• Traditional approaches to mechanical ventilation use tidal volumes of 10 to 15 ml per kilogram of body weight and may cause stretch-induced lung injury in patients with acute lung injury and the acute respiratory distress syndrome. (nih.gov)
  • In patients with acute lung injury and the acute respiratory distress syndrome, mechanical ventilation with a lower tidal volume than is traditionally used results in decreased mortality and increases the number of days without ventilator use. (nih.gov)
  • In patient-triggered modes of mechanical ventilation, the size of V T is determined by the interplay between many factors, which are related to either the patient (lung compliance, lung resistance, effort intensity), the machine (driving pressure, set inspiratory time), or the quality of synchronization between patient effort and mechanical breath. (rcjournal.com)
  • The transition from controlled mechanical ventilation to spontaneous breathing is challenging for the size of V T . The issue is further complicated by the large number of spontaneous breathing modes with different names and different functionality available across the ICU ventilators. (rcjournal.com)
  • Recently, a large prospective cohort study reported the practice of mechanical ventilation for ARDS 2 and found that the mean set V T was 7.7 mL/kg IBW. (rcjournal.com)
  • The main objective of this work was to study the variability of V T across different patient-triggered modes of mechanical ventilation in ARDS with different respiratory patterns. (rcjournal.com)
  • In particular, we were looking at the discrepancy across patient-triggered modes of mechanical ventilation from a fixed 6-mL/kg IBW set V T in various conditions of respiratory mechanics, breathing frequency (f), and patient effort. (rcjournal.com)
  • High-frequency ventilation is a type of mechanical ventilation which utilizes a respiratory rate greater than four times the normal value. (wikipedia.org)
  • High-frequency ventilation may be used alone, or in combination with conventional mechanical ventilation. (wikipedia.org)
  • In general, those devices that need conventional mechanical ventilation do not produce the same lung protective effects as those that can operate without tidal breathing. (wikipedia.org)
  • Introduction: Mechanical ventilation is a commonly performed procedure in the emergency department (ED). Approximately 240,000 patients per year receive mechanical ventilation in the ED representing 0.23% of ED visits. (temple.edu)
  • Our secondary outcome was the number of patients who had tidal volumes set at ≥ 8 mL/kg at 60 minutes after initiation of mechanical ventilation. (temple.edu)
  • Data was available for 107 patients (82%) who were in the ED at 60 minutes after initiation of mechanical ventilation. (temple.edu)
  • Conclusion: The vast majority of tidal volumes ≥ 8 mL/kg during mechanical ventilation occurs in females. (temple.edu)
  • In recent years, intraoperative lung-protective mechanical ventilation (LPV) has been reportedly able to attenuate ventilator-induced lung injuries (VILI). (springer.com)
  • Lung protective mechanical ventilation significantly improved intraoperative pulmonary oxygenation function and pulmonary compliance in patients experiencing various abdominal laparoscopic surgeries, but it could not ameliorate early postoperative atelectasis and oxygenation function on the first day after surgery. (springer.com)
  • Contents, major trauma, numerous blood solution transfusions or mechanical ventilation with higher tidal volume, are amongst the varied injurious stimuli that will bring about ARDS (1). (ezh2inhibitor.com)
  • Patients experiencing critical illness necessitating mechanical ventilation have high mortality rates. (emra.org)
  • Additionally, survivors of critically ill mechanical ventilation experience high morbidity. (emra.org)
  • In ARDS, RV overload can occur due to mechanical ventilation and the pathologic features of the syndrome itself. (medscape.com)
  • The benefits of the protective mechanical ventilation with low tidal volume (V T ) resulting in improved outcome have been convincingly proved in patients with acute respiratory distress syndrome (ARDS) in large clinical studies and meta-analyses ( 2 , 3 ). (frontiersin.org)
  • Noninvasive mechanical ventilation (NIV) is widely used in the acute care setting for acute respiratory failure (ARF) across a variety of aetiologies. (ersjournals.com)
  • Importance Long-term acute care hospitals (LTCHs) are common sites of postacute care for patients recovering from severe respiratory failure requiring mechanical ventilation (MV). However, federal payment reform led to the closure of many LTCHs in the US, and it is unclear how closure of LTCHs may have affected upstream care patterns at short-stay. (researchgate.net)
  • Background: Mechanical ventilation is a life-saving intervention for critically ill newborn infants with respiratory failure admitted to a neonatal intensive care unit (NICU). (mendeley.com)
  • Mechanical ventilation has several short-term, as well as long-term complications. (mendeley.com)
  • Weaning aims to support the transfer from full mechanical ventilation support to spontaneous breathing activity. (mendeley.com)
  • Objectives: To assess the efficacy of protocolized versus non-protocolized ventilator weaning for newborn infants in reducing the duration of invasive mechanical ventilation, the duration of weaning, and shortening the NICU and hospital length of stay. (mendeley.com)
  • To establish whether protocolized weaning is safe and clinically effective in reducing the duration of mechanical ventilation without increasing the risk of adverse events. (mendeley.com)
  • We did not find any randomized, quasi-randomized or cluster-randomized controlled trials conducted on weaning from mechanical ventilation in newborn infants. (mendeley.com)
  • Authors' conclusions: Based on the results of this review, there is no evidence to support or refute the superiority or inferiority of weaning by protocol over non-protocol weaning on duration of invasive mechanical ventilation in newborn infants. (mendeley.com)
  • Noninvasive ventilation has been studied as a means of reducing complications among patients being weaned from invasive mechanical ventilation. (cmaj.ca)
  • We included trials comparing extubation and immediate application of noninvasive ventilation with continued invasive weaning in adults on mechanical ventilation. (cmaj.ca)
  • Patients with acute respiratory failure often require endotracheal intubation and mechanical ventilation to sustain life. (cmaj.ca)
  • Beyond sepsis-induced inflammation, a mechanical ventilation regimen can also propagate ventilator-related injury that may precipitate ARDS. (ceufast.com)
  • Invasive ventilation, including conventional mechanical ventilation and high-frequency oscillatory ventilation, refers to respiratory support delivered directly to a patient's lower airways via an endotracheal (ET) or tracheostomy tube. (fphcare.com)
  • Lung-protective ventilation (LPV) refers to mechanical ventilation strategies that use tidal volumes and pressures closer to physiological values than conventional mechanical ventilation settings. (fphcare.com)
  • When those cannulas are used, mechanical ventilation is necessary because of the open communication between the thoracic cavity and the atmosphere. (vin.com)
  • Mechanical ventilation might not be required. (vin.com)
  • Gas inhalation and mechanical ventilation are recommended for thoracoscopy. (vin.com)
  • The Drinker and Shaw tank-type ventilator of 1929 was one of the first negative-pressure machines widely used for mechanical ventilation. (medscape.com)
  • Intensive use of positive-pressure mechanical ventilation gained momentum during the polio epidemic in Scandinavia and the United States in the early 1950s. (medscape.com)
  • Many factors affect the decision to begin mechanical ventilation. (medscape.com)
  • Because no mode of mechanical ventilation can cure a disease process, the patient should have a correctable underlying problem that can be resolved with the support of mechanical ventilation. (medscape.com)
  • Because intubation and mechanical ventilation alter first-line patient defenses, they greatly increase the risk for nosocomial bacterial pneumonia. (cdc.gov)
  • Higher doses of dexamethasone probably increased the number of days alive without invasive mechanical ventilation and circulatory support but had no effect on days alive without renal replacement therapy. (bvsalud.org)
  • invasive mechanical ventilation, with an expected duration of MV of at least 24h. (who.int)
  • There is no specific treatment or vaccines for the nCoV, however outbreak-specific basis, the Mechanical Ventilation of severe precautions for aerosolyzed generating there are ongoing R&D efforts for MERS-CoV. (who.int)
  • Conditional recommendations are made against the use of azithromycin, hydroxychloroquine combined with azithromycin, colchicine, and remdesivir, in the latter case specifically in patients requiring invasive mechanical ventilation. (bvsalud.org)
  • Patients with a mean age of 47 years had a mortality rate of 3 to 5%, oxygen therapy was necessary in 42% of these patients, 5% were admitted to the ICU, 2.3% underwent invasive mechanical ventilation (IMV), and of these, 1.4% died 6,7 . (bvsalud.org)
  • Advanced leak compensation in invasive and non-invasive ventilation for pressure modes, as well as volume modes. (dremed.com)
  • Although it is effective, invasive ventilation is associated with complications including respiratory muscle weakness, upper airway pathology, ventilator-associated pneumonia 1 and sinusitis. (cmaj.ca)
  • Two weeks of daily supervised inspiratory muscle training significantly improves inspiratory muscle strength and health-related quality of life in patients recently weaned from invasive ventilation. (bmj.com)
  • For invasive ventilation, follow the lung protective strategy of ARDSnet, utilizing low tidal volume ventilation. (ebmedicine.net)
  • What is invasive ventilation? (fphcare.com)
  • This diagram shows an invasive ventilation system incorporating a heated humidifier that warms and moistens the air. (fphcare.com)
  • Why is humidity important for invasive ventilation? (fphcare.com)
  • These strategies aim to prevent ventilator-associated lung injury and are largely considered standard practice for invasive ventilation. (fphcare.com)
  • Introduction: during the global COVID-19 pandemic, non-invasive ventilation has become a widely utilized method for treating patients experiencing acute respiratory failure. (bvsalud.org)
  • Noninvasive pressure ventilation is frequently employed as a standard approach for managing acute respiratory failure resulting from COVID-19 pneumonia, as opposed to invasive ventilation methods. (bvsalud.org)
  • Therefore, this study aimed to determine the risk of mortality among COVID-19 patients receiving non-invasive ventilation. (bvsalud.org)
  • Moreover, patients with a tidal volume greater than 500 ml were more likely to pass away [AOR =2.2 95% CI 1.11,4.43], as were those who were on non-invasive ventilation (NIV) for more than 8 days [AOR = 0.24 95% CI.08, 0.81]. (bvsalud.org)
  • Non-invasive ventilation for over eight days showed a protective effect. (bvsalud.org)
  • Introduction: Hospitalised patients with coronavirus disease 2019 (COVID-19) as a result of SARS-CoV-2 infection have a high mortality rate and frequently require noninvasive respiratory support or invasive ventilation. (bvsalud.org)
  • Coefficient of variation of V T was greater for low f and volume control-mandatory minute ventilation and pressure control modes. (rcjournal.com)
  • Furthermore, pregnant women also experience respiratory changes in lung volumes, minute ventilation, and acid-base status. (medscape.com)
  • Trend overviews of the past 12 months displaying: pressure, breath rate, percentage of triggered breaths, peak inspiratory patient flow, estimated exhaled tidal volume, leak, Ti/Ttot and minute ventilation. (dremed.com)
  • Respiratory rate during quiet breathing decreased in all subjects when stimulated, whereas minute ventilation increased by 1.05-2.07 L/min. (iospress.com)
  • It has previously been shown that tidal volume and minute ventilation decrease in rats exposed to ozone [1]. (cdc.gov)
  • In addition to confirming the results of the effects of O3 on tidal volume and minute ventilation, this study demonstrates a decrease in acceleration during the transition from deflation to inflation. (cdc.gov)
  • Optimal PEEP is used to maintain alveolar inflation and promote ventilation-to-perfusion matching. (wikipedia.org)
  • This analysis illustrates the importance of using high-frequency ventilation in infant respiratory distress syndrome and of optimizing the amount of PEEP. (nih.gov)
  • When the lungs are in a derecruited state, the combinations of frequency, PEEP, and tidal volume that yield adequate ventilation with safe distention of recruited alveoli are severely limited. (nih.gov)
  • We tested the hypothesis that the lung-protective ventilation strategy including a low tidal volume, an appropriate level of PEEP and periodic recruitment maneuvers could improve intraoperative oxygenation function, pulmonary mechanics, and early postoperative atelectasis. (springer.com)
  • She was ventilated by pressure-controlled ventilation, volume-guaranteed mode (PCV-VG®, GE Healthcare, Little Chalfont, England) at a tidal volume (TV) of 450 mL, respiratory rate of 12 breaths/min, positive end-expiratory pressure (PEEP) of 5 cmH 2 O, and upper limit of peak inspiratory pressure (PIP) of 30 cmH 2 O, with 50% oxygen. (hindawi.com)
  • HFJV minimizes movement of the thorax and abdomen and facilitates surgical procedures where even slight motion artifact from spontaneous or intermittent positive pressure ventilation may significantly affect the duration and success of the procedure (for example atrial fibrillation ablation). (wikipedia.org)
  • With the development of safe endotracheal tubes with high-volume, low-pressure cuffs, positive-pressure ventilation replaced the iron lung. (medscape.com)
  • This intervention should not be started without thoughtful consideration because intubation and positive-pressure ventilation are not without potentially harmful effects. (medscape.com)
  • It revealed that 11.7% [CI: 8.7-15.2] of COVID-19 patients who received non-invasive positive pressure ventilation died, as being critical for COVID-19 patients was a main cause of noninvasive initiation. (bvsalud.org)
  • Ventilation and diffusion will increase drastically through the respiratory system in a reaction to exercise your breathing rate and debt will increase if your ventilation rises, the inspiratory centre controls this by stimulating the diaphragm and external intercostal muscles. (bartleby.com)
  • Sometimes, the test will be preceded by a period of quiet breathing in and out from the sensor (tidal volume), or the rapid breath in (forced inspiratory part) will come before the forced exhalation. (wikidoc.org)
  • Inspiratory Hold: Convenience for taking X-ray pictures of the patient during ventilation, availability for clinician to assess patient's static pulmonary mechanics. (dremed.com)
  • The signal to terminate the inspiratory activity of the machine is either a preset volume (for a volume-cycled ventilator), a preset pressure limit (for a pressure-cycled ventilator), or a preset time factor (for a time-cycled ventilator). (medscape.com)
  • 150 (Vf) breaths per minute) and very small tidal volumes. (wikipedia.org)
  • Ventilating newborn infants can be challenging due to small tidal volumes, high breathing frequencies, and the use of uncuffed endotracheal tubes. (mendeley.com)
  • One-lung ventilation technique with selective intubation of either the left or the right lungs will allow a better exposure of specific area of the thoracic cavity. (vin.com)
  • A bronchial blocker can be used instead of selective intubation to achieve one-lung ventilation. (vin.com)
  • Severe acute respiratory failure in adults causes high mortality despite improvements in ventilation techniques and other treatments (eg, steroids, prone positioning, bronchoscopy, and inhaled nitric oxide). (scienceopen.com)
  • ventilation/perfusion. (ersjournals.com)
  • As the osmotic diuresis continues, the intravascular volume is profoundly depleted, which further decreases renal perfusion and the ability of the kidneys to remove glucose from the blood. (ems1.com)
  • The body of literature has shown that using heated humidification rather than passive devices allows for the effective implementation of LPV, facilitating reductions in tidal volumes and PaCO 2 14,15 without affecting cerebral perfusion. (fphcare.com)
  • This leads to stiffening of the lungs and eventually triggering mismatch in ventilation-perfusion. (sbwire.com)
  • Major consequences of atelectasis include underventilation (with hypoxia and ventilation/perfusion [V/Q] mismatch) and pneumonia. (msdmanuals.com)
  • The Bunnell Life Pulse High-Frequency Ventilator is also indicated for use in ventilating critically ill infants with respiratory distress syndrome (RDS) complicated by pulmonary air leaks who are, in the opinion of their physicians, failing on conventional ventilation. (wikipedia.org)
  • These adverse effects include: Pneumothorax Pneumopericardium Pneumoperitoneum Pneumomediastinum Pulmonary interstitial emphysema Intraventricular hemorrhage Necrotizing tracheobronchitis Bronchopulmonary dysplasia High-frequency jet ventilation is contraindicated in patients requiring tracheal tubes smaller than 2.5 mm ID. (wikipedia.org)
  • In individuals with acute cardiogenic dysfunction or volume overload, the alveolar edema is TLR3 review generated by a speedy improve inside the hydrostatic stress within the pulmonary capillaries (two) and has a low protein concentration compared to plasma (3).Annals of Translational Medicine. (ezh2inhibitor.com)
  • Protective perioperative ventilation has been shown to improve outcomes and reduce the incidence of postoperative pulmonary complications. (frontiersin.org)
  • Indices of ventilation distribution such as alveolar-based mean dilution number (AMDN) and pulmonary clearance delay (PCD) were calculated. (ersjournals.com)
  • Spirometry (meaning the measuring of breath ) is the most common of the Pulmonary Function Tests (PFTs), measuring lung function, specifically the measurement of the amount (volume) and/or speed (flow) of air that can be inhaled and exhaled. (wikidoc.org)
  • Objective To determine the ability of lung ultrasound (LUS) of the dependent region to detect real-time changes in lung volume, identify opening and closing pressures of the lung, and detect pulmonary hysteresis. (bmj.com)
  • and b) the convective flow cost necessary to achieve a unit of alveolar ventilation. (nih.gov)
  • Simple solutions for each of these cost functions were formulated using established models of gas exchange and lung mechanics, including the effects of lung inflation tidal volume and respiratory frequency in alveolar ventilation, nonlinear lung tissue compliance, and alveolar recruitment and derecruitment. (nih.gov)
  • High alveolar ventilation brings more O2 into the alveoli, increasing O2 , and rapidly eliminating CO2 from the lungs (for chemical abbreviations see Table 2). (bartleby.com)
  • Large tidal volume and low frequency ventilation result in (i) better ventilation of dependent well-perfused alveoli which improves V/Q matching (small area of alveolar dead space as above in figure I). (ii) Gas emptying from slow alveoli to reach the mouth, whereas it would have remained in the airways with small frequent breaths. (capnography.com)
  • With conventional ventilation where tidal volumes (VT) exceed dead space(VDEAD), gas exchange is largely related to bulk flow of gas to the alveoli. (wikipedia.org)
  • An inert tracer gas washin/washout technique using a pulsed ultrasonic flow meter is presented to measure functional residual capacity (FRC) and ventilation distribution in spontaneously breathing and unsedated infants. (ersjournals.com)
  • Measurement of functional residual capacity and ventilation distribution using a sulphur hexafluoride washin/washout and an ultrasonic flow meter proved to be highly accurate and reproducible in a lung model and in healthy, spontaneously breathing and unsedated infants. (ersjournals.com)
  • Infants with small airways disease such as wheezing disorders, cystic fibrosis and chronic lung disease have hyperinflated lungs and ventilation inhomogeneities 1 , 2 . (ersjournals.com)
  • To quantify the degree of functional abnormalities of the lung and to study the therapeutic effect of inhaled bronchodilators or topical anti-inflammatory drugs, an accurate and easy-to-use technique to measure lung volume and ventilation distribution in infants is necessary. (ersjournals.com)
  • The aim of this study was to develop a simple technique able to measure lung volume (FRC) and ventilation inhomogeneities in spontaneously breathing infants without altering the infant's breathing and reducing problems due to leak. (ersjournals.com)
  • We therefore conducted a trial to determine whether ventilation with lower tidal volumes would improve the clinical outcomes in these patients. (nih.gov)
  • Limiting tidal volume (V T ) in patients with ARDS may not be achieved once patient-triggered breaths occur. (rcjournal.com)
  • Pressure support with guaranteed volume could be tested in patients with ARDS. (rcjournal.com)
  • In patients with ARDS, it has been shown that setting ventilator tidal volume (V T ) to 6 mL/kg ideal body weight (IBW) actually accommodates a 4-8-mL/kg IBW range, which when set at the ventilator can improve survival. (rcjournal.com)
  • Cite this: Few Eligible ARDS Patients Receive Low Tidal Volume Ventilation - Medscape - Aug 30, 2017. (medscape.com)
  • This study is a large pragmatic stepped-wedge trial of electronic health record (EHR)-based implementation strategies informed by behavioral economic principles to increase lung-protective ventilation (LPV) utilization among all mechanically ventilated (MV), adult patients. (nih.gov)
  • Prior literature has shown that as many as 40% of ED patients do not receive lung protective ventilation. (temple.edu)
  • We suggest that objective measurements, such as a tape measure and tidal volume card, be used when setting tidal volumes for all patients, especially females. (temple.edu)
  • We treated two patients with difficult ventilation caused by distal migration of a double-lumen endotracheal tube (DLT) during robotic thymectomy. (hindawi.com)
  • In patients with intact lungs, i.e., those without ARDS, the use of protective perioperative ventilation as "secondary" preventive measure can dramatically improve postoperative outcomes and reduce the risk of PPC ( 9 ). (frontiersin.org)
  • The Trilogy EV300 ventilator delivers enhanced performance in noninvasive (NIV) and invasive (IV) ventilation, so patients can be treated with a single device throughout their hospital stay, regardless of changing conditions. (philips.co.uk)
  • Trilogy EV300 provides noninvasive (NIV) and invasive (IV) ventilation for a wide range of adult and pediatric patients. (philips.co.uk)
  • ECMO is also used to support patients with the acute viral pneumonia associated with COVID-19 in cases where artificial ventilation alone is not sufficient to sustain blood oxygenation levels. (wikipedia.org)
  • Beginning in early February 2020, doctors in China have increasingly been using ECMO as an adjunct support for patients presenting with acute viral pneumonia associated with SARS-CoV-2 infection ( COVID-19 ) when, with ventilation alone, the blood oxygenation levels still remain too low to sustain the patient. (wikipedia.org)
  • Ongoing research in the area of fluid conservation and lung-protective ventilation strategies have demonstrated improvements in survival rate of patients. (sbwire.com)
  • Although patients receiving mechanically assisted ventilation do not represent a major proportion of patients who have nosocomial pneumonia, they are at highest risk for acquiring the infection. (cdc.gov)
  • It refers to the volume of ventilated air that does not participate in gas exchange, caused by any additional equipment after the Y-piece of the ventilator circuit. (fphcare.com)
  • Concepts that the military developed during World War II to deliver oxygen and gas volume to fighter pilots operating at high altitude were incorporated into the design of the modern positive-pressure ventilator. (medscape.com)
  • Volume-cycled ventilation is the most common form of ventilator cycling used in adult medicine because it provides a consistent breath-to-breath tidal volume. (medscape.com)
  • Termination of the delivered breath is signaled when a set volume leaves the ventilator. (medscape.com)
  • Noninvasive weaning had no significant effect on the duration of ventilation related to weaning, but significantly reduced rates of tracheostomy (RR 0.19, 95% CI 0.08 to 0.47) and reintubation (RR 0.65, 95% CI 0.44 to 0.97). (cmaj.ca)
  • HFJV does NOT allow: setting specific tidal volume, sampling ETCO2 (and because of this, frequent ABGs are required to measure PaCO2). (wikipedia.org)
  • We compared spirometry during unassisted and FES-assisted quiet breathing and coughing, and measured the effect of stimulation on end-tidal CO2 (EtCO2) during quiet breathing. (iospress.com)
  • This was a planned subgroup analysis of study looking at interventions to improve adherence to recommended tidal volume settings. (temple.edu)
  • A diagnostic view provides esophageal (Pes) and transpulmonary (PL) pressure waveforms, with key parameters for safety assessment of controlled and spontaneous ventilation. (getinge.com)
  • The data is monitored by DirectView software, which helps you manage patient ventilation therapy and assist with identifying the need for any adjustments. (dremed.com)
  • The ventilator's many compatible accessories, including multiple disposable circuits, with advanced technology and software, enhance patient ventilation as well as maintain effective treatment and improve patient care. (dremed.com)
  • [6] Precisely calculated Dynamic compliance (Cdyn) and Stress index (SI) complete the picture, helping you detect changes in lung volume and verify over-distension. (getinge.com)
  • Conclusion LUS was able to detect large changes in total and regional lung volume in real time and correctly identified opening and closing pressures but lacked the precision to detect small changes in lung volume. (bmj.com)
  • Tidal volume is the amout of air taken in and relsed from the body in each breath so in vigerous exercise your tidal volume will be much higher contrasting with your body at a normal relaxed pace This is usually around 500cm cubed. (bartleby.com)
  • Severe injuries to the central nervous system that result in abolished or very high respiratory drive, for whom it is not possible to maintain protective tidal volume. (who.int)
  • 6 mL/kg was significantly increased with spontaneous breaths patient-triggered by pressure support (OR 19.36, 95% CI 12.37-30.65) and significantly reduced in APRV (OR 0.44, 95% CI 0.26-0.72) and pressure support with guaranteed volume mode. (rcjournal.com)
  • 6 mL/kg was significantly reduced in APRV and pressure support with guaranteed volume mode. (rcjournal.com)
  • Maternal blood volume increases from 25-52% by late pregnancy. (medscape.com)
  • [ 4 ] The plasma volume increases by 45-50%, compared with a 20% increase in red blood cell mass. (medscape.com)
  • During pregnancy, blood volume increases 1-1.5 L, total body sodium levels increase by 950 mEq/L, and the volume of total body water is 6-8 L, 4 L of which is extracellular. (medscape.com)
  • Methods LUS was performed on preterm lambs (n=20) during in vivo mapping of the pressure-volume relationship of the respiratory system using the super-syringe method. (bmj.com)