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ImmunizationGenetic VectorsImmunization ProgramsImmunization ScheduleImmunization, SecondaryInsect VectorsVaccinationImmunization, PassiveDisease VectorsMice, Inbred BALB CVaccines, SyntheticVaccines, DNAVaccinesAntibody FormationImmunoglobulin GAdministration, IntranasalAntibodies, BacterialAdjuvants, ImmunologicAdenoviridaeAntibodies, ViralGene Transfer TechniquesTransduction, GeneticViral VaccinesImmunity, MucosalTetanus ToxoidMice, Inbred C57BLMeasles VaccineLentivirusInfluenza VaccinesMolecular Sequence DataVaccines, AttenuatedDependovirusTetanusImmunoglobulin AInjections, IntramuscularDiphtheria-Tetanus-Pertussis VaccineVaccines, InactivatedAIDS VaccinesMeaslesImmunity, CellularHepatitis B VaccinesEnzyme-Linked Immunosorbent AssayTransgenesMeasles-Mumps-Rubella VaccineArthropod VectorsDiphtheria ToxoidT-LymphocytesAntigens, BacterialEpitopesCell LineImmunoglobulin A, SecretoryAntibody SpecificityBase SequenceImmunity, Maternally-AcquiredCD8-Positive T-LymphocytesInjections, IntradermalSupport Vector MachinesVaccines, CombinedSpleenCholera ToxinAntibodiesImmunity, ActivePertussis VaccineCross ReactionsImmunity, HumoralT-Lymphocytes, CytotoxicAmino Acid SequenceNeutralization TestsHemocyaninFreund's AdjuvantVaccines, SubunitMass VaccinationMumps VaccineBiolisticsAntigensInterferon-gammaRubella VaccineAnophelesProtozoan VaccinesTransfectionLymphocyte ActivationVaccines, ConjugateRecombinant ProteinsCancer VaccinesGene ExpressionCloning, MolecularDiphtheriaPoliomyelitisToxoidsAdministration, OralRetroviridaeVaccinia virusDisease Models, AnimalRecombinant Fusion ProteinsMalaria VaccinesCD4-Positive T-LymphocytesRabbitsDose-Response Relationship, ImmunologicTime FactorsHaemophilus Vaccines
VaccinesAntigensVaccineViralImmunityDiseasesAdvisory CommitteeVaccinationLentiviral vectorExpressed by adenoviralMiceDisease vector controlAdenoviral vectoredAntibodyBorne diseaseMosquitoesGene deliveryClinic2023ResponsesRoyalty-freeControlFeverEfficacyGeneticOccurHumanRecommendationsPotentReferPublic HealthIconsVirusTemperatureArticle
Vaccines13
  • These include messenger ribonucleic acid (mRNA) vaccines, protein subunit and virus-like particle (VLP) vaccines, and non-replicating viral vector vaccines. (canada.ca)
  • An authorized viral vector COVID-19 vaccine may be offered to individuals 18 years of age and over, without contraindications to the vaccine, when all other authorized COVID-19 vaccines are contraindicated. (canada.ca)
  • Here we report the design of novel vectored Plasmodium falciparum vaccines capable of overcoming such limitations. (ox.ac.uk)
  • These vectored vaccines should allow assessment in humans of the safety and efficacy of inducing strong cellular as well as cross-strain humoral immunity to P. falciparum MSP-1. (ox.ac.uk)
  • Immunisation with purified Coxiella burnetii phase I lipopolysaccharide confers partial protection in mice independently of co-administered adenovirus vectored vaccines. (ox.ac.uk)
  • Antibodies elicited by purified C. burnetii lipopolysaccharide (LPS) correlate with protection against Q fever, while antigens encoded by adenoviral vectored vaccines can induce cellular immune responses which aid clearing of intracellular pathogens. (ox.ac.uk)
  • There are a number of alternate vaccination strategies in current development which may circumvent the need for annual re-vaccination, including new platform technologies such as viral-vectored vaccines. (mdpi.com)
  • We discuss the different vectored vaccines that have been or are currently in clinical trials, with a forward-looking focus on immunogens that may be protective against seasonal and pandemic influenza infection, in the context of viral-vectored vaccines. (mdpi.com)
  • Vaccines are NOT immunizations. (aspenbloompetcare.com)
  • The vaccines that rely on viral vectors, such as those produced by Johnson & Johnson and AstraZeneca, "are stored at much nicer temperatures," says Anna Blakney, PhD, a vaccine developer and assistant professor in the Michael Smith Laboratories and the School of Biomedical Engineering, University of British Columbia, in Vancouver, Canada. (medscape.com)
  • The Immunization Program provides flu vaccinations during community flu clinics and supports local health care providers through the Vaccines for Children (VFC) Program. (countyofglenn.net)
  • The thrombosis with thrombocytopenia syndrome, or TTS, is a new syndrome that's been recognized to occur after receiving adenoviral vector COVID-19 vaccines. (cdc.gov)
  • Both vaccines contain replication-incompetent adenoviral vectors (human [Ad26.COV2.S] for J&J and chimpanzee [ChAdOx1] for AstraZeneca) that encode the spike glycoprotein of SARS-CoV-2, the virus that causes COVID-19. (cdc.gov)
Antigens8
  • or (f) living vectored cells expressing specific heterologous antigens. (who.int)
  • Notably, vaccination with DREP-GP and DREP-VP40, which produces both GP and VP40 antigens, induced a significantly higher level of anti-GP IgG2a antibody and increased IFN-γ secreting CD8 + T-cell responses relative to vaccination with DREP-GP or DREP-VP40 vector alone. (frontiersin.org)
  • Our study indicates that co-expression of GP and VP40 antigens based on the SFV replicon vector generates EBOV VLPs in vitro , and vaccination with recombinant DREP vectors containing GP and VP40 antigens induces Ebola antigen-specific humoral and cellular immune responses in mice. (frontiersin.org)
  • Lentiviral vectors encoding antigens are promising vaccine candidates because they transduce dendritic cells (DC) in vivo and prime CTL responses. (elsevierpure.com)
  • We developed a CD8 + T-cell-based vaccine platform based on intramuscular (i.m.) injection of a DNA vector coding for antigens of interest fused at the C-terminus of a biologically inactive Human Immunodeficiency Virus (HIV)-Type 1 Nef protein (Nef mut ) having an unusually high efficiency of incorporation into EVs. (nature.com)
  • Upon i.m. injection of DNA vectors expressing Nef mut -derivatives, nanovesicles containing antigens fused with Nef mut are released by muscle cells, can freely circulate into the body, and can be internalized by antigen-presenting cells (APCs). (nature.com)
  • In this project we are interested to develop a vaccine using selected T. gondii antigens and explore the efficacy of delivering the vaccine using viral vectors. (europa.eu)
  • The project focussed on the development and testing of recombinant virus vectors to deliver T. gondii antigens in vivo to stimulate specific protective immune responses. (europa.eu)
Vaccine13
  • These data provide evidence that a single administration of an IN-defective sinLV elicits a significant immune response in the absence of vector integration and may be a safe and useful strategy for vaccine development. (duke.edu)
  • COVID-19 Vaccine, Viral Vector (Johnson and Johnson/Janssen) is no longer commercially available in the U.S and the Emergency Use Authorization has been revoked as of 6/1/2023. (medlineplus.gov)
  • The companion vaccine trial RV305 was designed to permit the evaluation of the immunologic impact of late boosting with either the boosting protein antigen alone, the canarypox viral vector ALVAC alone, or a combination of both. (nih.gov)
  • The adenoviral vectored vaccine constructs alone elicited strong cellular immunity, but this response was not correlative with protection in mice. (ox.ac.uk)
  • Poly(propyleneimine) dendrimer and dendrosome based genetic immunization against Hepatitis B.". Vaccine. (wikipedia.org)
  • Immunization with a bivalent adenovirus-vectored tuberculosis vaccine provides markedly improved protection over its monovalent counterpart against pulmonary tuberculosis. (nih.gov)
  • Immunisation of mice with the recombinant viruses did result in induction of specific antibody responses showing that the approach had some efficacy and would be worth pursuing with the long term aim of producing a safe and effective vaccine against T. gondii tissue cysts in food animals. (europa.eu)
  • Could rotavirus vaccine platforms aid in the immunization campaign against SARS-CoV-2? (news-medical.net)
  • The vaccine adjuvants sector is witnessing an upward trend globally, fuelled by the rise in prevalence of zoonotic diseases and the growing need for effective immunization. (reportlinker.com)
  • Examples include immunizations for vaccine-preventable disease, especially childhood immunization and the monitoring of immunization status in clinic, daycare, school, and home settings. (waldenu.edu)
  • As a reminder, in the United States, currently, the only authorized adenoviral vectored COVID-19 vaccine is the Janssen or Johnson & Johnson COVID-19 vaccine. (cdc.gov)
  • Second-generation vectors are being developed based on the licensed VSV-EBOV vaccine. (nih.gov)
  • CDC wil convene an emergency meeting of the Advisory Committee on Immunization Practices (ACIP) on Wednesday, April 14, 2021, to further review these cases and assess potential implications on vaccine policy. (cdc.gov)
Viral7
  • In this study, we constructed a recombinant Alphavirus Semliki Forest virus (SFV) replicon vector DREP to express EBOV GP and matrix viral protein (VP40). (frontiersin.org)
  • Most functional responses increased upon protein boosting, regardless of the viral vector-priming agent incorporation. (nih.gov)
  • VIRAL INFECTION - thin line vector icon set. (istockphoto.com)
  • 2 , 3 Viral gene transfer strategies [retroviruses, 4 adenoviruses, 5 adeno-associated viruses, 6 , 7 herpes viruses, 8 lentiviruses, 9 and Epstein-Barr viruses (EBV) 10 ] show by far the highest transfection efficiencies, whereas nonviral vectors are limited in their efficacy to deliver genes. (genengnews.com)
  • The following methods and tools for gene therapeutic vectors are not restricted to a specific type of therapeutical system or application and hence can be adapted to improve both viral and nonviral vectors. (genengnews.com)
  • A set of viral vectors was thus generated, all of which contained SARS-CoV-2 coding sequences for the spike S1 subunit, the NTD, the RBD, extended RBD, and the S2 core region that contains its fusion domain. (news-medical.net)
  • The platform was developed to counteract emerging neglected viral pathogens with low worldwide infectious disease impact but of significant local/regional public health concern utilizing the concept of emergency immunization in the form of ring vaccination. (nih.gov)
Immunity1
  • Simian adenoviral vectors were used in an effort to circumvent preexisting immunity to human adenoviruses. (ox.ac.uk)
Diseases11
  • St. Elizabeth Business Health offers complete business or leisure travel immunization consultations with a licensed physician utilizing the current information available on diseases and illnesses affecting travelers. (stelizabeth.com)
  • Integrated vector management (IVM) is an acknowledged strategy of choice for the prevention and control of vector-borne diseases. (who.int)
  • and the expansion of emerging and re-emerging vector-borne diseases. (who.int)
  • Prevention of vector borne diseases was the theme of World Health Day 2014 . (worldbank.org)
  • Furthermore, it is used for immunization and as a potential therapeutic for gene replacement therapy in various inherited or acquired diseases. (genengnews.com)
  • Mosquito and Vector Control utilizes abatement methods to reduce nuisance mosquito populations and lower the threat of mosquito-borne diseases. (countyofglenn.net)
  • Nurses work in communicable disease surveillance and control, teach and monitor bloodborne pathogen control, and advise on prevention of vector-borne diseases. (waldenu.edu)
  • The material in this report originated in the National Center for Immunization and Respiratory Diseases, Anne Schuchat, MD, Director. (cdc.gov)
  • In Uganda, we focus on vector-borne diseases including Crimean-Congo hemorrhagic fever and Rift Valley fever. (nih.gov)
  • I had the pleasure of attending this conference along with several colleagues from the National Center for Zoonotic, Vector-borne, and Enteric Diseases (NCZVED). (cdc.gov)
  • Immunization currently prevents 2-3 million deaths every year from diseases like diphtheria, tetanus, pertussis, influenza and measles. (who.int)
Advisory Committee2
  • Immunization of health-care workers: recommendations of the Advisory Committee on Immunization Practices [ACIP] and the Hospital Infection Control Practices Advisory Committee [HICPAC]. (cdc.gov)
  • This report updates the previously published summary of recommendations of the Advisory Committee on Immunization Practices (ACIP) and the Healthcare (formerly Hospital) Infection Control Practices Advisory Committee (HICPAC) for vaccinating health-care personnel (HCP) in the United States ( 1 ). (cdc.gov)
Vaccination5
  • Vaccination of BALB/c mice with DREP-GP, DREP-VP40, or DREP-GP+DREP-VP40 vectors, followed by immediate electroporation resulted in a mixed IgG subclass production, which recognized EBOV GP and/or VP40 proteins. (frontiersin.org)
  • Vaccination is the primary intervention used to curb influenza virus infection, and the WHO recommends immunization for at-risk individuals to mitigate disease. (mdpi.com)
  • At or preferably before the appointment, you will want to provide copies of all available immunization records (including the International Certificate of Vaccination, commonly referred to as the yellow card). (mayoclinic.org)
  • Three weeks after the second immunization, virus replication was reduced in mice best responding to vaccination by more than 3-logs compared to the control group. (nature.com)
  • Here we presented a rare case of acute vestibular neuritis after the adenoviral vector-based COVID-19 vaccination. (springer.com)
Lentiviral vector2
  • Scholars@Duke publication: Successful immunization with a single injection of non-integrating lentiviral vector. (duke.edu)
  • We evaluated the ability of an integrase (IN)-defective self-inactivating lentiviral vector (sinLV) for the delivery of human immunodeficiency virus-1 (HIV-1) envelope sequences in mice to elicit specific immune responses. (duke.edu)
Expressed by adenoviral1
  • Inserts were expressed by adenoviral and poxviral vectors and employed in heterologous prime-boost regimens. (ox.ac.uk)
Mice2
  • Direct injection of the OVA-, Ii-OVA-, or TfR-OVA-expressing vectors into mice resulted in a CD4 + T cell response, as shown by expansion of adoptively transferred OT-II T cells and upregulation of CD44 on these cells. (elsevierpure.com)
  • The Ii-OVA vector was the most potent inducer of IFN-γ-secreting CD4 + and CD8 + T cells and was the only vector to protect mice completely from challenge with OVA-expressing tumor cells. (elsevierpure.com)
Disease vector control1
  • Implementation of integrated vector management for disease vector control in the Eastern Mediterranean: where are we and where are we going? (who.int)
Adenoviral vectored1
  • In the present study, the immunogenicity and the protection induced by adenoviral vectored constructs formulated with the addition of LPS were assessed. (ox.ac.uk)
Antibody2
  • The IN-defective sinLV elicited specific and long-lasting immune responses, as evaluated up to 90 days from the immunization by enzyme-linked immunosorbent spot (ELISPOT) and intracellular staining (ICS) for interferon-gamma (IFN-gamma) assays in both splenocytes and bone marrow (BM) cells, chromium release assay in splenocytes, and antibody detection in sera, without integration of the vector into the host genome. (duke.edu)
  • Although previous data showed elevated levels of IgG antibodies in both boosting arms, regardless of ALVAC-HIV vector incorporation, the effect on shaping antibody effector function remains unclear. (nih.gov)
Borne disease3
  • In 2021, DVBD faced both vector-borne disease (VBD) threats and the COVID-19 pandemic. (cdc.gov)
  • Lyme disease is the most common vector-borne disease in the United States, affecting approximately 476,000 Americans every year. (cdc.gov)
  • Dengue is the main vector borne disease prevalent in Sri Lanka . (worldbank.org)
Mosquitoes2
  • Other vectors (lice, mosquitoes, some species of ticks, inanimate objects) can transmit the spirochete mechanically to a susceptible host whenever the piercing apparatus becomes contaminated with blood that contains Borrelia . (merckvetmanual.com)
  • BACKGROUND: The level of human exposure to arbovirus vectors, the Aedes mosquitoes, is mainly assessed by entomological methods which are labour intensive, difficult to sustain at a large scale and are affected if transmission and exposure levels are low. (bvsalud.org)
Gene delivery2
  • Dendrosomes have been explored as vectors in gene delivery and genetic immunization. (wikipedia.org)
  • 12 , 13 Nevertheless, independently of used gene delivery strategy, optimized and improved DNA vectors are essential and will boost the promising field of gene therapy further to the clinics. (genengnews.com)
Clinic2
  • This review summarizes different DNA vector modifications to enhance biological efficacy and efficiency of therapeutical vectors, aiming for low toxicity, high specificity, and biological efficacy-the cornerstones for successful translation of gene therapy into the clinic. (genengnews.com)
  • Clinic services provided by Public Health include immunizations (flu only). (countyofglenn.net)
20231
Responses1
  • We assessed memory space B-cell responses 2 weeks after the last around of immunization as previously referred to.30,35 Specifically, we assessed total IgG, IgM, and IgA-secreting cells, aswell as OSP-specific IgG, IgM, and IgA-secreting cells. (lacbiosafety.org)
Royalty-free1
  • Browse 100,500+ cold and flu stock illustrations and vector graphics available royalty-free, or search for child with a cold or sick to find more great stock images and vector art. (istockphoto.com)
Control2
  • and scaling up of vector control interventions through universal access. (who.int)
  • and Japanese encephalitis, which is well under control thanks to an immunization program. (worldbank.org)
Fever1
Efficacy2
  • This review summarizes different DNA vector modifications to enhance biological efficacy and efficiency of therapeutical vectors ( Figures 1 and 2 ). (genengnews.com)
  • Schematic overview of sequence regions that can be modified to improve efficacy of vectors. (genengnews.com)
Genetic2
  • Poly (propyleneimine) dendrosome based genetic immunization against Hepatitis B was found to be highly effective as compared to Dendrimer-Plasmid DNA complex. (wikipedia.org)
  • Gene therapy represents the delivery of therapeutic factors as genetic information encoded on a DNA vector and has also become a potent tool in tissue engineering and regenerative medicine. (genengnews.com)
Occur1
Human2
  • These results will affect surveillance studies of that white-tailed deer are a reservoir for the human agent vector and reservoir populations. (cdc.gov)
  • Immunization is a key component of primary health care and an indisputable human right. (who.int)
Recommendations1
  • Additionally, immunization recommendations differ for people who are moderately to severely immunocompromised. (medscape.com)
Potent1
  • Our review provides the means to either construct a potent gene therapeutic vector de novo or to specifically address a bottleneck in the chain of events mandatory for therapeutic success. (genengnews.com)
Refer1
Public Health1
Icons2
Virus1
  • Two different virus vector systems were evaluated. (europa.eu)
Temperature1
  • Thermometer vector icon with snow cold temperature scale for. (istockphoto.com)
Article2
  • Is the Subject Area "Passive immunization" applicable to this article? (plos.org)
  • Le présent article décrit et apporte la preuve des progrès réalisés par les pays de la Région OMS de la Méditerranée orientale dans l'adoption de cette stratégie et sa traduction en action à l'échelle nationale. (who.int)