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  • Renin-Angiot
  • Other factors such as high blood pressure, activation of sympathetic system which releases norepinephrine, activation of renin-angiotensin system which releases renin and anti-diuretic hormones are important contributors of cardiac remodelling. (wikipedia.org)
  • genes
  • Plasma miRNAs associated with LV reverse remodeling in humans are dysregulated in animal HF and target clusters of genes involved in mechanisms implicated in HF. (ovid.com)
  • outcomes
  • This article examines the relationship between LV remodeling and clinical outcomes of heart failure syndrome from several different perspectives. (biomedsearch.com)
  • clinical
  • P=0.01) that provided risk discrimination for LV reverse remodeling superior to a clinical model (C statistic, 0.58 for a clinical model versus 0.71 for RNA-based model). (ovid.com)
  • rats
  • Rats were given a single dose of MCT (50 mg/kg) subcutaneously (s.c.) to establish the RV remodeling model, followed by treatment with 10 or 20 mg/kg Ost via daily gavage for 28 days. (ovid.com)
  • Overall, the present results indicate that Ost suppresses the RV remodeling process induced by MCT in rats, which may be at least partially mediated through the reduction of myocardial apoptosis and inflammation. (ovid.com)
  • Objectives To investigate the effects of miR-31 on blood pressure and left ventricular remodelling in spontaneously hypertensive rats (SHRs). (bmj.com)
  • Besides
  • Besides that, it also includes molecular remodeling of gap junctions, especially those composed by Connexin43 proteins (Cx43) in the ventricles that affect cell-to-cell propagation of the electrical impulse, and changes in the sodium channels that modify excitability. (frontiersin.org)
  • chamber
  • Early work by Pfeffer and Braunwald ( 6 ) in a rodent MI model showed that a greater degree of myocardial injury was associated with a greater degree of chamber remodeling over time. (onlinejacc.org)
  • size
  • Surgical ventricular reconstruction (SVR) reduces the size of a patient's failing, enlarged heart to ensure that blood is pumped out of the heart, and through the body efficiently enough to allow them to participate in a full, active life. (montefiore.org)
  • inflammation
  • To further investigate the roles of apoptosis and inflammation in the effects of Ost on MCT-induced RV remodeling, apoptosis-related factors and inflammatory-associated factors were examined by western blot. (ovid.com)
  • study
  • This study was designed to investigate the effect of Ost on RV remodeling and the underlying mechanism. (ovid.com)
  • stress
  • 13,15 Pn shows a dynamic expression profile, both developmentally and in adult tissues that are undergoing remodeling or active stress. (ahajournals.org)