Ventricular cardiomyocyte membrane potential. Medical search. Frequent questions

For example, the patch-clamp technique allows for a detailed analysis of membrane potential and ion channel function by electrically controlling individual cardiac myocytes. (fau.de)
For example, within the left ventricular free wall, APD is much longer in endocardial than in epicardial myocytes with the consequence that endocardial myocytes repolarize last, although they become depolarized first. (fau.de)
Neonatal rat ventricular myocytes were stimulated with recombinant human FABP3 proteins, and then the differences of cell viability and cell death between groups were verifiedtrypan blue assay and MTT assay. (shsmu.edu.cn)
A lot more particularly, the regioisomer 11,12-EET has been shown to be a potent activator on the ion channels sensitive to ATP, to directly decrease the membrane action potential in rat myocytes (Lu et al. (pteninhibitor.com)
To address these hypotheses, we examined contractility, Ca 2+ handling, and ROS levels in individual cardiomyocytes isolated from control hearts, diabetic OVE26 hearts, and diabetic hearts overexpressing antioxidant protein metallothionein (MT). Our data showed that diabetic myocytes exhibited significantly reduced peak shortening, prolonged duration of shortening/relengthening, and decreased maximal velocities of shortening/relengthening as well as slowed intracellular Ca 2+ decay compared with control myocytes. (diabetesjournals.org)
Methods: Mouse and cultured cardiomyocytes (neonatal rat ventricular myocytes and human embryonic stem cell-derived cardiomyocytes) I/R models were used to investigate the effects of SAHA on mitochondria. (wustl.edu)
In particular, the induction of stem cells to differentiate into muscle cells (myocytes) is useful for muscle transplantation and therapeutic purposes, as well as providing potential human disease models in culture (e.g. for testing pharmaceuticals). (justia.com)
And some specific myocytes are capable of generating the cardiac action potential (electric impulse). (microbenotes.com)
It is a small oval-shaped mass of specialized myocytes called the pacemaker cells that produces a cardiac action potential. (microbenotes.com)
It is a small oval-shaped node of specialized myocytes that relay the cardiac impulse from the atrium towards the ventricle for ventricular contraction. (microbenotes.com)
Incubation of electrically-paced ventricular myocytes with a membrane-permeant Ins(1,4,5) P 3 ester provoked the occurrence of spontaneous diastolic Ca 2+ transients with the same characteristics and sensitivity to 2-APB as the events stimulated by endothelin-1. (biologists.com)
In addition to evoking spontaneous Ca 2+ transients, stimulation of ventricular myocytes with the Ins(1,4,5) P 3 ester caused a positive inotropic effect. (biologists.com)

Decreased ATP levels may thus not only impair contractility but may also lower the mitochondrial membrane potential and thus impair impulse generation and conduction along the cardiac conduction system, manifesting as arrhythmias [ 6 ]. (journalmc.org)
Moreover, pretreatment of cardiomyocytes with SAHA resulted in a 4-fold decrease in I/R-induced loss of mitochondrial membrane potential and a 25%-40% reduction in cytosolic ROS levels. (wustl.edu)
However, loss-of-function of ATG7 in cardiomyocytes or mouse myocardium abolished the protective effects of SAHA on ROS levels, mitochondrial membrane potential, mtDNA levels, and mitochondrial mass. (wustl.edu)

Repolarization is accomplished by channels that open slowly and are mostly activated at the end of the action potential (slow delayed-rectifier channels) and channels that open quickly but are inactivated until the end of the action potential (rapid delayed rectifier channels). (wikipedia.org)
It is well established that regional differences in action potential duration (APD) in different areas of the heart are of great importance for a normal course of repolarization. (fau.de)
2001), and to boost recovery of ventricular repolarization following ischemia reperfusion injury (Batchu et al. (pteninhibitor.com)
Additionally, membrane-bound ATPase utilizes ATP for depolarization and repolarization of cell membranes. (journalmc.org)
Action potencial clamp fingerprints of K+ currents in canine cardiomyocytes : their role in ventricular repolarization / Bányász T., Magyar J., Szentandrássy N., Horváth B., Birinyi P., Szentmiklósi J., Nánási P. (unideb.hu)
The current peaked 4.4 +/- 0.7 ms after the action potential upstroke and rapidly decayed to zero with a time constant of 7.4 +/- 0.6 ms. I(Kr) gradually increased during the plateau, peaked 7 ms before the time of maximum rate of repolarization (V(max)(-)) at -54.2 +/- 1.7 mV, had peak amplitude of 0.62 +/- 0.08 pA/pF, and integral of 57.6 +/- 6.7 fC/pF. (unideb.hu)
CONCLUSION: Terminal repolarization is dominated by I(K1), but action potential duration is influenced by several ion currents simultaneously. (unideb.hu)

Specific decreasing of Na+ channel expression on the lateral membrane of cardiomyocytes causes fatal arrhythmias in Brugada syndrome. (ritsumei.ac.jp)
Patients with Duchenne muscular dystrophy (DMD) commonly present with severe ventricular arrhythmias that contribute to heart failure. (jci.org)
Patients with Danon disease require frequent follow-up, with particular attention to the potential for atrial or ventricular arrhythmias and CHF. (medscape.com)

The depolarization of the membrane allows calcium channels to open as well. (wikipedia.org)
This outward potassium current causes a small dip in membrane potential shortly after depolarization. (wikipedia.org)
The Swarm delivers variable intensity blue-light optogenetic stimulation to enable membrane depolarization and red or lime-light excitation to enable fluorescence detection of the resulting changes in membrane potential or calcium levels, respectively. (frontiersin.org)
Block of Cx43 hemichannels or a reduction in Cx43 levels (using Dmd mdx Cx43 +/- mice) prevents the abnormal increase in membrane permeability, plasma membrane depolarization, and Iso-evoked electrical activity in these cells. (jci.org)
Cocaine inhibits the transient inward flux of sodium across the cell membrane during depolarization and causes local anesthesia. (medscape.com)
Increased intracellular concentrations of calcium have been suggested as a cause of depolarization of the cardiac membrane and, therefore, a trigger of sustained action potentials, extra systoles, and tachycardia (sinus, supraventricular, or ventricular). (medscape.com)
While punctuate red emission reflects mitochondrial inner membrane potential (ΔΨm)-dependent accumulation of probe dimers in actively respiring mitochondria, diffuse cytosolic green fluorescence indicates monomers of the probe released into cytoplasm after mitochondrial depolarization, lack of fluorescence is indicative for probe release from necrotic or late-stage apoptotic cells. (cuni.cz)

Experimental Strategy We determined the consequences of spermidine within a style of MI, SpragueCDawley rats with long lasting ligation from the still left anterior descending artery, and in cultured neonatal rat cardiomyocytes (NRCs) subjected to angiotensin II (Ang II). (revoluciondelosgladiolos.org)
Methods and Results: Experiments were performed with patterned growth cell cultures of neonatal rat ventricular cardiomyocytes coated with cardiac myofibroblasts. (unibe.ch)

Microparticles are larger than exosomes of plasma membrane origin, contain miRNAs, and actively control cell communication process [ 15 ]. (hindawi.com)
The protein localizes to the plasma membrane andpericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and othersignaling molecules. (sciencepop.org)
However, how microdomain localization in the plasma membrane affects the function of these complexes is unknown. (imperial.ac.uk)

Following myocardial infarction (MI), the myocardium is prone to calcium-driven alternans, which typically precedes ventricular tachycardia and fibrillation. (frontiersin.org)
At 1?mg 2 from the 6 SB 334867 JDTic (and 0/6 placebo) topics experienced an individual asymptomatic event of multiple beats of nonsustained ventricular tachycardia (NSVT). (sciencepop.org)

The heart achieves the coordinated contraction of the atrial and ventricular chambers due to the precise timing of the cardiac conduction system (CCS), a specialized complex and heterogeneous network of cells that initiate and allow propagation of action potentials through the heart. (medscape.com)
Likewise, by manipulating the retinoid pathway, the Keller group reported the dependence of atrial/ventricular specification on early mesoderm patterning and further identified surface markers RALDH2 and CD235a to efficiently distinguish atrial and ventricular subtypes respectively [ 8 ]. (biomedcentral.com)

There is a growing body of evidence which demonstrates that following ACS, microRNAs might inhibit fibroblast proliferation and scarring, as well as harmful apoptosis of cardiomyocytes, and stimulate fibroblast reprogramming into induced cardiac progenitor cells. (archivesofmedicalscience.com)

Ion channels are particularly important in shaping the action potential and in initiating the contraction. (fau.de)
Electromechanical coupling is the process that links electrical signals from the cell membrane, i.e. action potentials, to the mechanical action of the cell, i.e. the contraction. (fau.de)
ATP is required by the actomyosin adenosine triphosphatase (ATPase) for contraction and relaxation of cardiomyocytes. (journalmc.org)
Its main function is to coordinate the atrial contraction and the ventricular contraction. (microbenotes.com)
The heart's contraction and relaxation are regulated by the cardiac electric impulse (cardiac action potential) and its transmission. (microbenotes.com)

The induction of cardiomyocyte differentiation in stem cells is especially useful in developing therapeutic methods and products for heart disease and abnormal heart conditions. (justia.com)
We aim to study the coupling between LTCC and β adrenergic receptors in different cardiomyocyte microdomains, the distinct involvement of PKA and CAMKII (Ca2+/calmodulin-dependent protein kinase II) and explore how this functional complex is disrupted in heart failure.Methods:Global signaling between LTCCs and β adrenergic receptors was assessed with whole-cell current recordings and western blot analysis. (imperial.ac.uk)
METHODS: Inward rectifier K(+) current (I(K1)), rapid delayed rectifier K(+) current (I(Kr)), and transient outward K(+) current (I(to)) were dissected under action potential clamp conditions using BaCl(2), E-4031, and 4-aminopyridine, respectively. (unideb.hu)
METHODS: We used the Muscular Dystrophy Surveillance, Tracking, and Research Network (MD STARnet) to characterize associations between corticosteroid use and onset of abnormal left ventricular (LV) function or abnormal percent predicted forced vital capacity (ppFVC) among 398 non-ambulatory boys with DMD. (cdc.gov)

The particular pathophysiological mechanism leading to ventricular dilatation and systolic dysfunction is poorly comprehended. (journalmc.org)
The defensive ramifications of spermidine on cardiomyocyte apoptosis and cardiac dysfunction had been abolished with the autophagy inhibitor chloroquine, indicating that spermidine exerted cardioprotective results at least through marketing autophagic flux partially, by activating the AMPK/mTOR signalling pathway. (revoluciondelosgladiolos.org)
Cardiac dysfunction was observed as a decrease in mean arterial pressure (MAP), heart rate (HR), left ventricular rate of peak positive and negative pressure change {(+) and (-) LV dP/dt} and elevated left ventricular end diastolic pressure (LVEDP) following ISP administration. (scialert.net)

This study adopted primary cardiomyocytes and I/R in rats to evaluate the ferroptosis and changing of Nrf2-SLC7A11/heme oxygenase-1 (HO-1) in vitro and in vivo. (bvsalud.org)
Downregulation of miR-432-5p has been confirmed in H/R cardiomyocytes (in vitro) and cardiomyocytes in myocardial infarction rats (in vivo). (bvsalud.org)
2009). These investigations significantly increased interest in CYP2J2 with regard to its enzymology, localized expression, and also the want for an in vitro model method suitable for studying the enzyme's value in sustaining cardiomyocyte homeostasis.This operate was supported by the National Institutes of Wellness National Heart, Lung and Blood Institute [R01HL096706]. (pteninhibitor.com)
Chronic overexpression of MT or acute in vitro treatment with the flavoprotein inhibitor diphenyleneiodonium or the angiotensin II type I receptor antagonist losartan eliminated excess ROS production in diabetic cardiomyocytes. (diabetesjournals.org)
Apart from contributing to fibrotic remodeling, myofibroblasts induce arrhythmogenic slow conduction and ectopic activity in cardiomyocytes after establishment of heterocellular electrotonic coupling in vitro. (unibe.ch)

Aims: The FDA-approved histone deacetylase (HDAC) inhibitor, suberoylanilide hydroxamic acid (SAHA, Vorinostat) has been shown to induce cardiomyocyte autophagy and blunt ischemia/reperfusion (I/R) injury when administered at the time of reperfusion. (wustl.edu)

Upregulation of miR-432-5p inhibited ferroptosis of cardiomyocytes induced by RAS-selective lethal 3 (RSL3), an inhibitor of GPX4 and ferroptosis inducer through decreasing the binding protein of Nrf2, Keap1, which was confirmed by bioinformatics and mutation assay. (bvsalud.org)
To investigate the effects and potential mechanisms of fatty acid binding protein 3 (FABP3) on cell survival under hypoxia. (shsmu.edu.cn)

Here, we report that remodeled Cx43 protein forms Cx43 hemichannels in the lateral membrane of Dmd mdx cardiomyocytes and that the β-adrenergic agonist isoproterenol (Iso) aberrantly activates these hemichannels. (jci.org)

Last, a new glycogen storage cardiomyopathy associated with ventricular preexcitation and progressive conduction system degeneration will be reviewed. (medscape.com)
Simulations also demonstrated that β-adrenergic receptor stimulation in this specific region reduced the formation of conduction block and the probability of premature ventricular activation propagation. (frontiersin.org)
This is exacerbated by changes in the expression of membrane ion channels and under-expression and reorganization of gap junctions ( Luke and Saffitz, 1991 ) in the infarct border zone also slowing conduction ( Tse, 2016 ). (frontiersin.org)
however, only a few of them are specialized for the conduction of the cardiac action potential. (microbenotes.com)
In parallel, conduction velocities increased dose-dependently to values indistinguishable from cardiomyocyte-only preparations and ectopic activity measured continuously over 24 hours was completely suppressed. (unibe.ch)

Single PV cardiomyocytes were isolated from the canine PVs. (biomedcentral.com)
The action potential and ionic currents were investigated in isolated single canine PV cardiomyocytes before and after sodium nitroprusside (80 μM,) using the whole-cell patch clamp technique. (biomedcentral.com)
The aim of the present study was to give a parametric description of the most important K(+) currents flowing during canine ventricular action potential. (unideb.hu)
As I(to) was not active during the plateau, and neither I(K1) nor I(Kr) was frequency-dependent, other currents must be responsible for the frequency dependence of action potential duration at normal and slow heart rates in canine ventricular cells. (unideb.hu)
In the present work, therefore, the concentration-dependent effects of SEA0400 and KB-R7943 on INa/Ca and ICa were studied and compared in canine ventricular cardiomyocytes using the whole-cell configuration of the patch clamp technique. (unideb.hu)

As a demonstration of the versatility of the Swarm, we also developed an assay measuring cardiac action potential and calcium waveform properties simultaneously under paced conditions using human induced pluripotent stem (iPS) cell-derived cardiomyocytes as an additional counter screen for cardiac toxicity. (frontiersin.org)
A study by Hashem et al using induced pluripotent stem cell-derived cardiomyocytes indicated that LAMP2 protein deficiency in Danon disease results in autophagic flux impairment, which in turn causes excessive oxidative stress and, subsequently, cardiomyocyte apoptosis. (medscape.com)

This study is aimed to study the effects of nitroprusside (NO donor), on the ionic currents and arrhythmogenic activity of single cardiomyocytes from the PVs. (biomedcentral.com)
Therefore, the purpose of this study was to study the effects of nitroprusside on the ionic currents and arrhythmogenic activity of single PV cardiomyocytes. (biomedcentral.com)
So far, it is not known whether α-smooth muscle actin (α-SMA) containing stress fibers, the cytoskeletal components that set myofibroblasts apart from resident fibroblasts, are essential for myofibroblasts to develop arrhythmogenic interactions with cardiomyocytes. (unibe.ch)
Objective: We investigated whether pharmacological ablation of α-SMA containing stress fibers by actin-targeting drugs affects arrhythmogenic myofibroblast-cardiomyocyte cross-talk. (unibe.ch)

In conclusion, miR-432-5p inhibits the ferroptosis in cardiomyocytes induced by H/R by activating Nrf2/SLC7A11 axis by degrading Keap1 and is a potential drug target for clinical myocardial infarction treatment. (bvsalud.org)
a composite of myocardial infarction, stroke, new acute decompensated heart failure, venous thromboembolism, ventricular or atrial arrhythmia, pericardial effusion, or aborted cardiac arrest) among consecutively hospitalized adults with COVID-19, using multivariable binary logistic regression analysis. (stanford.edu)

We validate optical actuation by virally introducing optogenetic drivers in rat and human cardiomyocytes or through the modular use of dedicated light-sensitive somatic 'spark' cells. (nature.com)
In contrast to nonpacemaker cells, SA and AV nodal cells predominantly use calcium channels for the initial upstroke in phase 0 (Fig. 1) and lack sodium ion channels for the rapid initial upstroke in phase 1 of their action potentials. (medscape.com)
It is surrounded by the perinodal cells and the connective tissues insulating the action potential generated within the SA node. (microbenotes.com)
Cardiomyocytes (CMs) derived from human pluripotent stem cells (hPSCs) provide a valuable cell source for regenerative therapy, disease modeling, and drug screening. (biomedcentral.com)
After ablation of this cytoskeletal component, cells lose their arrhythmic effects on cardiomyocytes, even if heterocellular electrotonic coupling is sustained. (unibe.ch)
In recent years, extensive research has established that some immune cells either reside in the heart or have very complicated interactions with cardiomyocytes through permanent blood circulation. (biomedcentral.com)

Transplantation of cadaveric heart donors emerges as a potential therapy for CVD and has been performed since the first case in 1967. (biomedcentral.com)

The syndrome is caused by changes in the structure and function of certain cardiac ion channels and reduced expression of Connexin 43 (Cx43) in the Right Ventricle (RV), predominantly in the Right Ventricular Outflow Tract (VSVD), causing electromechanical abnormalities. (bvsalud.org)

Its main function is to spontaneously generate the cardiac action potential (electrical impulses), hence it is called the natural pacemaker. (microbenotes.com)

Currently required preclinical cardiotoxicity testing (part of the drug development process, Fig. 1 ) specifically focuses on a drug's blocking action on the hERG K + channel, which provides one of the main repolarizing currents in cardiomyocytes. (nature.com)

Intravenous delivery of liposome carriers of miR-432-5p remarkably ameliorated cardiomyocyte impairment in the I/R animal model. (bvsalud.org)
T, p.V183F) displayed only askeletal muscle pathology and a mild impairment of membrane trafficking of both POPDC isoforms. (imperial.ac.uk)
In contrast, variants such as BVES p.Q153X or POPDC2 p.W188X were associated with a greater impairment of membrane trafficking. (imperial.ac.uk)

HN - 2008 BX - Lateral Sinus MH - Atrial Septum UI - D054087 MN - A07.541.459.249 MS - The thin membrane-like muscular structure separating the right and the left upper chambers (HEART ATRIA) of a heart. (bvsalud.org)

CONCLUSION: Our study emphasized the critical roles of the dysregulated AS profiles in MIRI development, investigated the potential functions of MIRI-associated RASGs, and identified regulatory RBPs involved in AS regulation. (bvsalud.org)

Res effectively suppress the cardiomyocytes hypertrophy and apoptosis induced by ISO, characterized by the reduction of the myocardial cell surface area, the ANP gene expression, the LDH and MDA leakage amount and the rate of cell apoptosis, while decrease of the protein expression of GRP78, GRP94 and CHOP, and reverse the expression of Bcl-2 and Bax. (karger.com)

The improvement of preclinical cardiotoxicity testing, discovery of new ion-channel-targeted drugs, and phenotyping and use of stem cell-derived cardiomyocytes and other biologics all necessitate high-throughput (HT), cellular-level electrophysiological interrogation tools. (nature.com)
The Mouse Cytokine Array, Panel A utilizes capture antibodies spotted onto a nitrocellulose membrane to allow high-throughput multi-analyte profiling of 40 cytokines, chemokines, and more in a single sample. (rndsystems.com)

The beginning of the action potential, phase 0, specialized membrane proteins (voltage-gated sodium channels) in the cell membrane selectively allow sodium ions to enter the cell. (wikipedia.org)
The transverse tubular system (t-system) in ventricular cardiomyocytes consists of many tubelike membrane invaginations that originate from the cell surface and reach deeply into the cell. (fau.de)
FABP3 contributes to cell survival and apoptosisregulating intracellular ROS and mitochondrial membrane potentials under hypoxia. (shsmu.edu.cn)
The major human cardiomyocyte cell line demonstrated related mRNA-expression profiles of P450 enzymes to adult human ventricular tissue. (pteninhibitor.com)
Key Outcomes Spermidine improved cardiomyocyte viability and reduced cell necrosis in NRCs treated with angiotensin II. (revoluciondelosgladiolos.org)

Besides, the of PARP and caspase 3 protein, the level of reactive oxygen species (ROS), and mitochondrial membrane potentials under hypoxia were compared between groups for more confirmation. (shsmu.edu.cn)

This cardiomyopathy may be due to either organ-based damage, such as fibrosis, or to direct damage to cardiomyocytes. (diabetesjournals.org)

AbbreviationsAMPKAMP activated proteins kinaseAng IIangiotensin IICCK\8cell keeping track of package\8CQchloroquineDCFH\DAdichlorofluoresein diacetateHW/BWheart fat/body weightLVleft ventricleLVEFleft ventricular ejection fractionLVFSleft ventricular fractional shorteningLVIDdLV inner diameters at diastoleLVIDsLV inner diameters at systoleMDAmalondiadehydeMImyocardial infarctionmTORmammalian focus on of rapamycinNRCsneonatal rat cardiomyocytesPIpropidium iodideWGAwheat germ agglutinin What's currently known Spermidine may induce autophagy and displays protective results against age group\related illnesses. (revoluciondelosgladiolos.org)
Samples are mixed with a cocktail of biotinylated detection antibodies (Step 1) and then incubated with the array membrane which is spotted in duplicate with capture antibodies to specific target proteins (Step 2) . (rndsystems.com)

On echocardiography, the characteristic appearance includes a thickened ventricular septum and left ventricular posterior wall without an obvious etiology (eg, hypertension, aortic stenosis). (medscape.com)

Zhang and colleagues investigated the role of Noggin and retinoid signaling in the specification of CM subtypes, which led to the increased proportions of atrial or ventricular-like CM populations [ 7 ]. (biomedcentral.com)

When an action potential is generated, the membrane potential rises above this level in four distinct phases. (wikipedia.org)
During this phase, the membrane slowly depolarizes until the threshold for a new action potential is reached. (medscape.com)
Elevated cytosolic calcium can provoke oscillatory depolarizations of the cardiac membrane and trigger sustained action potential generation and extra systoles. (medscape.com)
Besides conducting the electric impulse, the Purkinje Fibers are also capable of generating a cardiac action potential. (microbenotes.com)
Short QT Interval Syndromes The short QT interval syndromes (SQTS) are extremely rare congenital or very rarely acquired disorders of cardiac ion channel function or regulation that shorten ventricular myocyte action potential. (msdmanuals.com)

DCM is frequently associated with heart failure, cardiac rhythm abnormalities and intra-ventricular thrombus formation. (journalmc.org)

2015). Poor prognoses after MI derive from undesirable cardiac structural adjustments, deteriorated cardiac function, and irreversible cardiomyocyte death (White et al. (revoluciondelosgladiolos.org)
Channelopathies are a group of genetic, autoimmune, or inflammatory conditions that alter cardiomyocyte ion channel function in a manner that predisposes to bradyarrhythmias or tachyarrhythmias in the absence of a structural heart disorder. (msdmanuals.com)
and inflammatory disorders producing cytokinins that affect cardiomyocyte ion channel function are increasingly being recognized. (msdmanuals.com)
In this review, we focus on the role of cardiomyocyte-derived and cardiac fibroblast-derived microRNAs that are involved in the regulation of genes associated with cardiomyocyte and fibroblast function and in atherosclerosis-related cardiac ischemia. (archivesofmedicalscience.com)

As the membrane voltage rises (to about 40 mV) sodium channels close due to a process called inactivation. (wikipedia.org)
As sodium channels close calcium provides current to maintain the potential around 20 mV. (wikipedia.org)
The Swarm was able to record pseudo-action potentials stably across all 24 objectives and provided pharmacological characterization of diverse sodium channel blockers. (frontiersin.org)

Compared with recombinant CYP2J2, terfenadine was hydroxylated in cardiomyocytes at a comparable Km value of 1.5 mM. (pteninhibitor.com)

Fig. 2: A 3D confocal microscopic image of the t-system in a cardiomyocyte. (fau.de)

We propose that the identified RASEs and RBPs could serve as important regulators and potential therapeutic targets in MIRI treatment in the future. (bvsalud.org)

In failing cardiomyocytes, from both rodents and humans, this transverse tubule coupling between LTCC and β2AR was lost. (imperial.ac.uk)

The heart contains abundant mitochondria, which constitute approximately 40% of total cardiomyocyte volume [ 5 ]. (journalmc.org)
Lastly, PGC-1α gene expression was induced by SAHA in NRVMs and mouse heart subjected to I/R, and loss of PGC-1α abrogated SAHA's mitochondrial protective effects in cardiomyocytes. (wustl.edu)

The activation of the Nrf2-SLC7A11/HO-1 pathway protects cardiomyocytes from ferroptosis. (bvsalud.org)

In addition, high glucose and angiotensin II promoted significantly increased generation of ROS in diabetic cardiomyocytes. (diabetesjournals.org)

Anatomy44

Organisms16

Diseases11

Chemicals and Drugs93

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes63

Disciplines and Occupations4

Technology, Industry, Agriculture4

Information Science3

Health Care1

Myocytes12

Mitochondrial membrane potential3

Repolarization7

Arrhythmias3

Depolarization7

Neonatal rat2

Plasma membrane3

Tachycardia2

Atrial and ventricular2

Apoptosis of cardiomyocytes1

Contraction5

Methods4

Dysfunction3

Vitro5

Ischemia reperfusion1

Binding protein2

Lateral membrane1

Conduction5

Canine5

Induced plur2

Arrhythmogenic4

Myocardial infarction2

Cells6

Transplantation1

Electromechanical1

Pacemaker1

Currents1

Impairment3

Sinus1

Conclusion1

Hypertrophy1

High-throughput2

Cell5

Reactive1

Fibrosis1

Proteins2

Left1

Populations1

Action potential5

Abnormalities1

Function4

Sodium3

Recombinant1

Microscopic1

Therapeutic1

Transverse1

Heart2

Pathway1

Significantly increased1