• We investigated whether cytolytic melittin peptides could inhibit HIV-1 infectivity when carried in a nanoparticle construct that might be used as a topical vaginal virucide. (msu.edu)
  • The mechanism of pore formation of lytic peptides, such as melittin from bee venom, is thought to involve binding to the membrane surface, followed by insertion at threshold levels of bound peptide. (nih.gov)
  • Venom from snakes, bees and scorpions contains proteins and peptides which, when separated from the other components and tested individually, can attach to cancer cell membranes. (scienceblog.com)
  • He says that synthetic peptides mimicking components from other venoms, such as those from snakes or scorpions, also work well in the nanoparticles as a possible cancer therapy. (scienceblog.com)
  • The scientists were able to separate the useful peptides and protein from the venom, making them target specifically the malignant cells and evading ones that were healthy. (weeksmd.com)
  • The researchers discovered that venom from snakes, scorpions, and bees contain peptides and proteins that will attach to cancer cell walls. (issels.com)
  • This venom contains antimicrobial peptides which are effective against a broad range of gram-positive/negative bacteria [ 4 ]. (biomedcentral.com)
  • The efficacy of antimicrobial peptides derived from the venom on septic and non-septic inflammations, wound healing, and regulation of adaptive immune system have also been studied [ 5 ]. (biomedcentral.com)
  • His colleague Dr. Pelin Erkoc-Erik, first author of the publication, explains: „We examined the effects of melittin peptides on cell damage and the release of messenger substances and inflammatory markers - in both cancerous and non-cancerous human cells. (senckenberg.de)
  • The researchers agree that the melittin peptides discovered in the wild bee species indeed reveal new and less aggressive activities and thus possibly promise potential for future pharmaceutical applications. (senckenberg.de)
  • Useful peptides for pain include Thymosins, ARA290, BPC157, pentosan polysufate and a unique peptide derived from venom, melittin . (mediproholistichealth.com)
  • Melittin is the main component (40-60% of the dry weight) and the major pain-producing substance of honeybee (Apis mellifera) venom. (wikipedia.org)
  • He says that in the honeybee study, his team identified a substance in the venom called melittin that keeps the cancer cells from multiplying. (scienceblog.com)
  • Dr. Weeks' Comment: Since pioneering apitherapy in the USA - as founder of the American Apitherapy Society, it has been a privilege to watch the scientific community become increasingly enamored with the therapeutic potential of venoms in general and honeybee venom in particular. (weeksmd.com)
  • When the researchers examined venom from a honeybee, they identified melittin, a substance that prevents the multiplying of cancer cells. (weeksmd.com)
  • Early research showed that melittin, an ingredient in honeybee venom, may be used to treat HER2-positive and triple-negative breast cancers. (facingourrisk.org)
  • Dr. Ciara Duffy says honeybee venom destroys multiple types of breast cancer, even the hard to treat triple-negative variety. (studyfinds.org)
  • The synthetic product mirrored the majority of the anti-cancer effects of honeybee venom," the Australian scientist adds. (studyfinds.org)
  • Honeybee venom has been used in traditional medicine for centuries as an anti-inflammatory. (senckenberg.de)
  • Melittin from honeybee venom has long been known to have a strong effect in laboratory experiments. (senckenberg.de)
  • Some of them are known from the honeybee, others we have newly discovered through our combined analysis of the molecules, the proteins, and the genome of the wild bee venom. (senckenberg.de)
  • The Pharmacological Potential of Novel Melittin Variants from the Honeybee and Solitary Bees against Inflammation and Cancer. (senckenberg.de)
  • Ciara Duffy, the 25-year old PhD researcher behind the study, declared that honeybee venom extracts were "extremely potent" and that a specific concentration of honeybee venom could kill 100% of cancer cells. (beemission.com)
  • Nobody had previously compared the effects of honeybee venom or melittin across all the different subtypes of breast cancer and normal cells, Dr. Duffy explained. (beemission.com)
  • Dr. Duffy, from the Harry Perkins Institute of Medical Research and The University of Western Australia, conducted this research as part of her PhD. She began by collecting Perth honeybee venom because Perth bees are some of the healthiest bees in the world. (beemission.com)
  • The honeybee venom, and a compound in it called melittin, rapidly destroyed aggressive hard-to-treat triple-negative breast cancer (TNBC) and HER-2-enriched breast cancer cells in a lab setting according to Australian scientists. (beemission.com)
  • Dr. Duffy reported that the melittin in honeybee venom had the remarkable effect of being able to substantially reduce the chemical messages of cancer cells that are essential to cancer cell growth and cell division within 20 minutes. (beemission.com)
  • While melittin is a natural substance that occurs in honeybee venom, it can be synthetically produced. (beemission.com)
  • However, in honey bees, melittin is not only expressed in the venom gland, but also in other tissues when infected with pathogens. (wikipedia.org)
  • The two venom molecules, melittin and secapin, that are over-expressed in honey bees infected with various pathogens, possibly indicate a role for melittin in the immune response of bees to infectious diseases. (wikipedia.org)
  • Bees make so little venom that it's not feasible to extract it and separate out the substance time after time for lab testing or for later clinical use. (scienceblog.com)
  • First, when bees sting they release a chemical called melittin into their victim. (livescience.com)
  • Bees produce such a small amount of venom that extracting a sufficient amount of the substance from them for laboratory testing or clinical use is impractical. (issels.com)
  • Manuka PollenVENZ is innovative natural product formulated from special blend of NZ Manuka honey and Bee venom VENZ™, collected by ApiHealth NZ Ltd from New Zealand bees with use of ApiHealth patented technology (NZ patent #329585). (apihealth.com)
  • Three of these products: beeswax, venom, and royal jelly, are chemically synthesised by the bees themselves. (positivehealth.com)
  • The history of venom collection is a fatal tale for honey bees. (howstuffworks.com)
  • Bees were forced to sting hard surfaces, such as plastic or rubber, for venom collection, a practice that was fatal to the bee when her stinger inevitably separated from her abdomen after hard-surface-stinging injuries. (howstuffworks.com)
  • Alternatively, venom was also harvested by crushing honey bees - a practice which, yes, was also fatal for the bees. (howstuffworks.com)
  • When bee venom is delivered via syringe, it's first collected not by crushing honey bees but, usually, with an electroshock treatment that's mild enough not to injure the bees yet strong enough to annoy them into stinging. (howstuffworks.com)
  • Do all bees carry this special venom? (studyfinds.org)
  • BACKGROUND: Melittin is a small molecule polypeptide extracted from the abdominal cavity of bees, which is used to treat inflammatory diseases and relieve pain. (bvsalud.org)
  • In a study published in the journal „Toxins", researchers at the Hessian LOEWE Center for Translational Biodiversity Genomics (LOEWE-TBG) are now showing another facet of the importance of wild bees: in their venoms, which have been little studied so far, they were able to detect more original variants of melittin, a peptide of 26 amino acids and major component of bee venom. (senckenberg.de)
  • For example, von Reumont, a co-leader in the European Venom Network ( COST Action EUVEN ), is involved in a project that is conducting more detailed research on the evolution and use of venoms in bees and other invertebrates, including to treat cancer. (senckenberg.de)
  • The venom of wild bees such as the violet carpenter bee ( Xylocopa violacea ), with its main component melittin, is less aggressive than that of honeybees, a team from the LOEWE Centre TBG discovered. (senckenberg.de)
  • Armed with their main defense mechanism, bees will only sting as a last resort as their stingers are often ripped off their bodies together with the venom sac after they drive it through their target, causing the bee's death. (schoolofbees.com)
  • It is important that you remove the stinger as soon as possible because even if it is severed from the main body of the bee, it continues to pump bee venom and also release a pheromone that signals the other bees to attack. (schoolofbees.com)
  • The bees were put to sleep with carbon dioxide and kept on ice before the venom barb was pulled out from the bee's abdomen and the venom extracted by careful dissection. (beemission.com)
  • Bee venom (BV) is usually associated with pain since, when humans are stung by bees, local inflammation and even an allergic reaction can be produced. (uvigo.es)
  • These bees secrete melittin every time they sting somebody and that venom is very toxic to humans. (911honeybeeremoval.com)
  • Bee venom is a clear, odorless liquid substance secreted from the venom glands in the abdomen of worker bees (Apis mellifera L.) and collected in the venom sac located at the base of the bee's stinger. (beeandyou.eu)
  • Only 0.1 micrograms of dry venom can be obtained from one bee, and approximately 10,000 bees are needed to obtain 1 gram of dry venom. (beeandyou.eu)
  • The two main biopeptides of Apis mellifera BV, namely, melittin (MEL) and phospholipase A2 (PLA2), are suspected to be the biomolecules responsible for the anticancer activity. (hal.science)
  • It was possible to perceive a seasonal variation on the venom contents of melittin and phospholipase A2. (blogspot.com)
  • Additionally, two enzymes , hyaluronidase and phospholipase A2 (bvPLA2), together make up between 11 and 15 percent of bee venom. (howstuffworks.com)
  • The venom contains phospholipase, hyaluronidases, and the antigen 5 protein, which is the most allergenic. (msdmanuals.com)
  • Melittin and phospholipase A2 (PLA2) are the most abundant and studied compounds of BV. (uvigo.es)
  • This study found that melittin can kill cancer cells. (facingourrisk.org)
  • We found that melittin can completely destroy cancer cell membranes within 60 minutes. (studyfinds.org)
  • We found that melittin can be used with small molecules or chemotherapies, such as docetaxel, to treat highly-aggressive types of breast cancer. (studyfinds.org)
  • It was found that melittin forms holes in breast cancer membranes, which potentially enables treatments to enter the cell and enhance the cell death. (beemission.com)
  • Since a limited number of studies regarding the effects of melittin on the immune system have been carried out, we aimed to evaluate the effects of melittin on BALB/c mice immune system parameters. (biomedcentral.com)
  • One of which is bee venom that contains a peptide called melittin having antimicrobial and anticancer effects. (biomedcentral.com)
  • Honey Bee Venom (Apis mellifera) contains Anti-coagulation Factors and Increases the Blood-clotting time. (apihealth.com)
  • Bee venom works in a way that it fools the skin into thinking it has been lightly stung with the toxin melittin, which causes the body to direct blood towards the area, stimulating the production of collagen and elastin. (brookstone.com)
  • Nanoparticles carrying melittin (a major component in bee venom) fuse with HIV, destroying the virus's protective envelope. (thewellnessprogramme.com)
  • Free melittin and melittin-loaded nanoparticles were prepared and compared for cytotoxicity and their ability to inhibit infectivity by CXCR4 and CCR5 tropic HIV-1 strains. (msu.edu)
  • TZM-bl reporter cells expressing luciferase under the control of the HIV-1 promoter were incubated with HIV-1 NLHX (CXCR4) or HIV-1 NLYU2 (CCR5) viral strains and different doses of soluble CD4 (positive control) or free melittin to determine infectivity and viability. (msu.edu)
  • 2 μM were not cytotoxic and were highly effective in reducing HIV-1 infectivity for both CXCR4 and CCR5 strains in TZM-bl reporter cells, while VK2 vaginal cell viability was adversely affected at all free melittin doses tested. (msu.edu)
  • Large amounts of free melittin can cause a lot of damage. (scitechdaily.com)
  • The principal function of melittin as a component of bee venom is to cause pain and destruction of tissue of intruders that threaten a beehive. (wikipedia.org)
  • Nanoparticles carrying a toxin found in bee venom can destroy human immunodeficiency virus (HIV) while leaving surrounding cells unharmed, researchers at Washington University School of Medicine in St. Louis have shown. (scitechdaily.com)
  • The lead author of the study from the University of Illinois said the researchers safely used toxins from venom in tiny nanometer particles to treat melanoma and breast cancer cells in a lab setting. (weeksmd.com)
  • However, researchers have not been able to harness the promising properties of anti-cancer into the form of a drug, because the injection of venom likely would cause side effects that could be serious such as nerve cell and heart muscle damage, bleeding beneath the skin and unwanted clotting. (weeksmd.com)
  • Researchers have also tried to alleviate different allergic reactions brought by the use of melittin through altering its molecular structure to reduce its possible side effects [ 6 ]. (biomedcentral.com)
  • It also contains a compound called melittin which researchers say helps this natural remedy stop the disease with remarkable speed. (studyfinds.org)
  • With a specifically concentrated dose of the venom, researchers are able to kill 100 percent of cancer cells. (studyfinds.org)
  • By studying the venom, researchers hope to gain insights into potential medical applications and develop new treatments for various conditions. (petexperta.com)
  • A team of researchers from Frankfurt am Main and Giessen has now discovered milder melittin variants in evolutionarily older wild bee species that seem to be more usable for pharmacology. (senckenberg.de)
  • Researchers in Australia tested venom from garden-variety honeybees sourced in Western Australia, Ireland and England. (beemission.com)
  • The researchers also found that the melittin compound alone is effective in "shutting down" or disrupting cancer cell growth. (beemission.com)
  • Using hundreds of honeybees, a new study reveals the venom in these insects' stingers quickly kills breast cancer cells. (studyfinds.org)
  • Dr. Duffy's tests on 312 honeybees and bumblebees from Perth, Western Australia reveal bumblebee venom does not induce cancer cell death. (studyfinds.org)
  • The venom of Africanized honeybees is no more potent than that of other honeybees but causes more severe consequences because these insects attack in swarms and inflict multiple stings, increasing the dose of venom. (msdmanuals.com)
  • She used venom from 312 honeybees and bumblebees to investigate its anti-cancer properties and its effect on the clinical sub-types of breast cancer, including types with limited treatment options. (beemission.com)
  • The direct insertion of melittin leads to pore formation, whereas the parallel conformation is inactive and prevents other melittin molecules from inserting, hence preventing pore formation. (nih.gov)
  • The scientists mixed melittin with small molecules called monomers, and then started a chemical reaction that links those building blocks into long chains, and makes them solidify. (disabled-world.com)
  • 18 different bioactive molecules were found in the composition of bee venom. (fountainmagazine.com)
  • They also verified that bee venom contains a substance called melittin that prevents cancer cells from spreading. (issels.com)
  • Melittin is also being researched as an active substance against microbes and cancer cells. (senckenberg.de)
  • Formulated with vital compounds such as gold, bee venom powder, ginkgo biloba, retinol, and the Dead Sea minerals, advanced technology overnight treatment provides your skin a pure delight. (brookstone.com)
  • Bee sting therapy, commonly called bee venom therapy (BVT), is the medical use of the toxic compounds in honey-bee venom (BV), also known as apitoxin, in a therapeutic way. (howstuffworks.com)
  • Bee sting venom contains several beneficial compounds. (bestdealprima.com)
  • The chemotherapy drug docetaxel more effectively killed breast cancer cells in mice when combined with melittin. (facingourrisk.org)
  • The combination of melittin and docetaxel was extremely efficient in reducing tumor growth in mice. (studyfinds.org)
  • The technique of combining melittin and docetaxel (a chemotherapy medication) was extremely efficient in reducing tumor growth in mice, according to Dr. Duffy. (beemission.com)
  • That antigen was melittin, the main toxin in bee venom. (disabled-world.com)
  • Mellition, which is composed of 26 amino acids, is the main toxin molecule of the bee venom. (fountainmagazine.com)
  • BV therapy is part of a larger medical philosophy and treatment called apitherapy (bee therapy), a type of holistic therapy that uses not only bee venom for its healing properties, but several bee products, including beeswax, honey, pollen, propolis (bee glue) and royal jelly in treatments. (howstuffworks.com)
  • This article explores the multifaceted world of apitherapy, focusing on bee venom therapy and its potential applications in both human and veterinary medicine. (debuglies.com)
  • Her study in the journal npj Precision Oncology finds the venom not only eradicates these cancers, it also breaks up a cancerous cell's ability to reproduce. (studyfinds.org)
  • Bee venom has previously been found to have anti-cancer properties for other cancers such as melanoma. (beemission.com)
  • We show that in membranes composed of zwitterionic lipids, i.e. phosphatidylcholine, melittin not only forms pores but also inhibits pore formation. (nih.gov)
  • Since melittin attacks double-layered membranes indiscriminately, this concept is not limited to HIV. (scitechdaily.com)
  • Snake, scorpion and bee venom has peptide and proteins that are able to attach to the membranes of cancer cells. (weeksmd.com)
  • They have devised a method for targeting venom proteins specifically to malignant cells while sparing healthy ones, which reduces or eliminates side effects that the toxins would otherwise cause. (scienceblog.com)
  • Neuropeptides: Carpenter ant venom may also contain neuropeptides, which are small proteins that can affect the nervous system of their target. (petexperta.com)
  • Their success in the animal kingdom is largely because of the chemistry and the applications of their products: honey, beeswax, bee venom, propolis, pollen, and royal jelly. (positivehealth.com)
  • Bee venom contains a potent toxin called melittin that can poke holes in the protective envelope that surrounds HIV, and other viruses. (scitechdaily.com)
  • The venom was extremely potent," the researcher from the Harry Perkins Institute of Medical Research says in a media release . (studyfinds.org)
  • Your skin reacts to Bee Venom as an irritation as if it has been lightly stung with Melittin. (aoteanz.com)
  • About 2 million people in the U.S. are allergic to the venom of stinging insects, according to WebMD, and even those who aren't allergic can be afraid because of the acute pain caused by those fuzzy little critters . (livescience.com)
  • As we dig deeper into the characteristics and effects of carpenter ant venom, we gain valuable insights into the fascinating behavior of these wood-building insects. (petexperta.com)
  • Bee, snake or scorpion venom could form the basis of a new generation of cancer-fighting drugs, scientists will report here today. (scienceblog.com)
  • Scorpion, snake and bee venom might sound like more of a health nightmare and not a cure, but the three could be used in drugs that are made to fight cancer, a recent study shows. (weeksmd.com)
  • While being able to kill cancer cells and prevent them from multiplying is good news by itself, another important breakthrough is Dr Pan's success at concentrating the focus of scorpion, snake, and bee venom on the cancer cells without destroying healthy cells and ultimately harming the patient. (issels.com)
  • Scorpion venom has a long history in both ancient Egyptian medicine and in traditional Chinese medicine. (howstuffworks.com)
  • As long as you're not allergic to bee venom, your immune system will react to the sting by sending fluids there to flush out the melittin, causing swelling and redness. (livescience.com)
  • Bee venom support the immune system in health condition and contribute production of endogenous cortisol in the adrenal glands, which protect body from unfavourable environmental factors and provide joint mobility support. (apihealth.com)
  • Melittin also triggers the immune system cells that prevent the formation of free radicals, which normally damage cells and tissue. (fountainmagazine.com)
  • According to our results, melittin at 0.75 and 1.5 mg/kg doses could not induce significant changes on immune parameters and as a result, melittin was found to be safe for the mice immune system. (biomedcentral.com)
  • Honey bee venom is a valuable natural compound which is suggested (in studies) as a candidate for the treatment of various ailments such as arthritis, gout, rheumatism, and other disorders related to the immune system [ 3 ]. (biomedcentral.com)
  • Since melittin has multiple claimed therapeutic features and in other side, there is a limited number of studies regarding its effects on the immune system, we aimed to evaluate the immunotoxic/immunomodulatory properties of melittin in BALB/c mice with a tiered approach immunotoxicity screening. (biomedcentral.com)
  • We have safely used venom toxins in tiny nanometer-sized particles to treat breast cancer and melanoma cells in the laboratory," says Dipanjan Pan, Ph.D., who led the study. (scienceblog.com)
  • Using toxins to heal what ails us may sound like contradictory, and perhaps even dangerous, advice - but for at least 5,000 years humans have relied on venom, of all things, for medicinal purposes. (howstuffworks.com)
  • When threatened, they can deliver painful stings that release venom into the attacker. (petexperta.com)
  • Individuals allergic to bee stings should avoid using bee venom in any form. (beeandyou.eu)
  • The present work aims to evaluate the cytotoxic effect of the A. mellifera venom on human colon carcinoma cells (HCT116), and to assess the synergistic effect of MEL and PLA2 on these cells. (hal.science)
  • Results obtained showed a strong cytotoxicity effect induced by the A. mellifera venom and to a lower extent MEL or PLA2 alone. (hal.science)
  • These findings confirm the cytotoxic effect of the A. mellifera venom and highlight the presence of synergistic potential activities between MEL and PLA2, possibly inducing membrane disruption of HCT116 cancer cells. (hal.science)
  • Melittin triggers the synthesis of the cortisol hormone that suppresses inflammation and increases the resistance of cell walls. (fountainmagazine.com)
  • Formic acid: The venom may contain formic acid, which can cause a burning sensation and inflammation when injected into a predator or prey. (petexperta.com)
  • The longer the stinger stays in the skin, the more venom is released, continuing its toxic assault for up to a minute. (livescience.com)
  • While it's possible for the worker bee to sting more than once, it's actually the injury to her stinger apparatus - the venom sac, abdominal muscles and nerve center becoming crushed or dislodged - rather than the act of stinging that's fatal to the bee. (howstuffworks.com)
  • Apids typically sting once and dislodge their barbed stinger into the wound, introducing venom and killing the insect. (msdmanuals.com)
  • When a bee stinger is activated, it releases more than just venom. (thewellnessprogramme.com)
  • The scientists gave lab mice lethal injections of melittin, which breaks open and kills cells. (disabled-world.com)
  • Melittin inhibits protein kinase C, Ca2+/calmodulin-dependent protein kinase II, myosin light chain kinase, and Na+/K+-ATPase (synaptosomal membrane). (wikipedia.org)
  • The purpose of this study was to investigate the effects of melittin on production performance, antioxidant function, immune function, heat shock protein, intestinal morphology, and cecal microbiota of heat-stressed quails. (bvsalud.org)
  • In sum, our results demonstrate for the first time that dietary melittin could improve the adverse effects of heat stress on antioxidant function, immune function, heat shock protein, intestinal morphology, and cecal microbiota in quails, consequently improving their production performance under heat stress. (bvsalud.org)
  • We have performed molecular dynamics (MD) simulation of the thermal denaturation of one protein and one peptide-ubiquitin and melittin. (typeset.io)
  • Hymenoptera venoms cause local toxic reactions in all people and allergic reactions only in those previously sensitized. (msdmanuals.com)
  • The amount of venom in a bee varies depending on the season and the bee's structure, ranging from 0.05-0.3 ml/bee. (beeandyou.eu)
  • Study authors say melittin can also help current cancer treatments like chemotherapy. (studyfinds.org)
  • The study also tested whether melittin can be used in combination with existing chemotherapy drugs in treating highly aggressive types of breast cancer. (beemission.com)
  • Melittin nanoparticles safely and significantly decreased CXCR4 (IC(50) 2.4 μM and IC(90) 6.9 μM) and CCR5 (IC(50) 3.6 μM and IC(90) 11.4 μM) strain infectivity of TZM-bl reporter cells. (msu.edu)
  • Animals that then immediately received an injection of the melittin-targeting plastic antibody showed a significantly higher survival rate than those that did not receive the nanoparticles. (disabled-world.com)
  • As a result of binding and removal of melittin by NPs in vivo, the mortality and peripheral toxic symptoms due to melittin [bee venom compound] were significantly diminished. (bibliotecapleyades.net)
  • Dietary melittin significantly increased growth performance, serum and liver antioxidative function, immune function, intestinal VH and VH/CD, and cecal microbiota Shannon index in heat-stressed quails (P (bvsalud.org)
  • Melittin significantly decreased small intestinal CD, and HSP70 and HSP90 mRNA levels in the viscera (P (bvsalud.org)
  • While the bee-related health benefits of honey, royal jelly, and pollen are well known, bee venom is more of a mystery. (barynya.com)
  • Bee venom (BV) has been shown to possess in vitro anticancer effects against several types of cancer cells. (hal.science)
  • Injection of melittin into animals and humans causes pain sensation. (wikipedia.org)
  • Melittin is toxic to humans and destructive because it pokes holes in cell walls. (howstuffworks.com)
  • Only 22 percent of honey-bee venom is pharmacologically active - the remainder is just water. (howstuffworks.com)
  • This takes the venom directly to the targeted cancer cells without allowing it to leak into the bloodstream of patients and damage the heart, nerve cells, or other healthy tissue. (issels.com)
  • Scientists are optimistic about attacking cancer cells with the poisonous venoms most of us desperately try to avoid. (issels.com)
  • Scientists are interested in unraveling the chemical components of the venom and how they contribute to the ant's predatory behavior and defense mechanisms. (petexperta.com)
  • By studying their venom composition , scientists can develop targeted strategies for controlling Argentine ant infestations and minimizing their potential harm to native species and environments. (petexperta.com)
  • Scientists caution that further research and testing is needed to see if the venom can work on scale as a cancer-fighting drug. (beemission.com)
  • In just 20 minutes, melittin breaks down the chemical messages breast cancer cells transmits to trigger both cell growth and cell division. (studyfinds.org)
  • Venom was also tested against hormone receptor positive breast cancer cells and normal breast cells. (studyfinds.org)
  • This study demonstrates how melittin interferes with signaling pathways within breast cancer cells to reduce cell replication. (studyfinds.org)
  • He finds it significant that this study demonstrates how melittin interferes with signaling pathways within breast cancer cells, the chemical messages that are fundamental for cancer cell growth and reproduction, to reduce cell replication. (beemission.com)
  • The report discovers melittin also forms numerous pores (tiny holes) in the breast cancer cell membrane. (studyfinds.org)
  • Female BALB /c mice were treated intraperitoneally (i.p) with 0.75 and 1.5 mg/kg doses of melittin for 14 days (5 doses per week). (biomedcentral.com)
  • Future investigations appear warranted to explore the antiviral prophylactic potential of melittin nanoparticles to capture, disrupt and prevent initial infection with HIV-1 or potentially other enveloped viruses. (msu.edu)
  • Melittin a 26-amino acid peptide is the most important active constituent of honey bee venom that forms up to 50% of its dry weight [ 6 ], with significant antimicrobial and antiviral properties [ 7 ]. (biomedcentral.com)
  • RESULTS: Here, melittin was verified to inhibit the cell proliferation and migration of CPRC. (bvsalud.org)
  • In 1935, Forapin, which was isolated from bee venom, was introduced into the market. (fountainmagazine.com)
  • ?? , ?????? ??? ????? ????? ??? (Bee venom therapy, 1935). (barynya.com)
  • Syringes make it easier to inject venom, but before there were needles there were, well, stingers. (howstuffworks.com)
  • While the study dissects live bee stingers to extract melittin, it finds this compound can be successfully reproduced in labs. (studyfinds.org)
  • Melittin-loaded nanoparticles were formulated and different doses tested against VK2 vaginal epithelial cells to determine cell viability. (msu.edu)
  • Based on VK2 viability, melittin nanoparticles were tested for prevention of CXCR4 and CCR5 tropic HIV-1 infectivity and viability of TZM-bl reporter cells. (msu.edu)
  • Melittin also activates nociceptor (pain receptor) cells through a variety of mechanisms. (wikipedia.org)
  • Melittin can open thermal nociceptor TRPV1 channels via cyclooxygenase metabolites resulting in depolarization of nociceptor cells. (wikipedia.org)
  • Indeed, in addition to anti-viral therapy, the paper's senior author, Samuel A. Wickline, MD, the J. Russell Hornsby Professor of Biomedical Sciences, has shown melittin-loaded nanoparticles to be effective in killing tumor cells. (scitechdaily.com)
  • The new study shows that melittin loaded onto these nanoparticles does not harm normal cells. (scitechdaily.com)
  • They are using nanoparticles to deliver bee venom called melittin through the body to kill cancerous tumor cells. (computerworld.com)
  • At the same time, the study finds bee venom does little harm to normal cells. (studyfinds.org)
  • The observation that melittin can suppress the growth of the cells is "incredibly exciting" according to Western Australia's Chief Scientist, Professor Peter Klinken. (beemission.com)
  • Nanoparticles carrying a toxin found in bee venom is also believed to destroy human immunodeficiency virus (HIV) while leaving surrounding cells unharmed, reports Washington University. (thewellnessprogramme.com)
  • Consider yourself lucky if your dog belongs to the majority that is not allergic to bee venom. (schoolofbees.com)
  • Melittin is a basic peptide consisting of 26 amino acids. (wikipedia.org)