immunosuppressive treatment regimens may be effective in treating newly diagnosed chronic graft-versus-host disease caused by stem cell transplant. (bioportfolio.com)
  • A pediatric case of squamous cell cancer in situ in the setting of sclerodermatous graft-versus-host disease and voriconazole treatment. (bioportfolio.com)
  • To see if a clobetasol rinse is a safe and effective treatment for oral graft-versus-host disease. (clinicaltrials.gov)
  • On June 29, 2011, Mesoblast announced that it received clearance from the Food and Drug Administration to begin a Phase 2 trial with its MPC cells for treatment of disc degenerative disease. (wikipedia.org)
  • Ibrutinib is used to treat chronic lymphocytic leukemia, Waldenstrom's macroglobulinemia, and as a second-line treatment for mantle cell lymphoma, marginal zone lymphoma, and chronic graft vs host disease. (wikipedia.org)
  • Transfusion
  • This enables management and investigation of any suspected transfusion related disease transmission or transfusion reaction. (wikipedia.org)
  • Leukoreduced blood products are less likely to cause HLA alloimmunization (development of antibodies against specific blood types), febrile non-hemolytic transfusion reaction, cytomegalovirus infection, and platelet-transfusion refractoriness. (wikipedia.org)
  • transplant
  • The interplay of APC, T cells and cytokines is such that, in a mouse transplant model - with mismatch only between donor T cells and host APC, but not between donor and host gut-donor T cells still efficiently killed host gut cells, suggesting that tissue destruction can be achieved with a by-stander effect (Teshima et al, 2002b). (slideshare.net)
  • The acute or fulminant form of the disease (aGvHD) is normally observed within the first 100 days post-transplant, and is a major challenge to transplants owing to associated morbidity and mortality. (wikipedia.org)
  • tissue
  • This testing can identify circulating lymphocytes with a different HLA type than the tissue cells of the host. (wikipedia.org)
  • Immune cells (white blood cells) in the donated tissue (the graft) recognize the recipient (the host) as foreign (nonself). (wikipedia.org)
  • Such components include: Microenvironmental factors like tonicity, pH, oxygen pressure and the redox status of immune cells Mechanical factors, such as tissue pressure, cellular stiffness and cell motility Cell membrane physics such as membrane composition and particles The research field of immunophysics aims to investigate the influence of these physicochemical parameters on the function of the immune system in health and disease. (wikipedia.org)
  • gene
  • In the first paper "Prediction of Graft-Versus-Host Disease by Gene-Expression Profiling of Donors" Claude Perreault and colleagues from the University of Montreal tested whether some donors may react more strongly against recipient cells than others. (medindia.net)
  • Using microarrays, they measured the gene-expression profiles of CD4+ and CD8+ T cells from 50 donors and were able to show that donor gene-expression profile in these cells had a strong influence on the occurrence of graft-versus-host disease in the recipient. (medindia.net)
  • cells
  • Antigen-specific memory T cells against viruses or other microbial molecules can be found in both TCM and TEM subsets. (wikipedia.org)
  • In mice, TCM cells have been shown to confer superior protection against viruses, bacteria, and cancer in several different model systems compared with TEM cells. (wikipedia.org)
  • multidisciplinary team
  • He also describes how the institution's world-class multidisciplinary team of experts excels in treating this complicated disease and how doctors work continuously to better understand and more effectively treat it. (cityofhope.org)
  • newly
  • Along with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. (wikipedia.org)
  • infection
  • They can spread disease and cause you to get an infection. (drugs.com)
  • In a classification of the oral lesions in HIV disease, OHL is grouped as "lesions strongly associated with HIV infection" (group I). It could also be classed as an opportunistic, viral disease. (wikipedia.org)
  • Uncontrolled lytic infection is manifested as oral hairy leukoplakia in immunocompromised hosts. (wikipedia.org)