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CarboplatinPaclitaxelGemcitabineInjectionInfusionShown that cisplatinActivity of cisplatinOxaliplatinDocetaxelIntravenouslyChemotherapy drugsCDDPCancerPlatinum-containinVinorelbineSynergizesChemoTumorRenalMedicationLymphPregnancyAntibioticsReversibleKidney diseaseMagnesiumKidneysUnderwentDripTreatmentClinicalPICCMammaryDrugSide effectsEffectsMiceSevereLiverNeedleCommonlyPregnantCombinationDoctorMinutes
Carboplatin2
  • Standard treatment for women with stage III ovarian cancer has been surgical removal of the tumor (debulking), followed by six to eight courses of IV chemotherapy given every three weeks with a platinum drug, such as cisplatin or carboplatin, and a taxane drug, such as paclitaxel. (ohsu.edu)
  • Chemotherapy will be one of the following regimens: pemetrexed plus cisplatin or pemetrexed plus carboplatin. (clincosm.com)
Paclitaxel1
  • and IV paclitaxel followed by IP cisplatin and the subsequent administration of IP paclitaxel. (ohsu.edu)
Gemcitabine1
Injection11
  • It is given by injection into a vein. (wikipedia.org)
  • You may have a severe allergic reaction within minutes of receiving a cisplatin injection. (drugs.com)
  • This leaflet answers some common questions about DBL Cisplatin Injection. (news-medical.net)
  • DBL Cisplatin Injection belongs to a group of medicines known as antineoplastic or cytotoxic agents. (news-medical.net)
  • DBL Cisplatin Injection is a platinum-containing medicine and is used as an anticancer drug to interfere with the growth of cancer cells and eventually destroy them. (news-medical.net)
  • DBL Cisplatin Injection may be used alone or with other anticancer therapies. (news-medical.net)
  • DBL Cisplatin Injection has been chosen as your therapy, as the benefits of treatment are expected to be greater than the unwanted or side effects. (news-medical.net)
  • The active ingredient in DBL Cisplatin Injection passes into breast milk and there is a possibility that your baby may be affected. (news-medical.net)
  • Durvalumab, tremelimumab, pembrolizumab, and chemotherapy are given as an injection over time into a vein, also called an IV infusion. (clincosm.com)
  • TNF-α appears to play a central role in the cisplatin induced renal injury by activation of a large network of chemokines and cytokines in the kidney following cisplatin injection. (biomedcentral.com)
  • This drug is given by injection into your dog's veins. (crittear.com)
Infusion4
  • Cisplatin is administered intravenously as short-term infusion in normal saline for treatment of solid and haematological malignancies. (wikipedia.org)
  • Cisplatin is given as an infusion into a vein. (drugs.com)
  • The pemetrexed will be given over 10 minutes and the cisplatin infusion takes about two hours. (ankr.us)
  • The chemotherapy drugs used for non-small cell lung cancer are usually given through a vein as an intravenous (IV) infusion. (nyulangone.org)
Shown that cisplatin2
  • Recent studies have shown that cisplatin noncompetitively inhibits an archetypal, membrane-bound mechanosensitive sodium-hydrogen ion transporter known as NHE-1. (wikipedia.org)
  • Recent reports have shown that cisplatin induced nephrotoxicity is characterized by activation of pro-inflammatory cytokines and chemokines. (biomedcentral.com)
Activity of cisplatin2
  • The addition of PARP inhibitor veliparib with ATR inhibitor M6620 (VX-970) allows for impairment of DNA repair, the induction of a BRCA null phenotype, and potentiation of the antitumor activity of cisplatin. (survivornet.com)
  • To best of our knowledge this is the first report which shows that pre-treatment of rosiglitazone synergizes the anticancer activity of cisplatin and minimizes cisplatin induced nephrotoxicity in DMBA induced breast cancer. (biomedcentral.com)
Oxaliplatin2
  • Key words: advanced gastric cancer, chemotherapy, oxaliplatin, pemetrexed, phase II trial addition, cisplatin-based combinations are difficult toadminister in this often-debilitated population and have the Patients suffering from advanced gastric cancer (AGC) remain potential for severe toxicity. (aboutdrugspdf.com)
  • To date, chemotherapy relies heavily upon 5-fluorouracil (5-FU) and/or Oxaliplatin is a third-generation platinum derivative with cisplatin, with 5-FU-cisplatin (CF) and epirubicin-cisplatin- a more favorable toxicity profile than cisplatin [4]. (aboutdrugspdf.com)
Docetaxel2
  • The patient underwent two courses of neoadjuvant chemotherapy (NAC) with docetaxel, cisplatin, and 5-fluorouracil (DCF). (springeropen.com)
  • does not cause ototoxicity or nephrotoxicity and its A recent phase III study comparing docetaxel-cisplatin-5-FU administration does not require aggressive i.v. hydration. (aboutdrugspdf.com)
Intravenously2
  • Amifostine comes as a powder to be mixed with liquid to be injected intravenously (into a vein) by a doctor or nurse in a medical facility. (medlineplus.gov)
  • Chemotherapy for stomach cancer is usually given by a needle into a vein (intravenously). (cancer.ca)
Chemotherapy drugs2
CDDP2
  • Due to drug resistance, the clinical response to cisplatin (CDDP) from patients with liver cancer is unsatisfactory. (ijbs.com)
  • Chemotherapy, including cisplatin (CDDP), remains a potent treatment for patients with late-stage liver cancer [ 2 , 3 ]. (ijbs.com)
Cancer17
  • Cisplatin is used together with other cancer drugs to treat bladder cancer , testicular cancer , or ovarian cancer . (drugs.com)
  • How often and how many times you receive cisplatin will depend on the type of cancer you have. (drugs.com)
  • CISPLATIN (SIS pla tin) treats some types of cancer. (chemocare.com)
  • Amifostine is used protect the kidneys from harmful effects of the chemotherapy drug cisplatin in patients that receive this medication for the treatment of ovarian cancer. (medlineplus.gov)
  • Researchers think combining cisplatin with 2 other drugs could block proteins that support cancer cell growth. (survivornet.com)
  • Veliparib (ABT-888) is a potent PARP 1/2 inhibitor with clinical evidence of potentiation of antitumor activity in combination with cisplatin in breast cancer gene (BRCA) mutation carriers and patients with sporadic triple-negative breast cancer. (survivornet.com)
  • The combined methods, which deliver drugs into a vein and directly into the abdomen, extend overall survival for women with advanced ovarian cancer by about a year. (ohsu.edu)
  • Her Attempted liver resection could not be carried out, as it was found that the cancer had spread to become "involved" with the portal vein and arteries near the bile duct. (cancer.org)
  • 21 Cycle 2 Day 1 2 Dexamethasone Cytarabine Cisplatin Page 2 DEXAMETHASONE, CYTARABINE, AND CISPLATIN (DHAP) INTRAVENOUS CANCER TREATMENT EDUCATION Other medications Other medications may be ordered for you to prevent or treat certain side effects. (ivcanceredsheets.com)
  • Page 3 DEXAMETHASONE, CYTARABINE, AND CISPLATIN (DHAP) INTRAVENOUS CANCER TREATMENT EDUCATION Common Side Effects Common side effects that have been known to happen in patients receiving DHAP are listed in the left side of this table. (ivcanceredsheets.com)
  • Pemetrexed and cisplatin can be given with other cancer drugs. (ankr.us)
  • The high activity of the JNK promotes poor progression and mediates cisplatin resistance in liver cancer, leading to a poor prognosis of liver cancer. (ijbs.com)
  • Mechanistically, the highly activated JNK phosphorylated c-Jun and ATF2 formed a heterodimer to upregulate the expression of Galectin-1, leading to promoting cisplatin resistance in liver cancer. (ijbs.com)
  • Collectively, our results underline that the high activity of JNK/c-Jun-ATF2/Galectin-1 mediates cisplatin resistance in liver cancer and provides an optional scheme for dynamic monitoring of molecular activity in vivo . (ijbs.com)
  • 2004 SCC R.tip 1/4 tongue Oct. 2005 R. Neck SCC cancer/Chemo Cisplatin 2x/8wks. (oralcancersupport.org)
  • Antineoplastic drug cisplatin remains the drug of choice for various solid tumours including breast cancer. (biomedcentral.com)
  • The present study was undertaken to assess the effect of rosiglitazone, a PPARγ agonist and an anti-inflammatory agent, on cisplatin induced nephrotoxicity, and its anticancer activity in DMBA induced breast cancer rats. (biomedcentral.com)
Platinum-containin1
  • Cisplatin is in a class of medications known as platinum-containing compounds . (ankr.us)
Vinorelbine5
  • This leaflet provides information on a course of chemotherapy called cisplatin and vinorelbine. (nhs.wales)
  • What is cisplatin and vinorelbine chemotherapy? (nhs.wales)
  • Why am I having cisplatin and vinorelbine chemotherapy? (nhs.wales)
  • It is usual to have cisplatin and vinorelbine chemotherapy every three weeks for up to six cycles. (nhs.wales)
  • On day 1 you will be given the cisplatin chemotherapy in a drip, and the vinorelbine as capsules. (nhs.wales)
Synergizes1
Chemo1
  • The process of infusing the chemo through arm veins, eventually damages the veins (for me it was after 3 mths), making it difficult to get blood samples and to find a vein to use for the infusions. (cholangiocarcinoma.org)
Tumor2
  • Finally, PRL and cisplatin combination treatment significantly delayed naturally developed breast tumor growth in neu transgenic mice. (ommegaonline.org)
  • The tumor extends into the renal vein in 40% of cases. (medscape.com)
Renal2
  • In conclusion, it was found that the administration of L. fermentum probiotic, and particularly its postbiotic in cisplatin-induced CKD mice, showed promising effects and could successfully improve renal function in the animal model of CKD. (biomedcentral.com)
  • Venous drainage flows directly into the inferior vena cava on the right side and into the left renal vein on the left side. (medscape.com)
Medication4
  • Cisplatin is a chemotherapy medication used to treat a number of cancers. (wikipedia.org)
  • Cisplatin may also be used for purposes not listed in this medication guide. (drugs.com)
  • This medication is injected into a vein. (chemocare.com)
  • This medication is available as a solution to be given into the vein by a healthcare professional. (rxwiki.com)
Lymph1
Pregnancy3
  • Tell your doctor right away if a pregnancy occurs while either the mother or the father is using cisplatin. (drugs.com)
  • However, it is important to use birth control to prevent pregnancy because cisplatin can harm an unborn baby. (drugs.com)
  • It is recommended that you and your doctor discuss your need for cisplatin treatment during pregnancy and the possible risks and benefits of using cisplatin during pregnancy. (news-medical.net)
Antibiotics1
  • Other drugs (such as the aminoglycoside antibiotic class) may also cause ototoxicity, and the administration of this class of antibiotics in patients receiving cisplatin is generally avoided. (wikipedia.org)
Reversible1
  • Nervous system problems may occur up to several weeks after you receive cisplatin, and these effects may not be reversible. (drugs.com)
Kidney disease2
  • Avoid becoming pregnant by using effective birth control during your treatment with cisplatin and for at least 26 weeks after you stop treatment (at least 31 weeks if have kidney disease). (news-medical.net)
  • It is recommended that you use effective contraception while you are using cisplatin and for at least 14 weeks after you stop treatment (at least 19 weeks if you have kidney disease). (news-medical.net)
Magnesium2
  • The hypocalcaemia seems to occur in those with low serum magnesium secondary to cisplatin, so it is not primarily due to the cisplatin. (wikipedia.org)
  • Your doctor may want you to take calcium or magnesium by mouth or by vein (IV) to keep those levels normal. (stjude.org)
Kidneys3
  • Cisplatin can affect your nervous system, increase your risk of bleeding or infection , or harm your kidneys. (drugs.com)
  • When amifostine is used to protect the kidneys against the harmful effects of cisplatin, it is usually given over 15 minutes starting 30 minutes before you receive your chemotherapy treatment. (medlineplus.gov)
  • You will be given extra fluids through your drip before and after the cisplatin to protect your kidneys. (ankr.us)
Underwent1
  • 1. Among patients with persistent atrial fibrillation (AF) treated with cardiac ablation, those who underwent pulmonary vein (PVI) and posterior wall isolation (PWI) had no significant difference in outcomes compared to those who underwent PVI alone. (2minutemedicine.com)
Drip1
  • Your chemotherapy is given through a drip into a vein in the back of your hand or arm. (nhs.wales)
Treatment5
  • Common neurological side effects of cisplatin include visual perception and hearing disorder, which can occur soon after treatment begins. (wikipedia.org)
  • Males: Tell your doctor or pharmacist if your partner intends to become pregnant while you are being given cisplatin, or shortly after you have stopped treatment. (news-medical.net)
  • Treatment schedule Your treatment will be given into your vein through an intravenous (IV) line. (ivcanceredsheets.com)
  • Rosiglitazone pre-treatment to cisplatin increases the expression of p38, PPAR-γ in mammary tumours and shows maximum tumour reduction. (biomedcentral.com)
  • Furthermore, cisplatin induced changes in histone acetylation, phosphorylation and methylation of histone H3 in mammary tumours was ameliorated by pre-treatment of rosiglitazone. (biomedcentral.com)
Clinical1
  • Cisplatin has a number of side effects that can limit its use: Nephrotoxicity (kidney damage) is the primary dose-limiting side effect and is of major clinical concern. (wikipedia.org)
PICC2
  • Alternatively it may be suggested that a fine tube called a PICC line is inserted into one of the large veins in your upper arm. (nhs.wales)
  • a fine tube that is put into a vein in your arm and goes up into a vein in your chest ( PICC line ). (ankr.us)
Mammary1
  • The current study aimed to investigate the feasibility of using prolactin (PRL), a hormone intimately involved in mammary gland development, in combination with cisplatin as an alternative to target breast CSC (BCSC). (ommegaonline.org)
Drug2
  • In September 2022, the U.S. Food and Drug Administration (FDA) approved sodium thiosulfate under the brand name Pedmark to lessen the risk of ototoxicity and hearing loss in people receiving cisplatin. (wikipedia.org)
  • https://www.rxlist.com/cisplatin-side-effects-drug-center.htm. (my20yearscancer.com)
Side effects5
  • While triggering apoptosis through interfering with DNA replication remains the primary mechanism of cisplatin, this has not been found to contribute to neurological side effects. (wikipedia.org)
  • Cisplatin may cause serious side effects. (drugs.com)
  • Since the growth of normal body cells may also be affected by cisplatin, other effects may also occur (see Side Effects). (news-medical.net)
  • Before you start pemetrexed and cisplatin, take medicines to help reduce side effects. (ankr.us)
  • What side effects can cisplatin and pemetrexed cause? (ankr.us)
Effects1
  • As the possible harmful effects to the infant are not known, breastfeeding is not recommended while you are receiving cisplatin. (news-medical.net)
Mice2
  • CKD mice were induced by a single dose of cisplatin 10 mg/kg, intraperitoneally. (biomedcentral.com)
  • We administered silver nanoparticles with particle diameters of 10, 50, and 200 nm (SnP10, SnP50, and SnP200, respectively) to mice through the tail vein. (e-kenkyu.com)
Severe1
  • Ototoxicity and hearing loss associated with cisplatin can be severe and is considered to be a dose-limiting side effect. (wikipedia.org)
Liver1
  • Furthermore, liver injury was induced by co-administering SnP10 with carbon tetrachloride, streptomycin, or cisplatin. (e-kenkyu.com)
Needle1
  • The definition of an IV is an abbreviation for intravenous, a procedure where a needle inserted directly into a vein to deliver liquids to the blood stream. (moviecultists.com)
Commonly1
  • P: Cisplatin (sis-PLA-tin): Platinol Common uses This regimen is mostly commonly used for Diffuse Large B-Cell Lymphoma but may be used for other diagnoses. (ivcanceredsheets.com)
Pregnant1
Combination1
  • Nausea and vomiting: cisplatin is one of the most emetogenic chemotherapy agents, but this symptom is managed with prophylactic antiemetics (ondansetron, granisetron, etc.) in combination with corticosteroids. (wikipedia.org)
Doctor2
Minutes1
  • Amifostine is a liquid given by the vein (IV) for 5-15 minutes. (stjude.org)